ID   PTH_ANAVT               Reviewed;         213 AA.
AC   Q3M4P0;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 28.
DE   RecName: Full=Peptidyl-tRNA hydrolase;
DE            Short=PTH;
DE            EC=3.1.1.29;
GN   Name=pth; OrderedLocusNames=Ava_4448;
OS   Anabaena variabilis (strain ATCC 29413 / PCC 7937).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Anabaena.
OX   NCBI_TaxID=240292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.;
RT   "Complete sequence of Anabaena variabilis ATCC 29413.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The natural substrate for this enzyme may be peptidyl-
CC       tRNAs which drop off the ribosome during protein synthesis (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: N-substituted aminoacyl-tRNA + H(2)O = N-
CC       substituted amino acid + tRNA.
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the PTH family.
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DR   EMBL; CP000117; ABA24046.1; -; Genomic_DNA.
DR   RefSeq; YP_324941.1; -.
DR   GeneID; 3680382; -.
DR   GenomeReviews; CP000117_GR; Ava_4448.
DR   KEGG; ava:Ava_4448; -.
DR   NMPDR; fig|240292.3.peg.4963; -.
DR   HOGENOM; Q3M4P0; -.
DR   OMA; Q3M4P0; IKFKTGG.
DR   BioCyc; AVAR240292:AVA_4448-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004045; F:aminoacyl-tRNA hydrolase activity; IEA:HAMAP.
DR   GO; GO:0006412; P:translation; IEA:HAMAP.
DR   HAMAP; MF_00083; -; 1.
DR   InterPro; IPR001328; Pept_tRNA_hydro.
DR   InterPro; IPR018171; Pept_tRNA_hydro_CS.
DR   Gene3D; G3DSA:3.40.50.1470; Pept_tRNA_hydro; 1.
DR   PANTHER; PTHR17224; Pept_tRNA_hydro; 1.
DR   Pfam; PF01195; Pept_tRNA_hydro; 1.
DR   ProDom; PD005324; PeptRNAhydrolase; 1.
DR   TIGRFAMs; TIGR00447; pth; 1.
DR   PROSITE; PS01195; PEPT_TRNA_HYDROL_1; 1.
DR   PROSITE; PS01196; PEPT_TRNA_HYDROL_2; FALSE_NEG.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Hydrolase.
FT   CHAIN         1    213       Peptidyl-tRNA hydrolase.
FT                                /FTId=PRO_0000264002.
SQ   SEQUENCE   213 AA;  23077 MW;  71A8F069FBC03BBF CRC64;
     MTEPVTQPAL VIPQLIVGLG NPEPKYDQTR HNIGFAAVDA LARAWNISLA ENRKFQGQYG
     EGTAPGGVKI RLLKPLTYMN RSGQAIQAVT SWYKLSGESV LVIYDDLDLP LGKTRLRLSG
     SAGGHNGMKS AIAHLSTQNF PRLRIGIGKP KNAVNGDNSE TVSHVLGKFS ATETQLMSLV
     LQFVVECVEL SLKQGVEKAM NRCNSYTVEA PKS
//