ID   TRMB_ANAVT              Reviewed;         215 AA.
AC   Q3M3Q5;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=tRNA (guanine-N(7)-)-methyltransferase;
DE            EC=2.1.1.33;
DE   AltName: Full=tRNA(m7G46)-methyltransferase;
GN   Name=trmB; OrderedLocusNames=Ava_4784;
OS   Anabaena variabilis (strain ATCC 29413 / PCC 7937).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Anabaena.
OX   NCBI_TaxID=240292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.;
RT   "Complete sequence of Anabaena variabilis ATCC 29413.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the formation of N(7)-methylguanine at
CC       position 46 (m7G46) in tRNA (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-
CC       homocysteine + tRNA containing N(7)-methylguanine.
CC   -!- PATHWAY: tRNA modification; N(7)-methylguanine-tRNA biosynthesis.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. TrmB
CC       family.
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DR   EMBL; CP000117; ABA24381.1; -; Genomic_DNA.
DR   RefSeq; YP_325276.1; -.
DR   GeneID; 3679437; -.
DR   GenomeReviews; CP000117_GR; Ava_4784.
DR   KEGG; ava:Ava_4784; -.
DR   NMPDR; fig|240292.3.peg.3610; -.
DR   HOGENOM; Q3M3Q5; -.
DR   OMA; Q3M3Q5; KRRVVQP.
DR   BioCyc; AVAR240292:AVA_4784-MON; -.
DR   GO; GO:0008176; F:tRNA (guanine-N7-)-methyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006400; P:tRNA modification; IEA:HAMAP.
DR   HAMAP; MF_01057; -; 1.
DR   InterPro; IPR003358; tRNA_(Gua-N-7)_MeTrfase.
DR   PANTHER; PTHR23417:SF1; Methyltransf_4; 1.
DR   Pfam; PF02390; Methyltransf_4; 1.
DR   TIGRFAMs; TIGR00091; CHP91; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Methyltransferase; S-adenosyl-L-methionine;
KW   Transferase; tRNA processing.
FT   CHAIN         1    215       tRNA (guanine-N(7)-)-methyltransferase.
FT                                /FTId=PRO_0000229153.
FT   BINDING      43     43       S-adenosyl-L-methionine (By similarity).
FT   BINDING      68     68       S-adenosyl-L-methionine (By similarity).
FT   BINDING      95     95       S-adenosyl-L-methionine (By similarity).
FT   BINDING     121    121       S-adenosyl-L-methionine (By similarity).
FT   BINDING     125    125       Substrate (By similarity).
FT   BINDING     157    157       Substrate (Potential).
SQ   SEQUENCE   215 AA;  24541 MW;  EA13CC417B1D94D9 CRC64;
     MSALPFVRVR QHVNPLAQKY LTPANPLEWE KVYSSPHQPL HLDIGCARGR FVLQMAQVEP
     RWNFLGLEIR EPLVIEANQF RSQLGLSNLH YLYCNANNSL QPLLSSLPTG ILQRVTIQFP
     DPWFKTRHAK RRVVQPELVQ DIANYLAVGG VVFLQSDMEF VAVEMCDRFA ANPAFKKVGS
     GEWLSENPLP VATERETTTQ NRGEPVYRAL FERIS
//