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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei637ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAVAR240292:G7WH-5980-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Ava_4936
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeTrichormus
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000092891 – 872Leucine--tRNA ligaseAdd BLAST872

Proteomic databases

PRIDEiQ3M3A3

Interactioni

Protein-protein interaction databases

STRINGi240292.Ava_4936

Structurei

3D structure databases

ProteinModelPortaliQ3M3A3
SMRiQ3M3A3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi634 – 638"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q3M3A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSRYNPAIL EEKWQKTWVE LGLDKTQTQS NKPKFYALSM FPYPSGSLHM
60 70 80 90 100
GHVRNYTITD VIARLKRMQG YRVLHPMGWD AFGLPAENAA IDRGVPPANW
110 120 130 140 150
TYQNITQMRQ QLQRLGLSID WDSEVATCSP DYYKWTQWIF LQFLQAGLAY
160 170 180 190 200
QKEAAVNWDP IDQTVLANEQ VDNEGRSWRS GAIVERKLLR QWFLKITDYA
210 220 230 240 250
EELLNDLDKL TGWPERVKLM QANWIGKSVG AYLEFPIVGS TEKIAVYTTR
260 270 280 290 300
PDTVYGVSYV VLAPEHPLTK QVTSKTQQAV VDTFIQEVTN QSELERTAED
310 320 330 340 350
KPKRGVATGG KAINPFTGEE VPIWIADYVL YEYGTGAVMG VPAHDVRDFK
360 370 380 390 400
FAQRYDLPID FVIAAPDDVA GFDLSPTSET EEVTQVVQIE YNQAYTEPGI
410 420 430 440 450
LINSGAFTGM TSTDAKQAIV KYATEKGFGK ERIQYRLRDW LISRQRYWGA
460 470 480 490 500
PIPVIHCPNC GIVPVPDKDL PVILPEEVEF TGRGGSPLAQ LESWVNVPCP
510 520 530 540 550
TCGSPAKRET DTMDTFIDSS WYFLRFTDAR NEAQVFESAK TNDWMPVDQY
560 570 580 590 600
VGGIEHAILH LLYSRFFTKV LRDRGLLNFD EPFERLLTQG MVQGLTYFNP
610 620 630 640 650
NKGGKDKWVP SHLVNPNDPR DPQTGEPLQR LYATMSKSKG NGVAPEDVIA
660 670 680 690 700
KYGVDTARMF ILFKAPPEKD LEWDEADVEG QFRFLNRVWR LVTDYVASGV
710 720 730 740 750
NPKNKSGELS KSEKDLRRAI HSAIQSVTED LEDEYQFNTA ISELMKLSNA
760 770 780 790 800
LTDANGKDSR VYAEGIHTLV VLLAPFAPHI AEELWQLLGN SESVHTQTWP
810 820 830 840 850
AFDPAALVAD EITLVIQVNG KKRADIQVPS QADKAELEKY ARESEVVQRH
860 870
LEGKEIKKVI VVPGKLVNFV VG
Length:872
Mass (Da):98,513
Last modified:October 25, 2005 - v1
Checksum:i20AB279E2EC4045C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000117 Genomic DNA Translation: ABA24533.1

Genome annotation databases

EnsemblBacteriaiABA24533; ABA24533; Ava_4936
KEGGiava:Ava_4936

Entry informationi

Entry nameiSYL_ANAVT
AccessioniPrimary (citable) accession number: Q3M3A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2005
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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