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Q3M343 (Q3M343_ANAVT) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Coproporphyrinogen-III oxidase, aerobic 2 HAMAP MF_00333
Short name=Coprogen oxidase 2 HAMAP MF_00333
Short name=Coproporphyrinogenase 2 HAMAP MF_00333
EC=1.3.3.3 HAMAP MF_00333
Gene names
Name:hemF2 HAMAP MF_00333
Ordered Locus Names:Ava_4996
OrganismAnabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]
Taxonomic identifier240292 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333 SAAS SAAS018375

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333 SAAS SAAS018375

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333 SAAS SAAS018375

Subunit structure

Homodimer By similarity. HAMAP MF_00333 SAAS SAAS018375

Subcellular location

Cytoplasm By similarity HAMAP MF_00333.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family. HAMAP MF_00333

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region75 – 8410Important for dimerization By similarity HAMAP MF_00333
Region135 – 1373Substrate binding By similarity HAMAP MF_00333
Region287 – 32236Important for dimerization By similarity HAMAP MF_00333
Region305 – 3106Substrate binding By similarity HAMAP MF_00333

Sites

Active site1331Proton donor By similarity HAMAP MF_00333
Binding site1191Substrate By similarity HAMAP MF_00333
Site1971Important for dimerization By similarity HAMAP MF_00333

Sequences

Sequence LengthMass (Da)Tools
Q3M343 [UniParc].

Last modified October 25, 2005. Version 1.
Checksum: 2200A290FD30FA4B

FASTA34740,006
        10         20         30         40         50         60 
MGRHSDNSLQ ESPNHTELLI SPTNTIPKDS RQRSQQFMQN LQDEICTALE QIDGKASFHQ 

        70         80         90        100        110        120 
DYWERAEGGE GRTRVIREGR VFEQGGVNFS AVWGNSLPAS ILAQRPEAAG HEFFATGTSM 

       130        140        150        160        170        180 
VLHPRNPYVP TVHLNYRYFE AGPIWWFGGG ADLTPYYAFE EDAVHFHQTL KNACDVHNPE 

       190        200        210        220        230        240 
YYPAFKRWCD EYFYLRHRQE QRGIGGIFFD YQDASGKLYI GTQADSPAAI YSQKVGNVTR 

       250        260        270        280        290        300 
NWEDIFAFVQ SCGQAFLPAY LPIVERRQAT EYGDRQRNFQ LYRRGRYVEF NLVYDRGTVF 

       310        320        330        340 
GLQTKGRTES ILMSLPPLAR WEYCYEPKAG SPEAELTEVF LQPRDWA

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References

[1]"Complete sequence of Anabaena variabilis ATCC 29413."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29413 / PCC 7937.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000117 Genomic DNA. Translation: ABA24593.1.
RefSeqYP_325488.1. NC_007413.1.

3D structure databases

ProteinModelPortalQ3M343.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3M343.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3679048.
GenomeReviewsGene locus Ava_4996 in contig CP000117_GR.
KEGGava:Ava_4996.
NMPDRfig|240292.3.peg.3598.
PATRIC35431545. VBIAnaVar43351_6289.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0408.
HOGENOMHBG631180.
OMAGKEPVWW.
PhylomeDBQ3M343.
ProtClustDBPRK05330.

Family and domain databases

HAMAPMF_00333. Coprogen_oxidas.
[Tree]
InterProIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
KOK00228.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 2 hits.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
SUPFAMSSF102886. Coprogen_oxidas. 1 hit.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ3M343_ANAVT
AccessionPrimary (citable) accession number: Q3M343
Entry history
Integrated into UniProtKB/TrEMBL: October 25, 2005
Last sequence update: October 25, 2005
Last modified: December 14, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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