ID   HIS3_ANAVT              Reviewed;         116 AA.
AC   Q3M244;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=Phosphoribosyl-AMP cyclohydrolase;
DE            Short=PRA-CH;
DE            EC=3.5.4.19;
GN   Name=hisI; OrderedLocusNames=Ava_B0230;
OS   Anabaena variabilis (strain ATCC 29413 / PCC 7937).
OG   Plasmid pAnaA.
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Anabaena.
OX   NCBI_TaxID=240292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.;
RT   "Complete sequence of plasmid A of Anabaena variabilis ATCC 29413.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-AMP + H(2)O = 1-(5-
CC       phosphoribosyl)-5-((5-
CC       phosphoribosylamino)methylideneamino)imidazole-4-carboxamide.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the PRA-CH family.
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DR   EMBL; CP000119; ABA24942.1; -; Genomic_DNA.
DR   RefSeq; YP_320131.1; -.
DR   GeneID; 3677698; -.
DR   GenomeReviews; CP000119_GR; Ava_B0230.
DR   KEGG; ava:Ava_B0230; -.
DR   NMPDR; fig|240292.3.peg.5510; -.
DR   HOGENOM; Q3M244; -.
DR   OMA; Q3M244; LWLKGES.
DR   BioCyc; AVAR240292:AVA_B0230-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004635; F:phosphoribosyl-AMP cyclohydrolase activity; IEA:HAMAP.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_01021; -; 1.
DR   InterPro; IPR002496; PRA_CycHdrlase.
DR   Pfam; PF01502; PRA-CH; 1.
DR   ProDom; PD002610; PRA_cyclohydro; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW   Histidine biosynthesis; Hydrolase; Plasmid.
FT   CHAIN         1    116       Phosphoribosyl-AMP cyclohydrolase.
FT                                /FTId=PRO_0000229807.
SQ   SEQUENCE   116 AA;  13300 MW;  4A4E8E2D4E658B88 CRC64;
     MNQNLLWFEK LKFNNQDLIP AIAQDYRDGT VLMMAWMNSE SIQKTLSTGE AHYWSRSRSQ
     LWHKGATSGH IQKVKELFYD CDGDTILLKV EQIGDIACHT GARSCFFNAV PIYPQS
//