ID   Q3M1D8_TRIV2            Unreviewed;      2361 AA.
AC   Q3M1D8;
DT   25-OCT-2005, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2005, sequence version 1.
DT   27-MAR-2024, entry version 124.
DE   SubName: Full=Serine/threonine protein kinase and signal transduction histidine kinase with GAF and PAS/PAC sensor {ECO:0000313|EMBL:ABA25205.1};
DE            EC=2.7.11.1 {ECO:0000313|EMBL:ABA25205.1};
DE            EC=2.7.13.3 {ECO:0000313|EMBL:ABA25205.1};
GN   OrderedLocusNames=Ava_C0117 {ECO:0000313|EMBL:ABA25205.1};
OS   Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis).
OG   Plasmid pAnaC {ECO:0000313|Proteomes:UP000002533}.
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae;
OC   Trichormus.
OX   NCBI_TaxID=240292 {ECO:0000313|EMBL:ABA25205.1, ECO:0000313|Proteomes:UP000002533};
RN   [1] {ECO:0000313|Proteomes:UP000002533}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29413 / PCC 7937 {ECO:0000313|Proteomes:UP000002533};
RX   PubMed=25197444; DOI=10.4056/sigs.3899418;
RA   Thiel T., Pratte B.S., Zhong J., Goodwin L., Copeland A., Lucas S., Han C.,
RA   Pitluck S., Land M.L., Kyrpides N.C., Woyke T.;
RT   "Complete genome sequence of Anabaena variabilis ATCC 29413.";
RL   Stand. Genomic Sci. 9:562-573(2014).
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DR   EMBL; CP000121; ABA25205.1; -; Genomic_DNA.
DR   KEGG; ava:Ava_C0117; -.
DR   eggNOG; COG0515; Bacteria.
DR   eggNOG; COG2203; Bacteria.
DR   eggNOG; COG3899; Bacteria.
DR   eggNOG; COG4585; Bacteria.
DR   HOGENOM; CLU_000445_34_1_3; -.
DR   Proteomes; UP000002533; Plasmid pAnaC.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR   CDD; cd00130; PAS; 4.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 1.20.5.1930; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 5.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013656; PAS_4.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR013655; PAS_fold_3.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR   NCBIfam; TIGR00229; sensory_box; 5.
DR   PANTHER; PTHR43642; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G; 1.
DR   PANTHER; PTHR43642:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF01590; GAF; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF07730; HisKA_3; 1.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF08447; PAS_3; 1.
DR   Pfam; PF08448; PAS_4; 2.
DR   Pfam; PF13426; PAS_9; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00065; GAF; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00086; PAC; 4.
DR   SMART; SM00091; PAS; 5.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 5.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50113; PAC; 4.
DR   PROSITE; PS50112; PAS; 4.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ABA25205.1};
KW   Membrane {ECO:0000256|SAM:Phobius}; Plasmid {ECO:0000313|EMBL:ABA25205.1};
KW   Serine/threonine-protein kinase {ECO:0000313|EMBL:ABA25205.1};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ABA25205.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT   TRANSMEM        915..939
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          7..271
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          1505..1541
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          1584..1636
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          1655..1709
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          1737..1789
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          1864..1912
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          1913..1985
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          1989..2042
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          2043..2112
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          2174..2361
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
SQ   SEQUENCE   2361 AA;  266086 MW;  C106EDFCF5840B70 CRC64;
     MITLPGIAIQ NKIYESSNSL VYRGIREDGV EIVVKMLKLD YPSPQELTRY RQEYKIIRSL
     NLEGVIKAYS QQDYQRTLVI LLEDFGGESL EKWMQKRPDI FCPMPLSTFL GIAIALCDIL
     GRIHAANIIH KDINPGNIVF NLDTGVVKII DFGVATQFNR TNPTFKSPHV LEGTLAYLSP
     EQTGRMNRML DYRTDFYSLG VTFYELLTGQ LPFPTQDILE LVHCHIAKPP IPVHELNATI
     PKPISGIILK LMAKNAEDRY QSAWGIKADL ERCAGQLAEM GQINAMSLGL QDVSEQFCIP
     QKLYGREVQT KALLAAFDRV ARKETFGEIC QLESGIENAQ FNVELMLVAG YAGVGKTALV
     QELYKPITAK HGYFISGKFD QFRRNIPYSA IVDALQKLVQ QLLGEPDEQV QQWQERLLTA
     LGSNGQIIID VIPEVELIIG KQPPVPEVGA TEAQNRFNRI FQNFVRVFCS KEHPLVIFLD
     DLQWSDSATL KLIELILLDE QTHYLFLIGA YRDSEVHPTH PLVLTLLELR NQGAVLQEIT
     LAPLTLEPLS QLIAETLGRN IDTVRSLAQL VLRKTEGNPF FVGEFLRMLY SENLLIFNAK
     QLSWQWDIAQ IQARNITDNV VELLLLQLKK LPNETRQILR LAACVGSEFD LETLAIACEK
     SPKIISLDLL AAINAGLIQP LSELDENLLV QDYKFLHDRV QQAAYALIDE SHKQVVHLQI
     GGNLLEKTSP EQRSDRLFEI IDHLNQGLEL VTARSERTEI ARLNLMAGQK AKAATAYEAA
     FKYFTTGLKL LNWESWLSEY DLTLTLYSEA AEAAYLQGCF DEMEQLVEVV LARAKTVVDK
     VQVYDSSIQR YLSQGNLKEA LKIGLEVLKL LGVILPENPS ELDVQGGLES TAALLAQREI
     EDLSNLPEMT APEPLAAMSI LANIGAAAFI VSPALFMLIT CKTVNLSINY GNAIWSPLYY
     AGYGFVLCGV VQDIELGYKF GQLALSLAER LNTKKGKAKA LQLFSDHVMQ WKVHLKETIP
     LLVEAYQEGV ETGDFETAGY AAYDVCYNSF FVGESLTQLE QKTATYSKAV DRIRRESPST
     WIAIVWQTIL NLLDRSLNPS RLVGRVCNEE QALPHALAVK DGTAIQMLYL HKVILCYLFE
     EYHQAVQTAI LARQHFEEVT AIKVLPVFCF YHSLTLLSLL LDASNSEKLA LLNCVNTNQE
     KMQKWAEHAP MNYLHKFYLV EAEKARVLGQ FLEAEELYEQ AIAGAAENEY IQEEALTYEL
     AAKHYLARGR SKIAQTYMKE AHYCYDRWGA IAKVKDLETR YPQFFSQSSR AASTSIPTTA
     ATISNPFHTA FDLAAVMKAS QAISREIELK QLLRSLMQTL IENAGAQTGY LILENSEEWS
     IEAACELNTD ENACATQVLQ SIPIADQLPE SIIQYVIRTL KAVTLNDATR EGAFINEPYI
     QQNQPQSIFC LPLLNQAKLV GVLYLENRLA AGVFTPERSQ VLQLLSTQAA IAIENANLYS
     ELRAKESKIT QFLEAIPVGI AIVDAEGRPY YTNQCGNQLT GKETDTSIAP EQFSEAYQLY
     VAGTDQIYPA ESLPIVRALR GERIRTEDIE IRRDHVSILI EARGTPVFDR QGNITYAIAT
     FQDITERKQA EKLLADYNCT LEQQVAERTA ALRQSEANYR NLIQTANSII LRTDRQGRIR
     YMNDYGLSFF GYEEDQILGR TLLETIVPET ETSGRDLKQF VHDLFHNLEA PLPQAYLQTE
     NENLCRNGRR VWIAWSNQAI FNEQGDVVEI LSVGNDTTQR RQAEEALQRS EAKFRNIFEN
     SQVGIFRTRL SDGLLLDANQ RYANLLGFDS SEEMIGLEHA TDYYLNTSDR QQFLEVLKRD
     REVRSYEAQG RKRDGTVFWG LFSAYLNADD DYIEGVIADI SDLKQTEAAL QTSEERLRLA
     LTASNQGLYD FDLKTEERIV NPEYALMLGY DPATFHETIP EWIARLHPDD RESVVATYRA
     CITGEIPNFQ VEYRLRTQDG QWKWIRSVGK IVTWNESGEP IRALGVVTDI NDRKQAEAAL
     QASEAELRAL FSAIPDPLFV FSAEGRFLEI MVLERNLLWQ PFEEMIGKTM HQLGREEADE
     FLGYIQQVLR TQQILTVEYG AFLNGREMWF SARIAPISHD QVIWLVRDIT AQKQAEEASI
     LEERNRMARE IHDTLAQAFT GILAQVGAAK QVLTDDVEAA QAHLDLIKEL ARTGLTEARR
     SVIALRPQLL EEGSLQSALH RLVAQIRAAA TDTTLYYEIE GAVYSLPTEV ENNLLRIGQE
     ALTNAIRYAN ADEIRVELVY DRDQFCLRVR DNGQGFGVGS ISASEGFGLL GMSERAERIG
     AQLTIRSQPG QGTEIIVTVN P
//