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Protein
Submitted name:

Serine/threonine protein kinase and signal transduction histidine kinase with GAF and PAS/PAC sensor

Gene

Ava_C0117

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphorelay sensor kinase activity Source: InterPro
  3. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseImported, Transferase

Keywords - Biological processi

Two-component regulatory systemSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciAVAR240292:GCY3-5601-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Serine/threonine protein kinase and signal transduction histidine kinase with GAF and PAS/PAC sensorImported (EC:2.7.11.1Imported, EC:2.7.13.3Imported)
Gene namesi
Ordered Locus Names:Ava_C0117Imported
Encoded oniPlasmid pAnaCImported
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)Imported
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena
ProteomesiUP000002533: Plasmid pAnaC

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi240292.Ava_C0117.

Structurei

3D structure databases

ProteinModelPortaliQ3M1D8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0515.
KOiK00903.
OMAiRIHAANI.
OrthoDBiEOG6HTNS7.

Family and domain databases

Gene3Di3.30.450.40. 1 hit.
3.30.565.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003594. HATPase_C.
IPR011009. Kinase-like_dom.
IPR027417. P-loop_NTPase.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR013656. PAS_4.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
IPR000719. Prot_kinase_dom.
IPR011712. Sig_transdc_His_kin_sub3_dim/P.
IPR005467. Sig_transdc_His_kinase_core.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02518. HATPase_c. 1 hit.
PF07730. HisKA_3. 1 hit.
PF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
PF08448. PAS_4. 1 hit.
PF13188. PAS_8. 1 hit.
PF13426. PAS_9. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00065. GAF. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00086. PAC. 4 hits.
SM00091. PAS. 5 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF55781. SSF55781. 1 hit.
SSF55785. SSF55785. 5 hits.
SSF55874. SSF55874. 1 hit.
SSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 5 hits.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50113. PAC. 4 hits.
PS50112. PAS. 4 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3M1D8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MITLPGIAIQ NKIYESSNSL VYRGIREDGV EIVVKMLKLD YPSPQELTRY
60 70 80 90 100
RQEYKIIRSL NLEGVIKAYS QQDYQRTLVI LLEDFGGESL EKWMQKRPDI
110 120 130 140 150
FCPMPLSTFL GIAIALCDIL GRIHAANIIH KDINPGNIVF NLDTGVVKII
160 170 180 190 200
DFGVATQFNR TNPTFKSPHV LEGTLAYLSP EQTGRMNRML DYRTDFYSLG
210 220 230 240 250
VTFYELLTGQ LPFPTQDILE LVHCHIAKPP IPVHELNATI PKPISGIILK
260 270 280 290 300
LMAKNAEDRY QSAWGIKADL ERCAGQLAEM GQINAMSLGL QDVSEQFCIP
310 320 330 340 350
QKLYGREVQT KALLAAFDRV ARKETFGEIC QLESGIENAQ FNVELMLVAG
360 370 380 390 400
YAGVGKTALV QELYKPITAK HGYFISGKFD QFRRNIPYSA IVDALQKLVQ
410 420 430 440 450
QLLGEPDEQV QQWQERLLTA LGSNGQIIID VIPEVELIIG KQPPVPEVGA
460 470 480 490 500
TEAQNRFNRI FQNFVRVFCS KEHPLVIFLD DLQWSDSATL KLIELILLDE
510 520 530 540 550
QTHYLFLIGA YRDSEVHPTH PLVLTLLELR NQGAVLQEIT LAPLTLEPLS
560 570 580 590 600
QLIAETLGRN IDTVRSLAQL VLRKTEGNPF FVGEFLRMLY SENLLIFNAK
610 620 630 640 650
QLSWQWDIAQ IQARNITDNV VELLLLQLKK LPNETRQILR LAACVGSEFD
660 670 680 690 700
LETLAIACEK SPKIISLDLL AAINAGLIQP LSELDENLLV QDYKFLHDRV
710 720 730 740 750
QQAAYALIDE SHKQVVHLQI GGNLLEKTSP EQRSDRLFEI IDHLNQGLEL
760 770 780 790 800
VTARSERTEI ARLNLMAGQK AKAATAYEAA FKYFTTGLKL LNWESWLSEY
810 820 830 840 850
DLTLTLYSEA AEAAYLQGCF DEMEQLVEVV LARAKTVVDK VQVYDSSIQR
860 870 880 890 900
YLSQGNLKEA LKIGLEVLKL LGVILPENPS ELDVQGGLES TAALLAQREI
910 920 930 940 950
EDLSNLPEMT APEPLAAMSI LANIGAAAFI VSPALFMLIT CKTVNLSINY
960 970 980 990 1000
GNAIWSPLYY AGYGFVLCGV VQDIELGYKF GQLALSLAER LNTKKGKAKA
1010 1020 1030 1040 1050
LQLFSDHVMQ WKVHLKETIP LLVEAYQEGV ETGDFETAGY AAYDVCYNSF
1060 1070 1080 1090 1100
FVGESLTQLE QKTATYSKAV DRIRRESPST WIAIVWQTIL NLLDRSLNPS
1110 1120 1130 1140 1150
RLVGRVCNEE QALPHALAVK DGTAIQMLYL HKVILCYLFE EYHQAVQTAI
1160 1170 1180 1190 1200
LARQHFEEVT AIKVLPVFCF YHSLTLLSLL LDASNSEKLA LLNCVNTNQE
1210 1220 1230 1240 1250
KMQKWAEHAP MNYLHKFYLV EAEKARVLGQ FLEAEELYEQ AIAGAAENEY
1260 1270 1280 1290 1300
IQEEALTYEL AAKHYLARGR SKIAQTYMKE AHYCYDRWGA IAKVKDLETR
1310 1320 1330 1340 1350
YPQFFSQSSR AASTSIPTTA ATISNPFHTA FDLAAVMKAS QAISREIELK
1360 1370 1380 1390 1400
QLLRSLMQTL IENAGAQTGY LILENSEEWS IEAACELNTD ENACATQVLQ
1410 1420 1430 1440 1450
SIPIADQLPE SIIQYVIRTL KAVTLNDATR EGAFINEPYI QQNQPQSIFC
1460 1470 1480 1490 1500
LPLLNQAKLV GVLYLENRLA AGVFTPERSQ VLQLLSTQAA IAIENANLYS
1510 1520 1530 1540 1550
ELRAKESKIT QFLEAIPVGI AIVDAEGRPY YTNQCGNQLT GKETDTSIAP
1560 1570 1580 1590 1600
EQFSEAYQLY VAGTDQIYPA ESLPIVRALR GERIRTEDIE IRRDHVSILI
1610 1620 1630 1640 1650
EARGTPVFDR QGNITYAIAT FQDITERKQA EKLLADYNCT LEQQVAERTA
1660 1670 1680 1690 1700
ALRQSEANYR NLIQTANSII LRTDRQGRIR YMNDYGLSFF GYEEDQILGR
1710 1720 1730 1740 1750
TLLETIVPET ETSGRDLKQF VHDLFHNLEA PLPQAYLQTE NENLCRNGRR
1760 1770 1780 1790 1800
VWIAWSNQAI FNEQGDVVEI LSVGNDTTQR RQAEEALQRS EAKFRNIFEN
1810 1820 1830 1840 1850
SQVGIFRTRL SDGLLLDANQ RYANLLGFDS SEEMIGLEHA TDYYLNTSDR
1860 1870 1880 1890 1900
QQFLEVLKRD REVRSYEAQG RKRDGTVFWG LFSAYLNADD DYIEGVIADI
1910 1920 1930 1940 1950
SDLKQTEAAL QTSEERLRLA LTASNQGLYD FDLKTEERIV NPEYALMLGY
1960 1970 1980 1990 2000
DPATFHETIP EWIARLHPDD RESVVATYRA CITGEIPNFQ VEYRLRTQDG
2010 2020 2030 2040 2050
QWKWIRSVGK IVTWNESGEP IRALGVVTDI NDRKQAEAAL QASEAELRAL
2060 2070 2080 2090 2100
FSAIPDPLFV FSAEGRFLEI MVLERNLLWQ PFEEMIGKTM HQLGREEADE
2110 2120 2130 2140 2150
FLGYIQQVLR TQQILTVEYG AFLNGREMWF SARIAPISHD QVIWLVRDIT
2160 2170 2180 2190 2200
AQKQAEEASI LEERNRMARE IHDTLAQAFT GILAQVGAAK QVLTDDVEAA
2210 2220 2230 2240 2250
QAHLDLIKEL ARTGLTEARR SVIALRPQLL EEGSLQSALH RLVAQIRAAA
2260 2270 2280 2290 2300
TDTTLYYEIE GAVYSLPTEV ENNLLRIGQE ALTNAIRYAN ADEIRVELVY
2310 2320 2330 2340 2350
DRDQFCLRVR DNGQGFGVGS ISASEGFGLL GMSERAERIG AQLTIRSQPG
2360
QGTEIIVTVN P
Length:2,361
Mass (Da):266,086
Last modified:October 25, 2005 - v1
Checksum:iC106EDFCF5840B70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000121 Genomic DNA. Translation: ABA25205.1.
RefSeqiWP_011316785.1. NC_007412.1.
YP_320394.1. NC_007412.1.

Genome annotation databases

EnsemblBacteriaiABA25205; ABA25205; Ava_C0117.
GeneIDi3677825.
KEGGiava:Ava_C0117.
PATRICi35419948. VBIAnaVar43351_0549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000121 Genomic DNA. Translation: ABA25205.1.
RefSeqiWP_011316785.1. NC_007412.1.
YP_320394.1. NC_007412.1.

3D structure databases

ProteinModelPortaliQ3M1D8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi240292.Ava_C0117.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA25205; ABA25205; Ava_C0117.
GeneIDi3677825.
KEGGiava:Ava_C0117.
PATRICi35419948. VBIAnaVar43351_0549.

Phylogenomic databases

eggNOGiCOG0515.
KOiK00903.
OMAiRIHAANI.
OrthoDBiEOG6HTNS7.

Enzyme and pathway databases

BioCyciAVAR240292:GCY3-5601-MONOMER.

Family and domain databases

Gene3Di3.30.450.40. 1 hit.
3.30.565.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003594. HATPase_C.
IPR011009. Kinase-like_dom.
IPR027417. P-loop_NTPase.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR013656. PAS_4.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
IPR000719. Prot_kinase_dom.
IPR011712. Sig_transdc_His_kin_sub3_dim/P.
IPR005467. Sig_transdc_His_kinase_core.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02518. HATPase_c. 1 hit.
PF07730. HisKA_3. 1 hit.
PF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
PF08448. PAS_4. 1 hit.
PF13188. PAS_8. 1 hit.
PF13426. PAS_9. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00065. GAF. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00086. PAC. 4 hits.
SM00091. PAS. 5 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF55781. SSF55781. 1 hit.
SSF55785. SSF55785. 5 hits.
SSF55874. SSF55874. 1 hit.
SSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 5 hits.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50113. PAC. 4 hits.
PS50112. PAS. 4 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of plasmid C of Anabaena variabilis ATCC 29413."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiQ3M1D8_ANAVT
AccessioniPrimary (citable) accession number: Q3M1D8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 25, 2005
Last sequence update: October 25, 2005
Last modified: February 4, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported, PlasmidImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.