Unreviewed, UniProtKB/TrEMBL Q3LX95 (Q3LX95_HUMAN)

Names and origin

Protein names

Submitted name:
    Serine protease inhibitor Kazal-type 5 short isoform EMBL ABA06536.1

Gene names

Name:

SPINK5 EMBL ABA06536.1

Organism

Homo sapiens (Human) EMBL ABA06536.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	916 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

Ontologies

Keywords
Molecular function	Hydrolase Protease
Gene Ontology (GO)
Molecular function	peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q3LX95-1 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: 30A4C74BDE062114	FASTA	916	104,073
	10 20 30 40 50 60 MKIATVSVLL PLALCLIQDA ASKNEDQEMC HEFQAFMKNG KLFCPQDKKF FQSLDGIMFI 70 80 90 100 110 120 NKCATCKMIL EKEAKSQKRA RHLARAPKAT APTELNCDDF KKGERDGDFI CPDYYEAVCG 130 140 150 160 170 180 TDGKTYDNRC ALCAENAKTG SQIGVKSEGE CKSSNPEQDV CSAFRPFVRD GRLGCTREND 190 200 210 220 230 240 PVLGPDGKTH GNKCAMCAEL FLKEAENAKR EGETRIRRNA EKDFCKEYEK QVRNGRLFCT 250 260 270 280 290 300 RESDPVRGPD GRMHGNKCAL CAEIFKRRFS EENSKTDQNL GKAEEKTKVK REIVKLCSQY 310 320 330 340 350 360 QNQAKNGILF CTRENDPIRG PDGKMHGNLC SMCQVYFQAE NEEKKKAEAR ARNKRESGKA 370 380 390 400 410 420 TSYAELCNEY RKLVRNGKLA CTRENDPIQG PDGKVHGNTC SMCEVFFQAE EEEKKKKEGE 430 440 450 460 470 480 SRNKRQSKST ASFEELCSEY RKSRKNGRLF CTRENDPIQG PDGKMHGNTC SMCEAFFQQE 490 500 510 520 530 540 ERARAKAKRE AAKEICSEFR DQVRNGTLIC TREHNPVRGP DGKMHGNKCA MCASVFKLEE 550 560 570 580 590 600 EEKKNDKEEK GKVEAEKVKR EAVQELCSEY RHYVRNGRLP CTRENDPIEG LDGKIHGNTC 610 620 630 640 650 660 SMCEAFFQQE AKEKERAEPR AKVKREAEKE TCDEFRRLLQ NGKLFCTREN DPVRGPDGKT 670 680 690 700 710 720 HGNKCAMCKA VFQKENEERK RKEEEDQRNA AGHGSSGGGG GNTQDECAEY QEQMKNGRLS 730 740 750 760 770 780 CTRESDPVRD ADGKSYNNQC TMCKAKLERE AERKNEYSRS RSNGTGSESG KDTCDEFRSQ 790 800 810 820 830 840 MKNGKLICTR ESDPVRGPDG KTHGNKCTMC KEKLEREAAE KKKKEDEDRS NTGERSNTGE 850 860 870 880 890 900 RSNDKEDLCR EFRSMQRNGK LICTRENNPV RGPYGKMHIN KCAMCQSIFD REANERKKKD 910 EEKSSSKPSN NAKVIY

References

[1]	"SPINK5, the defective gene in netherton syndrome, encodes multiple LEKTI isoforms derived from alternative pre-mRNA processing." Tartaglia-Polcini A., Bonnart C., Micheloni A., Cianfarani F., Andre A., Zambruno G., Hovnanian A., D'Alessio M. J. Invest. Dermatol. 126:315-324(2006) [PubMed: 16374478] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	Tartaglia Polcini A., Zambruno G., D'Alessio M. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ149929 mRNA. Translation: ABA06536.1.
RefSeq	NP_001121171.1.
UniGene	Hs.331555
3D structure databases
SMR	Q3LX95. Positions 23-77, 356-423, 426-478.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000133710. Homo sapiens. [Contig view]
GeneID	11005.
Organism-specific databases
HGNC	HGNC:15464. SPINK5.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q3LX95.
Gene expression databases
ArrayExpress	Q3LX95.
Family and domain databases
InterPro	IPR002350. Prot_inh_Kazal. IPR011497. Prot_Inh_Kazal_2. [Graphical view]
Pfam	PF07648. Kazal_2. 13 hits. [Graphical view]
SMART	SM00280. KAZAL. 12 hits. [Graphical view]
PROSITE	PS00282. KAZAL. 1 hit. [Graphical view]

Entry information

Entry name

Q3LX95_HUMAN

Accession

Primary (citable) accession number: Q3LX95

Entry history

Integrated into UniProtKB/TrEMBL:	October 25, 2005
Last sequence update:	October 25, 2005
Last modified:	September 23, 2008
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)