Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine zipper putative tumor suppressor 2

Gene

Lzts2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.UniRule annotation2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine zipper putative tumor suppressor 2UniRule annotation
Alternative name(s):
Protein LAPSER1UniRule annotation
Gene namesi
Name:Lzts2
Synonyms:Lapser1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359249. Lzts2.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB-HAMAP
  • cytoplasm Source: UniProtKB-SubCell
  • microtubule Source: UniProtKB-KW
  • midbody Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670Leucine zipper putative tumor suppressor 2PRO_0000367896Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei249 – 2491PhosphoserineBy similarity
Modified residuei296 – 2961PhosphoserineCombined sources
Modified residuei571 – 5711PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3LUD4.
PRIDEiQ3LUD4.

PTM databases

iPTMnetiQ3LUD4.
PhosphoSiteiQ3LUD4.

Interactioni

Subunit structurei

Interacts with CTNNB1 (By similarity). Interacts with KATNB1. Also interacts with gamma-tubulin and KIF23.By similarity2 Publications

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042095.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 333333Required for centrosomal localizationBy similarityAdd
BLAST
Regioni448 – 670223Sufficient for interaction with CTNNB1By similarityAdd
BLAST
Regioni451 – 670220Sufficient for interaction with KATNB1 and for inhibition of katanin-mediated microtubule severingBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili329 – 650322UniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi632 – 64110Nuclear export signalUniRule annotation

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi188 – 306119Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the LZTS2 family.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGJE. Eukaryota.
ENOG4111JZA. LUCA.
HOGENOMiHOG000230889.
HOVERGENiHBG052381.
InParanoidiQ3LUD4.
PhylomeDBiQ3LUD4.

Family and domain databases

HAMAPiMF_03026. LZTS2.
InterProiIPR028597. LZTS2.
[Graphical view]
PANTHERiPTHR19354:SF4. PTHR19354:SF4. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3LUD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIVQTLPVP LEPARETATA PQTPAMGSVS SLISGRPCPG GPAPQRHHGV
60 70 80 90 100
PGPTFFRQQD GLLRGGYEAQ EPLCPAVPPR KTVPGNSFTY VNEDFRTESP
110 120 130 140 150
PSPSSDVEDP REHQAHNAHL RGPPPKLIPV SGKLEKNMEK ILIRPTAFKP
160 170 180 190 200
VLPKPRGAPS LPGFLGPRAA GLSGSQGSLT QLFGGPASSS SSSSSSSAAD
210 220 230 240 250
KPLALSGWAS GCPSGTLSDS GRNSLSSLPT YSTGGAEPTA NSPGGHLPSH
260 270 280 290 300
GPGRGPLPGP ARGVPTGPSH SDSGRSSSSK STGSLGARVA GGLLGSGARA
310 320 330 340 350
SPGSSSGGDR SPPPPPPPPP SDEALLHCVL EGKLRDREAE LQQLRDSVDE
360 370 380 390 400
SEAAVCQAFG ARQRRWPGER EDCASHAQQA TQRVQRAQQL LQLQVFQLQQ
410 420 430 440 450
EKRQLQDDFA QLLQEREQLE RRCATFEREQ QELGPRLEET KWEVCQKSGE
460 470 480 490 500
ISLLKQQLKE SQAELVQKGS ELVALRVALR EARAALRVSE GHARGLQEAA
510 520 530 540 550
RARELELEAC SQELQRYRQE AEQLREKARH LDAEAAGLRE PPVPPATTDP
560 570 580 590 600
FLLAESDEAK VQRAAAGTGG SLRAQVERLR QELQREQRRG DEQRNSFEGE
610 620 630 640 650
RLAWQAEKEQ VIRYQKQLQH NYVQMYRRNR QLEQELQQLS LELEARELAD
660 670
LGLSEPAPCI CLEEITATEI
Length:670
Mass (Da):72,493
Last modified:November 13, 2007 - v2
Checksum:i9637FAA7B631E9A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY928801 mRNA. Translation: AAX28869.1.
DQ176638 mRNA. Translation: ABA06435.2.
RefSeqiNP_001014269.2. NM_001014247.2.
UniGeneiRn.23951.

Genome annotation databases

GeneIDi365468.
KEGGirno:365468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY928801 mRNA. Translation: AAX28869.1.
DQ176638 mRNA. Translation: ABA06435.2.
RefSeqiNP_001014269.2. NM_001014247.2.
UniGeneiRn.23951.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042095.

PTM databases

iPTMnetiQ3LUD4.
PhosphoSiteiQ3LUD4.

Proteomic databases

PaxDbiQ3LUD4.
PRIDEiQ3LUD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi365468.
KEGGirno:365468.

Organism-specific databases

CTDi84445.
RGDi1359249. Lzts2.

Phylogenomic databases

eggNOGiENOG410IGJE. Eukaryota.
ENOG4111JZA. LUCA.
HOGENOMiHOG000230889.
HOVERGENiHBG052381.
InParanoidiQ3LUD4.
PhylomeDBiQ3LUD4.

Miscellaneous databases

PROiQ3LUD4.

Family and domain databases

HAMAPiMF_03026. LZTS2.
InterProiIPR028597. LZTS2.
[Graphical view]
PANTHERiPTHR19354:SF4. PTHR19354:SF4. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "LAPSER1 is a putative cytokinetic tumor suppressor that shows the same centrosome and midbody subcellular localization pattern as p80 katanin."
    Sudo H., Maru Y.
    FASEB J. 21:2086-2100(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH GAMMA-TUBULIN, KIF23 AND KATNB1, SUBCELLULAR LOCATION.
    Strain: Wistar.
  2. "ProSAPiP1, a novel PSD protein that links spar to the PDZ domain of ProSAP2/Shank3."
    Wendholt D., Spilker C., Schmitt A., Dolnik A., Smalla K.-H., Proepper C., Sobue K., Gundelfinger E.D., Kreutz M.R., Boeckers T.M.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing."
    Sudo H., Maru Y.
    Hum. Mol. Genet. 17:2524-2540(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH KATNB1, SUBCELLULAR LOCATION.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-296, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLZTS2_RAT
AccessioniPrimary (citable) accession number: Q3LUD4
Secondary accession number(s): Q24K74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 13, 2007
Last modified: June 8, 2016
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.