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Protein

Leucine zipper putative tumor suppressor 2

Gene

Lzts2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.UniRule annotation2 Publications

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • positive regulation of cell death Source: RGD
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine zipper putative tumor suppressor 2UniRule annotation
Alternative name(s):
Protein LAPSER1UniRule annotation
Gene namesi
Name:Lzts2
Synonyms:Lapser1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359249 Lzts2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003678961 – 670Leucine zipper putative tumor suppressor 2Add BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei249PhosphoserineBy similarity1
Modified residuei296PhosphoserineCombined sources1
Modified residuei571PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3LUD4
PRIDEiQ3LUD4

PTM databases

iPTMnetiQ3LUD4
PhosphoSitePlusiQ3LUD4

Interactioni

Subunit structurei

Interacts with CTNNB1 (By similarity). Interacts with KATNB1. Also interacts with gamma-tubulin and KIF23.By similarity2 Publications

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042095

Structurei

3D structure databases

SMRiQ3LUD4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 333Required for centrosomal localizationBy similarityAdd BLAST333
Regioni448 – 670Sufficient for interaction with CTNNB1By similarityAdd BLAST223
Regioni451 – 670Sufficient for interaction with KATNB1 and for inhibition of katanin-mediated microtubule severingBy similarityAdd BLAST220

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili329 – 650UniRule annotationAdd BLAST322

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi632 – 641Nuclear export signalUniRule annotation10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi188 – 306Ser-richAdd BLAST119

Sequence similaritiesi

Belongs to the LZTS2 family.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGJE Eukaryota
ENOG4111JZA LUCA
HOGENOMiHOG000230889
HOVERGENiHBG052381
InParanoidiQ3LUD4
PhylomeDBiQ3LUD4

Family and domain databases

HAMAPiMF_03026 LZTS2, 1 hit
InterProiView protein in InterPro
IPR028597 LZTS2
PANTHERiPTHR19354:SF4 PTHR19354:SF4, 1 hit

Sequencei

Sequence statusi: Complete.

Q3LUD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIVQTLPVP LEPARETATA PQTPAMGSVS SLISGRPCPG GPAPQRHHGV
60 70 80 90 100
PGPTFFRQQD GLLRGGYEAQ EPLCPAVPPR KTVPGNSFTY VNEDFRTESP
110 120 130 140 150
PSPSSDVEDP REHQAHNAHL RGPPPKLIPV SGKLEKNMEK ILIRPTAFKP
160 170 180 190 200
VLPKPRGAPS LPGFLGPRAA GLSGSQGSLT QLFGGPASSS SSSSSSSAAD
210 220 230 240 250
KPLALSGWAS GCPSGTLSDS GRNSLSSLPT YSTGGAEPTA NSPGGHLPSH
260 270 280 290 300
GPGRGPLPGP ARGVPTGPSH SDSGRSSSSK STGSLGARVA GGLLGSGARA
310 320 330 340 350
SPGSSSGGDR SPPPPPPPPP SDEALLHCVL EGKLRDREAE LQQLRDSVDE
360 370 380 390 400
SEAAVCQAFG ARQRRWPGER EDCASHAQQA TQRVQRAQQL LQLQVFQLQQ
410 420 430 440 450
EKRQLQDDFA QLLQEREQLE RRCATFEREQ QELGPRLEET KWEVCQKSGE
460 470 480 490 500
ISLLKQQLKE SQAELVQKGS ELVALRVALR EARAALRVSE GHARGLQEAA
510 520 530 540 550
RARELELEAC SQELQRYRQE AEQLREKARH LDAEAAGLRE PPVPPATTDP
560 570 580 590 600
FLLAESDEAK VQRAAAGTGG SLRAQVERLR QELQREQRRG DEQRNSFEGE
610 620 630 640 650
RLAWQAEKEQ VIRYQKQLQH NYVQMYRRNR QLEQELQQLS LELEARELAD
660 670
LGLSEPAPCI CLEEITATEI
Length:670
Mass (Da):72,493
Last modified:November 13, 2007 - v2
Checksum:i9637FAA7B631E9A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY928801 mRNA Translation: AAX28869.1
DQ176638 mRNA Translation: ABA06435.2
RefSeqiNP_001014269.2, NM_001014247.2
UniGeneiRn.23951

Genome annotation databases

GeneIDi365468
KEGGirno:365468

Similar proteinsi

Entry informationi

Entry nameiLZTS2_RAT
AccessioniPrimary (citable) accession number: Q3LUD4
Secondary accession number(s): Q24K74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 13, 2007
Last modified: May 23, 2018
This is version 70 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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