ID   KCNK9_MOUSE             Reviewed;         402 AA.
AC   Q3LS21; B2RT82;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   24-JAN-2024, entry version 125.
DE   RecName: Full=Potassium channel subfamily K member 9;
DE   AltName: Full=Acid-sensitive potassium channel protein TASK-3;
DE   AltName: Full=TWIK-related acid-sensitive K(+) channel 3;
GN   Name=Kcnk9; Synonyms=Task3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=NMRI; TISSUE=Cerebellum;
RA   Czirjak G., Enyedi P.;
RT   "Zinc and mercuric ions distinguish mouse TRESK from the other two-pore-
RT   domain K+ channels.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: pH-dependent, voltage-insensitive, background potassium
CC       channel protein. {ECO:0000250|UniProtKB:Q9NPC2}.
CC   -!- SUBUNIT: Homodimer. Heterodimer with KCNK1.
CC       {ECO:0000250|UniProtKB:Q9NPC2}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NPC2};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NPC2}.
CC   -!- SIMILARITY: Belongs to the two pore domain potassium channel
CC       (TC 1.A.1.8) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ185133; ABA28314.1; -; mRNA.
DR   EMBL; BC139167; AAI39168.1; -; mRNA.
DR   EMBL; BC139168; AAI39169.1; -; mRNA.
DR   CCDS; CCDS27515.1; -.
DR   RefSeq; NP_001029048.1; NM_001033876.1.
DR   AlphaFoldDB; Q3LS21; -.
DR   SMR; Q3LS21; -.
DR   STRING; 10090.ENSMUSP00000038729; -.
DR   GlyCosmos; Q3LS21; 1 site, No reported glycans.
DR   GlyGen; Q3LS21; 1 site.
DR   PhosphoSitePlus; Q3LS21; -.
DR   PaxDb; 10090-ENSMUSP00000038729; -.
DR   Antibodypedia; 27582; 134 antibodies from 22 providers.
DR   DNASU; 223604; -.
DR   Ensembl; ENSMUST00000044624.8; ENSMUSP00000038729.7; ENSMUSG00000036760.8.
DR   GeneID; 223604; -.
DR   KEGG; mmu:223604; -.
DR   UCSC; uc007wbk.1; mouse.
DR   AGR; MGI:3521816; -.
DR   CTD; 51305; -.
DR   MGI; MGI:3521816; Kcnk9.
DR   VEuPathDB; HostDB:ENSMUSG00000036760; -.
DR   eggNOG; KOG4404; Eukaryota.
DR   GeneTree; ENSGT00940000159791; -.
DR   HOGENOM; CLU_022504_4_0_1; -.
DR   InParanoid; Q3LS21; -.
DR   OMA; TAWFGQV; -.
DR   OrthoDB; 600333at2759; -.
DR   PhylomeDB; Q3LS21; -.
DR   TreeFam; TF313947; -.
DR   Reactome; R-MMU-1299316; TWIK-releated acid-sensitive K+ channel (TASK).
DR   Reactome; R-MMU-5576886; Phase 4 - resting membrane potential.
DR   BioGRID-ORCS; 223604; 3 hits in 80 CRISPR screens.
DR   PRO; PR:Q3LS21; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; Q3LS21; Protein.
DR   Bgee; ENSMUSG00000036760; Expressed in lumbar subsegment of spinal cord and 76 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0008021; C:synaptic vesicle; ISO:MGI.
DR   GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:0005267; F:potassium channel activity; ISO:MGI.
DR   GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IDA:MGI.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IDA:MGI.
DR   GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006813; P:potassium ion transport; ISO:MGI.
DR   GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR003280; 2pore_dom_K_chnl.
DR   InterPro; IPR003092; 2pore_dom_K_chnl_TASK.
DR   InterPro; IPR013099; K_chnl_dom.
DR   InterPro; IPR005407; KCNK9.
DR   PANTHER; PTHR11003:SF75; POTASSIUM CHANNEL SUBFAMILY K MEMBER 9; 1.
DR   PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR   Pfam; PF07885; Ion_trans_2; 2.
DR   PIRSF; PIRSF038061; K_channel_subfamily_K_type; 1.
DR   PRINTS; PR01333; 2POREKCHANEL.
DR   PRINTS; PR01585; TASK3CHANNEL.
DR   PRINTS; PR01095; TASKCHANNEL.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Ion channel; Ion transport; Membrane;
KW   Potassium; Potassium channel; Potassium transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..402
FT                   /note="Potassium channel subfamily K member 9"
FT                   /id="PRO_0000101755"
FT   TOPO_DOM        1..8
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..88
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        89..101
FT                   /note="Pore-forming; Name=Pore-forming 1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..107
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        129..158
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        180..194
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        195..207
FT                   /note="Pore-forming; Name=Pore-forming 2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        208..218
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        240..402
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        53
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   402 AA;  44911 MW;  F735D78B303EA158 CRC64;
     MKRQNVRTLS LIACTFTYLL VGAAVFDALE SDHEMREEEK LKAEEVRLRG KYNISSDDYQ
     QLELVILQSE PHRAGVQWKF AGSFYFAITV ITTIGYGHAA PGTDAGKAFC MFYAVLGIPL
     TLVMFQSLGE RMNTFVRYLL KRIKKCCGMR NTEVSMENMV TVGFFSCMGT LCLGAAAFSQ
     CEDWSFFHAY YYCFITLTTI GFGDFVALQA KGALQRKPFY VAFSFMYILV GLTVIGAFLN
     LVVLRFLTMN TDEELLEGEV AEILAGNPRR VSVRAPQRRK RHHAMYFLRK YGRTLCYLCF
     PGTNWGKDDD DDDDDDVVDN VVVTAPISAP APAPAPAPAP AAVAAGATIR SVRATVHTVS
     CRVEEIPPDV LRNTYFRSVF GAIPPGMHTC GDHRLHLRRK SI
//