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Q3LS21

- KCNK9_MOUSE

UniProt

Q3LS21 - KCNK9_MOUSE

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Protein

Potassium channel subfamily K member 9

Gene

Kcnk9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

pH-dependent, voltage-insensitive, background potassium channel protein.By similarity

GO - Molecular functioni

  1. potassium channel activity Source: UniProtKB-KW
  2. voltage-gated ion channel activity Source: UniProtKB-KW

GO - Biological processi

  1. cochlea development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199069. TWIK-releated acid-sensitive K+ channel (TASK).

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 9
Alternative name(s):
Acid-sensitive potassium channel protein TASK-3
TWIK-related acid-sensitive K(+) channel 3
Gene namesi
Name:Kcnk9
Synonyms:Task3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:3521816. Kcnk9.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Ensembl
  3. synaptic vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Potassium channel subfamily K member 9PRO_0000101755Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ3LS21.

PTM databases

PhosphoSiteiQ3LS21.

Expressioni

Gene expression databases

BgeeiQ3LS21.
CleanExiMM_KCNK9.
GenevestigatoriQ3LS21.

Structurei

3D structure databases

ProteinModelPortaliQ3LS21.
SMRiQ3LS21. Positions 18-242.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicSequence Analysis
Topological domaini30 – 8859ExtracellularSequence AnalysisAdd
BLAST
Topological domaini102 – 1076ExtracellularSequence Analysis
Topological domaini129 – 15830CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini180 – 19415ExtracellularSequence AnalysisAdd
BLAST
Topological domaini208 – 21811ExtracellularSequence AnalysisAdd
BLAST
Topological domaini240 – 402163CytoplasmicSequence AnalysisAdd
BLAST

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei89 – 10113Pore-forming; Name=Pore-forming 1Sequence AnalysisAdd
BLAST
Intramembranei195 – 20713Pore-forming; Name=Pore-forming 2Sequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalSequence AnalysisAdd
BLAST
Transmembranei108 – 12821HelicalSequence AnalysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence AnalysisAdd
BLAST
Transmembranei219 – 23921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259548.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000231463.
HOVERGENiHBG052239.
InParanoidiQ3LS21.
KOiK04919.
OMAiECESTGK.
OrthoDBiEOG7B05DC.
PhylomeDBiQ3LS21.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005407. KCNK9.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01585. TASK3CHANNEL.
PR01095. TASKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q3LS21-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRQNVRTLS LIACTFTYLL VGAAVFDALE SDHEMREEEK LKAEEVRLRG
60 70 80 90 100
KYNISSDDYQ QLELVILQSE PHRAGVQWKF AGSFYFAITV ITTIGYGHAA
110 120 130 140 150
PGTDAGKAFC MFYAVLGIPL TLVMFQSLGE RMNTFVRYLL KRIKKCCGMR
160 170 180 190 200
NTEVSMENMV TVGFFSCMGT LCLGAAAFSQ CEDWSFFHAY YYCFITLTTI
210 220 230 240 250
GFGDFVALQA KGALQRKPFY VAFSFMYILV GLTVIGAFLN LVVLRFLTMN
260 270 280 290 300
TDEELLEGEV AEILAGNPRR VSVRAPQRRK RHHAMYFLRK YGRTLCYLCF
310 320 330 340 350
PGTNWGKDDD DDDDDDVVDN VVVTAPISAP APAPAPAPAP AAVAAGATIR
360 370 380 390 400
SVRATVHTVS CRVEEIPPDV LRNTYFRSVF GAIPPGMHTC GDHRLHLRRK

SI
Length:402
Mass (Da):44,911
Last modified:October 25, 2005 - v1
Checksum:iF735D78B303EA158
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ185133 mRNA. Translation: ABA28314.1.
BC139167 mRNA. Translation: AAI39168.1.
BC139168 mRNA. Translation: AAI39169.1.
CCDSiCCDS27515.1.
RefSeqiNP_001029048.1. NM_001033876.1.
UniGeneiMm.386856.

Genome annotation databases

EnsembliENSMUST00000044624; ENSMUSP00000038729; ENSMUSG00000036760.
GeneIDi223604.
KEGGimmu:223604.
UCSCiuc007wbk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ185133 mRNA. Translation: ABA28314.1 .
BC139167 mRNA. Translation: AAI39168.1 .
BC139168 mRNA. Translation: AAI39169.1 .
CCDSi CCDS27515.1.
RefSeqi NP_001029048.1. NM_001033876.1.
UniGenei Mm.386856.

3D structure databases

ProteinModelPortali Q3LS21.
SMRi Q3LS21. Positions 18-242.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q3LS21.

Proteomic databases

PRIDEi Q3LS21.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044624 ; ENSMUSP00000038729 ; ENSMUSG00000036760 .
GeneIDi 223604.
KEGGi mmu:223604.
UCSCi uc007wbk.1. mouse.

Organism-specific databases

CTDi 51305.
MGIi MGI:3521816. Kcnk9.

Phylogenomic databases

eggNOGi NOG259548.
GeneTreei ENSGT00760000118858.
HOGENOMi HOG000231463.
HOVERGENi HBG052239.
InParanoidi Q3LS21.
KOi K04919.
OMAi ECESTGK.
OrthoDBi EOG7B05DC.
PhylomeDBi Q3LS21.
TreeFami TF313947.

Enzyme and pathway databases

Reactomei REACT_199069. TWIK-releated acid-sensitive K+ channel (TASK).

Miscellaneous databases

NextBioi 376755.
PROi Q3LS21.
SOURCEi Search...

Gene expression databases

Bgeei Q3LS21.
CleanExi MM_KCNK9.
Genevestigatori Q3LS21.

Family and domain databases

InterProi IPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005407. KCNK9.
[Graphical view ]
Pfami PF07885. Ion_trans_2. 2 hits.
[Graphical view ]
PIRSFi PIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSi PR01333. 2POREKCHANEL.
PR01585. TASK3CHANNEL.
PR01095. TASKCHANNEL.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Zinc and mercuric ions distinguish mouse TRESK from the other two-pore-domain K+ channels."
    Czirjak G., Enyedi P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NMRI.
    Tissue: Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiKCNK9_MOUSE
AccessioniPrimary (citable) accession number: Q3LS21
Secondary accession number(s): B2RT82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 25, 2005
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3