Potassium channel subfamily K member 9

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Q3LS21 (KCNK9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 60. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Potassium channel subfamily K member 9

Alternative name(s):
Acid-sensitive potassium channel protein TASK-3
TWIK-related acid-sensitive K(+) channel 3

Gene names

Name:	Kcnk9
Synonyms:	Task3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	pH-dependent, voltage-insensitive, background potassium channel protein By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cochlea development Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: Compara synaptic vesicle Inferred from electronic annotation. Source: Compara
Molecular_function	potassium channel activity Inferred from electronic annotation. Source: UniProtKB-KW voltage-gated ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 402

402

Potassium channel subfamily K member 9

PRO_0000101755

Regions

Topological domain

1 – 8

Cytoplasmic Potential

Transmembrane

9 – 29

Helical; Potential

Topological domain

30 – 88

Extracellular Potential

Intramembrane

89 – 101

Pore-forming; Name=Pore-forming 1; Potential

Topological domain

102 – 107

Extracellular Potential

Transmembrane

108 – 128

Helical; Potential

Topological domain

129 – 158

Cytoplasmic Potential

Transmembrane

159 – 179

Helical; Potential

Topological domain

180 – 194

Extracellular Potential

Intramembrane

195 – 207

Pore-forming; Name=Pore-forming 2; Potential

Topological domain

208 – 218

Extracellular Potential

Transmembrane

219 – 239

Helical; Potential

Topological domain

240 – 402

163

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q3LS21 [UniParc].

Last modified October 25, 2005. Version 1.
Checksum: F735D78B303EA158
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FASTA

402

44,911

        10         20         30         40         50         60 
MKRQNVRTLS LIACTFTYLL VGAAVFDALE SDHEMREEEK LKAEEVRLRG KYNISSDDYQ 

        70         80         90        100        110        120 
QLELVILQSE PHRAGVQWKF AGSFYFAITV ITTIGYGHAA PGTDAGKAFC MFYAVLGIPL 

       130        140        150        160        170        180 
TLVMFQSLGE RMNTFVRYLL KRIKKCCGMR NTEVSMENMV TVGFFSCMGT LCLGAAAFSQ 

       190        200        210        220        230        240 
CEDWSFFHAY YYCFITLTTI GFGDFVALQA KGALQRKPFY VAFSFMYILV GLTVIGAFLN 

       250        260        270        280        290        300 
LVVLRFLTMN TDEELLEGEV AEILAGNPRR VSVRAPQRRK RHHAMYFLRK YGRTLCYLCF 

       310        320        330        340        350        360 
PGTNWGKDDD DDDDDDVVDN VVVTAPISAP APAPAPAPAP AAVAAGATIR SVRATVHTVS 

       370        380        390        400 
CRVEEIPPDV LRNTYFRSVF GAIPPGMHTC GDHRLHLRRK SI

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Zinc and mercuric ions distinguish mouse TRESK from the other two-pore-domain K+ channels." Czirjak G., Enyedi P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: NMRI. Tissue: Cerebellum.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ185133 mRNA. Translation: ABA28314.1. BC139167 mRNA. Translation: AAI39168.1. BC139168 mRNA. Translation: AAI39169.1.
IPI	IPI00351571.
RefSeq	NP_001029048.1. NM_001033876.1.
UniGene	Mm.386856.
3D structure databases
ProteinModelPortal	Q3LS21.
SMR	Q3LS21. Positions 22-245.
ModBase	Search...
PTM databases
PhosphoSite	Q3LS21.
Proteomic databases
PRIDE	Q3LS21.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000044624; ENSMUSP00000038729; ENSMUSG00000036760.
GeneID	223604.
KEGG	mmu:223604.
UCSC	uc007wbk.1. mouse.
Organism-specific databases
CTD	51305.
MGI	MGI:3521816. Kcnk9.
Phylogenomic databases
eggNOG	NOG259548.
GeneTree	ENSGT00680000099680.
HOGENOM	HOG000231463.
HOVERGEN	HBG052239.
InParanoid	B2RT82.
KO	K04919.
OMA	ECESTGK.
OrthoDB	EOG4VX25V.
Gene expression databases
Bgee	Q3LS21.
CleanEx	MM_KCNK9.
Genevestigator	Q3LS21.
GermOnline	ENSMUSG00000036760. Mus musculus.
Family and domain databases
InterPro	IPR003280. 2pore_dom_K_chnl. IPR003092. 2pore_dom_K_chnl_TASK. IPR022306. 2pore_dom_K_chnl_TASK/TWIK. IPR005407. 2pore_dom_K_chnl_TASK3. IPR013099. Ion_trans_2. [Graphical view]
PANTHER	PTHR11003:SF17. PTHR11003:SF17. 1 hit.
Pfam	PF07885. Ion_trans_2. 2 hits. [Graphical view]
PIRSF	PIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTS	PR01333. 2POREKCHANEL. PR01585. TASK3CHANNEL. PR01095. TASKCHANNEL.
ProtoNet	Search...
Other
NextBio	376755.
SOURCE	Search...

Entry information

Entry name

KCNK9_MOUSE

Accession

Primary (citable) accession number: Q3LS21
Secondary accession number(s): B2RT82

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	October 25, 2005
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents