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Q3LS21 (KCNK9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel subfamily K member 9
Alternative name(s):
Acid-sensitive potassium channel protein TASK-3
TWIK-related acid-sensitive K(+) channel 3
Gene names
Name:Kcnk9
Synonyms:Task3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length402 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

pH-dependent, voltage-insensitive, background potassium channel protein By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 402402Potassium channel subfamily K member 9
PRO_0000101755

Regions

Topological domain1 – 88Cytoplasmic Potential
Transmembrane9 – 2921Helical; Potential
Topological domain30 – 8859Extracellular Potential
Intramembrane89 – 10113Pore-forming; Name=Pore-forming 1; Potential
Topological domain102 – 1076Extracellular Potential
Transmembrane108 – 12821Helical; Potential
Topological domain129 – 15830Cytoplasmic Potential
Transmembrane159 – 17921Helical; Potential
Topological domain180 – 19415Extracellular Potential
Intramembrane195 – 20713Pore-forming; Name=Pore-forming 2; Potential
Topological domain208 – 21811Extracellular Potential
Transmembrane219 – 23921Helical; Potential
Topological domain240 – 402163Cytoplasmic Potential

Amino acid modifications

Glycosylation531N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q3LS21 [UniParc].

Last modified October 25, 2005. Version 1.
Checksum: F735D78B303EA158

FASTA40244,911
        10         20         30         40         50         60 
MKRQNVRTLS LIACTFTYLL VGAAVFDALE SDHEMREEEK LKAEEVRLRG KYNISSDDYQ 

        70         80         90        100        110        120 
QLELVILQSE PHRAGVQWKF AGSFYFAITV ITTIGYGHAA PGTDAGKAFC MFYAVLGIPL 

       130        140        150        160        170        180 
TLVMFQSLGE RMNTFVRYLL KRIKKCCGMR NTEVSMENMV TVGFFSCMGT LCLGAAAFSQ 

       190        200        210        220        230        240 
CEDWSFFHAY YYCFITLTTI GFGDFVALQA KGALQRKPFY VAFSFMYILV GLTVIGAFLN 

       250        260        270        280        290        300 
LVVLRFLTMN TDEELLEGEV AEILAGNPRR VSVRAPQRRK RHHAMYFLRK YGRTLCYLCF 

       310        320        330        340        350        360 
PGTNWGKDDD DDDDDDVVDN VVVTAPISAP APAPAPAPAP AAVAAGATIR SVRATVHTVS 

       370        380        390        400 
CRVEEIPPDV LRNTYFRSVF GAIPPGMHTC GDHRLHLRRK SI 

« Hide

References

« Hide 'large scale' references
[1]"Zinc and mercuric ions distinguish mouse TRESK from the other two-pore-domain K+ channels."
Czirjak G., Enyedi P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: NMRI.
Tissue: Cerebellum.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ185133 mRNA. Translation: ABA28314.1.
BC139167 mRNA. Translation: AAI39168.1.
BC139168 mRNA. Translation: AAI39169.1.
RefSeqNP_001029048.1. NM_001033876.1.
UniGeneMm.386856.

3D structure databases

ProteinModelPortalQ3LS21.
SMRQ3LS21. Positions 18-242.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ3LS21.

Proteomic databases

PRIDEQ3LS21.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000044624; ENSMUSP00000038729; ENSMUSG00000036760.
GeneID223604.
KEGGmmu:223604.
UCSCuc007wbk.1. mouse.

Organism-specific databases

CTD51305.
MGIMGI:3521816. Kcnk9.

Phylogenomic databases

eggNOGNOG259548.
GeneTreeENSGT00730000110395.
HOGENOMHOG000231463.
HOVERGENHBG052239.
InParanoidB2RT82.
KOK04919.
OMAECESTGK.
OrthoDBEOG7B05DC.
PhylomeDBQ3LS21.
TreeFamTF313947.

Gene expression databases

BgeeQ3LS21.
CleanExMM_KCNK9.
GenevestigatorQ3LS21.

Family and domain databases

InterProIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005407. KCNK9.
[Graphical view]
PfamPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSPR01333. 2POREKCHANEL.
PR01585. TASK3CHANNEL.
PR01095. TASKCHANNEL.
ProtoNetSearch...

Other

NextBio376755.
PROQ3LS21.
SOURCESearch...

Entry information

Entry nameKCNK9_MOUSE
AccessionPrimary (citable) accession number: Q3LS21
Secondary accession number(s): B2RT82
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 25, 2005
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot