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Q3LS21

- KCNK9_MOUSE

UniProt

Q3LS21 - KCNK9_MOUSE

Protein

Potassium channel subfamily K member 9

Gene

Kcnk9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (25 Oct 2005)
      Previous versions | rss
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    Functioni

    pH-dependent, voltage-insensitive, background potassium channel protein.By similarity

    GO - Molecular functioni

    1. potassium channel activity Source: UniProtKB-KW
    2. voltage-gated ion channel activity Source: UniProtKB-KW

    GO - Biological processi

    1. cochlea development Source: Ensembl

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199069. TWIK-releated acid-sensitive K+ channel (TASK).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel subfamily K member 9
    Alternative name(s):
    Acid-sensitive potassium channel protein TASK-3
    TWIK-related acid-sensitive K(+) channel 3
    Gene namesi
    Name:Kcnk9
    Synonyms:Task3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:3521816. Kcnk9.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Ensembl
    3. synaptic vesicle Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 402402Potassium channel subfamily K member 9PRO_0000101755Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ3LS21.

    PTM databases

    PhosphoSiteiQ3LS21.

    Expressioni

    Gene expression databases

    BgeeiQ3LS21.
    CleanExiMM_KCNK9.
    GenevestigatoriQ3LS21.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3LS21.
    SMRiQ3LS21. Positions 18-242.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 88CytoplasmicSequence Analysis
    Topological domaini30 – 8859ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini102 – 1076ExtracellularSequence Analysis
    Topological domaini129 – 15830CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 19415ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini208 – 21811ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini240 – 402163CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei89 – 10113Pore-forming; Name=Pore-forming 1Sequence AnalysisAdd
    BLAST
    Intramembranei195 – 20713Pore-forming; Name=Pore-forming 2Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei219 – 23921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG259548.
    GeneTreeiENSGT00730000110395.
    HOGENOMiHOG000231463.
    HOVERGENiHBG052239.
    InParanoidiB2RT82.
    KOiK04919.
    OMAiECESTGK.
    OrthoDBiEOG7B05DC.
    PhylomeDBiQ3LS21.
    TreeFamiTF313947.

    Family and domain databases

    InterProiIPR003280. 2pore_dom_K_chnl.
    IPR013099. 2pore_dom_K_chnl_dom.
    IPR003092. 2pore_dom_K_chnl_TASK.
    IPR005407. KCNK9.
    [Graphical view]
    PfamiPF07885. Ion_trans_2. 2 hits.
    [Graphical view]
    PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
    PRINTSiPR01333. 2POREKCHANEL.
    PR01585. TASK3CHANNEL.
    PR01095. TASKCHANNEL.

    Sequencei

    Sequence statusi: Complete.

    Q3LS21-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRQNVRTLS LIACTFTYLL VGAAVFDALE SDHEMREEEK LKAEEVRLRG    50
    KYNISSDDYQ QLELVILQSE PHRAGVQWKF AGSFYFAITV ITTIGYGHAA 100
    PGTDAGKAFC MFYAVLGIPL TLVMFQSLGE RMNTFVRYLL KRIKKCCGMR 150
    NTEVSMENMV TVGFFSCMGT LCLGAAAFSQ CEDWSFFHAY YYCFITLTTI 200
    GFGDFVALQA KGALQRKPFY VAFSFMYILV GLTVIGAFLN LVVLRFLTMN 250
    TDEELLEGEV AEILAGNPRR VSVRAPQRRK RHHAMYFLRK YGRTLCYLCF 300
    PGTNWGKDDD DDDDDDVVDN VVVTAPISAP APAPAPAPAP AAVAAGATIR 350
    SVRATVHTVS CRVEEIPPDV LRNTYFRSVF GAIPPGMHTC GDHRLHLRRK 400
    SI 402
    Length:402
    Mass (Da):44,911
    Last modified:October 25, 2005 - v1
    Checksum:iF735D78B303EA158
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ185133 mRNA. Translation: ABA28314.1.
    BC139167 mRNA. Translation: AAI39168.1.
    BC139168 mRNA. Translation: AAI39169.1.
    CCDSiCCDS27515.1.
    RefSeqiNP_001029048.1. NM_001033876.1.
    UniGeneiMm.386856.

    Genome annotation databases

    EnsembliENSMUST00000044624; ENSMUSP00000038729; ENSMUSG00000036760.
    GeneIDi223604.
    KEGGimmu:223604.
    UCSCiuc007wbk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ185133 mRNA. Translation: ABA28314.1 .
    BC139167 mRNA. Translation: AAI39168.1 .
    BC139168 mRNA. Translation: AAI39169.1 .
    CCDSi CCDS27515.1.
    RefSeqi NP_001029048.1. NM_001033876.1.
    UniGenei Mm.386856.

    3D structure databases

    ProteinModelPortali Q3LS21.
    SMRi Q3LS21. Positions 18-242.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q3LS21.

    Proteomic databases

    PRIDEi Q3LS21.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044624 ; ENSMUSP00000038729 ; ENSMUSG00000036760 .
    GeneIDi 223604.
    KEGGi mmu:223604.
    UCSCi uc007wbk.1. mouse.

    Organism-specific databases

    CTDi 51305.
    MGIi MGI:3521816. Kcnk9.

    Phylogenomic databases

    eggNOGi NOG259548.
    GeneTreei ENSGT00730000110395.
    HOGENOMi HOG000231463.
    HOVERGENi HBG052239.
    InParanoidi B2RT82.
    KOi K04919.
    OMAi ECESTGK.
    OrthoDBi EOG7B05DC.
    PhylomeDBi Q3LS21.
    TreeFami TF313947.

    Enzyme and pathway databases

    Reactomei REACT_199069. TWIK-releated acid-sensitive K+ channel (TASK).

    Miscellaneous databases

    NextBioi 376755.
    PROi Q3LS21.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3LS21.
    CleanExi MM_KCNK9.
    Genevestigatori Q3LS21.

    Family and domain databases

    InterProi IPR003280. 2pore_dom_K_chnl.
    IPR013099. 2pore_dom_K_chnl_dom.
    IPR003092. 2pore_dom_K_chnl_TASK.
    IPR005407. KCNK9.
    [Graphical view ]
    Pfami PF07885. Ion_trans_2. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF038061. K_channel_subfamily_K_type. 1 hit.
    PRINTSi PR01333. 2POREKCHANEL.
    PR01585. TASK3CHANNEL.
    PR01095. TASKCHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. "Zinc and mercuric ions distinguish mouse TRESK from the other two-pore-domain K+ channels."
      Czirjak G., Enyedi P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: NMRI.
      Tissue: Cerebellum.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiKCNK9_MOUSE
    AccessioniPrimary (citable) accession number: Q3LS21
    Secondary accession number(s): B2RT82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: October 25, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3