Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Potassium channel subfamily K member 9

Gene

Kcnk9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

pH-dependent, voltage-insensitive, background potassium channel protein.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_321759. TWIK-releated acid-sensitive K+ channel (TASK).

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 9
Alternative name(s):
Acid-sensitive potassium channel protein TASK-3
TWIK-related acid-sensitive K(+) channel 3
Gene namesi
Name:Kcnk9
Synonyms:Task3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:3521816. Kcnk9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicSequence Analysis
Transmembranei9 – 2921HelicalSequence AnalysisAdd
BLAST
Topological domaini30 – 8859ExtracellularSequence AnalysisAdd
BLAST
Intramembranei89 – 10113Pore-forming; Name=Pore-forming 1Sequence AnalysisAdd
BLAST
Topological domaini102 – 1076ExtracellularSequence Analysis
Transmembranei108 – 12821HelicalSequence AnalysisAdd
BLAST
Topological domaini129 – 15830CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence AnalysisAdd
BLAST
Topological domaini180 – 19415ExtracellularSequence AnalysisAdd
BLAST
Intramembranei195 – 20713Pore-forming; Name=Pore-forming 2Sequence AnalysisAdd
BLAST
Topological domaini208 – 21811ExtracellularSequence AnalysisAdd
BLAST
Transmembranei219 – 23921HelicalSequence AnalysisAdd
BLAST
Topological domaini240 – 402163CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Potassium channel subfamily K member 9PRO_0000101755Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ3LS21.

PTM databases

PhosphoSiteiQ3LS21.

Expressioni

Gene expression databases

BgeeiQ3LS21.
CleanExiMM_KCNK9.
GenevestigatoriQ3LS21.

Structurei

3D structure databases

ProteinModelPortaliQ3LS21.
SMRiQ3LS21. Positions 18-242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259548.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000231463.
HOVERGENiHBG052239.
InParanoidiQ3LS21.
KOiK04919.
OMAiSCRVEEI.
OrthoDBiEOG7B05DC.
PhylomeDBiQ3LS21.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005407. KCNK9.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01585. TASK3CHANNEL.
PR01095. TASKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q3LS21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRQNVRTLS LIACTFTYLL VGAAVFDALE SDHEMREEEK LKAEEVRLRG
60 70 80 90 100
KYNISSDDYQ QLELVILQSE PHRAGVQWKF AGSFYFAITV ITTIGYGHAA
110 120 130 140 150
PGTDAGKAFC MFYAVLGIPL TLVMFQSLGE RMNTFVRYLL KRIKKCCGMR
160 170 180 190 200
NTEVSMENMV TVGFFSCMGT LCLGAAAFSQ CEDWSFFHAY YYCFITLTTI
210 220 230 240 250
GFGDFVALQA KGALQRKPFY VAFSFMYILV GLTVIGAFLN LVVLRFLTMN
260 270 280 290 300
TDEELLEGEV AEILAGNPRR VSVRAPQRRK RHHAMYFLRK YGRTLCYLCF
310 320 330 340 350
PGTNWGKDDD DDDDDDVVDN VVVTAPISAP APAPAPAPAP AAVAAGATIR
360 370 380 390 400
SVRATVHTVS CRVEEIPPDV LRNTYFRSVF GAIPPGMHTC GDHRLHLRRK

SI
Length:402
Mass (Da):44,911
Last modified:October 25, 2005 - v1
Checksum:iF735D78B303EA158
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ185133 mRNA. Translation: ABA28314.1.
BC139167 mRNA. Translation: AAI39168.1.
BC139168 mRNA. Translation: AAI39169.1.
CCDSiCCDS27515.1.
RefSeqiNP_001029048.1. NM_001033876.1.
UniGeneiMm.386856.

Genome annotation databases

EnsembliENSMUST00000044624; ENSMUSP00000038729; ENSMUSG00000036760.
GeneIDi223604.
KEGGimmu:223604.
UCSCiuc007wbk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ185133 mRNA. Translation: ABA28314.1.
BC139167 mRNA. Translation: AAI39168.1.
BC139168 mRNA. Translation: AAI39169.1.
CCDSiCCDS27515.1.
RefSeqiNP_001029048.1. NM_001033876.1.
UniGeneiMm.386856.

3D structure databases

ProteinModelPortaliQ3LS21.
SMRiQ3LS21. Positions 18-242.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ3LS21.

Proteomic databases

PRIDEiQ3LS21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044624; ENSMUSP00000038729; ENSMUSG00000036760.
GeneIDi223604.
KEGGimmu:223604.
UCSCiuc007wbk.1. mouse.

Organism-specific databases

CTDi51305.
MGIiMGI:3521816. Kcnk9.

Phylogenomic databases

eggNOGiNOG259548.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000231463.
HOVERGENiHBG052239.
InParanoidiQ3LS21.
KOiK04919.
OMAiSCRVEEI.
OrthoDBiEOG7B05DC.
PhylomeDBiQ3LS21.
TreeFamiTF313947.

Enzyme and pathway databases

ReactomeiREACT_321759. TWIK-releated acid-sensitive K+ channel (TASK).

Miscellaneous databases

NextBioi376755.
PROiQ3LS21.
SOURCEiSearch...

Gene expression databases

BgeeiQ3LS21.
CleanExiMM_KCNK9.
GenevestigatoriQ3LS21.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005407. KCNK9.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01585. TASK3CHANNEL.
PR01095. TASKCHANNEL.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Zinc and mercuric ions distinguish mouse TRESK from the other two-pore-domain K+ channels."
    Czirjak G., Enyedi P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NMRI.
    Tissue: Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiKCNK9_MOUSE
AccessioniPrimary (citable) accession number: Q3LS21
Secondary accession number(s): B2RT82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 25, 2005
Last modified: April 29, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.