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Q3LIE5 (ADPRM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase

EC=3.6.1.13
EC=3.6.1.16
EC=3.6.1.53
Alternative name(s):
ADPRibase-Mn
CDP-choline phosphohydrolase
Gene names
Name:ADPRM
Synonyms:C17orf48
ORF Names:MDS006, Nbla03831
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress By similarity.

Catalytic activity

CDP-choline + H2O = CMP + phosphocholine.

ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate.

CDP-glycerol + H2O = CMP + sn-glycerol 3-phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the ADPRibase-Mn family.

Sequence caution

The sequence AAF87317.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q3LIE5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q3LIE5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     202-205: LSEP → ELFL
     206-342: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
PRO_0000286567

Sites

Metal binding251Zinc 1 By similarity
Metal binding271Zinc 1 By similarity
Metal binding741Zinc 1 By similarity
Metal binding741Zinc 2 By similarity
Metal binding1101Zinc 2 By similarity
Metal binding2411Zinc 2 By similarity
Metal binding2781Zinc 2 By similarity
Metal binding2801Zinc 1 By similarity

Amino acid modifications

Modified residue11N-acetylmethionine Ref.6

Natural variations

Alternative sequence202 – 2054LSEP → ELFL in isoform 2.
VSP_025092
Alternative sequence206 – 342137Missing in isoform 2.
VSP_025093
Natural variant921L → R.
Corresponds to variant rs34940296 [ dbSNP | Ensembl ].
VAR_032125
Natural variant3371E → G.
Corresponds to variant rs406446 [ dbSNP | Ensembl ].
VAR_032126

Experimental info

Sequence conflict1131F → S in BAF85318. Ref.4
Sequence conflict2021L → F in AAF87317. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 2DBD4499D9DA2AC2

FASTA34239,529
        10         20         30         40         50         60 
MDDKPNPEAL SDSSERLFSF GVIADVQFAD LEDGFNFQGT RRRYYRHSLL HLQGAIEDWN 

        70         80         90        100        110        120 
NESSMPCCVL QLGDIIDGYN AQYNASKKSL ELVMDMFKRL KVPVHHTWGN HEFYNFSREY 

       130        140        150        160        170        180 
LTHSKLNTKF LEDQIVHHPE TMPSEDYYAY HFVPFPKFRF ILLDAYDLSV LGVDQSSPKY 

       190        200        210        220        230        240 
EQCMKILREH NPNTELNSPQ GLSEPQFVQF NGGFSQEQLN WLNEVLTFSD TNQEKVVIVS 

       250        260        270        280        290        300 
HLPIYPDASD NVCLAWNYRD ALAVIWSHEC VVCFFAGHTH DGGYSEDPFG VYHVNLEGVI 

       310        320        330        340 
ETAPDSQAFG TVHVYPDKMM LKGRGRVPDR IMNYKKERAF HC 

« Hide

Isoform 2 [UniParc].

Checksum: C830ED5DC8F1C833
Show »

FASTA20524,010

References

[1]"Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."
Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.
Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Neuroblastoma.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Thymus.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Placenta and Testis.
[5]"Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
Huang C., Zhang C., Tu Y., Gu W., Wang Y., Han Z., Chen Z., Zhou J., Gu J., Huang Q., Yu Y., Xu S., Ren S., Fu G.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-217 (ISOFORM 1).
Tissue: Hematopoietic stem cell.
[6]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB073393 mRNA. Translation: BAE45723.1.
AK292629 mRNA. Translation: BAF85318.1.
CH471108 Genomic DNA. Translation: EAW89995.1.
CH471108 Genomic DNA. Translation: EAW89996.1.
BC001294 mRNA. Translation: AAH01294.1.
BC070155 mRNA. Translation: AAH70155.1.
AF168715 mRNA. Translation: AAF87317.1. Frameshift.
RefSeqNP_064618.3. NM_020233.4.
UniGeneHs.47668.
Hs.708369.

3D structure databases

ProteinModelPortalQ3LIE5.
SMRQ3LIE5. Positions 17-334.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121302. 1 interaction.
STRING9606.ENSP00000369099.

PTM databases

PhosphoSiteQ3LIE5.

Polymorphism databases

DMDM121942723.

Proteomic databases

PaxDbQ3LIE5.
PRIDEQ3LIE5.

Protocols and materials databases

DNASU56985.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000379774; ENSP00000369099; ENSG00000170222. [Q3LIE5-1]
ENST00000468843; ENSP00000431622; ENSG00000170222. [Q3LIE5-3]
GeneID56985.
KEGGhsa:56985.
UCSCuc002gmt.3. human. [Q3LIE5-1]

Organism-specific databases

CTD56985.
GeneCardsGC17P010600.
HGNCHGNC:30925. ADPRM.
HPAHPA023265.
HPA023820.
neXtProtNX_Q3LIE5.
PharmGKBPA142672231.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1409.
HOGENOMHOG000154875.
HOVERGENHBG100432.
InParanoidQ3LIE5.
KOK01517.
OMALAWNYRD.
OrthoDBEOG757CXK.
PhylomeDBQ3LIE5.
TreeFamTF331229.

Gene expression databases

BgeeQ3LIE5.
CleanExHS_C17orf48.
GenevestigatorQ3LIE5.

Family and domain databases

InterProIPR004843. Calcineurin-like_PHP_apaH.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi56985.
NextBio62667.
PROQ3LIE5.

Entry information

Entry nameADPRM_HUMAN
AccessionPrimary (citable) accession number: Q3LIE5
Secondary accession number(s): A8K9B4 expand/collapse secondary AC list , D3DTS4, Q9BVD4, Q9NRU8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: November 8, 2005
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM