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Q3LIE5

- ADPRM_HUMAN

UniProt

Q3LIE5 - ADPRM_HUMAN

Protein

Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase

Gene

ADPRM

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress By similarity.By similarity

    Catalytic activityi

    CDP-choline + H2O = CMP + phosphocholine.
    ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate.
    CDP-glycerol + H2O = CMP + sn-glycerol 3-phosphate.

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi25 – 251Zinc 1By similarity
    Metal bindingi27 – 271Zinc 1By similarity
    Metal bindingi74 – 741Zinc 1By similarity
    Metal bindingi74 – 741Zinc 2By similarity
    Metal bindingi110 – 1101Zinc 2By similarity
    Metal bindingi241 – 2411Zinc 2By similarity
    Metal bindingi278 – 2781Zinc 2By similarity
    Metal bindingi280 – 2801Zinc 1By similarity

    GO - Molecular functioni

    1. ADP-ribose diphosphatase activity Source: UniProtKB-EC
    2. CDP-glycerol diphosphatase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase (EC:3.6.1.13, EC:3.6.1.16, EC:3.6.1.53)
    Alternative name(s):
    ADPRibase-Mn
    CDP-choline phosphohydrolase
    Gene namesi
    Name:ADPRM
    Synonyms:C17orf48
    ORF Names:MDS006, Nbla03831
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:30925. ADPRM.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672231.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Manganese-dependent ADP-ribose/CDP-alcohol diphosphatasePRO_0000286567Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ3LIE5.
    PaxDbiQ3LIE5.
    PRIDEiQ3LIE5.

    PTM databases

    PhosphoSiteiQ3LIE5.

    Expressioni

    Gene expression databases

    BgeeiQ3LIE5.
    CleanExiHS_C17orf48.
    GenevestigatoriQ3LIE5.

    Organism-specific databases

    HPAiHPA023265.
    HPA023820.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    BioGridi121302. 1 interaction.
    STRINGi9606.ENSP00000369099.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3LIE5.
    SMRiQ3LIE5. Positions 17-334.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ADPRibase-Mn family.Curated

    Phylogenomic databases

    eggNOGiCOG1409.
    HOGENOMiHOG000154875.
    HOVERGENiHBG100432.
    InParanoidiQ3LIE5.
    KOiK01517.
    OMAiLAWNYRD.
    OrthoDBiEOG757CXK.
    PhylomeDBiQ3LIE5.
    TreeFamiTF331229.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3LIE5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDDKPNPEAL SDSSERLFSF GVIADVQFAD LEDGFNFQGT RRRYYRHSLL    50
    HLQGAIEDWN NESSMPCCVL QLGDIIDGYN AQYNASKKSL ELVMDMFKRL 100
    KVPVHHTWGN HEFYNFSREY LTHSKLNTKF LEDQIVHHPE TMPSEDYYAY 150
    HFVPFPKFRF ILLDAYDLSV LGVDQSSPKY EQCMKILREH NPNTELNSPQ 200
    GLSEPQFVQF NGGFSQEQLN WLNEVLTFSD TNQEKVVIVS HLPIYPDASD 250
    NVCLAWNYRD ALAVIWSHEC VVCFFAGHTH DGGYSEDPFG VYHVNLEGVI 300
    ETAPDSQAFG TVHVYPDKMM LKGRGRVPDR IMNYKKERAF HC 342
    Length:342
    Mass (Da):39,529
    Last modified:November 8, 2005 - v1
    Checksum:i2DBD4499D9DA2AC2
    GO
    Isoform 2 (identifier: Q3LIE5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         202-205: LSEP → ELFL
         206-342: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:205
    Mass (Da):24,010
    Checksum:iC830ED5DC8F1C833
    GO

    Sequence cautioni

    The sequence AAF87317.1 differs from that shown. Reason: Frameshift at several positions.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti113 – 1131F → S in BAF85318. (PubMed:15489334)Curated
    Sequence conflicti202 – 2021L → F in AAF87317. (PubMed:12880961)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti92 – 921L → R.
    Corresponds to variant rs34940296 [ dbSNP | Ensembl ].
    VAR_032125
    Natural varianti337 – 3371E → G.
    Corresponds to variant rs406446 [ dbSNP | Ensembl ].
    VAR_032126

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei202 – 2054LSEP → ELFL in isoform 2. 2 PublicationsVSP_025092
    Alternative sequencei206 – 342137Missing in isoform 2. 2 PublicationsVSP_025093Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB073393 mRNA. Translation: BAE45723.1.
    AK292629 mRNA. Translation: BAF85318.1.
    CH471108 Genomic DNA. Translation: EAW89995.1.
    CH471108 Genomic DNA. Translation: EAW89996.1.
    BC001294 mRNA. Translation: AAH01294.1.
    BC070155 mRNA. Translation: AAH70155.1.
    AF168715 mRNA. Translation: AAF87317.1. Frameshift.
    CCDSiCCDS11159.2. [Q3LIE5-1]
    RefSeqiNP_064618.3. NM_020233.4. [Q3LIE5-1]
    UniGeneiHs.47668.
    Hs.708369.

    Genome annotation databases

    EnsembliENST00000379774; ENSP00000369099; ENSG00000170222. [Q3LIE5-1]
    ENST00000468843; ENSP00000431622; ENSG00000170222. [Q3LIE5-3]
    GeneIDi56985.
    KEGGihsa:56985.
    UCSCiuc002gmt.3. human. [Q3LIE5-1]

    Polymorphism databases

    DMDMi121942723.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB073393 mRNA. Translation: BAE45723.1 .
    AK292629 mRNA. Translation: BAF85318.1 .
    CH471108 Genomic DNA. Translation: EAW89995.1 .
    CH471108 Genomic DNA. Translation: EAW89996.1 .
    BC001294 mRNA. Translation: AAH01294.1 .
    BC070155 mRNA. Translation: AAH70155.1 .
    AF168715 mRNA. Translation: AAF87317.1 . Frameshift.
    CCDSi CCDS11159.2. [Q3LIE5-1 ]
    RefSeqi NP_064618.3. NM_020233.4. [Q3LIE5-1 ]
    UniGenei Hs.47668.
    Hs.708369.

    3D structure databases

    ProteinModelPortali Q3LIE5.
    SMRi Q3LIE5. Positions 17-334.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121302. 1 interaction.
    STRINGi 9606.ENSP00000369099.

    PTM databases

    PhosphoSitei Q3LIE5.

    Polymorphism databases

    DMDMi 121942723.

    Proteomic databases

    MaxQBi Q3LIE5.
    PaxDbi Q3LIE5.
    PRIDEi Q3LIE5.

    Protocols and materials databases

    DNASUi 56985.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379774 ; ENSP00000369099 ; ENSG00000170222 . [Q3LIE5-1 ]
    ENST00000468843 ; ENSP00000431622 ; ENSG00000170222 . [Q3LIE5-3 ]
    GeneIDi 56985.
    KEGGi hsa:56985.
    UCSCi uc002gmt.3. human. [Q3LIE5-1 ]

    Organism-specific databases

    CTDi 56985.
    GeneCardsi GC17P010600.
    HGNCi HGNC:30925. ADPRM.
    HPAi HPA023265.
    HPA023820.
    neXtProti NX_Q3LIE5.
    PharmGKBi PA142672231.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1409.
    HOGENOMi HOG000154875.
    HOVERGENi HBG100432.
    InParanoidi Q3LIE5.
    KOi K01517.
    OMAi LAWNYRD.
    OrthoDBi EOG757CXK.
    PhylomeDBi Q3LIE5.
    TreeFami TF331229.

    Miscellaneous databases

    GenomeRNAii 56985.
    NextBioi 62667.
    PROi Q3LIE5.

    Gene expression databases

    Bgeei Q3LIE5.
    CleanExi HS_C17orf48.
    Genevestigatori Q3LIE5.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."
      Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.
      Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Neuroblastoma.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Thymus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta and Testis.
    5. "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
      Huang C., Zhang C., Tu Y., Gu W., Wang Y., Han Z., Chen Z., Zhou J., Gu J., Huang Q., Yu Y., Xu S., Ren S., Fu G.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-217 (ISOFORM 1).
      Tissue: Hematopoietic stem cell.
    6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiADPRM_HUMAN
    AccessioniPrimary (citable) accession number: Q3LIE5
    Secondary accession number(s): A8K9B4
    , D3DTS4, Q9BVD4, Q9NRU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3