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Protein

Keratin-associated protein 24-1

Gene

KRTAP24-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32439-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 24-1
Gene namesi
Name:KRTAP24-1
Synonyms:KAP24.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:33902. KRTAP24-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188694.
PharmGKBiPA162393751.

Polymorphism and mutation databases

BioMutaiKRTAP24-1.
DMDMi88909179.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002239151 – 254Keratin-associated protein 24-1Add BLAST254

Proteomic databases

PaxDbiQ3LI83.
PeptideAtlasiQ3LI83.
PRIDEiQ3LI83.

PTM databases

PhosphoSitePlusiQ3LI83.

Expressioni

Tissue specificityi

Specific expression in the middle/upper hair cuticle.1 Publication

Gene expression databases

CleanExiHS_KRTAP24-1.

Organism-specific databases

HPAiCAB034141.
HPA031325.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000339238.

Structurei

3D structure databases

ProteinModelPortaliQ3LI83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati193 – 202110
Repeati203 – 212210
Repeati213 – 222310
Repeati223 – 232410
Repeati233 – 242510
Repeati243 – 252610

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni193 – 2526 X 10 AA repeats of Y-[ILR]-[SVPC]-[NRTS]-[SNTG]-X-[QHRP]-[PSY]-[QSL]-[SRK]Add BLAST60

Sequence similaritiesi

Belongs to the PMG family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J97W. Eukaryota.
ENOG41113BD. LUCA.
GeneTreeiENSGT00730000111541.
HOGENOMiHOG000113252.
HOVERGENiHBG081876.
InParanoidiQ3LI83.
OMAiQGNLWLL.
OrthoDBiEOG091G0JB9.
PhylomeDBiQ3LI83.
TreeFamiTF337331.

Family and domain databases

InterProiIPR007659. Keratin_matx.
IPR007951. KRTAP_PMG.
[Graphical view]
PANTHERiPTHR23260. PTHR23260. 1 hit.
PfamiPF05287. PMG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3LI83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAGSMSTTG YPGVCSTTSY RTHCYIPVTS SVTLSSSDLS PTFGHCLPSS
60 70 80 90 100
YQGNLWLLDY CQESYGEAPT CKSPSCEPKT CSTTGCDPSN SSVPCNSPSA
110 120 130 140 150
GQVFSVCETT NVSPSPSCSP STQTNGYVCN CHIPTRNASK ACQTLRNGSN
160 170 180 190 200
CFGQLNCLSK SFQTLNHCRL STLGYKSYQN PCFIPSYVSP LCYISNSCQP
210 220 230 240 250
QSYLVRNYHY SSYRPTSCRP LSYLSRSFRS LSYIPSTFPP LRYLCSGSRP

LKCY
Length:254
Mass (Da):27,719
Last modified:November 8, 2005 - v1
Checksum:i18A51653AF7FDB59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096935 mRNA. Translation: BAE46350.1.
AM238513 mRNA. Translation: CAJ87483.1.
CCDSiCCDS42915.1.
RefSeqiNP_001078924.1. NM_001085455.2.
UniGeneiHs.580883.

Genome annotation databases

EnsembliENST00000340345; ENSP00000339238; ENSG00000188694.
GeneIDi643803.
KEGGihsa:643803.
UCSCiuc002ynv.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096935 mRNA. Translation: BAE46350.1.
AM238513 mRNA. Translation: CAJ87483.1.
CCDSiCCDS42915.1.
RefSeqiNP_001078924.1. NM_001085455.2.
UniGeneiHs.580883.

3D structure databases

ProteinModelPortaliQ3LI83.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000339238.

PTM databases

PhosphoSitePlusiQ3LI83.

Polymorphism and mutation databases

BioMutaiKRTAP24-1.
DMDMi88909179.

Proteomic databases

PaxDbiQ3LI83.
PeptideAtlasiQ3LI83.
PRIDEiQ3LI83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340345; ENSP00000339238; ENSG00000188694.
GeneIDi643803.
KEGGihsa:643803.
UCSCiuc002ynv.3. human.

Organism-specific databases

CTDi643803.
GeneCardsiKRTAP24-1.
HGNCiHGNC:33902. KRTAP24-1.
HPAiCAB034141.
HPA031325.
neXtProtiNX_Q3LI83.
OpenTargetsiENSG00000188694.
PharmGKBiPA162393751.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J97W. Eukaryota.
ENOG41113BD. LUCA.
GeneTreeiENSGT00730000111541.
HOGENOMiHOG000113252.
HOVERGENiHBG081876.
InParanoidiQ3LI83.
OMAiQGNLWLL.
OrthoDBiEOG091G0JB9.
PhylomeDBiQ3LI83.
TreeFamiTF337331.

Enzyme and pathway databases

BioCyciZFISH:G66-32439-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.

Miscellaneous databases

GenomeRNAii643803.
PROiQ3LI83.

Gene expression databases

CleanExiHS_KRTAP24-1.

Family and domain databases

InterProiIPR007659. Keratin_matx.
IPR007951. KRTAP_PMG.
[Graphical view]
PANTHERiPTHR23260. PTHR23260. 1 hit.
PfamiPF05287. PMG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKR241_HUMAN
AccessioniPrimary (citable) accession number: Q3LI83
Secondary accession number(s): Q1XDX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 8, 2005
Last modified: November 30, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Has a low cysteine content when compared to the majority of known KAP family members. Possesses several C-terminal tyrosine-containing tandem decameric repeat structures.

Caution

It is uncertain whether Met-1 or Met-6 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.