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Protein

Keratin-associated protein 27-1

Gene

KRTAP27-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 27-1
Gene namesi
Name:KRTAP27-1
Synonyms:KAP27.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000206107.2.
HGNCiHGNC:33864. KRTAP27-1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393770.

Polymorphism and mutation databases

BioMutaiKRTAP27-1.
DMDMi121942690.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003079161 – 207Keratin-associated protein 27-1Add BLAST207

Proteomic databases

PaxDbiQ3LI81.
PRIDEiQ3LI81.

Expressioni

Gene expression databases

BgeeiENSG00000206107.
CleanExiHS_KRTAP27-1.

Organism-specific databases

HPAiHPA021522.
HPA048826.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000372286.

Structurei

3D structure databases

ProteinModelPortaliQ3LI81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMG family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4726. Eukaryota.
ENOG410XY8D. LUCA.
GeneTreeiENSGT00730000111539.
HOGENOMiHOG000113256.
HOVERGENiHBG094601.
InParanoidiQ3LI81.
OMAiSTYEPTC.
OrthoDBiEOG091G0P1W.
PhylomeDBiQ3LI81.
TreeFamiTF337331.

Family and domain databases

InterProiView protein in InterPro
IPR007951. KRTAP_PMG.
PANTHERiPTHR19051. PTHR19051. 1 hit.
PfamiView protein in Pfam
PF05287. PMG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3LI81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHSHCHSLR SFHNAPPLSA ITHGTNPITF EDRLCLPSSF HSRTCFLDNF
60 70 80 90 100
QETCNETTSC QMTNCEQDLF TDDSCVQSNC FPGVVQTTYS NSRPCERTAC
110 120 130 140 150
QSESSSAGLA CVSQPCQSES TQQMGFVAQS CQPASLKGNS CPPKTSKSKN
160 170 180 190 200
FETLERASSQ CQCQSQNPES SSCRPLVNVA PEPQLLESSP GVEPTCCVTG

GSQLPSK
Length:207
Mass (Da):22,345
Last modified:November 8, 2005 - v1
Checksum:i094D8B31C20B7980
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05347999A → V. Corresponds to variant dbSNP:rs2244485Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096937 mRNA. Translation: BAE46352.1.
CCDSiCCDS33532.1.
RefSeqiNP_001071179.1. NM_001077711.1.
UniGeneiHs.580881.

Genome annotation databases

EnsembliENST00000382835; ENSP00000372286; ENSG00000206107.
GeneIDi643812.
KEGGihsa:643812.
UCSCiuc002ynx.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKR271_HUMAN
AccessioniPrimary (citable) accession number: Q3LI81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 8, 2005
Last modified: September 27, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families