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Protein

Keratin-associated protein 15-1

Gene

KRTAP15-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 15-1
Gene namesi
Name:KRTAP15-1
Synonyms:KAP15.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000186970.4.
HGNCiHGNC:18927. KRTAP15-1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134911178.

Polymorphism and mutation databases

BioMutaiKRTAP15-1.
DMDMi209572640.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002239171 – 137Keratin-associated protein 15-1Add BLAST137

Proteomic databases

PaxDbiQ3LI76.
PRIDEiQ3LI76.

PTM databases

PhosphoSitePlusiQ3LI76.

Expressioni

Gene expression databases

CleanExiHS_KRTAP15-1.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi129062. 1 interactor.
IntActiQ3LI76. 67 interactors.
STRINGi9606.ENSP00000334866.

Structurei

3D structure databases

ProteinModelPortaliQ3LI76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMG family.Curated

Phylogenomic databases

eggNOGiENOG410J2YJ. Eukaryota.
ENOG41119RP. LUCA.
GeneTreeiENSGT00390000012339.
HOGENOMiHOG000234032.
HOVERGENiHBG052275.
InParanoidiQ3LI76.
OMAiQTSCTLA.
OrthoDBiEOG091G0PYN.
PhylomeDBiQ3LI76.
TreeFamiTF337331.

Family and domain databases

InterProiView protein in InterPro
IPR007951. KRTAP_PMG.
PANTHERiPTHR19051. PTHR19051. 1 hit.
PfamiView protein in Pfam
PF05287. PMG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3LI76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYNCSSGNF SSCCFGSYLR YPVSTYNLFY PSNAIYSPNT CQLGSSLYNG
60 70 80 90 100
CQETYCEPTS CQTSCTLARS YQTSCYCPKN SIFCSPRQTN YIRSLGCGNT
110 120 130
GLGSLGCGST GFQSLDCGSS FYHPTTFSSR NFQATCY
Length:137
Mass (Da):14,979
Last modified:October 14, 2008 - v2
Checksum:i8C68B00CDF87837D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04701943L → M2 PublicationsCorresponds to variant dbSNP:rs2832873Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096942 mRNA. Translation: BAE46357.1.
BC104927 mRNA. Translation: AAI04928.1.
BC104925 mRNA. Translation: AAI04926.1.
CCDSiCCDS13593.1.
RefSeqiNP_853654.1. NM_181623.1.
UniGeneiHs.553654.

Genome annotation databases

EnsembliENST00000334067; ENSP00000334866; ENSG00000186970.
GeneIDi254950.
KEGGihsa:254950.
UCSCiuc002yod.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKR151_HUMAN
AccessioniPrimary (citable) accession number: Q3LI76
Secondary accession number(s): Q2M3F4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: October 14, 2008
Last modified: September 27, 2017
This is version 74 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families