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Protein

Keratin-associated protein 15-1

Gene

KRTAP15-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 15-1
Gene namesi
Name:KRTAP15-1
Synonyms:KAP15.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:18927. KRTAP15-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134911178.

Polymorphism and mutation databases

BioMutaiKRTAP15-1.
DMDMi209572640.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 137137Keratin-associated protein 15-1PRO_0000223917Add
BLAST

Proteomic databases

PaxDbiQ3LI76.
PRIDEiQ3LI76.

PTM databases

PhosphoSiteiQ3LI76.

Expressioni

Gene expression databases

CleanExiHS_KRTAP15-1.

Organism-specific databases

HPAiHPA019534.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000334866.

Structurei

3D structure databases

ProteinModelPortaliQ3LI76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMG family.Curated

Phylogenomic databases

eggNOGiENOG410J2YJ. Eukaryota.
ENOG41119RP. LUCA.
GeneTreeiENSGT00390000012339.
HOGENOMiHOG000234032.
HOVERGENiHBG052275.
InParanoidiQ3LI76.
OMAiQTSCTLA.
OrthoDBiEOG7DNNWM.
PhylomeDBiQ3LI76.
TreeFamiTF337331.

Family and domain databases

InterProiIPR007951. KRTAP_PMG.
[Graphical view]
PANTHERiPTHR19051. PTHR19051. 1 hit.
PfamiPF05287. PMG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3LI76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYNCSSGNF SSCCFGSYLR YPVSTYNLFY PSNAIYSPNT CQLGSSLYNG
60 70 80 90 100
CQETYCEPTS CQTSCTLARS YQTSCYCPKN SIFCSPRQTN YIRSLGCGNT
110 120 130
GLGSLGCGST GFQSLDCGSS FYHPTTFSSR NFQATCY
Length:137
Mass (Da):14,979
Last modified:October 14, 2008 - v2
Checksum:i8C68B00CDF87837D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431L → M.2 Publications
Corresponds to variant rs2832873 [ dbSNP | Ensembl ].
VAR_047019

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096942 mRNA. Translation: BAE46357.1.
BC104927 mRNA. Translation: AAI04928.1.
BC104925 mRNA. Translation: AAI04926.1.
CCDSiCCDS13593.1.
RefSeqiNP_853654.1. NM_181623.1.
UniGeneiHs.553654.

Genome annotation databases

EnsembliENST00000334067; ENSP00000334866; ENSG00000186970.
GeneIDi254950.
KEGGihsa:254950.
UCSCiuc002yod.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096942 mRNA. Translation: BAE46357.1.
BC104927 mRNA. Translation: AAI04928.1.
BC104925 mRNA. Translation: AAI04926.1.
CCDSiCCDS13593.1.
RefSeqiNP_853654.1. NM_181623.1.
UniGeneiHs.553654.

3D structure databases

ProteinModelPortaliQ3LI76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000334866.

PTM databases

PhosphoSiteiQ3LI76.

Polymorphism and mutation databases

BioMutaiKRTAP15-1.
DMDMi209572640.

Proteomic databases

PaxDbiQ3LI76.
PRIDEiQ3LI76.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334067; ENSP00000334866; ENSG00000186970.
GeneIDi254950.
KEGGihsa:254950.
UCSCiuc002yod.4. human.

Organism-specific databases

CTDi254950.
GeneCardsiKRTAP15-1.
HGNCiHGNC:18927. KRTAP15-1.
HPAiHPA019534.
neXtProtiNX_Q3LI76.
PharmGKBiPA134911178.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2YJ. Eukaryota.
ENOG41119RP. LUCA.
GeneTreeiENSGT00390000012339.
HOGENOMiHOG000234032.
HOVERGENiHBG052275.
InParanoidiQ3LI76.
OMAiQTSCTLA.
OrthoDBiEOG7DNNWM.
PhylomeDBiQ3LI76.
TreeFamiTF337331.

Miscellaneous databases

GenomeRNAii254950.
PROiQ3LI76.

Gene expression databases

CleanExiHS_KRTAP15-1.

Family and domain databases

InterProiIPR007951. KRTAP_PMG.
[Graphical view]
PANTHERiPTHR19051. PTHR19051. 1 hit.
PfamiPF05287. PMG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of complete keratin-associated protein (KAP) gene cluster spanning 800 kb region on human chromosome 21q22.11."
    Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-43.
    Tissue: Hair root.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-43.

Entry informationi

Entry nameiKR151_HUMAN
AccessioniPrimary (citable) accession number: Q3LI76
Secondary accession number(s): Q2M3F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: October 14, 2008
Last modified: June 8, 2016
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.