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Protein

Keratin-associated protein 19-4

Gene

KRTAP19-4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 19-4
Gene namesi
Name:KRTAP19-4
Synonyms:KAP19.4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:18939. KRTAP19-4.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134984740.

Polymorphism and mutation databases

BioMutaiKRTAP19-4.
DMDMi88909170.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002239061 – 84Keratin-associated protein 19-4Add BLAST84

Proteomic databases

PaxDbiQ3LI73.
PeptideAtlasiQ3LI73.
PRIDEiQ3LI73.

PTM databases

iPTMnetiQ3LI73.
PhosphoSitePlusiQ3LI73.

Expressioni

Gene expression databases

CleanExiHS_KRTAP19-4.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Protein-protein interaction databases

IntActiQ3LI73. 3 interactors.
STRINGi9606.ENSP00000335567.

Structurei

3D structure databases

ProteinModelPortaliQ3LI73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KRTAP type 19 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00760000120425.
HOGENOMiHOG000113245.
OMAiEEPMCAT.
OrthoDBiEOG091G1BUQ.

Family and domain databases

InterProiView protein in InterPro
IPR021743. KRTAP_type6/8/16/19/20/21.
PfamiView protein in Pfam
PF11759. KRTAP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3LI73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYYGSYYRG LGYGCGGFGG LGYGYGCGCG SFRRLGYGCG FGGNGYGYCR
60 70 80
PSCYGGYGFS ILLKSYPEDT ISEVIRRSFN LTKY
Length:84
Mass (Da):9,106
Last modified:November 8, 2005 - v1
Checksum:iDEE899C59F81C419
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05347548Y → C1 PublicationCorresponds to variant dbSNP:rs2298437Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096945 mRNA. Translation: BAE46360.1.
BC117197 mRNA. Translation: AAI17198.1.
BC117199 mRNA. Translation: AAI17200.1.
CCDSiCCDS33534.1.
RefSeqiNP_853641.1. NM_181610.1.
UniGeneiHs.553693.

Genome annotation databases

EnsembliENST00000334058; ENSP00000335567; ENSG00000186967.
GeneIDi337971.
KEGGihsa:337971.
UCSCiuc011acz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKR194_HUMAN
AccessioniPrimary (citable) accession number: Q3LI73
Secondary accession number(s): Q17RT4, Q17RT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 8, 2005
Last modified: March 15, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families