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Protein

Keratin-associated protein 19-5

Gene

KRTAP19-5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 19-5
Gene namesi
Name:KRTAP19-5
Synonyms:KAP19.5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:18940. KRTAP19-5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134992782.

Polymorphism and mutation databases

BioMutaiKRTAP19-5.
DMDMi88909171.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7272Keratin-associated protein 19-5PRO_0000223907Add
BLAST

Proteomic databases

PRIDEiQ3LI72.

Expressioni

Gene expression databases

CleanExiHS_KRTAP19-5.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CAMK2BQ135543EBI-1048945,EBI-1058722
DAB1O755533EBI-1048945,EBI-7875264
DAZAP2Q150383EBI-1048945,EBI-724310
HEL-S-101V9HW273EBI-1048945,EBI-10178933
MAGED1Q9Y5V33EBI-1048945,EBI-716006
PSMA3P257883EBI-1048945,EBI-348380
RBPMSQ930624EBI-1048945,EBI-740322
RHOXF2Q9BQY43EBI-1048945,EBI-372094
VAC14Q08AM63EBI-1048945,EBI-2107455

Protein-protein interaction databases

BioGridi130655. 11 interactions.
IntActiQ3LI72. 9 interactions.
STRINGi9606.ENSP00000334985.

Structurei

3D structure databases

ProteinModelPortaliQ3LI72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KRTAP type 19 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00730000112254.
HOGENOMiHOG000113246.
OMAiYGFSSCY.

Family and domain databases

InterProiIPR021743. KRTAP_type6/8/16/19/20.
[Graphical view]
PfamiPF11759. KRTAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3LI72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYYGNYYGG LGYGYGGFDD LGYGYGCGCG SFRRLGYGGG YGGYGYGSGF
60 70
GGYGYRSCRP SCYGGYGFSG FY
Length:72
Mass (Da):7,624
Last modified:November 8, 2005 - v1
Checksum:iEEBDA9D9506BCCD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096946 mRNA. Translation: BAE46361.1.
BC100836 mRNA. Translation: AAI00837.1.
BC100837 mRNA. Translation: AAI00838.1.
BC100838 mRNA. Translation: AAI00839.1.
BC100839 mRNA. Translation: AAI00840.1.
BC113020 mRNA. Translation: AAI13021.1.
BC113021 mRNA. Translation: AAI13022.1.
CCDSiCCDS13597.1.
RefSeqiNP_853642.1. NM_181611.1.
UniGeneiHs.553694.

Genome annotation databases

EnsembliENST00000334151; ENSP00000334985; ENSG00000186977.
GeneIDi337972.
KEGGihsa:337972.
UCSCiuc011ada.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096946 mRNA. Translation: BAE46361.1.
BC100836 mRNA. Translation: AAI00837.1.
BC100837 mRNA. Translation: AAI00838.1.
BC100838 mRNA. Translation: AAI00839.1.
BC100839 mRNA. Translation: AAI00840.1.
BC113020 mRNA. Translation: AAI13021.1.
BC113021 mRNA. Translation: AAI13022.1.
CCDSiCCDS13597.1.
RefSeqiNP_853642.1. NM_181611.1.
UniGeneiHs.553694.

3D structure databases

ProteinModelPortaliQ3LI72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130655. 11 interactions.
IntActiQ3LI72. 9 interactions.
STRINGi9606.ENSP00000334985.

Polymorphism and mutation databases

BioMutaiKRTAP19-5.
DMDMi88909171.

Proteomic databases

PRIDEiQ3LI72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334151; ENSP00000334985; ENSG00000186977.
GeneIDi337972.
KEGGihsa:337972.
UCSCiuc011ada.2. human.

Organism-specific databases

CTDi337972.
GeneCardsiGC21M031873.
HGNCiHGNC:18940. KRTAP19-5.
neXtProtiNX_Q3LI72.
PharmGKBiPA134992782.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00730000112254.
HOGENOMiHOG000113246.
OMAiYGFSSCY.

Miscellaneous databases

GenomeRNAii337972.
NextBioi96829.
PROiQ3LI72.

Gene expression databases

CleanExiHS_KRTAP19-5.

Family and domain databases

InterProiIPR021743. KRTAP_type6/8/16/19/20.
[Graphical view]
PfamiPF11759. KRTAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of complete keratin-associated protein (KAP) gene cluster spanning 800 kb region on human chromosome 21q22.11."
    Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hair root.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiKR195_HUMAN
AccessioniPrimary (citable) accession number: Q3LI72
Secondary accession number(s): A4IF22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 8, 2005
Last modified: July 22, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.