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Reviewed, UniProtKB/Swiss-Prot Q3LI72 (KR195_HUMAN)

Last modified July 7, 2009. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Keratin-associated protein 19-5
Gene names
Name: KRTAP19-5
Synonyms: KAP19.5
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length72 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Subunit structure

Interacts with hair keratins By similarity.

Sequence similarities

Belongs to the KRTAP type 19 family.

Ontologies

Keywords
   Cellular componentKeratin
   DomainRepeat
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentintermediate filament

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CDC20Q128341EBI-1048945,EBI-367462

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7272Keratin-associated protein 19-5
PRO_0000223907

Sequences

Sequence LengthMass (Da)Tools
Q3LI72-1 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: EEBDA9D9506BCCD7

FASTA727,624
        10         20         30         40         50         60 
MNYYGNYYGG LGYGYGGFDD LGYGYGCGCG SFRRLGYGGG YGGYGYGSGF GGYGYRSCRP 

        70 
SCYGGYGFSG FY 

« Hide

References

« Hide 'large scale' references
[1]"Identification of complete keratin-associated protein (KAP) gene cluster spanning 800 kb region on human chromosome 21q22.11."
Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hair root.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

AB096946 mRNA. Translation: BAE46361.1.
BC100836 mRNA. Translation: AAI00837.1.
BC100837 mRNA. Translation: AAI00838.1.
BC100838 mRNA. Translation: AAI00839.1.
BC100839 mRNA. Translation: AAI00840.1.
BC113020 mRNA. Translation: AAI13021.1.
BC113021 mRNA. Translation: AAI13022.1.
IPIIPI00373952.
RefSeqNP_853642.1.
UniGeneHs.553694

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ3LI72. 2 interactions.

Genome annotation databases

EnsemblENSG00000186977. Homo sapiens. [Contig view]
GeneID337972.
KEGGhsa:337972.
UCSCuc002yoi.1. human.

Organism-specific databases

GeneCardsGC21M030796.
HGNCHGNC:18940. KRTAP19-5.
PharmGKBPA134992782.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ3LI72.
HOVERGENQ3LI72.
OMAQ3LI72. MSHYSNY.

Gene expression databases

ArrayExpressQ3LI72.
CleanExHS_KRTAP19-5.

Family and domain databases

ProtoNetSearch...

Other Resources

NextBio96829.

Entry information

Entry nameKR195_HUMAN
AccessionPrimary (citable) accession number: Q3LI72
Secondary accession number(s): A4IF22
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 8, 2005
Last modified: July 7, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents