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Q3LI72

- KR195_HUMAN

UniProt

Q3LI72 - KR195_HUMAN

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Protein

Keratin-associated protein 19-5

Gene
KRTAP19-5, KAP19.5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 19-5
Gene namesi
Synonyms:KAP19.5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:18940. KRTAP19-5.

Subcellular locationi

GO - Cellular componenti

  1. intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134992782.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7272Keratin-associated protein 19-5PRO_0000223907Add
BLAST

Proteomic databases

PRIDEiQ3LI72.

Expressioni

Gene expression databases

CleanExiHS_KRTAP19-5.
GenevestigatoriQ3LI72.

Interactioni

Subunit structurei

Interacts with hair keratins By similarity.

Protein-protein interaction databases

BioGridi130655. 1 interaction.
STRINGi9606.ENSP00000334985.

Structurei

3D structure databases

ProteinModelPortaliQ3LI72.

Family & Domainsi

Sequence similaritiesi

Belongs to the KRTAP type 19 family.

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000113246.
OMAiCYRTSYY.

Family and domain databases

InterProiIPR021743. KRTAP_type6/8/16/19/20.
[Graphical view]
PfamiPF11759. KRTAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3LI72-1 [UniParc]FASTAAdd to Basket

« Hide

MNYYGNYYGG LGYGYGGFDD LGYGYGCGCG SFRRLGYGGG YGGYGYGSGF   50
GGYGYRSCRP SCYGGYGFSG FY 72
Length:72
Mass (Da):7,624
Last modified:November 8, 2005 - v1
Checksum:iEEBDA9D9506BCCD7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB096946 mRNA. Translation: BAE46361.1.
BC100836 mRNA. Translation: AAI00837.1.
BC100837 mRNA. Translation: AAI00838.1.
BC100838 mRNA. Translation: AAI00839.1.
BC100839 mRNA. Translation: AAI00840.1.
BC113020 mRNA. Translation: AAI13021.1.
BC113021 mRNA. Translation: AAI13022.1.
CCDSiCCDS13597.1.
RefSeqiNP_853642.1. NM_181611.1.
UniGeneiHs.553694.

Genome annotation databases

EnsembliENST00000334151; ENSP00000334985; ENSG00000186977.
GeneIDi337972.
KEGGihsa:337972.
UCSCiuc011ada.2. human.

Polymorphism databases

DMDMi88909171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB096946 mRNA. Translation: BAE46361.1 .
BC100836 mRNA. Translation: AAI00837.1 .
BC100837 mRNA. Translation: AAI00838.1 .
BC100838 mRNA. Translation: AAI00839.1 .
BC100839 mRNA. Translation: AAI00840.1 .
BC113020 mRNA. Translation: AAI13021.1 .
BC113021 mRNA. Translation: AAI13022.1 .
CCDSi CCDS13597.1.
RefSeqi NP_853642.1. NM_181611.1.
UniGenei Hs.553694.

3D structure databases

ProteinModelPortali Q3LI72.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 130655. 1 interaction.
STRINGi 9606.ENSP00000334985.

Polymorphism databases

DMDMi 88909171.

Proteomic databases

PRIDEi Q3LI72.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334151 ; ENSP00000334985 ; ENSG00000186977 .
GeneIDi 337972.
KEGGi hsa:337972.
UCSCi uc011ada.2. human.

Organism-specific databases

CTDi 337972.
GeneCardsi GC21M031873.
HGNCi HGNC:18940. KRTAP19-5.
neXtProti NX_Q3LI72.
PharmGKBi PA134992782.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000113246.
OMAi CYRTSYY.

Miscellaneous databases

GenomeRNAii 337972.
NextBioi 96829.
PROi Q3LI72.

Gene expression databases

CleanExi HS_KRTAP19-5.
Genevestigatori Q3LI72.

Family and domain databases

InterProi IPR021743. KRTAP_type6/8/16/19/20.
[Graphical view ]
Pfami PF11759. KRTAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of complete keratin-associated protein (KAP) gene cluster spanning 800 kb region on human chromosome 21q22.11."
    Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hair root.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiKR195_HUMAN
AccessioniPrimary (citable) accession number: Q3LI72
Secondary accession number(s): A4IF22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 8, 2005
Last modified: July 9, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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