Reviewed, UniProtKB/Swiss-Prot Q3LI72 (KR195_HUMAN)

Names and origin

Protein names

Recommended name:
    Keratin-associated protein 19-5

Gene names

Name:	KRTAP19-5
Synonyms:	KAP19.5

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	72 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Subunit structure	Interacts with hair keratins By similarity.
Sequence similarities	Belongs to the KRTAP type 19 family.

Ontologies

Keywords
Cellular component	Keratin
Domain	Repeat
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CDC20	Q12834	1	EBI-1048945,EBI-367462

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 72	72	Keratin-associated protein 19-5		PRO_0000223907

Sequences

	Sequence		Length	Mass (Da)
	Q3LI72-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: EEBDA9D9506BCCD7	FASTA	72	7,624
	10 20 30 40 50 60 MNYYGNYYGG LGYGYGGFDD LGYGYGCGCG SFRRLGYGGG YGGYGYGSGF GGYGYRSCRP 70 SCYGGYGFSG FY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of complete keratin-associated protein (KAP) gene cluster spanning 800 kb region on human chromosome 21q22.11." Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hair root.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB096946 mRNA. Translation: BAE46361.1. BC100836 mRNA. Translation: AAI00837.1. BC100837 mRNA. Translation: AAI00838.1. BC100838 mRNA. Translation: AAI00839.1. BC100839 mRNA. Translation: AAI00840.1. BC113020 mRNA. Translation: AAI13021.1. BC113021 mRNA. Translation: AAI13022.1.
IPI	IPI00373952.
RefSeq	NP_853642.1.
UniGene	Hs.553694
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q3LI72. 2 interactions.
Genome annotation databases
Ensembl	ENSG00000186977. Homo sapiens. [Contig view]
GeneID	337972.
KEGG	hsa:337972.
UCSC	uc002yoi.1. human.
Organism-specific databases
GeneCards	GC21M030796.
HGNC	HGNC:18940. KRTAP19-5.
PharmGKB	PA134992782.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q3LI72.
HOVERGEN	Q3LI72.
OMA	Q3LI72. MSHYSNY.
Gene expression databases
ArrayExpress	Q3LI72.
CleanEx	HS_KRTAP19-5.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	96829.

Entry information

Entry name

KR195_HUMAN

Accession

Primary (citable) accession number: Q3LI72
Secondary accession number(s): A4IF22

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	November 8, 2005
Last modified:	July 7, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)