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Q3LI72 (KR195_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin-associated protein 19-5
Gene names
Name:KRTAP19-5
Synonyms:KAP19.5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length72 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Subunit structure

Interacts with hair keratins By similarity.

Sequence similarities

Belongs to the KRTAP type 19 family.

Ontologies

Keywords
   Cellular componentKeratin
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintermediate filament

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7272Keratin-associated protein 19-5
PRO_0000223907

Sequences

Sequence LengthMass (Da)Tools
Q3LI72 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: EEBDA9D9506BCCD7

FASTA727,624
        10         20         30         40         50         60 
MNYYGNYYGG LGYGYGGFDD LGYGYGCGCG SFRRLGYGGG YGGYGYGSGF GGYGYRSCRP 

        70 
SCYGGYGFSG FY 

« Hide

References

« Hide 'large scale' references
[1]"Identification of complete keratin-associated protein (KAP) gene cluster spanning 800 kb region on human chromosome 21q22.11."
Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hair root.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB096946 mRNA. Translation: BAE46361.1.
BC100836 mRNA. Translation: AAI00837.1.
BC100837 mRNA. Translation: AAI00838.1.
BC100838 mRNA. Translation: AAI00839.1.
BC100839 mRNA. Translation: AAI00840.1.
BC113020 mRNA. Translation: AAI13021.1.
BC113021 mRNA. Translation: AAI13022.1.
RefSeqNP_853642.1. NM_181611.1.
UniGeneHs.553694.

3D structure databases

ProteinModelPortalQ3LI72.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid130655. 1 interaction.
STRING9606.ENSP00000334985.

Polymorphism databases

DMDM88909171.

Proteomic databases

PRIDEQ3LI72.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334151; ENSP00000334985; ENSG00000186977.
GeneID337972.
KEGGhsa:337972.
UCSCuc011ada.2. human.

Organism-specific databases

CTD337972.
GeneCardsGC21M031873.
HGNCHGNC:18940. KRTAP19-5.
neXtProtNX_Q3LI72.
PharmGKBPA134992782.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000113246.
OMACYRTSYY.

Gene expression databases

CleanExHS_KRTAP19-5.
GenevestigatorQ3LI72.

Family and domain databases

InterProIPR021743. KRTAP_type6/8/16/19/20.
[Graphical view]
PfamPF11759. KRTAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi337972.
NextBio96829.
PROQ3LI72.

Entry information

Entry nameKR195_HUMAN
AccessionPrimary (citable) accession number: Q3LI72
Secondary accession number(s): A4IF22
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 8, 2005
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM