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Protein

Keratin-associated protein 19-5

Gene

KRTAP19-5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 19-5
Gene namesi
Name:KRTAP19-5
Synonyms:KAP19.5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000186977.2.
HGNCiHGNC:18940. KRTAP19-5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134992782.

Polymorphism and mutation databases

BioMutaiKRTAP19-5.
DMDMi88909171.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002239071 – 72Keratin-associated protein 19-5Add BLAST72

Proteomic databases

PaxDbiQ3LI72.
PeptideAtlasiQ3LI72.
PRIDEiQ3LI72.

PTM databases

iPTMnetiQ3LI72.
PhosphoSitePlusiQ3LI72.

Expressioni

Gene expression databases

BgeeiENSG00000186977.
CleanExiHS_KRTAP19-5.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi130655. 11 interactors.
IntActiQ3LI72. 76 interactors.
STRINGi9606.ENSP00000334985.

Structurei

3D structure databases

ProteinModelPortaliQ3LI72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KRTAP type 19 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KCJM. Eukaryota.
ENOG4110NWA. LUCA.
GeneTreeiENSGT00730000112254.
HOGENOMiHOG000113246.
OMAiCRRPSHY.

Family and domain databases

InterProiView protein in InterPro
IPR021743. KRTAP_type6/8/16/19/20/21.
PfamiView protein in Pfam
PF11759. KRTAP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3LI72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYYGNYYGG LGYGYGGFDD LGYGYGCGCG SFRRLGYGGG YGGYGYGSGF
60 70
GGYGYRSCRP SCYGGYGFSG FY
Length:72
Mass (Da):7,624
Last modified:November 8, 2005 - v1
Checksum:iEEBDA9D9506BCCD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096946 mRNA. Translation: BAE46361.1.
BC100836 mRNA. Translation: AAI00837.1.
BC100837 mRNA. Translation: AAI00838.1.
BC100838 mRNA. Translation: AAI00839.1.
BC100839 mRNA. Translation: AAI00840.1.
BC113020 mRNA. Translation: AAI13021.1.
BC113021 mRNA. Translation: AAI13022.1.
CCDSiCCDS13597.1.
RefSeqiNP_853642.1. NM_181611.1.
UniGeneiHs.553694.

Genome annotation databases

EnsembliENST00000334151; ENSP00000334985; ENSG00000186977.
GeneIDi337972.
KEGGihsa:337972.
UCSCiuc011ada.3. human.

Similar proteinsi

Entry informationi

Entry nameiKR195_HUMAN
AccessioniPrimary (citable) accession number: Q3LI72
Secondary accession number(s): A4IF22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 8, 2005
Last modified: October 25, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families