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Q3LI72

- KR195_HUMAN

UniProt

Q3LI72 - KR195_HUMAN

Protein

Keratin-associated protein 19-5

Gene

KRTAP19-5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin-associated protein 19-5
    Gene namesi
    Name:KRTAP19-5
    Synonyms:KAP19.5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:18940. KRTAP19-5.

    Subcellular locationi

    GO - Cellular componenti

    1. intermediate filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134992782.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7272Keratin-associated protein 19-5PRO_0000223907Add
    BLAST

    Proteomic databases

    PRIDEiQ3LI72.

    Expressioni

    Gene expression databases

    CleanExiHS_KRTAP19-5.
    GenevestigatoriQ3LI72.

    Interactioni

    Subunit structurei

    Interacts with hair keratins.By similarity

    Protein-protein interaction databases

    BioGridi130655. 1 interaction.
    STRINGi9606.ENSP00000334985.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3LI72.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the KRTAP type 19 family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    HOGENOMiHOG000113246.
    OMAiCYRTSYY.

    Family and domain databases

    InterProiIPR021743. KRTAP_type6/8/16/19/20.
    [Graphical view]
    PfamiPF11759. KRTAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3LI72-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNYYGNYYGG LGYGYGGFDD LGYGYGCGCG SFRRLGYGGG YGGYGYGSGF   50
    GGYGYRSCRP SCYGGYGFSG FY 72
    Length:72
    Mass (Da):7,624
    Last modified:November 8, 2005 - v1
    Checksum:iEEBDA9D9506BCCD7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB096946 mRNA. Translation: BAE46361.1.
    BC100836 mRNA. Translation: AAI00837.1.
    BC100837 mRNA. Translation: AAI00838.1.
    BC100838 mRNA. Translation: AAI00839.1.
    BC100839 mRNA. Translation: AAI00840.1.
    BC113020 mRNA. Translation: AAI13021.1.
    BC113021 mRNA. Translation: AAI13022.1.
    CCDSiCCDS13597.1.
    RefSeqiNP_853642.1. NM_181611.1.
    UniGeneiHs.553694.

    Genome annotation databases

    EnsembliENST00000334151; ENSP00000334985; ENSG00000186977.
    GeneIDi337972.
    KEGGihsa:337972.
    UCSCiuc011ada.2. human.

    Polymorphism databases

    DMDMi88909171.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB096946 mRNA. Translation: BAE46361.1 .
    BC100836 mRNA. Translation: AAI00837.1 .
    BC100837 mRNA. Translation: AAI00838.1 .
    BC100838 mRNA. Translation: AAI00839.1 .
    BC100839 mRNA. Translation: AAI00840.1 .
    BC113020 mRNA. Translation: AAI13021.1 .
    BC113021 mRNA. Translation: AAI13022.1 .
    CCDSi CCDS13597.1.
    RefSeqi NP_853642.1. NM_181611.1.
    UniGenei Hs.553694.

    3D structure databases

    ProteinModelPortali Q3LI72.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130655. 1 interaction.
    STRINGi 9606.ENSP00000334985.

    Polymorphism databases

    DMDMi 88909171.

    Proteomic databases

    PRIDEi Q3LI72.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334151 ; ENSP00000334985 ; ENSG00000186977 .
    GeneIDi 337972.
    KEGGi hsa:337972.
    UCSCi uc011ada.2. human.

    Organism-specific databases

    CTDi 337972.
    GeneCardsi GC21M031873.
    HGNCi HGNC:18940. KRTAP19-5.
    neXtProti NX_Q3LI72.
    PharmGKBi PA134992782.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000113246.
    OMAi CYRTSYY.

    Miscellaneous databases

    GenomeRNAii 337972.
    NextBioi 96829.
    PROi Q3LI72.

    Gene expression databases

    CleanExi HS_KRTAP19-5.
    Genevestigatori Q3LI72.

    Family and domain databases

    InterProi IPR021743. KRTAP_type6/8/16/19/20.
    [Graphical view ]
    Pfami PF11759. KRTAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of complete keratin-associated protein (KAP) gene cluster spanning 800 kb region on human chromosome 21q22.11."
      Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.
      Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hair root.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiKR195_HUMAN
    AccessioniPrimary (citable) accession number: Q3LI72
    Secondary accession number(s): A4IF22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3