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Protein

Keratin-associated protein 6-2

Gene

KRTAP6-2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 6-2
Gene namesi
Name:KRTAP6-2
Synonyms:KAP6.2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:18932. KRTAP6-2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134980095.

Polymorphism and mutation databases

BioMutaiKRTAP6-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6262Keratin-associated protein 6-2PRO_0000223899Add
BLAST

Proteomic databases

PaxDbiQ3LI66.
PRIDEiQ3LI66.

PTM databases

PhosphoSiteiQ3LI66.

Expressioni

Gene expression databases

CleanExiHS_KRTAP6-2.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000334560.

Structurei

3D structure databases

ProteinModelPortaliQ3LI66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KRTAP type 6 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00730000113256.
OMAiSGFANYY.

Family and domain databases

InterProiIPR021743. KRTAP_type6/8/16/19/20/21.
[Graphical view]
PfamiPF11759. KRTAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3LI66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGSYYGNYY GDHGYGCCGY EGLGYGYGSL RCGYSSCCGY GHGYGSRFFC
60
GCGYGCGSGY YY
Length:62
Mass (Da):6,654
Last modified:November 8, 2005 - v1
Checksum:i46DB5B92F0BEEBC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096952 mRNA. Translation: BAE46367.1.
CCDSiCCDS13600.1.
RefSeqiNP_853635.1. NM_181604.1.
UniGeneiHs.553690.

Genome annotation databases

EnsembliENST00000334897; ENSP00000334560; ENSG00000186930.
GeneIDi337967.
KEGGihsa:337967.
UCSCiuc011adc.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096952 mRNA. Translation: BAE46367.1.
CCDSiCCDS13600.1.
RefSeqiNP_853635.1. NM_181604.1.
UniGeneiHs.553690.

3D structure databases

ProteinModelPortaliQ3LI66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000334560.

PTM databases

PhosphoSiteiQ3LI66.

Polymorphism and mutation databases

BioMutaiKRTAP6-2.

Proteomic databases

PaxDbiQ3LI66.
PRIDEiQ3LI66.

Protocols and materials databases

DNASUi337967.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334897; ENSP00000334560; ENSG00000186930.
GeneIDi337967.
KEGGihsa:337967.
UCSCiuc011adc.3. human.

Organism-specific databases

CTDi337967.
GeneCardsiKRTAP6-2.
HGNCiHGNC:18932. KRTAP6-2.
neXtProtiNX_Q3LI66.
PharmGKBiPA134980095.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00730000113256.
OMAiSGFANYY.

Miscellaneous databases

GenomeRNAii337967.
NextBioi96809.
PROiQ3LI66.

Gene expression databases

CleanExiHS_KRTAP6-2.

Family and domain databases

InterProiIPR021743. KRTAP_type6/8/16/19/20/21.
[Graphical view]
PfamiPF11759. KRTAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of eight novel genes from keratin associated protein gene cluster on human chromosome 21q22.11."
    Obayashi I., Shibuya K., Kudoh J., Shimizu N.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiKRA62_HUMAN
AccessioniPrimary (citable) accession number: Q3LI66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 8, 2005
Last modified: May 11, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.