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Protein

Keratin-associated protein 6-1

Gene

KRTAP6-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 6-1
Gene namesi
Name:KRTAP6-1
Synonyms:C21orf103, KAP6.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000184724.5
HGNCiHGNC:18931 KRTAP6-1
neXtProtiNX_Q3LI64

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134988301

Polymorphism and mutation databases

BioMutaiKRTAP6-1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002238981 – 71Keratin-associated protein 6-1Add BLAST71

Proteomic databases

PaxDbiQ3LI64
PeptideAtlasiQ3LI64
PRIDEiQ3LI64

PTM databases

iPTMnetiQ3LI64
PhosphoSitePlusiQ3LI64

Expressioni

Gene expression databases

BgeeiENSG00000184724
CleanExiHS_KRTAP6-1

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ3LI64, 42 interactors
STRINGi9606.ENSP00000332690

Structurei

3D structure databases

ProteinModelPortaliQ3LI64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KRTAP type 6 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00810000126944
OMAiRSLCGYG

Sequencei

Sequence statusi: Complete.

Q3LI64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGSYYGNYY GTPGYGFCGY GGLGYGYGGL GCGYGSCCGC GFRRLGCGYG
60 70
YGSRSLCGYG YGCGSGSGYY Y
Length:71
Mass (Da):7,279
Last modified:November 8, 2005 - v1
Checksum:i233D648E50FB8858
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096954 mRNA Translation: BAE46369.1
CCDSiCCDS13602.1
RefSeqiNP_853633.1, NM_181602.1
UniGeneiHs.194301
Hs.553689

Genome annotation databases

EnsembliENST00000329122; ENSP00000332690; ENSG00000184724
GeneIDi337966
KEGGihsa:337966
UCSCiuc002yop.4 human

Similar proteinsi

Entry informationi

Entry nameiKRA61_HUMAN
AccessioniPrimary (citable) accession number: Q3LI64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 8, 2005
Last modified: February 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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