Q3LI64 (KRA61_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin-associated protein 6-1

Gene names

Name:	KRTAP6-1
Synonyms:	C21orf103, KAP6.1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	71 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Subunit structure	Interacts with hair keratins By similarity.
Sequence similarities	Belongs to the KRTAP type 6 family.

Ontologies

Keywords
Cellular component	Keratin
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytosol Inferred from direct assay PubMed 16780588. Source: UniProtKB intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 71	71	Keratin-associated protein 6-1		PRO_0000223898

Sequences

	Sequence		Length	Mass (Da)
	Q3LI64 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 233D648E50FB8858	FASTA	71	7,279
	10 20 30 40 50 60 MCGSYYGNYY GTPGYGFCGY GGLGYGYGGL GCGYGSCCGC GFRRLGCGYG YGSRSLCGYG 70 YGCGSGSGYY Y

References

[1]

"Identification of complete keratin-associated protein (KAP) gene cluster spanning 800 kb region on human chromosome 21q22.11." Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hair root.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB096954 mRNA. Translation: BAE46369.1.
IPI	IPI00332220.
RefSeq	NP_853633.1. NM_181602.1.
UniGene	Hs.194301. Hs.553689.
3D structure databases
ProteinModelPortal	Q3LI64.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000332690.
PTM databases
PhosphoSite	Q3LI64.
Polymorphism databases
DMDM	88909180.
Proteomic databases
PRIDE	Q3LI64.
Protocols and materials databases
DNASU	337966.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000329122; ENSP00000332690; ENSG00000184724.
GeneID	337966.
KEGG	hsa:337966.
UCSC	uc002yop.3. human.
Organism-specific databases
CTD	337966.
GeneCards	GC21M031985.
HGNC	HGNC:18931. KRTAP6-1.
neXtProt	NX_Q3LI64.
PharmGKB	PA134988301.
GenAtlas	Search...
Phylogenomic databases
OMA	GNYYGTR.
Gene expression databases
CleanEx	HS_KRTAP6-1.
Genevestigator	Q3LI64.
Family and domain databases
ProtoNet	Search...
Other
NextBio	96805.

Entry information

Entry name

KRA61_HUMAN

Accession

Primary (citable) accession number: Q3LI64

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	November 8, 2005
Last modified:	April 3, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.