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Q3LI64 (KRA61_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin-associated protein 6-1
Gene names
Name:KRTAP6-1
Synonyms:C21orf103, KAP6.1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length71 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Subunit structure

Interacts with hair keratins By similarity.

Sequence similarities

Belongs to the KRTAP type 6 family.

Ontologies

Keywords
   Cellular componentKeratin
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytosol

Inferred from direct assay PubMed 16780588. Source: UniProtKB

intermediate filament

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7171Keratin-associated protein 6-1
PRO_0000223898

Sequences

Sequence LengthMass (Da)Tools
Q3LI64 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 233D648E50FB8858

FASTA717,279
        10         20         30         40         50         60 
MCGSYYGNYY GTPGYGFCGY GGLGYGYGGL GCGYGSCCGC GFRRLGCGYG YGSRSLCGYG 

        70 
YGCGSGSGYY Y 

« Hide

References

[1]"Identification of complete keratin-associated protein (KAP) gene cluster spanning 800 kb region on human chromosome 21q22.11."
Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hair root.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB096954 mRNA. Translation: BAE46369.1.
CCDSCCDS13602.1.
RefSeqNP_853633.1. NM_181602.1.
UniGeneHs.194301.
Hs.553689.

3D structure databases

ProteinModelPortalQ3LI64.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000332690.

PTM databases

PhosphoSiteQ3LI64.

Proteomic databases

PRIDEQ3LI64.

Protocols and materials databases

DNASU337966.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000329122; ENSP00000332690; ENSG00000184724.
GeneID337966.
KEGGhsa:337966.
UCSCuc002yop.3. human.

Organism-specific databases

CTD337966.
GeneCardsGC21M031985.
HGNCHGNC:18931. KRTAP6-1.
neXtProtNX_Q3LI64.
PharmGKBPA134988301.
GenAtlasSearch...

Phylogenomic databases

OMAMSEKTIQ.

Gene expression databases

CleanExHS_KRTAP6-1.
GenevestigatorQ3LI64.

Family and domain databases

ProtoNetSearch...

Other

NextBio96805.
PROQ3LI64.

Entry information

Entry nameKRA61_HUMAN
AccessionPrimary (citable) accession number: Q3LI64
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 8, 2005
Last modified: July 9, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM