Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q3LI64

- KRA61_HUMAN

UniProt

Q3LI64 - KRA61_HUMAN

Protein

Keratin-associated protein 6-1

Gene

KRTAP6-1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin-associated protein 6-1
    Gene namesi
    Name:KRTAP6-1
    Synonyms:C21orf103, KAP6.1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:18931. KRTAP6-1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. intermediate filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134988301.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7171Keratin-associated protein 6-1PRO_0000223898Add
    BLAST

    Proteomic databases

    PRIDEiQ3LI64.

    PTM databases

    PhosphoSiteiQ3LI64.

    Expressioni

    Gene expression databases

    CleanExiHS_KRTAP6-1.
    GenevestigatoriQ3LI64.

    Interactioni

    Subunit structurei

    Interacts with hair keratins.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000332690.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3LI64.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the KRTAP type 6 family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    OMAiMSEKTIQ.

    Sequencei

    Sequence statusi: Complete.

    Q3LI64-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCGSYYGNYY GTPGYGFCGY GGLGYGYGGL GCGYGSCCGC GFRRLGCGYG   50
    YGSRSLCGYG YGCGSGSGYY Y 71
    Length:71
    Mass (Da):7,279
    Last modified:November 8, 2005 - v1
    Checksum:i233D648E50FB8858
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB096954 mRNA. Translation: BAE46369.1.
    CCDSiCCDS13602.1.
    RefSeqiNP_853633.1. NM_181602.1.
    UniGeneiHs.194301.
    Hs.553689.

    Genome annotation databases

    EnsembliENST00000329122; ENSP00000332690; ENSG00000184724.
    GeneIDi337966.
    KEGGihsa:337966.
    UCSCiuc002yop.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB096954 mRNA. Translation: BAE46369.1 .
    CCDSi CCDS13602.1.
    RefSeqi NP_853633.1. NM_181602.1.
    UniGenei Hs.194301.
    Hs.553689.

    3D structure databases

    ProteinModelPortali Q3LI64.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000332690.

    PTM databases

    PhosphoSitei Q3LI64.

    Proteomic databases

    PRIDEi Q3LI64.

    Protocols and materials databases

    DNASUi 337966.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329122 ; ENSP00000332690 ; ENSG00000184724 .
    GeneIDi 337966.
    KEGGi hsa:337966.
    UCSCi uc002yop.3. human.

    Organism-specific databases

    CTDi 337966.
    GeneCardsi GC21M031985.
    HGNCi HGNC:18931. KRTAP6-1.
    neXtProti NX_Q3LI64.
    PharmGKBi PA134988301.
    GenAtlasi Search...

    Phylogenomic databases

    OMAi MSEKTIQ.

    Miscellaneous databases

    NextBioi 96805.
    PROi Q3LI64.

    Gene expression databases

    CleanExi HS_KRTAP6-1.
    Genevestigatori Q3LI64.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Identification of complete keratin-associated protein (KAP) gene cluster spanning 800 kb region on human chromosome 21q22.11."
      Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.
      Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hair root.

    Entry informationi

    Entry nameiKRA61_HUMAN
    AccessioniPrimary (citable) accession number: Q3LI64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3