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Q3LI64

- KRA61_HUMAN

UniProt

Q3LI64 - KRA61_HUMAN

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Protein
Keratin-associated protein 6-1
Gene
KRTAP6-1, C21orf103, KAP6.1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 6-1
Gene namesi
Synonyms:C21orf103, KAP6.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:18931. KRTAP6-1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134988301.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7171Keratin-associated protein 6-1
PRO_0000223898Add
BLAST

Proteomic databases

PRIDEiQ3LI64.

PTM databases

PhosphoSiteiQ3LI64.

Expressioni

Gene expression databases

CleanExiHS_KRTAP6-1.
GenevestigatoriQ3LI64.

Interactioni

Subunit structurei

Interacts with hair keratins By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000332690.

Structurei

3D structure databases

ProteinModelPortaliQ3LI64.

Family & Domainsi

Sequence similaritiesi

Belongs to the KRTAP type 6 family.

Keywords - Domaini

Repeat

Phylogenomic databases

OMAiMSEKTIQ.

Sequencei

Sequence statusi: Complete.

Q3LI64-1 [UniParc]FASTAAdd to Basket

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MCGSYYGNYY GTPGYGFCGY GGLGYGYGGL GCGYGSCCGC GFRRLGCGYG   50
YGSRSLCGYG YGCGSGSGYY Y 71
Length:71
Mass (Da):7,279
Last modified:November 8, 2005 - v1
Checksum:i233D648E50FB8858
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB096954 mRNA. Translation: BAE46369.1.
CCDSiCCDS13602.1.
RefSeqiNP_853633.1. NM_181602.1.
UniGeneiHs.194301.
Hs.553689.

Genome annotation databases

EnsembliENST00000329122; ENSP00000332690; ENSG00000184724.
GeneIDi337966.
KEGGihsa:337966.
UCSCiuc002yop.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB096954 mRNA. Translation: BAE46369.1 .
CCDSi CCDS13602.1.
RefSeqi NP_853633.1. NM_181602.1.
UniGenei Hs.194301.
Hs.553689.

3D structure databases

ProteinModelPortali Q3LI64.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000332690.

PTM databases

PhosphoSitei Q3LI64.

Proteomic databases

PRIDEi Q3LI64.

Protocols and materials databases

DNASUi 337966.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329122 ; ENSP00000332690 ; ENSG00000184724 .
GeneIDi 337966.
KEGGi hsa:337966.
UCSCi uc002yop.3. human.

Organism-specific databases

CTDi 337966.
GeneCardsi GC21M031985.
HGNCi HGNC:18931. KRTAP6-1.
neXtProti NX_Q3LI64.
PharmGKBi PA134988301.
GenAtlasi Search...

Phylogenomic databases

OMAi MSEKTIQ.

Miscellaneous databases

NextBioi 96805.
PROi Q3LI64.

Gene expression databases

CleanExi HS_KRTAP6-1.
Genevestigatori Q3LI64.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Identification of complete keratin-associated protein (KAP) gene cluster spanning 800 kb region on human chromosome 21q22.11."
    Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hair root.

Entry informationi

Entry nameiKRA61_HUMAN
AccessioniPrimary (citable) accession number: Q3LI64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 8, 2005
Last modified: July 9, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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