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Protein

Keratin-associated protein 20-3

Gene

KRTAP20-3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 20-3
Gene namesi
Name:KRTAP20-3
Synonyms:KAP20.3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000206104.2.
HGNCiHGNC:34001. KRTAP20-3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393749.

Polymorphism and mutation databases

BioMutaiKRTAP20-3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003079151 – 44Keratin-associated protein 20-3Add BLAST44

Proteomic databases

PaxDbiQ3LI60.
PRIDEiQ3LI60.

PTM databases

iPTMnetiQ3LI60.
PhosphoSitePlusiQ3LI60.

Expressioni

Gene expression databases

BgeeiENSG00000206104.

Organism-specific databases

HPAiHPA053598.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000372276.

Family & Domainsi

Sequence similaritiesi

Belongs to the KRTAP type 20 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KC5J. Eukaryota.
ENOG41113FG. LUCA.
GeneTreeiENSGT00410000029383.
InParanoidiQ3LI60.
TreeFamiTF343720.

Sequencei

Sequence statusi: Complete.

Q3LI60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MSYYGNYYGG LGYGYDCKYS YTSGFGAFRI LDCGYRCGCG GVWI
Length:44
Mass (Da):4,909
Last modified:November 8, 2005 - v1
Checksum:i9055AE27F398E1F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096958 mRNA. Translation: BAE46373.1.
CCDSiCCDS46642.1.
RefSeqiNP_001121549.1. NM_001128077.1.
UniGeneiHs.580878.

Genome annotation databases

EnsembliENST00000382826; ENSP00000372276; ENSG00000206104.
GeneIDi337985.
KEGGihsa:337985.
UCSCiuc010gls.1. human.

Similar proteinsi

Entry informationi

Entry nameiKR203_HUMAN
AccessioniPrimary (citable) accession number: Q3LI60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 8, 2005
Last modified: September 27, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families