Q3LHN1 (KR213_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin-associated protein 21-3

Gene names

Name:	KRTAP21-3
Synonyms:	KAP21.3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	58 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Subunit structure

Interacts with hair keratins By similarity.

Ontologies

Keywords
Cellular component	Keratin
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 58	58	Keratin-associated protein 21-3		PRO_0000386448

Sequences

	Sequence		Length	Mass (Da)
	Q3LHN1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 61DA00333BEF8A45	FASTA	58	6,456
	10 20 30 40 50 MYFNYKSVCG SCGFGSCYGC GYGCIHSTHC GCNGYYGCYE NKYSVIDDLI FFASKKCH

References

[1]	"Identification of eight novel genes from keratin associated protein gene cluster on human chromosome 21q22.11." Obayashi I., Shibuya K., Kudoh J., Shimizu N. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB180042 mRNA. Translation: BAE46381.1.
IPI	IPI00654790.
RefSeq	NP_001157907.1. NM_001164435.1.
UniGene	Hs.580877.
3D structure databases
ProteinModelPortal	Q3LHN1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000444335; ENSP00000404517; ENSG00000231068.
GeneID	100288323.
KEGG	hsa:100288323.
UCSC	uc021wii.1. human.
Organism-specific databases
CTD	100288323.
GeneCards	GC21M032091.
HGNC	HGNC:34216. KRTAP21-3.
HPA	HPA046554.
neXtProt	NX_Q3LHN1.
PharmGKB	PA165378419.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG265068.
HOGENOM	HOG000132480.
OMA	IDDLIFF.
OrthoDB	EOG4G4GSQ.
Gene expression databases
Genevestigator	Q3LHN1.
Family and domain databases
ProtoNet	Search...
Other
NextBio	20778071.

Entry information

Entry name

KR213_HUMAN

Accession

Primary (citable) accession number: Q3LHN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 13, 2009
Last sequence update:	November 8, 2005
Last modified:	October 31, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.