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Q3LHN1 (KR213_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin-associated protein 21-3
Gene names
Name:KRTAP21-3
Synonyms:KAP21.3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length58 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Subunit structure

Interacts with hair keratins By similarity.

Ontologies

Keywords
   Cellular componentKeratin
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintermediate filament

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5858Keratin-associated protein 21-3
PRO_0000386448

Sequences

Sequence LengthMass (Da)Tools
Q3LHN1 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 61DA00333BEF8A45

FASTA586,456
        10         20         30         40         50 
MYFNYKSVCG SCGFGSCYGC GYGCIHSTHC GCNGYYGCYE NKYSVIDDLI FFASKKCH 

« Hide

References

[1]"Identification of eight novel genes from keratin associated protein gene cluster on human chromosome 21q22.11."
Obayashi I., Shibuya K., Kudoh J., Shimizu N.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB180042 mRNA. Translation: BAE46381.1.
CCDSCCDS54481.1.
RefSeqNP_001157907.1. NM_001164435.1.
UniGeneHs.580877.

3D structure databases

ProteinModelPortalQ3LHN1.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ3LHN1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000444335; ENSP00000404517; ENSG00000231068.
GeneID100288323.
KEGGhsa:100288323.
UCSCuc021wii.1. human.

Organism-specific databases

CTD100288323.
GeneCardsGC21M032091.
HGNCHGNC:34216. KRTAP21-3.
HPAHPA046554.
neXtProtNX_Q3LHN1.
PharmGKBPA165378419.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG265068.
HOGENOMHOG000132480.
OMASTHCGCN.
OrthoDBEOG7C8GMH.

Gene expression databases

GenevestigatorQ3LHN1.

Family and domain databases

ProtoNetSearch...

Other

NextBio20778071.
PROQ3LHN1.

Entry information

Entry nameKR213_HUMAN
AccessionPrimary (citable) accession number: Q3LHN1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: November 8, 2005
Last modified: July 9, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM