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Q3LHN1

- KR213_HUMAN

UniProt

Q3LHN1 - KR213_HUMAN

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Protein

Keratin-associated protein 21-3

Gene

KRTAP21-3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 21-3
Gene namesi
Name:KRTAP21-3
Synonyms:KAP21.3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:34216. KRTAP21-3.

Subcellular locationi

GO - Cellular componenti

  1. intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165378419.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5858Keratin-associated protein 21-3PRO_0000386448Add
BLAST

Proteomic databases

PRIDEiQ3LHN1.

Expressioni

Gene expression databases

GenevestigatoriQ3LHN1.

Organism-specific databases

HPAiHPA046554.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ3LHN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG265068.
GeneTreeiENSGT00550000076392.
HOGENOMiHOG000132480.
InParanoidiQ3LHN1.
OMAiSTHCGCN.
OrthoDBiEOG7C8GMH.

Sequencei

Sequence statusi: Complete.

Q3LHN1 [UniParc]FASTAAdd to Basket

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MYFNYKSVCG SCGFGSCYGC GYGCIHSTHC GCNGYYGCYE NKYSVIDDLI

FFASKKCH
Length:58
Mass (Da):6,456
Last modified:November 8, 2005 - v1
Checksum:i61DA00333BEF8A45
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB180042 mRNA. Translation: BAE46381.1.
CCDSiCCDS54481.1.
RefSeqiNP_001157907.1. NM_001164435.1.
UniGeneiHs.580877.

Genome annotation databases

EnsembliENST00000444335; ENSP00000404517; ENSG00000231068.
GeneIDi100288323.
KEGGihsa:100288323.
UCSCiuc021wii.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB180042 mRNA. Translation: BAE46381.1 .
CCDSi CCDS54481.1.
RefSeqi NP_001157907.1. NM_001164435.1.
UniGenei Hs.580877.

3D structure databases

ProteinModelPortali Q3LHN1.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q3LHN1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000444335 ; ENSP00000404517 ; ENSG00000231068 .
GeneIDi 100288323.
KEGGi hsa:100288323.
UCSCi uc021wii.1. human.

Organism-specific databases

CTDi 100288323.
GeneCardsi GC21M032091.
HGNCi HGNC:34216. KRTAP21-3.
HPAi HPA046554.
neXtProti NX_Q3LHN1.
PharmGKBi PA165378419.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG265068.
GeneTreei ENSGT00550000076392.
HOGENOMi HOG000132480.
InParanoidi Q3LHN1.
OMAi STHCGCN.
OrthoDBi EOG7C8GMH.

Miscellaneous databases

NextBioi 20778071.
PROi Q3LHN1.

Gene expression databases

Genevestigatori Q3LHN1.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Identification of eight novel genes from keratin associated protein gene cluster on human chromosome 21q22.11."
    Obayashi I., Shibuya K., Kudoh J., Shimizu N.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiKR213_HUMAN
AccessioniPrimary (citable) accession number: Q3LHN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: November 8, 2005
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM

External Data

Dasty 3