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Protein

Keratin-associated protein 21-3

Gene

KRTAP21-3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 21-3
Gene namesi
Name:KRTAP21-3
Synonyms:KAP21.3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:34216. KRTAP21-3.

Subcellular locationi

GO - Cellular componenti

  1. intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165378419.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5858Keratin-associated protein 21-3PRO_0000386448Add
BLAST

Proteomic databases

PRIDEiQ3LHN1.

Expressioni

Gene expression databases

GenevestigatoriQ3LHN1.

Organism-specific databases

HPAiHPA046554.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ3LHN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG265068.
GeneTreeiENSGT00550000076392.
HOGENOMiHOG000132480.
InParanoidiQ3LHN1.
OMAiSTHCGCN.
OrthoDBiEOG7C8GMH.

Sequencei

Sequence statusi: Complete.

Q3LHN1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYFNYKSVCG SCGFGSCYGC GYGCIHSTHC GCNGYYGCYE NKYSVIDDLI

FFASKKCH
Length:58
Mass (Da):6,456
Last modified:November 8, 2005 - v1
Checksum:i61DA00333BEF8A45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB180042 mRNA. Translation: BAE46381.1.
CCDSiCCDS54481.1.
RefSeqiNP_001157907.1. NM_001164435.1.
UniGeneiHs.580877.

Genome annotation databases

EnsembliENST00000444335; ENSP00000404517; ENSG00000231068.
GeneIDi100288323.
KEGGihsa:100288323.
UCSCiuc021wii.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB180042 mRNA. Translation: BAE46381.1.
CCDSiCCDS54481.1.
RefSeqiNP_001157907.1. NM_001164435.1.
UniGeneiHs.580877.

3D structure databases

ProteinModelPortaliQ3LHN1.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ3LHN1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000444335; ENSP00000404517; ENSG00000231068.
GeneIDi100288323.
KEGGihsa:100288323.
UCSCiuc021wii.1. human.

Organism-specific databases

CTDi100288323.
GeneCardsiGC21M032091.
HGNCiHGNC:34216. KRTAP21-3.
HPAiHPA046554.
neXtProtiNX_Q3LHN1.
PharmGKBiPA165378419.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG265068.
GeneTreeiENSGT00550000076392.
HOGENOMiHOG000132480.
InParanoidiQ3LHN1.
OMAiSTHCGCN.
OrthoDBiEOG7C8GMH.

Miscellaneous databases

NextBioi20778071.
PROiQ3LHN1.

Gene expression databases

GenevestigatoriQ3LHN1.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Identification of eight novel genes from keratin associated protein gene cluster on human chromosome 21q22.11."
    Obayashi I., Shibuya K., Kudoh J., Shimizu N.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiKR213_HUMAN
AccessioniPrimary (citable) accession number: Q3LHN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: November 8, 2005
Last modified: January 7, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.