Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q3LHN1

- KR213_HUMAN

UniProt

Q3LHN1 - KR213_HUMAN

Protein

Keratin-associated protein 21-3

Gene

KRTAP21-3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin-associated protein 21-3
    Gene namesi
    Name:KRTAP21-3
    Synonyms:KAP21.3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:34216. KRTAP21-3.

    Subcellular locationi

    GO - Cellular componenti

    1. intermediate filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165378419.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5858Keratin-associated protein 21-3PRO_0000386448Add
    BLAST

    Proteomic databases

    PRIDEiQ3LHN1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ3LHN1.

    Organism-specific databases

    HPAiHPA046554.

    Interactioni

    Subunit structurei

    Interacts with hair keratins.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ3LHN1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG265068.
    HOGENOMiHOG000132480.
    OMAiSTHCGCN.
    OrthoDBiEOG7C8GMH.

    Sequencei

    Sequence statusi: Complete.

    Q3LHN1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYFNYKSVCG SCGFGSCYGC GYGCIHSTHC GCNGYYGCYE NKYSVIDDLI   50
    FFASKKCH 58
    Length:58
    Mass (Da):6,456
    Last modified:November 8, 2005 - v1
    Checksum:i61DA00333BEF8A45
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB180042 mRNA. Translation: BAE46381.1.
    CCDSiCCDS54481.1.
    RefSeqiNP_001157907.1. NM_001164435.1.
    UniGeneiHs.580877.

    Genome annotation databases

    EnsembliENST00000444335; ENSP00000404517; ENSG00000231068.
    GeneIDi100288323.
    KEGGihsa:100288323.
    UCSCiuc021wii.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB180042 mRNA. Translation: BAE46381.1 .
    CCDSi CCDS54481.1.
    RefSeqi NP_001157907.1. NM_001164435.1.
    UniGenei Hs.580877.

    3D structure databases

    ProteinModelPortali Q3LHN1.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q3LHN1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000444335 ; ENSP00000404517 ; ENSG00000231068 .
    GeneIDi 100288323.
    KEGGi hsa:100288323.
    UCSCi uc021wii.1. human.

    Organism-specific databases

    CTDi 100288323.
    GeneCardsi GC21M032091.
    HGNCi HGNC:34216. KRTAP21-3.
    HPAi HPA046554.
    neXtProti NX_Q3LHN1.
    PharmGKBi PA165378419.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG265068.
    HOGENOMi HOG000132480.
    OMAi STHCGCN.
    OrthoDBi EOG7C8GMH.

    Miscellaneous databases

    NextBioi 20778071.
    PROi Q3LHN1.

    Gene expression databases

    Genevestigatori Q3LHN1.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Identification of eight novel genes from keratin associated protein gene cluster on human chromosome 21q22.11."
      Obayashi I., Shibuya K., Kudoh J., Shimizu N.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiKR213_HUMAN
    AccessioniPrimary (citable) accession number: Q3LHN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 13, 2009
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM

    External Data

    Dasty 3