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Protein

Keratin-associated protein 25-1

Gene

KRTAP25-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 25-1
Gene namesi
Name:KRTAP25-1
Synonyms:KAP25.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:34003. KRTAP25-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393758.

Polymorphism and mutation databases

BioMutaiKRTAP25-1.
DMDMi121942679.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 102102Keratin-associated protein 25-1PRO_0000308251Add
BLAST

Proteomic databases

PaxDbiQ3LHN0.

Expressioni

Gene expression databases

CleanExiHS_KRTAP25-1.

Organism-specific databases

HPAiHPA031438.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000398619.

Structurei

3D structure databases

ProteinModelPortaliQ3LHN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMG family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JFY1. Eukaryota.
ENOG4111AMQ. LUCA.
GeneTreeiENSGT00550000076318.
HOGENOMiHOG000113255.
InParanoidiQ3LHN0.
OMAiFQPACSD.
OrthoDBiEOG091G0XK1.
PhylomeDBiQ3LHN0.

Family and domain databases

InterProiIPR007951. KRTAP_PMG.
[Graphical view]
PANTHERiPTHR19051. PTHR19051. 1 hit.
PfamiPF05287. PMG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3LHN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHNRSQGFFF SSCHPQNHVS YGCQSPSFIF CRCQSLNFVS RTCYPLSYFS
60 70 80 90 100
YGNQTIGSIS NSFRSLNYVS HSFQPISFMH SSFQPACSDF VGWQSPFLRR

TC
Length:102
Mass (Da):11,738
Last modified:November 8, 2005 - v1
Checksum:i82872CA797F3F983
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401S → P.
Corresponds to variant rs8127420 [ dbSNP | Ensembl ].
VAR_060063

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB180043 mRNA. Translation: BAE46382.1.
CCDSiCCDS46640.1.
RefSeqiNP_001122070.1. NM_001128598.1.
UniGeneiHs.580882.

Genome annotation databases

EnsembliENST00000416044; ENSP00000398619; ENSG00000232263.
GeneIDi100131902.
KEGGihsa:100131902.
UCSCiuc010glr.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB180043 mRNA. Translation: BAE46382.1.
CCDSiCCDS46640.1.
RefSeqiNP_001122070.1. NM_001128598.1.
UniGeneiHs.580882.

3D structure databases

ProteinModelPortaliQ3LHN0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000398619.

Polymorphism and mutation databases

BioMutaiKRTAP25-1.
DMDMi121942679.

Proteomic databases

PaxDbiQ3LHN0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000416044; ENSP00000398619; ENSG00000232263.
GeneIDi100131902.
KEGGihsa:100131902.
UCSCiuc010glr.1. human.

Organism-specific databases

CTDi100131902.
GeneCardsiKRTAP25-1.
HGNCiHGNC:34003. KRTAP25-1.
HPAiHPA031438.
neXtProtiNX_Q3LHN0.
PharmGKBiPA162393758.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JFY1. Eukaryota.
ENOG4111AMQ. LUCA.
GeneTreeiENSGT00550000076318.
HOGENOMiHOG000113255.
InParanoidiQ3LHN0.
OMAiFQPACSD.
OrthoDBiEOG091G0XK1.
PhylomeDBiQ3LHN0.

Miscellaneous databases

GenomeRNAii100131902.
PROiQ3LHN0.

Gene expression databases

CleanExiHS_KRTAP25-1.

Family and domain databases

InterProiIPR007951. KRTAP_PMG.
[Graphical view]
PANTHERiPTHR19051. PTHR19051. 1 hit.
PfamiPF05287. PMG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKR251_HUMAN
AccessioniPrimary (citable) accession number: Q3LHN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 8, 2005
Last modified: September 7, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.