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Protein

Keratin-associated protein 25-1

Gene

KRTAP25-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 25-1
Gene namesi
Name:KRTAP25-1
Synonyms:KAP25.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:34003. KRTAP25-1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393758.

Polymorphism and mutation databases

BioMutaiKRTAP25-1.
DMDMi121942679.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003082511 – 102Keratin-associated protein 25-1Add BLAST102

Proteomic databases

PaxDbiQ3LHN0.
PRIDEiQ3LHN0.

Expressioni

Gene expression databases

BgeeiENSG00000232263.
CleanExiHS_KRTAP25-1.

Organism-specific databases

HPAiHPA031438.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000398619.

Structurei

3D structure databases

ProteinModelPortaliQ3LHN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMG family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JFY1. Eukaryota.
ENOG4111AMQ. LUCA.
GeneTreeiENSGT00550000076318.
HOGENOMiHOG000113255.
InParanoidiQ3LHN0.
OMAiFQPACSD.
OrthoDBiEOG091G0XK1.
PhylomeDBiQ3LHN0.

Family and domain databases

InterProiView protein in InterPro
IPR007951. KRTAP_PMG.
PANTHERiPTHR19051. PTHR19051. 1 hit.
PfamiView protein in Pfam
PF05287. PMG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3LHN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHNRSQGFFF SSCHPQNHVS YGCQSPSFIF CRCQSLNFVS RTCYPLSYFS
60 70 80 90 100
YGNQTIGSIS NSFRSLNYVS HSFQPISFMH SSFQPACSDF VGWQSPFLRR

TC
Length:102
Mass (Da):11,738
Last modified:November 8, 2005 - v1
Checksum:i82872CA797F3F983
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06006340S → P. Corresponds to variant dbSNP:rs8127420Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB180043 mRNA. Translation: BAE46382.1.
CCDSiCCDS46640.1.
RefSeqiNP_001122070.1. NM_001128598.1.
UniGeneiHs.580882.

Genome annotation databases

EnsembliENST00000416044; ENSP00000398619; ENSG00000232263.
GeneIDi100131902.
KEGGihsa:100131902.
UCSCiuc010glr.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKR251_HUMAN
AccessioniPrimary (citable) accession number: Q3LHN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 8, 2005
Last modified: August 30, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families