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Q3LFU0

- CP1A1_BALAC

UniProt

Q3LFU0 - CP1A1_BALAC

Protein

Cytochrome P450 1A1

Gene

CYP1A1

Organism
Balaenoptera acutorostrata (Common minke whale) (Balaena rostrata)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics By similarity.By similarity

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei228 – 2281SubstrateBy similarity
    Metal bindingi461 – 4611Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Gene namesi
    Name:CYP1A1
    OrganismiBalaenoptera acutorostrata (Common minke whale) (Balaena rostrata)
    Taxonomic identifieri9767 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaMysticetiBalaenopteridaeBalaenoptera

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 516516Cytochrome P450 1A1PRO_0000232910Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi71 – 711O-linked (GlcNAc)By similarity

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ3LFU0.
    SMRiQ3LFU0. Positions 36-512.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3LFU0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFSVFGLSIP ISATELLLAS ATFCLVFWVV RAWQPRVPKG LKSPPGPWSW    50
    PLIGHVLTLG KSPHLALSRL SQRYGDVLQI RIGCTPVLVL SGLDTIRQAL 100
    VRQGDDFKGR PDLYSFTLVA DGQSMTFNPD SGPVWAARRR LAQNALKSFS 150
    IASDPASSSS CYLEEHVSKE SEYLIGKFQE LMAGSGRFDP YRYVVVSVAN 200
    VICAMCFGRR YDHESQVLLS VVGLSNEFGA VAASGNPADF IPILRYLPNT 250
    ALDDFKDLNR RFYIFMQKML KEHYKTFEKG RIRDITDSLI EHCQGKRLDE 300
    NANIQLSDEK IVNVVMDLFG AGFDTVTTAI SWSLMYLVTS PSVQKKIQEE 350
    LDTVIGSARQ PRLSDRPRLP YLEAFILETF RHSSFLPFTI PHSTTRDTSL 400
    NGFYIPKGRC VFVNQWQINH DQKLWDDPSA FWPERFLTAD GTINKALSEK 450
    VILFGLGKRK CIGETIARWE VFLFLAILLQ QVEFRVTPGV KVDMTPVYGL 500
    TMKHAHCEHF QAHMRS 516
    Length:516
    Mass (Da):58,275
    Last modified:November 8, 2005 - v1
    Checksum:iC7FEC1B7CE9A0D6E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB231891 mRNA. Translation: BAE46562.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB231891 mRNA. Translation: BAE46562.1 .

    3D structure databases

    ProteinModelPortali Q3LFU0.
    SMRi Q3LFU0. Positions 36-512.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106944.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and mRNA expression of cytochrome P4501A1 and 1A2 in the liver of common minke whales (Balaenoptera acutorostrata)."
      Niimi S., Watanabe M.X., Kim E.Y., Iwata H., Yasunaga G., Fujise Y., Tanabe S.
      Mar. Pollut. Bull. 51:784-793(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A1_BALAC
    AccessioniPrimary (citable) accession number: Q3LFU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3