Reviewed, UniProtKB/Swiss-Prot Q3LFU0 (CP1A1_BALAC)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 1A1
    EC=1.14.14.1

Gene names

Name:

CYP1A1

Organism

Balaenoptera acutorostrata (Minke whale) (Lesser rorqual)

Taxonomic identifier

9767 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Cetacea › Mysticeti › Balaenopteridae › Balaenoptera

Protein attributes

Sequence length	516 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics By similarity.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein By similarity. Microsome membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 516	516	Cytochrome P450 1A1		PRO_0000232910
Sites
	Metal binding	461	1	Iron (heme axial ligand) By similarity
Amino acid modifications
	Modified residue	364	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3LFU0-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: C7FEC1B7CE9A0D6E	FASTA	516	58,275
	10 20 30 40 50 60 MFSVFGLSIP ISATELLLAS ATFCLVFWVV RAWQPRVPKG LKSPPGPWSW PLIGHVLTLG 70 80 90 100 110 120 KSPHLALSRL SQRYGDVLQI RIGCTPVLVL SGLDTIRQAL VRQGDDFKGR PDLYSFTLVA 130 140 150 160 170 180 DGQSMTFNPD SGPVWAARRR LAQNALKSFS IASDPASSSS CYLEEHVSKE SEYLIGKFQE 190 200 210 220 230 240 LMAGSGRFDP YRYVVVSVAN VICAMCFGRR YDHESQVLLS VVGLSNEFGA VAASGNPADF 250 260 270 280 290 300 IPILRYLPNT ALDDFKDLNR RFYIFMQKML KEHYKTFEKG RIRDITDSLI EHCQGKRLDE 310 320 330 340 350 360 NANIQLSDEK IVNVVMDLFG AGFDTVTTAI SWSLMYLVTS PSVQKKIQEE LDTVIGSARQ 370 380 390 400 410 420 PRLSDRPRLP YLEAFILETF RHSSFLPFTI PHSTTRDTSL NGFYIPKGRC VFVNQWQINH 430 440 450 460 470 480 DQKLWDDPSA FWPERFLTAD GTINKALSEK VILFGLGKRK CIGETIARWE VFLFLAILLQ 490 500 510 QVEFRVTPGV KVDMTPVYGL TMKHAHCEHF QAHMRS

References

[1]

"Molecular cloning and mRNA expression of cytochrome P4501A1 and 1A2 in the liver of common minke whales (Balaenoptera acutorostrata)." Niimi S., Watanabe M.X., Kim E.Y., Iwata H., Yasunaga G., Fujise Y., Tanabe S. Mar. Pollut. Bull. 51:784-793(2005) [PubMed: 16154599] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB231891 mRNA. Translation: BAE46562.1.
3D structure databases
SMR	Q3LFU0. Positions 36-512.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q3LFU0.
Enzyme and pathway databases
BRENDA	1.14.14.1. 289568.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008066. Cyt_P450_E_grp-I_CYP1. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit. PTHR19383:SF63. Cyt_P450_E_grp-I_CYP1. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR01683. EP450ICYP1A. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP1A1_BALAC

Accession

Primary (citable) accession number: Q3LFU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
Last sequence update:	November 8, 2005
Last modified:	October 13, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)