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Q3LFT9

- CP1A2_BALAC

UniProt

Q3LFT9 - CP1A2_BALAC

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Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Balaenoptera acutorostrata (Common minke whale) (Balaena rostrata)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation (By similarity).By similarity

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei226 – 2261SubstrateBy similarity
Metal bindingi458 – 4581Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A2 (EC:1.14.14.1)
Alternative name(s):
CYPIA2
Gene namesi
Name:CYP1A2
OrganismiBalaenoptera acutorostrata (Common minke whale) (Balaena rostrata)
Taxonomic identifieri9767 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaMysticetiBalaenopteridaeBalaenoptera

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 516515Cytochrome P450 1A2PRO_0000232906Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi69 – 691O-linked (GlcNAc)By similarity

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ3LFT9.
SMRiQ3LFT9. Positions 34-510.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3LFT9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALSQATPFS ATELLLASAT FCLVFWVVKA WQPRVPKGLK SPPGPWSWPL
60 70 80 90 100
IGHVLTLGKS PHLALSRLSQ RYGDVLQIRI GCTPVLVLSG LDTIRQALVR
110 120 130 140 150
QGDDFKGRPD LYSFTLVADG QSMTFNPDSG PVWAAQRRLA QNALNSFSVA
160 170 180 190 200
SDPASSSSCY LEMHVSKEAE ALIGKFQELM AGSGRFDPYD HVVVSVAKVI
210 220 230 240 250
GAMCFGQHFP QSSGEMVSLV RNTHDFVETA SSGSPVDFFP ILKYLPNPAL
260 270 280 290 300
QKYKSFNRRF LQFLWKMVQE HHQDFDKNRV QDIVGALFKH YEDNSRASGG
310 320 330 340 350
LMPQKKTVNL VNDIFAAGFD PITTAISWSL LYLVTNPEIQ RKIQQELDTV
360 370 380 390 400
IGRARRPRLS DRSQLPYLEA FILETFRHSS FVPFTIPHST IRDTTLNGFY
410 420 430 440 450
IPKELCVFIN QWQVNHDPKL WGDPSEFRPE RFLTSHDTTI SKTLSEKVML
460 470 480 490 500
FGMGKRRCIG EVLAKWEIFL FLAILLQQLE FSVPPGVKVD LTPTYGLTMK
510
PAPCEHVQAR LRFPIK
Length:516
Mass (Da):58,119
Last modified:January 23, 2007 - v3
Checksum:i6A2FEFA45A490D8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB231892 mRNA. Translation: BAE46563.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB231892 mRNA. Translation: BAE46563.1 .

3D structure databases

ProteinModelPortali Q3LFT9.
SMRi Q3LFT9. Positions 34-510.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106944.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and mRNA expression of cytochrome P4501A1 and 1A2 in the liver of common minke whales (Balaenoptera acutorostrata)."
    Niimi S., Watanabe M.X., Kim E.Y., Iwata H., Yasunaga G., Fujise Y., Tanabe S.
    Mar. Pollut. Bull. 51:784-793(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP1A2_BALAC
AccessioniPrimary (citable) accession number: Q3LFT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 49 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3