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Q3LFT9

- CP1A2_BALAC

UniProt

Q3LFT9 - CP1A2_BALAC

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Protein
Cytochrome P450 1A2
Gene
CYP1A2
Organism
Balaenoptera acutorostrata (Common minke whale) (Balaena rostrata)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation By similarity.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei226 – 2261Substrate By similarity
Metal bindingi458 – 4581Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A2 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA2
    Gene namesi
    Name:CYP1A2
    OrganismiBalaenoptera acutorostrata (Common minke whale) (Balaena rostrata)
    Taxonomic identifieri9767 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaMysticetiBalaenopteridaeBalaenoptera

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed By similarity
    Chaini2 – 516515Cytochrome P450 1A2
    PRO_0000232906Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi69 – 691O-linked (GlcNAc) By similarity

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ3LFT9.
    SMRiQ3LFT9. Positions 34-510.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3LFT9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALSQATPFS ATELLLASAT FCLVFWVVKA WQPRVPKGLK SPPGPWSWPL    50
    IGHVLTLGKS PHLALSRLSQ RYGDVLQIRI GCTPVLVLSG LDTIRQALVR 100
    QGDDFKGRPD LYSFTLVADG QSMTFNPDSG PVWAAQRRLA QNALNSFSVA 150
    SDPASSSSCY LEMHVSKEAE ALIGKFQELM AGSGRFDPYD HVVVSVAKVI 200
    GAMCFGQHFP QSSGEMVSLV RNTHDFVETA SSGSPVDFFP ILKYLPNPAL 250
    QKYKSFNRRF LQFLWKMVQE HHQDFDKNRV QDIVGALFKH YEDNSRASGG 300
    LMPQKKTVNL VNDIFAAGFD PITTAISWSL LYLVTNPEIQ RKIQQELDTV 350
    IGRARRPRLS DRSQLPYLEA FILETFRHSS FVPFTIPHST IRDTTLNGFY 400
    IPKELCVFIN QWQVNHDPKL WGDPSEFRPE RFLTSHDTTI SKTLSEKVML 450
    FGMGKRRCIG EVLAKWEIFL FLAILLQQLE FSVPPGVKVD LTPTYGLTMK 500
    PAPCEHVQAR LRFPIK 516
    Length:516
    Mass (Da):58,119
    Last modified:January 23, 2007 - v3
    Checksum:i6A2FEFA45A490D8F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB231892 mRNA. Translation: BAE46563.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB231892 mRNA. Translation: BAE46563.1 .

    3D structure databases

    ProteinModelPortali Q3LFT9.
    SMRi Q3LFT9. Positions 34-510.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106944.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and mRNA expression of cytochrome P4501A1 and 1A2 in the liver of common minke whales (Balaenoptera acutorostrata)."
      Niimi S., Watanabe M.X., Kim E.Y., Iwata H., Yasunaga G., Fujise Y., Tanabe S.
      Mar. Pollut. Bull. 51:784-793(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A2_BALAC
    AccessioniPrimary (citable) accession number: Q3LFT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: January 23, 2007
    Last modified: September 3, 2014
    This is version 46 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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