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Q3LFT9 (CP1A2_BALAC) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 1A2

EC=1.14.14.1
Alternative name(s):
CYPIA2
Gene names
Name:CYP1A2
OrganismBalaenoptera acutorostrata (Common minke whale) (Balaena rostrata)
Taxonomic identifier9767 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaMysticetiBalaenopteridaeBalaenoptera

Protein attributes

Sequence length516 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation By similarity.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein By similarity. Microsome membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 516515Cytochrome P450 1A2
PRO_0000232906

Sites

Metal binding4581Iron (heme axial ligand) By similarity
Binding site2261Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3LFT9 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 6A2FEFA45A490D8F

FASTA51658,119
        10         20         30         40         50         60 
MALSQATPFS ATELLLASAT FCLVFWVVKA WQPRVPKGLK SPPGPWSWPL IGHVLTLGKS 

        70         80         90        100        110        120 
PHLALSRLSQ RYGDVLQIRI GCTPVLVLSG LDTIRQALVR QGDDFKGRPD LYSFTLVADG 

       130        140        150        160        170        180 
QSMTFNPDSG PVWAAQRRLA QNALNSFSVA SDPASSSSCY LEMHVSKEAE ALIGKFQELM 

       190        200        210        220        230        240 
AGSGRFDPYD HVVVSVAKVI GAMCFGQHFP QSSGEMVSLV RNTHDFVETA SSGSPVDFFP 

       250        260        270        280        290        300 
ILKYLPNPAL QKYKSFNRRF LQFLWKMVQE HHQDFDKNRV QDIVGALFKH YEDNSRASGG 

       310        320        330        340        350        360 
LMPQKKTVNL VNDIFAAGFD PITTAISWSL LYLVTNPEIQ RKIQQELDTV IGRARRPRLS 

       370        380        390        400        410        420 
DRSQLPYLEA FILETFRHSS FVPFTIPHST IRDTTLNGFY IPKELCVFIN QWQVNHDPKL 

       430        440        450        460        470        480 
WGDPSEFRPE RFLTSHDTTI SKTLSEKVML FGMGKRRCIG EVLAKWEIFL FLAILLQQLE 

       490        500        510 
FSVPPGVKVD LTPTYGLTMK PAPCEHVQAR LRFPIK 

« Hide

References

[1]"Molecular cloning and mRNA expression of cytochrome P4501A1 and 1A2 in the liver of common minke whales (Balaenoptera acutorostrata)."
Niimi S., Watanabe M.X., Kim E.Y., Iwata H., Yasunaga G., Fujise Y., Tanabe S.
Mar. Pollut. Bull. 51:784-793(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB231892 mRNA. Translation: BAE46563.1.

3D structure databases

ProteinModelPortalQ3LFT9.
SMRQ3LFT9. Positions 34-510.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG106944.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP1A2_BALAC
AccessionPrimary (citable) accession number: Q3LFT9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 23, 2007
Last modified: December 11, 2013
This is version 45 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families