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Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Balaenoptera acutorostrata (Common minke whale) (Balaena rostrata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation.By similarity

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei226SubstrateBy similarity1
Metal bindingi458Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Lipid metabolism, Steroid metabolism, Sterol metabolism

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A2 (EC:1.14.14.1By similarity)
Alternative name(s):
CYPIA2
Cholesterol 25-hydroxylaseBy similarity
Gene namesi
Name:CYP1A2
OrganismiBalaenoptera acutorostrata (Common minke whale) (Balaena rostrata)
Taxonomic identifieri9767 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaMysticetiBalaenopteridaeBalaenoptera

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002329062 – 516Cytochrome P450 1A2Add BLAST515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69O-linked (GlcNAc)By similarity1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ3LFT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3LFT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSQATPFS ATELLLASAT FCLVFWVVKA WQPRVPKGLK SPPGPWSWPL
60 70 80 90 100
IGHVLTLGKS PHLALSRLSQ RYGDVLQIRI GCTPVLVLSG LDTIRQALVR
110 120 130 140 150
QGDDFKGRPD LYSFTLVADG QSMTFNPDSG PVWAAQRRLA QNALNSFSVA
160 170 180 190 200
SDPASSSSCY LEMHVSKEAE ALIGKFQELM AGSGRFDPYD HVVVSVAKVI
210 220 230 240 250
GAMCFGQHFP QSSGEMVSLV RNTHDFVETA SSGSPVDFFP ILKYLPNPAL
260 270 280 290 300
QKYKSFNRRF LQFLWKMVQE HHQDFDKNRV QDIVGALFKH YEDNSRASGG
310 320 330 340 350
LMPQKKTVNL VNDIFAAGFD PITTAISWSL LYLVTNPEIQ RKIQQELDTV
360 370 380 390 400
IGRARRPRLS DRSQLPYLEA FILETFRHSS FVPFTIPHST IRDTTLNGFY
410 420 430 440 450
IPKELCVFIN QWQVNHDPKL WGDPSEFRPE RFLTSHDTTI SKTLSEKVML
460 470 480 490 500
FGMGKRRCIG EVLAKWEIFL FLAILLQQLE FSVPPGVKVD LTPTYGLTMK
510
PAPCEHVQAR LRFPIK
Length:516
Mass (Da):58,119
Last modified:January 23, 2007 - v3
Checksum:i6A2FEFA45A490D8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB231892 mRNA. Translation: BAE46563.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB231892 mRNA. Translation: BAE46563.1.

3D structure databases

ProteinModelPortaliQ3LFT9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP1A2_BALAC
AccessioniPrimary (citable) accession number: Q3LFT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 23, 2007
Last modified: October 5, 2016
This is version 56 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.