ID   Q3LFT4_HUMAN            Unreviewed;       348 AA.
AC   Q3LFT4;
DT   08-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   08-NOV-2005, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   SubName: Full=PTCH protein-10 {ECO:0000313|EMBL:BAE45302.1};
DE   Flags: Fragment;
GN   Name=PTCH {ECO:0000313|EMBL:BAE45302.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAE45302.1};
RN   [1] {ECO:0000313|EMBL:BAE45302.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16203740; DOI=10.1093/hmg/ddi369;
RA   Nagao K., Togawa N., Fujii K., Uchikawa H., Kohno Y., Yamada M.,
RA   Miyashita T.;
RT   "Detecting tissue-specific alternative splicing and disease-associated
RT   aberrant splicing of the PTCH gene with exon junction microarrays.";
RL   Hum. Mol. Genet. 14:3379-3388(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   EMBL; AB233422; BAE45302.1; -; mRNA.
DR   AlphaFoldDB; Q3LFT4; -.
DR   PeptideAtlas; Q3LFT4; -.
DR   ChiTaRS; PTCH1; human.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR   PANTHER; PTHR46022:SF5; PROTEIN PATCHED HOMOLOG 1; 1.
DR   Pfam; PF12349; Sterol-sensing; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR   PROSITE; PS50156; SSD; 1.
PE   2: Evidence at transcript level;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        159..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        205..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        234..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          153..259
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAE45302.1"
FT   NON_TER         348
FT                   /evidence="ECO:0000313|EMBL:BAE45302.1"
SQ   SEQUENCE   348 AA;  38882 MW;  04E06AEC9AAAE642 CRC64;
     GHGYMDRPCL NPADPDCPAT APNKNSTKPL DMALVLNGGC HGLSRKYMHW QEELIVGGTV
     KNSTGKLVSA HALQTMFQLM TPKQMYEHFK GYEYVSHINW NEDKAAAILE AWQRTYVEVV
     HQSVAQNSTQ KVLSFTTTTL DDILKSFSDV SVIRVASGYL LMVLPFLALG VGVDDVFLLA
     HAFSETGQNK RIPFEDRTGE CLKRTGASVA LTSISNVTAF FMAALIPIPA LRAFSLQAAV
     VVVFNFAMVL LIFPAILSMD LYRREDRRLD IFCCFTSPCV SRVIQVEPQA YTDTHDNTRY
     SPPPPYSSHS FAHETQITMQ STVQLRTEYD PHTHVYYTTA EPRSEISV
//