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Protein

Putative ubiquitin carboxyl-terminal hydrolase 41

Gene

USP41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641NucleophilePROSITE-ProRule annotation
Active sitei318 – 3181Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: GO_Central
  2. ISG15-specific protease activity Source: GO_Central
  3. ubiquitin-specific protease activity Source: GO_Central
  4. ubiquitin thiolesterase activity Source: GO_Central

GO - Biological processi

  1. proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
  2. protein deubiquitination Source: GO_Central
  3. regulation of proteasomal protein catabolic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_115831. ISG15 antiviral mechanism.

Protein family/group databases

MEROPSiC19.070.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ubiquitin carboxyl-terminal hydrolase 41 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 41
Ubiquitin thioesterase 41
Ubiquitin-specific-processing protease 41
Gene namesi
Name:USP41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:20070. USP41.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Putative ubiquitin carboxyl-terminal hydrolase 41PRO_0000328882Add
BLAST

Proteomic databases

PaxDbiQ3LFD5.
PRIDEiQ3LFD5.

PTM databases

PhosphoSiteiQ3LFD5.

Expressioni

Gene expression databases

BgeeiQ3LFD5.
CleanExiHS_USP41.
GenevestigatoriQ3LFD5.

Interactioni

Protein-protein interaction databases

IntActiQ3LFD5. 1 interaction.
STRINGi9606.ENSP00000414922.

Structurei

3D structure databases

ProteinModelPortaliQ3LFD5.
SMRiQ3LFD5. Positions 28-352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 358304USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5077.
HOGENOMiHOG000294166.
HOVERGENiHBG054189.
InParanoidiQ3LFD5.
PhylomeDBiQ3LFD5.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3LFD5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGVLFRAHQ CQYVHPCVHV YVTVGLMDPL CERKEKASKQ ERENPLAHLA
60 70 80 90 100
AWGLVGLHNI GQTCCLNSLI QVFVMNVDFA RILKRITVPR GADEQRRSVP
110 120 130 140 150
FQMLLLLEKM QDSRQKAVWP LELAYCLQKY NVPLFVQHDA AQLYLKLWNL
160 170 180 190 200
IKDQIADVHL VERLQALYMI RMKDSLICLD CAMESSRNSS MLTLRLSFFD
210 220 230 240 250
VDSKPLKTLE DALHCFFQPR ELSSKSKCFC ENCGKKTRGK QVLKLTHLPQ
260 270 280 290 300
TLTIHLMRFS IRNSQTRKIC HSLYFPQSLD FSQILPMKRE SCDAEEQSGG
310 320 330 340 350
QYELFAVIAH VGMADSGHYC VYIRNAVDGK WFCFNDSNIC LVSWEDIQCT

YGNPNYHW
Length:358
Mass (Da):41,394
Last modified:April 8, 2008 - v2
Checksum:i6CBF79560927FB11
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti134 – 1341L → V in CAE47749. (PubMed:14715245)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti130 – 1301Y → C.
Corresponds to variant rs2542134 [ dbSNP | Ensembl ].
VAR_042574
Natural varianti325 – 3251N → S.
Corresponds to variant rs2277833 [ dbSNP | Ensembl ].
VAR_042575

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007731 Genomic DNA. No translation available.
AJ583822 mRNA. Translation: CAE47749.1.
AJ586979 mRNA. Translation: CAE52971.1.
UniGeneiHs.38260.

Genome annotation databases

EnsembliENST00000454608; ENSP00000414922; ENSG00000161133.
UCSCiuc011ahq.1. human.

Polymorphism databases

DMDMi182702223.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007731 Genomic DNA. No translation available.
AJ583822 mRNA. Translation: CAE47749.1.
AJ586979 mRNA. Translation: CAE52971.1.
UniGeneiHs.38260.

3D structure databases

ProteinModelPortaliQ3LFD5.
SMRiQ3LFD5. Positions 28-352.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3LFD5. 1 interaction.
STRINGi9606.ENSP00000414922.

Protein family/group databases

MEROPSiC19.070.

PTM databases

PhosphoSiteiQ3LFD5.

Polymorphism databases

DMDMi182702223.

Proteomic databases

PaxDbiQ3LFD5.
PRIDEiQ3LFD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000454608; ENSP00000414922; ENSG00000161133.
UCSCiuc011ahq.1. human.

Organism-specific databases

GeneCardsiGC22M020704.
HGNCiHGNC:20070. USP41.
neXtProtiNX_Q3LFD5.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5077.
HOGENOMiHOG000294166.
HOVERGENiHBG054189.
InParanoidiQ3LFD5.
PhylomeDBiQ3LFD5.

Enzyme and pathway databases

ReactomeiREACT_115831. ISG15 antiviral mechanism.

Miscellaneous databases

PROiQ3LFD5.

Gene expression databases

BgeeiQ3LFD5.
CleanExiHS_USP41.
GenevestigatoriQ3LFD5.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases."
    Quesada V., Diaz-Perales A., Gutierrez-Fernandez A., Garabaya C., Cal S., Lopez-Otin C.
    Biochem. Biophys. Res. Commun. 314:54-62(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-358.

Entry informationi

Entry nameiUBP41_HUMAN
AccessioniPrimary (citable) accession number: Q3LFD5
Secondary accession number(s): A8MXD0, Q70BM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: February 4, 2015
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.