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Q3LFD5

- UBP41_HUMAN

UniProt

Q3LFD5 - UBP41_HUMAN

Protein

Putative ubiquitin carboxyl-terminal hydrolase 41

Gene

USP41

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 2 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei64 – 641NucleophilePROSITE-ProRule annotation
    Active sitei318 – 3181Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    ReactomeiREACT_115831. ISG15 antiviral mechanism.

    Protein family/group databases

    MEROPSiC19.070.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative ubiquitin carboxyl-terminal hydrolase 41 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 41
    Ubiquitin thioesterase 41
    Ubiquitin-specific-processing protease 41
    Gene namesi
    Name:USP41
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:20070. USP41.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 358358Putative ubiquitin carboxyl-terminal hydrolase 41PRO_0000328882Add
    BLAST

    Proteomic databases

    PaxDbiQ3LFD5.
    PRIDEiQ3LFD5.

    PTM databases

    PhosphoSiteiQ3LFD5.

    Expressioni

    Gene expression databases

    BgeeiQ3LFD5.
    CleanExiHS_USP41.
    GenevestigatoriQ3LFD5.

    Interactioni

    Protein-protein interaction databases

    IntActiQ3LFD5. 1 interaction.
    STRINGi9606.ENSP00000414922.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3LFD5.
    SMRiQ3LFD5. Positions 53-352.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 358304USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5077.
    HOGENOMiHOG000294166.
    HOVERGENiHBG054189.
    InParanoidiQ3LFD5.
    PhylomeDBiQ3LFD5.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3LFD5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGVLFRAHQ CQYVHPCVHV YVTVGLMDPL CERKEKASKQ ERENPLAHLA    50
    AWGLVGLHNI GQTCCLNSLI QVFVMNVDFA RILKRITVPR GADEQRRSVP 100
    FQMLLLLEKM QDSRQKAVWP LELAYCLQKY NVPLFVQHDA AQLYLKLWNL 150
    IKDQIADVHL VERLQALYMI RMKDSLICLD CAMESSRNSS MLTLRLSFFD 200
    VDSKPLKTLE DALHCFFQPR ELSSKSKCFC ENCGKKTRGK QVLKLTHLPQ 250
    TLTIHLMRFS IRNSQTRKIC HSLYFPQSLD FSQILPMKRE SCDAEEQSGG 300
    QYELFAVIAH VGMADSGHYC VYIRNAVDGK WFCFNDSNIC LVSWEDIQCT 350
    YGNPNYHW 358
    Length:358
    Mass (Da):41,394
    Last modified:April 8, 2008 - v2
    Checksum:i6CBF79560927FB11
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti134 – 1341L → V in CAE47749. (PubMed:14715245)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti130 – 1301Y → C.
    Corresponds to variant rs2542134 [ dbSNP | Ensembl ].
    VAR_042574
    Natural varianti325 – 3251N → S.
    Corresponds to variant rs2277833 [ dbSNP | Ensembl ].
    VAR_042575

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007731 Genomic DNA. No translation available.
    AJ583822 mRNA. Translation: CAE47749.1.
    AJ586979 mRNA. Translation: CAE52971.1.
    UniGeneiHs.38260.

    Genome annotation databases

    EnsembliENST00000454608; ENSP00000414922; ENSG00000161133.
    UCSCiuc011ahq.1. human.

    Polymorphism databases

    DMDMi182702223.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007731 Genomic DNA. No translation available.
    AJ583822 mRNA. Translation: CAE47749.1 .
    AJ586979 mRNA. Translation: CAE52971.1 .
    UniGenei Hs.38260.

    3D structure databases

    ProteinModelPortali Q3LFD5.
    SMRi Q3LFD5. Positions 53-352.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q3LFD5. 1 interaction.
    STRINGi 9606.ENSP00000414922.

    Protein family/group databases

    MEROPSi C19.070.

    PTM databases

    PhosphoSitei Q3LFD5.

    Polymorphism databases

    DMDMi 182702223.

    Proteomic databases

    PaxDbi Q3LFD5.
    PRIDEi Q3LFD5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000454608 ; ENSP00000414922 ; ENSG00000161133 .
    UCSCi uc011ahq.1. human.

    Organism-specific databases

    GeneCardsi GC22M020704.
    HGNCi HGNC:20070. USP41.
    neXtProti NX_Q3LFD5.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5077.
    HOGENOMi HOG000294166.
    HOVERGENi HBG054189.
    InParanoidi Q3LFD5.
    PhylomeDBi Q3LFD5.

    Enzyme and pathway databases

    Reactomei REACT_115831. ISG15 antiviral mechanism.

    Miscellaneous databases

    PROi Q3LFD5.

    Gene expression databases

    Bgeei Q3LFD5.
    CleanExi HS_USP41.
    Genevestigatori Q3LFD5.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases."
      Quesada V., Diaz-Perales A., Gutierrez-Fernandez A., Garabaya C., Cal S., Lopez-Otin C.
      Biochem. Biophys. Res. Commun. 314:54-62(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-358.

    Entry informationi

    Entry nameiUBP41_HUMAN
    AccessioniPrimary (citable) accession number: Q3LFD5
    Secondary accession number(s): A8MXD0, Q70BM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 62 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3