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Protein

Epstein-Barr nuclear antigen 3

Gene

EBNA3

Organism
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Epstein-Barr nuclear antigen 3
Short name:
EBNA-3
Short name:
EBV nuclear antigen 3
Alternative name(s):
Epstein-Barr nuclear antigen 3A
Short name:
EBNA-3A
Short name:
EBV nuclear antigen 3A
Gene namesi
Name:EBNA3
ORF Names:BLRF3-BERF1
OrganismiEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri10376 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000007641 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003759361 – 935Epstein-Barr nuclear antigen 3Add BLAST935

Interactioni

Subunit structurei

Interacts with human UCKL1. Interacts with host CTPB1; this interaction seems important for EBNA3-mediated transcriptional repression. Interacts with host RBPJ (By similarity).By similarity

Protein-protein interaction databases

IntActiQ3KST2. 4 interactors.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MI5X-ray2.50C325-333[»]
3SJVX-ray3.10C/H/M/R325-333[»]
3SKMX-ray1.80C325-331[»]
3SKOX-ray1.60C325-333[»]
SMRiQ3KST2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae EBNA-3 family.Curated

Phylogenomic databases

OrthoDBiVOG0900002A.

Family and domain databases

InterProiView protein in InterPro
IPR007706. EBNA-3.
PfamiView protein in Pfam
PF05009. EBV-NA3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3KST2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKDRPGDPA LDDNMEEEVP STSVVQEQVS AGDWENVLIE LSDSSSEKEA
60 70 80 90 100
EDAQLEPAQK GTKRKRVDHD AGGSAPARPM LPPQPDLPGR EAILRRFPLD
110 120 130 140 150
LRTLLQAIGA AATRIDTRAI DQFFGSQISN TEMYIMYAMA IRQAIRDRRR
160 170 180 190 200
NPASRRDQAK WRLQTLAAGW PMGYQAYSSW MYSYTDHQTA PTFVQLQATL
210 220 230 240 250
GCTGGRRCHV TFSAGTFKPP RCTPGDRQWL YVQSSVGNIV QSCNPRYSIF
260 270 280 290 300
FDYMAIHRSL TKIWEEVLTP DQRVSFMEFL GFLQRTDLSY IKSFVSDALG
310 320 330 340 350
TTSIQTPWID DNSSTETAQA WNAGFLRGRA YGLDLLRTEG EHVEGATGET
360 370 380 390 400
REESEDTESD GDDEDLPCIV SRGGPKVKRP PIFIRRLHRL LLMRAGKRTE
410 420 430 440 450
QGKEVLEKAR GSTYGTPRPP VPKPRPEVPQ SDETATSHGS AQVPEPPTIH
460 470 480 490 500
LAAQGMAYPL HEQRGMAPCP VAQAPHTPLP PVSPGDQLPG VSSDGRVACA
510 520 530 540 550
PVPAPAGPIV RPWEPSLTQA AGQAFAPVRP QHMPVEPVPV PTVALERPVY
560 570 580 590 600
PKPVRPAPPK IAMQGPGETS GIRRARERWR PAPWTPNPPR SPSQMSVRDR
610 620 630 640 650
LARLRAEAQV KQASVEVQPP QVTQVSPQQP MEGPGAPFSQ VADVVHTPGV
660 670 680 690 700
PAMQPQYFDL PLIQPISQGA PVAPLRASMG PVPPVPATQP QYFDIPLTEP
710 720 730 740 750
INQGASAAHF LPQQPMEGPL VPEQWMFPGA ALSQSVRPGV AQSQYFDLPL
760 770 780 790 800
TQPITHGAPA AHFLHQPPME GPWVPEQWMF QGAPPSQGTD VVQHQLDALG
810 820 830 840 850
YPLHALNHPG VPVSPAVNQY HLSQAAFGLP IDEDESGEGS DTSEPCEALD
860 870 880 890 900
LSIHGRPCPQ APEWPVQGEG GQDATEVLDL SIHGRPRPRT PEWPVQGESG
910 920 930
QNVTDHEPRR VVVSAIVHMC QDDEFPDLQD PPDEA
Length:935
Mass (Da):102,426
Last modified:May 26, 2009 - v2
Checksum:iDABB76CCC45C2E5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY961628 Genomic DNA. Translation: AAY41118.1. Sequence problems.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY961628 Genomic DNA. Translation: AAY41118.1. Sequence problems.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MI5X-ray2.50C325-333[»]
3SJVX-ray3.10C/H/M/R325-333[»]
3SKMX-ray1.80C325-331[»]
3SKOX-ray1.60C325-333[»]
SMRiQ3KST2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3KST2. 4 interactors.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG0900002A.

Family and domain databases

InterProiView protein in InterPro
IPR007706. EBNA-3.
PfamiView protein in Pfam
PF05009. EBV-NA3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEBNA3_EBVG
AccessioniPrimary (citable) accession number: Q3KST2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: February 15, 2017
This is version 39 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.