ID   RDRP_PRV                Reviewed;        1014 AA.
AC   Q3KSM3;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   28-JUN-2023, entry version 53.
DE   RecName: Full=RNA-directed RNA polymerase;
DE            Short=RdRp;
DE            EC=2.7.7.48;
DE   AltName: Full=RNA replicase;
OS   Pieris rapae virus.
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Magsaviricetes;
OC   Nodamuvirales; Nodaviridae.
OX   NCBI_TaxID=327392;
OH   NCBI_TaxID=64459; Pieris rapae (Small white butterfly) (Artogeia rapae).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Liu C., Zhang J., Yi F., Wang J., Wang X., Hu Y.;
RT   "Sequence of the non-structural protein gene encoded by RNA1 of a new alpha
RT   noda-like virus isolated from Pieris rapae larvae in China.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-dependent RNA polymerase which replicates the viral
CC       genome composed of 2 RNA segments, RNA1 and RNA2. {ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU00539};
CC   -!- SIMILARITY: Belongs to the nodaviridae RNA polymerase family.
CC       {ECO:0000305}.
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DR   EMBL; AY962576; AAY27743.1; -; Genomic_RNA.
DR   SMR; Q3KSM3; -.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   CDD; cd23173; ps-ssRNAv_Nodaviridae_RdRp; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043647; Noda_Vmethyltr_dom.
DR   InterPro; IPR001205; RNA-dir_pol_C.
DR   InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR   Pfam; PF19222; Noda_Vmethyltr; 1.
DR   Pfam; PF00680; RdRP_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase; RNA-directed RNA polymerase; Transferase;
KW   Viral RNA replication.
FT   CHAIN           1..1014
FT                   /note="RNA-directed RNA polymerase"
FT                   /id="PRO_0000223688"
FT   DOMAIN          618..740
FT                   /note="RdRp catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00539"
FT   REGION          918..1014
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        983..1002
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1014 AA;  114607 MW;  0691D5F6E57F3D12 CRC64;
     MSSVIKTIVV KTLQCTVKCV CVGVRQQYGL LRRHPKTIAC ALVGGIIAHD VLHLYAAVYR
     VENPWEFVPT EGPRGVIVLR VYNALRFTAA KWRWNCWTIF GKFPFNSEQF SRIMETSTER
     KPDLRPLLVP AHETIEVYPC NNIHSHPRSA EFRSSANEYL VRSVRRAGYP PYVVSSSKRD
     FCDGNRFFYC PKDFGMQFRN DPISNNHALV FTDVDYYANM NRWLQLFLPT CLYTLVPTRL
     NYSNDEFAYR FENNEIVYNV TGGGEYRHSL WDYKGDTVTV VDEYGNLLIF DIEQRRVQGD
     EQHRLIWLLP KAKITDPLWI VGPTEWYDKL LVRKTVQQGR LKILWEPIAD DLSIGLHGSN
     YSVSLKGELF EAIRTRISCK DSTPYVSDVE RMLREAKHKN FLTDAPILYH CFQDDVIIRP
     NVVKTGSFPV TYNAIPKKAP SVTEDPKMPG QVVTTPLVSQ PALFAGKGFN ADKACIEGRI
     EKVRNVTKFP IKYVRYAAEF VKLVIPETIA GTGVPNSIGM IREEQDKVAQ RARFDRVAPI
     MSTQTENSIK AFIKTEMYAA AKAPRNISTM APEITIQSSA YSLPMAKIFK KIPWYCPGKN
     PKEITLRLAE VCLQDPDHEL EEGDYTCMDG TQSPDYSDLL LLPIYMRYFA KQYRGQFKNL
     YNQIYKQRAT TSSGVPYNPE MTIRSGSSIT THAGTLNNAF NIYAALRDMG YDETTAWDKV
     GAVFGDDSLN ANHQGEFHSY IEHVTKVLGM RYKSNLRERG QPVLFLGRYF VDPITSYDSF
     ADPMRTIGKL HATANKNVSV EQGAANKAHG YITTDSKTPI IGAWARRVLE ITKKKFKNGT
     GEEQYRCSNA WPQKDEAAIR AAMAAVLEVD EAQLIAQNEA VLKVNSLDQF PVVFDTYYDH
     KQLAEVDGQL VGTDLHIKEE DERQPETSID SVPSTGPPPS NGDPNAGGKP TDGPSKGKRK
     VKGRRPRTAG DPATLRLTDA GSSRRVKPPR KLRPEAKRGG RPIETLVFKN SSLS
//