Q3KSM3 (RDRP_PRV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: RNA-directed RNA polymerase Short name=RdRp EC=2.7.7.48 Alternative name(s): RNA replicase
Organism	Pieris rapae virus
Taxonomic identifier	327392 [NCBI]
Taxonomic lineage	Viruses › ssRNA viruses › ssRNA positive-strand viruses, no DNA stage › Nodaviridae › unclassified Nodaviridae
Virus host	Pieris rapae (Small white butterfly) (Artogeia rapae) [TaxID: 64459]

Protein attributes

Sequence length	1014 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2 Potential.
Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
Sequence similarities	Belongs to the nodaviridae RNA polymerase family. Contains 1 RdRp catalytic domain.

Ontologies

Keywords
Molecular function	Nucleotidyltransferase RNA-directed RNA polymerase Transferase
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro viral genome replication Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA binding Inferred from electronic annotation. Source: InterPro RNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1014	1014	RNA-directed RNA polymerase		PRO_0000223688
Regions
	Domain	618 – 740	123	RdRp catalytic

Sequences

	Sequence		Length	Mass (Da)
	Q3KSM3 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 0691D5F6E57F3D12	FASTA	1,014	114,607
	10 20 30 40 50 60 MSSVIKTIVV KTLQCTVKCV CVGVRQQYGL LRRHPKTIAC ALVGGIIAHD VLHLYAAVYR 70 80 90 100 110 120 VENPWEFVPT EGPRGVIVLR VYNALRFTAA KWRWNCWTIF GKFPFNSEQF SRIMETSTER 130 140 150 160 170 180 KPDLRPLLVP AHETIEVYPC NNIHSHPRSA EFRSSANEYL VRSVRRAGYP PYVVSSSKRD 190 200 210 220 230 240 FCDGNRFFYC PKDFGMQFRN DPISNNHALV FTDVDYYANM NRWLQLFLPT CLYTLVPTRL 250 260 270 280 290 300 NYSNDEFAYR FENNEIVYNV TGGGEYRHSL WDYKGDTVTV VDEYGNLLIF DIEQRRVQGD 310 320 330 340 350 360 EQHRLIWLLP KAKITDPLWI VGPTEWYDKL LVRKTVQQGR LKILWEPIAD DLSIGLHGSN 370 380 390 400 410 420 YSVSLKGELF EAIRTRISCK DSTPYVSDVE RMLREAKHKN FLTDAPILYH CFQDDVIIRP 430 440 450 460 470 480 NVVKTGSFPV TYNAIPKKAP SVTEDPKMPG QVVTTPLVSQ PALFAGKGFN ADKACIEGRI 490 500 510 520 530 540 EKVRNVTKFP IKYVRYAAEF VKLVIPETIA GTGVPNSIGM IREEQDKVAQ RARFDRVAPI 550 560 570 580 590 600 MSTQTENSIK AFIKTEMYAA AKAPRNISTM APEITIQSSA YSLPMAKIFK KIPWYCPGKN 610 620 630 640 650 660 PKEITLRLAE VCLQDPDHEL EEGDYTCMDG TQSPDYSDLL LLPIYMRYFA KQYRGQFKNL 670 680 690 700 710 720 YNQIYKQRAT TSSGVPYNPE MTIRSGSSIT THAGTLNNAF NIYAALRDMG YDETTAWDKV 730 740 750 760 770 780 GAVFGDDSLN ANHQGEFHSY IEHVTKVLGM RYKSNLRERG QPVLFLGRYF VDPITSYDSF 790 800 810 820 830 840 ADPMRTIGKL HATANKNVSV EQGAANKAHG YITTDSKTPI IGAWARRVLE ITKKKFKNGT 850 860 870 880 890 900 GEEQYRCSNA WPQKDEAAIR AAMAAVLEVD EAQLIAQNEA VLKVNSLDQF PVVFDTYYDH 910 920 930 940 950 960 KQLAEVDGQL VGTDLHIKEE DERQPETSID SVPSTGPPPS NGDPNAGGKP TDGPSKGKRK 970 980 990 1000 1010 VKGRRPRTAG DPATLRLTDA GSSRRVKPPR KLRPEAKRGG RPIETLVFKN SSLS

References

[1]	"Sequence of the non-structural protein gene encoded by RNA1 of a new alpha noda-like virus isolated from Pieris rapae larvae in China." Liu C., Zhang J., Yi F., Wang J., Wang X., Hu Y. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY962576 Genomic RNA. Translation: AAY27743.1.
3D structure databases
ProteinModelPortal	Q3KSM3.
ModBase	Search...
Proteomic databases
PRIDE	Q3KSM3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001205. RNA-dir_pol_C. IPR007094. RNA-dir_pol_PSvirus. [Graphical view]
Pfam	PF00680. RdRP_1. 1 hit. [Graphical view]
PROSITE	PS50507. RDRP_SSRNA_POS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RDRP_PRV

Accession

Primary (citable) accession number: Q3KSM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	November 8, 2005
Last modified:	May 1, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program