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Protein

RNA-directed RNA polymerase

Gene
N/A
Organism
Pieris rapae virus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2.Curated

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
RdRp
Alternative name(s):
RNA replicase
OrganismiPieris rapae virus
Taxonomic identifieri327392 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNodaviridaeunclassified Nodaviridae
Virus hostiPieris rapae (Small white butterfly) (Artogeia rapae) [TaxID: 64459]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10141014RNA-directed RNA polymerasePRO_0000223688Add
BLAST

Proteomic databases

PRIDEiQ3KSM3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini618 – 740123RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the nodaviridae RNA polymerase family.Curated
Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
[Graphical view]
PfamiPF00680. RdRP_1. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3KSM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVIKTIVV KTLQCTVKCV CVGVRQQYGL LRRHPKTIAC ALVGGIIAHD
60 70 80 90 100
VLHLYAAVYR VENPWEFVPT EGPRGVIVLR VYNALRFTAA KWRWNCWTIF
110 120 130 140 150
GKFPFNSEQF SRIMETSTER KPDLRPLLVP AHETIEVYPC NNIHSHPRSA
160 170 180 190 200
EFRSSANEYL VRSVRRAGYP PYVVSSSKRD FCDGNRFFYC PKDFGMQFRN
210 220 230 240 250
DPISNNHALV FTDVDYYANM NRWLQLFLPT CLYTLVPTRL NYSNDEFAYR
260 270 280 290 300
FENNEIVYNV TGGGEYRHSL WDYKGDTVTV VDEYGNLLIF DIEQRRVQGD
310 320 330 340 350
EQHRLIWLLP KAKITDPLWI VGPTEWYDKL LVRKTVQQGR LKILWEPIAD
360 370 380 390 400
DLSIGLHGSN YSVSLKGELF EAIRTRISCK DSTPYVSDVE RMLREAKHKN
410 420 430 440 450
FLTDAPILYH CFQDDVIIRP NVVKTGSFPV TYNAIPKKAP SVTEDPKMPG
460 470 480 490 500
QVVTTPLVSQ PALFAGKGFN ADKACIEGRI EKVRNVTKFP IKYVRYAAEF
510 520 530 540 550
VKLVIPETIA GTGVPNSIGM IREEQDKVAQ RARFDRVAPI MSTQTENSIK
560 570 580 590 600
AFIKTEMYAA AKAPRNISTM APEITIQSSA YSLPMAKIFK KIPWYCPGKN
610 620 630 640 650
PKEITLRLAE VCLQDPDHEL EEGDYTCMDG TQSPDYSDLL LLPIYMRYFA
660 670 680 690 700
KQYRGQFKNL YNQIYKQRAT TSSGVPYNPE MTIRSGSSIT THAGTLNNAF
710 720 730 740 750
NIYAALRDMG YDETTAWDKV GAVFGDDSLN ANHQGEFHSY IEHVTKVLGM
760 770 780 790 800
RYKSNLRERG QPVLFLGRYF VDPITSYDSF ADPMRTIGKL HATANKNVSV
810 820 830 840 850
EQGAANKAHG YITTDSKTPI IGAWARRVLE ITKKKFKNGT GEEQYRCSNA
860 870 880 890 900
WPQKDEAAIR AAMAAVLEVD EAQLIAQNEA VLKVNSLDQF PVVFDTYYDH
910 920 930 940 950
KQLAEVDGQL VGTDLHIKEE DERQPETSID SVPSTGPPPS NGDPNAGGKP
960 970 980 990 1000
TDGPSKGKRK VKGRRPRTAG DPATLRLTDA GSSRRVKPPR KLRPEAKRGG
1010
RPIETLVFKN SSLS
Length:1,014
Mass (Da):114,607
Last modified:November 8, 2005 - v1
Checksum:i0691D5F6E57F3D12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY962576 Genomic RNA. Translation: AAY27743.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY962576 Genomic RNA. Translation: AAY27743.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ3KSM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
[Graphical view]
PfamiPF00680. RdRP_1. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence of the non-structural protein gene encoded by RNA1 of a new alpha noda-like virus isolated from Pieris rapae larvae in China."
    Liu C., Zhang J., Yi F., Wang J., Wang X., Hu Y.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiRDRP_PRV
AccessioniPrimary (citable) accession number: Q3KSM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 8, 2005
Last modified: April 1, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.