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Protein

Sp110 nuclear body protein

Gene

Sp110

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a transcription factor. Plays a role in the innate immunity against intracellular pathogens. Required for resistance to M.tuberculosis and L.monocytogenes. Promotes apoptosis of infected cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processApoptosis, Immunity, Innate immunity, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Sp110 nuclear body protein
Alternative name(s):
Intracellular pathogen resistance protein 1
Gene namesi
Name:Sp110
Synonyms:Ipr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310173 Sp110

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002479621 – 478Sp110 nuclear body proteinAdd BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175PhosphoserineBy similarity1
Modified residuei177PhosphoserineBy similarity1
Modified residuei254PhosphoserineBy similarity1
Modified residuei305PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3KRF1
PRIDEiQ3KRF1

PTM databases

iPTMnetiQ3KRF1
PhosphoSitePlusiQ3KRF1

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053828

Structurei

3D structure databases

ProteinModelPortaliQ3KRF1
SMRiQ3KRF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 108HSRPROSITE-ProRule annotationAdd BLAST108
Domaini385 – 466SANDPROSITE-ProRule annotationAdd BLAST82

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi279 – 294Nuclear localization signalSequence analysisAdd BLAST16

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
HOGENOMiHOG000089984
HOVERGENiHBG006294
InParanoidiQ3KRF1
PhylomeDBiQ3KRF1
TreeFamiTF335091

Family and domain databases

Gene3Di3.10.390.10, 1 hit
InterProiView protein in InterPro
IPR004865 HSR_dom
IPR010919 SAND-like_dom_sf
IPR000770 SAND_dom
PfamiView protein in Pfam
PF03172 HSR, 1 hit
PF01342 SAND, 1 hit
SMARTiView protein in SMART
SM00258 SAND, 1 hit
SUPFAMiSSF63763 SSF63763, 1 hit
PROSITEiView protein in PROSITE
PS51414 HSR, 1 hit
PS50864 SAND, 1 hit

Sequencei

Sequence statusi: Complete.

Q3KRF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTLTKALEK ALLQHFIYTK LDIAYAINKP FPFFEALRDN SFITERMYKE
60 70 80 90 100
SLEACQNLVP LSKVVHNILT SLEQTFDPSM LLILFSKVNL REYPSLGAIC
110 120 130 140 150
RSFRNVGNAY EGRNRPAPTL LGASTNPAEG CSFQTLLPQP RSQALPPSHL
160 170 180 190 200
SSGLRIRDPG TTSLQITEIL DEQPSPSHPA APLPGYIREG KTTPVSSRDH
210 220 230 240 250
QRKDKEDSQE MPHHPSGPEA VVKDILTSKT NNRDDSGAQP PGSPGTMHVV
260 270 280 290 300
QDNSPAPNDP EVPQEAPCTP ANKKARKRKS CIWSNSKRRR QKKKPPQHKM
310 320 330 340 350
MGVASPGPGV QEKLKVVGQR TLNQDDSTRN VKVVTRTLRE RTRCAQTSSS
360 370 380 390 400
QEISKEASKP RARKRPQKRP HTAGRTIHVP EKSKDDAVDF LSPTLSVTCG
410 420 430 440 450
EARGTLFKEK LKQGSSEKCI QNEAGAWLTV KEFLKKGGKA TSKDWKKAIR
460 470
CNKKTLRSLE QDGFLFCTSK SKPQKECD
Length:478
Mass (Da):53,205
Last modified:November 8, 2005 - v1
Checksum:iDE3FB12100B37478
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105751 mRNA Translation: AAI05752.1
RefSeqiNP_001029309.1, NM_001034137.1
UniGeneiRn.6459

Genome annotation databases

GeneIDi301570
KEGGirno:301570
UCSCiRGD:1310173 rat

Similar proteinsi

Entry informationi

Entry nameiSP110_RAT
AccessioniPrimary (citable) accession number: Q3KRF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2006
Last sequence update: November 8, 2005
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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