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Protein

Sp110 nuclear body protein

Gene

Sp110

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May act as a transcription factor. Plays a role in the innate immunity against intracellular pathogens. Required for resistance to M.tuberculosis and L.monocytogenes. Promotes apoptosis of infected cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Immunity, Innate immunity, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sp110 nuclear body protein
Alternative name(s):
Intracellular pathogen resistance protein 1
Gene namesi
Name:Sp110
Synonyms:Ipr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310173. Sp110.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Sp110 nuclear body proteinPRO_0000247962Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei175 – 1751PhosphoserineBy similarity
Modified residuei177 – 1771PhosphoserineBy similarity
Modified residuei254 – 2541PhosphoserineBy similarity
Modified residuei305 – 3051PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3KRF1.
PRIDEiQ3KRF1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053828.

Structurei

3D structure databases

ProteinModelPortaliQ3KRF1.
SMRiQ3KRF1. Positions 383-471.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 108108HSRPROSITE-ProRule annotationAdd
BLAST
Domaini385 – 46682SANDPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi279 – 29416Nuclear localization signalSequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 HSR domain.PROSITE-ProRule annotation
Contains 1 SAND domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
HOGENOMiHOG000089984.
HOVERGENiHBG006294.
InParanoidiQ3KRF1.
OrthoDBiEOG7SR4MV.
PhylomeDBiQ3KRF1.
TreeFamiTF335091.

Family and domain databases

Gene3Di3.10.390.10. 1 hit.
InterProiIPR004865. HSR_dom.
IPR000770. SAND_dom.
IPR010919. SAND_dom-like.
[Graphical view]
PfamiPF01342. SAND. 1 hit.
PF03172. Sp100. 1 hit.
[Graphical view]
SMARTiSM00258. SAND. 1 hit.
[Graphical view]
SUPFAMiSSF63763. SSF63763. 1 hit.
PROSITEiPS51414. HSR. 1 hit.
PS50864. SAND. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3KRF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTLTKALEK ALLQHFIYTK LDIAYAINKP FPFFEALRDN SFITERMYKE
60 70 80 90 100
SLEACQNLVP LSKVVHNILT SLEQTFDPSM LLILFSKVNL REYPSLGAIC
110 120 130 140 150
RSFRNVGNAY EGRNRPAPTL LGASTNPAEG CSFQTLLPQP RSQALPPSHL
160 170 180 190 200
SSGLRIRDPG TTSLQITEIL DEQPSPSHPA APLPGYIREG KTTPVSSRDH
210 220 230 240 250
QRKDKEDSQE MPHHPSGPEA VVKDILTSKT NNRDDSGAQP PGSPGTMHVV
260 270 280 290 300
QDNSPAPNDP EVPQEAPCTP ANKKARKRKS CIWSNSKRRR QKKKPPQHKM
310 320 330 340 350
MGVASPGPGV QEKLKVVGQR TLNQDDSTRN VKVVTRTLRE RTRCAQTSSS
360 370 380 390 400
QEISKEASKP RARKRPQKRP HTAGRTIHVP EKSKDDAVDF LSPTLSVTCG
410 420 430 440 450
EARGTLFKEK LKQGSSEKCI QNEAGAWLTV KEFLKKGGKA TSKDWKKAIR
460 470
CNKKTLRSLE QDGFLFCTSK SKPQKECD
Length:478
Mass (Da):53,205
Last modified:November 8, 2005 - v1
Checksum:iDE3FB12100B37478
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105751 mRNA. Translation: AAI05752.1.
RefSeqiNP_001029309.1. NM_001034137.1.
UniGeneiRn.6459.

Genome annotation databases

GeneIDi301570.
KEGGirno:301570.
UCSCiRGD:1310173. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105751 mRNA. Translation: AAI05752.1.
RefSeqiNP_001029309.1. NM_001034137.1.
UniGeneiRn.6459.

3D structure databases

ProteinModelPortaliQ3KRF1.
SMRiQ3KRF1. Positions 383-471.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053828.

Proteomic databases

PaxDbiQ3KRF1.
PRIDEiQ3KRF1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi301570.
KEGGirno:301570.
UCSCiRGD:1310173. rat.

Organism-specific databases

CTDi3431.
RGDi1310173. Sp110.

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
HOGENOMiHOG000089984.
HOVERGENiHBG006294.
InParanoidiQ3KRF1.
OrthoDBiEOG7SR4MV.
PhylomeDBiQ3KRF1.
TreeFamiTF335091.

Miscellaneous databases

NextBioi648963.
PROiQ3KRF1.

Family and domain databases

Gene3Di3.10.390.10. 1 hit.
InterProiIPR004865. HSR_dom.
IPR000770. SAND_dom.
IPR010919. SAND_dom-like.
[Graphical view]
PfamiPF01342. SAND. 1 hit.
PF03172. Sp100. 1 hit.
[Graphical view]
SMARTiSM00258. SAND. 1 hit.
[Graphical view]
SUPFAMiSSF63763. SSF63763. 1 hit.
PROSITEiPS51414. HSR. 1 hit.
PS50864. SAND. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSP110_RAT
AccessioniPrimary (citable) accession number: Q3KRF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2006
Last sequence update: November 8, 2005
Last modified: February 17, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.