Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kelch domain-containing protein 2

Gene

Klhdc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch domain-containing protein 2
Gene namesi
Name:Klhdc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1306504. Klhdc2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Kelch domain-containing protein 2PRO_0000228994Add
BLAST

Proteomic databases

PaxDbiQ3KRE6.

Expressioni

Gene expression databases

GenevisibleiQ3KRE6. RN.

Interactioni

Subunit structurei

Directly interacts with CREB3, but not with CREB1, ATF4, ATF6, JUN, FOS, CEBPA.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006223.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati43 – 8947Kelch 1Add
BLAST
Repeati102 – 15554Kelch 2Add
BLAST
Repeati157 – 20246Kelch 3Add
BLAST
Repeati229 – 27850Kelch 4Add
BLAST
Repeati280 – 32950Kelch 5Add
BLAST
Repeati331 – 37747Kelch 6Add
BLAST

Sequence similaritiesi

Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG0379. Eukaryota.
ENOG410Y5WM. LUCA.
GeneTreeiENSGT00760000119086.
HOGENOMiHOG000006587.
HOVERGENiHBG067471.
InParanoidiQ3KRE6.
OMAiIWSQPIT.
OrthoDBiEOG75TMBP.
PhylomeDBiQ3KRE6.
TreeFamiTF314081.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR015915. Kelch-typ_b-propeller.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3KRE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGNEDARA EDMPGPAFEG YEAMELACPA ERSGHVAVSD GRHMFVWGGY
60 70 80 90 100
KSNQVRGLYD FYLPREELWI YNMETGRWKK INTEGDVPPS MSGSCAVCVD
110 120 130 140 150
RVLYLFGGHH SRGNTNKFYM LDSRSADRVL QWERIDCQGI PPSSKDKLGV
160 170 180 190 200
WVYKNKLIFF GGYGYLPEDK VLGTFEFDET SFWNSSHPRG WNDHVHILDT
210 220 230 240 250
ETFAWSQPIT TGKAPSPRAA HACATVGNKG FVFGGRYRDA RMNDLHYLNL
260 270 280 290 300
DTWEWNELIP QGICPVGRSW HSLTPVSSDH LFLFGGFTTE KQPLSDAWTY
310 320 330 340 350
CISKNEWIQF NHPYVEKPRL WHTACASDEG EVIVFGGCAN NLLVHHRAAH
360 370 380 390 400
SNEVLIFSVQ PKSLVRLSLE AVICFKEMLA NSWSCLPKHL LHSVNQRFGS

NNTSGS
Length:406
Mass (Da):45,926
Last modified:November 8, 2005 - v1
Checksum:iF06F8452B63BE0D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105756 mRNA. Translation: AAI05757.1.
RefSeqiNP_001029305.1. NM_001034133.1.
UniGeneiRn.129179.

Genome annotation databases

EnsembliENSRNOT00000006223; ENSRNOP00000006223; ENSRNOG00000004474.
GeneIDi299113.
KEGGirno:299113.
UCSCiRGD:1306504. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105756 mRNA. Translation: AAI05757.1.
RefSeqiNP_001029305.1. NM_001034133.1.
UniGeneiRn.129179.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006223.

Proteomic databases

PaxDbiQ3KRE6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006223; ENSRNOP00000006223; ENSRNOG00000004474.
GeneIDi299113.
KEGGirno:299113.
UCSCiRGD:1306504. rat.

Organism-specific databases

CTDi23588.
RGDi1306504. Klhdc2.

Phylogenomic databases

eggNOGiKOG0379. Eukaryota.
ENOG410Y5WM. LUCA.
GeneTreeiENSGT00760000119086.
HOGENOMiHOG000006587.
HOVERGENiHBG067471.
InParanoidiQ3KRE6.
OMAiIWSQPIT.
OrthoDBiEOG75TMBP.
PhylomeDBiQ3KRE6.
TreeFamiTF314081.

Miscellaneous databases

PROiQ3KRE6.

Gene expression databases

GenevisibleiQ3KRE6. RN.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR015915. Kelch-typ_b-propeller.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiKLDC2_RAT
AccessioniPrimary (citable) accession number: Q3KRE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 8, 2005
Last modified: June 8, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.