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Protein

Eukaryotic translation initiation factor 6

Gene

Eif6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis, Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Gene namesi
Name:Eif6
Synonyms:Itgb4bp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1305373. Eif6.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleusnucleolus UniRule annotation

  • Note: Shuttles between cytoplasm and nucleus/nucleolus.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Eukaryotic translation initiation factor 6PRO_0000402095Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei113 – 1131PhosphotyrosineBy similarity
Modified residuei165 – 1651PhosphothreonineUniRule annotationBy similarity
Modified residuei166 – 1661PhosphoserineUniRule annotationBy similarity
Modified residuei174 – 1741Phosphoserine; by CK1UniRule annotationBy similarity
Modified residuei175 – 1751Phosphoserine; by CK1UniRule annotationBy similarity
Modified residuei235 – 2351Phosphoserine; by PKCUniRule annotationBy similarity
Modified residuei239 – 2391PhosphoserineUniRule annotationBy similarity
Modified residuei243 – 2431PhosphoserineCombined sources

Post-translational modificationi

Phosphorylation at Ser-174 and Ser-175 by CSNK1D/CK1 promotes nuclear export.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3KRD8.
PRIDEiQ3KRD8.

PTM databases

iPTMnetiQ3KRD8.

Expressioni

Gene expression databases

ExpressionAtlasiQ3KRD8. baseline and differential.
GenevisibleiQ3KRD8. RN.

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1.UniRule annotation

Protein-protein interaction databases

BioGridi258203. 1 interaction.
STRINGi10116.ENSRNOP00000066257.

Structurei

3D structure databases

ProteinModelPortaliQ3KRD8.
SMRiQ3KRD8. Positions 1-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3185. Eukaryota.
COG1976. LUCA.
GeneTreeiENSGT00390000015972.
HOVERGENiHBG001300.
InParanoidiQ3KRD8.
KOiK03264.
OMAiNDWCAFT.
OrthoDBiEOG7V4B05.
PhylomeDBiQ3KRD8.

Family and domain databases

HAMAPiMF_00032. eIF_6.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3KRD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVRASFENN CEVGCFAKLT NTYCLVAIGG SENFYSVFEG ELSDTIPVVH
60 70 80 90 100
ASIAGCRIIG RMCVGNRHGL LVPNNTTDQE LQHIRNSLPD SVQIRRVEER
110 120 130 140 150
LSALGNVTTC NDYVALVHPD LDRETEEILA DVLKVEVFRQ TVADQVLVGS
160 170 180 190 200
YCVFSNQGGL VHPKTSIEDQ DELSSLLQVP LVAGTVNRGS EVIAAGMVVN
210 220 230 240
DWCAFCGLDT TSTELSVVES VFKLNEAKPS TIATSMRDSL IDSLT
Length:245
Mass (Da):26,571
Last modified:November 8, 2005 - v1
Checksum:i046FA8F06709F69A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474050 Genomic DNA. Translation: EDL85894.1.
BC105764 mRNA. Translation: AAI05765.1.
RefSeqiNP_001032429.1. NM_001037352.1.
XP_006235378.1. XM_006235316.2.
UniGeneiRn.190833.

Genome annotation databases

EnsembliENSRNOT00000073492; ENSRNOP00000066257; ENSRNOG00000049497.
GeneIDi305506.
KEGGirno:305506.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474050 Genomic DNA. Translation: EDL85894.1.
BC105764 mRNA. Translation: AAI05765.1.
RefSeqiNP_001032429.1. NM_001037352.1.
XP_006235378.1. XM_006235316.2.
UniGeneiRn.190833.

3D structure databases

ProteinModelPortaliQ3KRD8.
SMRiQ3KRD8. Positions 1-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi258203. 1 interaction.
STRINGi10116.ENSRNOP00000066257.

PTM databases

iPTMnetiQ3KRD8.

Proteomic databases

PaxDbiQ3KRD8.
PRIDEiQ3KRD8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000073492; ENSRNOP00000066257; ENSRNOG00000049497.
GeneIDi305506.
KEGGirno:305506.

Organism-specific databases

CTDi3692.
RGDi1305373. Eif6.

Phylogenomic databases

eggNOGiKOG3185. Eukaryota.
COG1976. LUCA.
GeneTreeiENSGT00390000015972.
HOVERGENiHBG001300.
InParanoidiQ3KRD8.
KOiK03264.
OMAiNDWCAFT.
OrthoDBiEOG7V4B05.
PhylomeDBiQ3KRD8.

Miscellaneous databases

PROiQ3KRD8.

Gene expression databases

ExpressionAtlasiQ3KRD8. baseline and differential.
GenevisibleiQ3KRD8. RN.

Family and domain databases

HAMAPiMF_00032. eIF_6.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIF6_RAT
AccessioniPrimary (citable) accession number: Q3KRD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: November 8, 2005
Last modified: June 8, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.