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Protein

Mitochondrial import receptor subunit TOM34

Gene

Tomm34

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM34
Alternative name(s):
Translocase of outer membrane 34 kDa subunit
Gene namesi
Name:Tomm34
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1309029. Tomm34.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003292951 – 309Mitochondrial import receptor subunit TOM34Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineCombined sources1
Modified residuei160PhosphoserineBy similarity1
Modified residuei186PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3KRD5.
PRIDEiQ3KRD5.

PTM databases

iPTMnetiQ3KRD5.
PhosphoSitePlusiQ3KRD5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000029799.
GenevisibleiQ3KRD5. RN.

Interactioni

Subunit structurei

Interacts with HSP90A, VCP, ATP6M, KIAA0665, AMPK, and DMAP1 through its TPR repeat.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049550.

Structurei

3D structure databases

ProteinModelPortaliQ3KRD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati9 – 42TPR 1Add BLAST34
Repeati51 – 84TPR 2Add BLAST34
Repeati86 – 118TPR 3Add BLAST33
Repeati193 – 226TPR 4Add BLAST34
Repeati227 – 260TPR 5Add BLAST34
Repeati262 – 294TPR 6Add BLAST33

Sequence similaritiesi

Belongs to the Tom34 family.Curated
Contains 6 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IQQM. Eukaryota.
ENOG410ZREI. LUCA.
GeneTreeiENSGT00840000129761.
HOGENOMiHOG000070537.
HOVERGENiHBG105545.
InParanoidiQ3KRD5.
KOiK17766.
OMAiNCNECIK.
OrthoDBiEOG091G0FFR.
PhylomeDBiQ3KRD5.
TreeFamiTF106202.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3KRD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKVSDSVE QLRAAGNQNF RNGQYGEASA LYERALRLLQ ARGSADPEEE
60 70 80 90 100
SVLYSNRAAC YLKDGNCTDC IKDCTSALAL VPFSIKPLLR RASAYEALEK
110 120 130 140 150
YSLAYVDYKT VLQIDNSVAS ALEGINRITR ALMDSLGPEW RLKLPPIPVV
160 170 180 190 200
PVSAQKRWSS LPSENHKETA KSKSKETTAT KNRVPSAGDV ERARVLKEEG
210 220 230 240 250
NELVKKGNHK KAIEKYSESL LFSSLESATY SNRALCHLVL KQYKEAEKDC
260 270 280 290 300
TEALKLDGKN VKAFYRRAQA YKALKDYKSS LADISSLLQI EPRNGPAHKL

RQEVNQNMN
Length:309
Mass (Da):34,461
Last modified:November 8, 2005 - v1
Checksum:i66793000104468CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105768 mRNA. Translation: AAI05769.1.
RefSeqiNP_001037709.1. NM_001044244.2.
UniGeneiRn.16749.

Genome annotation databases

EnsembliENSRNOT00000040156; ENSRNOP00000049550; ENSRNOG00000029799.
GeneIDi311621.
KEGGirno:311621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105768 mRNA. Translation: AAI05769.1.
RefSeqiNP_001037709.1. NM_001044244.2.
UniGeneiRn.16749.

3D structure databases

ProteinModelPortaliQ3KRD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049550.

PTM databases

iPTMnetiQ3KRD5.
PhosphoSitePlusiQ3KRD5.

Proteomic databases

PaxDbiQ3KRD5.
PRIDEiQ3KRD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000040156; ENSRNOP00000049550; ENSRNOG00000029799.
GeneIDi311621.
KEGGirno:311621.

Organism-specific databases

CTDi10953.
RGDi1309029. Tomm34.

Phylogenomic databases

eggNOGiENOG410IQQM. Eukaryota.
ENOG410ZREI. LUCA.
GeneTreeiENSGT00840000129761.
HOGENOMiHOG000070537.
HOVERGENiHBG105545.
InParanoidiQ3KRD5.
KOiK17766.
OMAiNCNECIK.
OrthoDBiEOG091G0FFR.
PhylomeDBiQ3KRD5.
TreeFamiTF106202.

Miscellaneous databases

PROiQ3KRD5.

Gene expression databases

BgeeiENSRNOG00000029799.
GenevisibleiQ3KRD5. RN.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOM34_RAT
AccessioniPrimary (citable) accession number: Q3KRD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.