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Protein

Aspartate--tRNA ligase, mitochondrial

Gene

Dars2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei265AspartateBy similarity1
Binding sitei534ATPBy similarity1
Binding sitei541AspartateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi265 – 267ATPBy similarity3
Nucleotide bindingi583 – 586ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate--tRNA ligase, mitochondrial (EC:6.1.1.12By similarity)
Alternative name(s):
Aspartyl-tRNA synthetase
Short name:
AspRS
Gene namesi
Name:Dars2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1308286 Dars2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46MitochondrionSequence analysisAdd BLAST46
ChainiPRO_000025073847 – 652Aspartate--tRNA ligase, mitochondrialAdd BLAST606

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei218PhosphothreonineCombined sources1
Modified residuei241PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3KRD0
PRIDEiQ3KRD0

PTM databases

iPTMnetiQ3KRD0
PhosphoSitePlusiQ3KRD0

Expressioni

Gene expression databases

BgeeiENSRNOG00000002813
GenevisibleiQ3KRD0 RN

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003828

Structurei

3D structure databases

ProteinModelPortaliQ3KRD0
SMRiQ3KRD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni243 – 246AspartateBy similarity4

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2411 Eukaryota
COG0173 LUCA
GeneTreeiENSGT00550000074971
HOGENOMiHOG000275159
HOVERGENiHBG055815
InParanoidiQ3KRD0
KOiK01876
OMAiYQLDVEM
OrthoDBiEOG091G04HW
PhylomeDBiQ3KRD0
TreeFamiTF314827

Family and domain databases

Gene3Di3.30.1360.30, 1 hit
HAMAPiMF_00044 Asp_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR004364 aa-tRNA-synt_II
IPR006195 aa-tRNA-synth_II
IPR004524 Asp-tRNA-ligase_1
IPR002312 Asp/Asn-tRNA-synth_IIb
IPR004115 GAD-like_sf
IPR029351 GAD_dom
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
PANTHERiPTHR22594:SF5 PTHR22594:SF5, 1 hit
PfamiView protein in Pfam
PF02938 GAD, 1 hit
PF00152 tRNA-synt_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit
PRINTSiPR01042 TRNASYNTHASP
SUPFAMiSSF50249 SSF50249, 1 hit
SSF55261 SSF55261, 1 hit
TIGRFAMsiTIGR00459 aspS_bact, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3KRD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLGSWLNRL GRGLSRPIGK TKQPIWGSLS RSLTLSSQRV PEFSSFVART
60 70 80 90 100
NTCGELRSSH LGQEVTLCGW IQYRRQNTFL VLRDCHGLVQ ILIPQDESAA
110 120 130 140 150
SVRRTLCEAP VESVVRVSGT VIARPLGQEN PKMPTGEIEI KAKTAELLNA
160 170 180 190 200
CKKLPFEIKD FVKKTEALRL QYRYLDLRSS QMQHNLRLRS QMVMKMREYL
210 220 230 240 250
CTLHGFVDIE TPTLFKRTPG GAKEFLVPSR EPGRFYSLPQ SPQQFKQLLM
260 270 280 290 300
VGGLDRYFQV ARCYRDEGSR PDRQPEFTQI DIEMSFVDQT GIQHLVEGLL
310 320 330 340 350
HYSWPEDKDP LVAPFPSMTF AEALATYGTD KPDTRFGMKI VDISDVFRNT
360 370 380 390 400
EIRFLQDALA KPQGTVKAIC VHEGAKYLRK EDIEFIRKFA AHHFSQEVLP
410 420 430 440 450
IFLNARKNWS SPFAKFITEE ERLELTRLME IQEDDMVLLT AGQHEKACSL
460 470 480 490 500
LGKLRLECAD LLETRGLALR DPALFSFLWV LDFPLFLAKE ESPTELESAH
510 520 530 540 550
HPFTAPHPGD IHLLYTEPEK VRGQHYDLVL NGNEIGGGSI RIHDAQLQRY
560 570 580 590 600
ILETLLKEDV KLLSHLLQAL DYGAPPHGGI ALGLDRLVCL VTGAPSIRDV
610 620 630 640 650
IAFPKSYRGH DLMSNAPDTV SPEDLKPYHI HVSWPTDSEE RASATPSKYL

SS
Length:652
Mass (Da):73,953
Last modified:November 8, 2005 - v1
Checksum:i6CB570CC05F30086
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105774 mRNA Translation: AAI05775.1
RefSeqiNP_001029315.1, NM_001034143.1
UniGeneiRn.137838

Genome annotation databases

EnsembliENSRNOT00000003828; ENSRNOP00000003828; ENSRNOG00000002813
GeneIDi304919
KEGGirno:304919
UCSCiRGD:1308286 rat

Similar proteinsi

Entry informationi

Entry nameiSYDM_RAT
AccessioniPrimary (citable) accession number: Q3KRD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 8, 2005
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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