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Protein

tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like

Gene

Dus3l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.By similarity

Cofactori

FMNBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei355FMNBy similarity1
Active sitei386Proton donorBy similarity1
Binding sitei425FMNBy similarity1
Binding sitei455FMNBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri110 – 140C3H1-type 1PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri148 – 178C3H1-type 2PROSITE-ProRule annotationAdd BLAST31
Nucleotide bindingi301 – 303FMNBy similarity3
Nucleotide bindingi487 – 489FMNBy similarity3
Nucleotide bindingi510 – 511FMNBy similarity2

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processtRNA processing
LigandFlavoprotein, FMN, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (EC:1.3.1.-)
Alternative name(s):
tRNA-dihydrouridine synthase 3-like
Gene namesi
Name:Dus3l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1563228 Dus3l

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002473442 – 640tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-likeAdd BLAST639

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei267PhosphoserineBy similarity1
Cross-linki406Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ3KRC5
PRIDEiQ3KRC5

PTM databases

iPTMnetiQ3KRC5
PhosphoSitePlusiQ3KRC5

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066698

Structurei

3D structure databases

ProteinModelPortaliQ3KRC5
SMRiQ3KRC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Dus family. Dus3 subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri110 – 140C3H1-type 1PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri148 – 178C3H1-type 2PROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2333 Eukaryota
COG0042 LUCA
HOVERGENiHBG062413
InParanoidiQ3KRC5
KOiK05544
PhylomeDBiQ3KRC5

Family and domain databases

CDDicd02801 DUS_like_FMN, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035587 DUS-like_FMN-bd
IPR001269 tRNA_hU_synthase
IPR018517 tRNA_hU_synthase_CS
IPR000571 Znf_CCCH
PANTHERiPTHR11082 PTHR11082, 1 hit
PfamiView protein in Pfam
PF01207 Dus, 1 hit
PF00642 zf-CCCH, 1 hit
PROSITEiView protein in PROSITE
PS01136 UPF0034, 1 hit
PS50103 ZF_C3H1, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3KRC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVAEVAAE SGGGGDSGVG ACERGVAPIK AQYRTTKERF HEYLDADKQE
60 70 80 90 100
GACQETPTEG PAEPEAKRIR LEDGQENGKT EVAVESHERQ VPKRARGQNK
110 120 130 140 150
SRPHMKPAHY DKERLCPSLL QESATPCAFG DRCRFLHDVG RYLETKPADL
160 170 180 190 200
GPHCVLFNTF GRCPYSMTCR FAGAHLGPEG QNLVQEEVVA RCAQLPSVRN
210 220 230 240 250
GLDRALQQQL RKRQVCFERA EQALSHLTQG PMPTIAPEST VATLTPKHSS
260 270 280 290 300
CHVQLDNVGG DGARQGSPVP TCGPLTDEDV VRLRPCEKKR LDISGKLYLA
310 320 330 340 350
PLTTCGNLPF RRICKRFGAD VTCGEMAMCT NLLQGQMSEW ALLKRHPCED
360 370 380 390 400
IFGVQLEGAF PDTMTKCAEL LNRTIDVDFV DINVGCPIDL VYKKGGGCAL
410 420 430 440 450
MNRSAKFQQI VRGMNEVLDV PLTVKMRTGV QERVSLAHRL LPELRNWGVA
460 470 480 490 500
LVTLHGRSRE QRYTRLADWP YIEQCAKVAS PMPLFGNGDI LSFEDANCAM
510 520 530 540 550
QTGVAGIMVA RGALLKPWLF TEIKEQRHWD ISSSERLDIL RDFTHYGLEH
560 570 580 590 600
WGSDTQGVER TRRFLLEWLS FLCRYVPVGL LERLPQRINE RPPYYLGRDY
610 620 630 640
LETLMASQQA ADWIRISEML LGPVPPGFVF LPKHKANAYK
Length:640
Mass (Da):71,540
Last modified:November 8, 2005 - v1
Checksum:iB52A62C52CA00E8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105780 mRNA Translation: AAI05781.1
RefSeqiNP_001030095.1, NM_001034923.1
UniGeneiRn.42187

Genome annotation databases

GeneIDi301122
KEGGirno:301122

Similar proteinsi

Entry informationi

Entry nameiDUS3L_RAT
AccessioniPrimary (citable) accession number: Q3KRC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 8, 2005
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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