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Protein

G-protein coupled receptor family C group 5 member C

Gene

Gprc5c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor family C group 5 member C
Gene namesi
Name:Gprc5c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1311408. Gprc5c.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 49ExtracellularSequence analysisAdd BLAST27
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 84CytoplasmicSequence analysisAdd BLAST14
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 119ExtracellularSequence analysisAdd BLAST14
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 154CytoplasmicSequence analysisAdd BLAST14
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 207ExtracellularSequence analysisAdd BLAST32
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 240CytoplasmicSequence analysisAdd BLAST12
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 278ExtracellularSequence analysisAdd BLAST17
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 441CytoplasmicSequence analysisAdd BLAST142

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000025113623 – 441G-protein coupled receptor family C group 5 member CAdd BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi190N-linked (GlcNAc...)Sequence analysis1
Modified residuei343PhosphoserineBy similarity1
Modified residuei382PhosphoserineBy similarity1
Modified residuei402PhosphoserineBy similarity1
Modified residuei405PhosphoserineBy similarity1
Modified residuei413PhosphotyrosineBy similarity1
Modified residuei422PhosphothreonineBy similarity1
Modified residuei434PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ3KRC4.
PRIDEiQ3KRC4.

PTM databases

iPTMnetiQ3KRC4.
PhosphoSitePlusiQ3KRC4.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004256.

Structurei

3D structure databases

ProteinModelPortaliQ3KRC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEI6. Eukaryota.
ENOG4110E9P. LUCA.
HOGENOMiHOG000116197.
HOVERGENiHBG051794.
InParanoidiQ3KRC4.
PhylomeDBiQ3KRC4.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3KRC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATHKTLLMC LGLPLFFPGA LAQNHAPPGC SPDLDPLYYN LCDRSGAWGI
60 70 80 90 100
VLEAVAGAGI ITTFVLTIIL VASLPFVQDT KKRSLLGTQV FFLLGTLGLF
110 120 130 140 150
CLVFACVVKP DFSTCASRRF LFGVLFAICF SCLIAHTLSL NFLARKNHGP
160 170 180 190 200
RGWVIFTVAL LLTLVEVIIN TEWLIITLVR GGGQVSTPGN GSADWTVTSP
210 220 230 240 250
CAIANMDFVM ALIYVMLLLL AAFLGAWPTL CGRFKRWRKH GVFVLLTTAT
260 270 280 290 300
SIAIWVVWIV MYTYGNKQHH SPTWDDPTLA IALAANAWTF VFFYVIPEVS
310 320 330 340 350
QVTKPSPEQS YQGDMYPTRG VGYETILKEQ TGQSMFVENK AFSMDEPASA
360 370 380 390 400
KRPVSPYSGY NGQLLTSVYQ PTEMALMHKG PSEGAYDVIL PRATANSQVM
410 420 430 440
GSANSTLRAE DMYMVQSHQV ATPTKDGKIS QDQSPKNKTR W
Length:441
Mass (Da):48,449
Last modified:October 3, 2006 - v2
Checksum:iC5185C88E1E4E687
GO

Sequence cautioni

The sequence AAI05782 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105781 mRNA. Translation: AAI05782.1. Different initiation.
UniGeneiRn.3658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105781 mRNA. Translation: AAI05782.1. Different initiation.
UniGeneiRn.3658.

3D structure databases

ProteinModelPortaliQ3KRC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004256.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ3KRC4.
PhosphoSitePlusiQ3KRC4.

Proteomic databases

PaxDbiQ3KRC4.
PRIDEiQ3KRC4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi1311408. Gprc5c.

Phylogenomic databases

eggNOGiENOG410IEI6. Eukaryota.
ENOG4110E9P. LUCA.
HOGENOMiHOG000116197.
HOVERGENiHBG051794.
InParanoidiQ3KRC4.
PhylomeDBiQ3KRC4.

Miscellaneous databases

PROiQ3KRC4.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPC5C_RAT
AccessioniPrimary (citable) accession number: Q3KRC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 2, 2016
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.