Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G-protein coupled receptor family C group 5 member C

Gene

Gprc5c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor family C group 5 member C
Gene namesi
Name:Gprc5c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1311408 Gprc5c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 49ExtracellularSequence analysisAdd BLAST27
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 84CytoplasmicSequence analysisAdd BLAST14
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 119ExtracellularSequence analysisAdd BLAST14
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 154CytoplasmicSequence analysisAdd BLAST14
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 207ExtracellularSequence analysisAdd BLAST32
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 240CytoplasmicSequence analysisAdd BLAST12
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 278ExtracellularSequence analysisAdd BLAST17
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 441CytoplasmicSequence analysisAdd BLAST142

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000025113623 – 441G-protein coupled receptor family C group 5 member CAdd BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei343PhosphoserineBy similarity1
Modified residuei382PhosphoserineBy similarity1
Modified residuei402PhosphoserineBy similarity1
Modified residuei405PhosphoserineBy similarity1
Modified residuei413PhosphotyrosineBy similarity1
Modified residuei422PhosphothreonineBy similarity1
Modified residuei434PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ3KRC4
PRIDEiQ3KRC4

PTM databases

iPTMnetiQ3KRC4
PhosphoSitePlusiQ3KRC4

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004256

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEI6 Eukaryota
ENOG4110E9P LUCA
HOGENOMiHOG000116197
HOVERGENiHBG051794
InParanoidiQ3KRC4
PhylomeDBiQ3KRC4

Family and domain databases

InterProiView protein in InterPro
IPR017978 GPCR_3_C
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PROSITEiView protein in PROSITE
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3KRC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATHKTLLMC LGLPLFFPGA LAQNHAPPGC SPDLDPLYYN LCDRSGAWGI
60 70 80 90 100
VLEAVAGAGI ITTFVLTIIL VASLPFVQDT KKRSLLGTQV FFLLGTLGLF
110 120 130 140 150
CLVFACVVKP DFSTCASRRF LFGVLFAICF SCLIAHTLSL NFLARKNHGP
160 170 180 190 200
RGWVIFTVAL LLTLVEVIIN TEWLIITLVR GGGQVSTPGN GSADWTVTSP
210 220 230 240 250
CAIANMDFVM ALIYVMLLLL AAFLGAWPTL CGRFKRWRKH GVFVLLTTAT
260 270 280 290 300
SIAIWVVWIV MYTYGNKQHH SPTWDDPTLA IALAANAWTF VFFYVIPEVS
310 320 330 340 350
QVTKPSPEQS YQGDMYPTRG VGYETILKEQ TGQSMFVENK AFSMDEPASA
360 370 380 390 400
KRPVSPYSGY NGQLLTSVYQ PTEMALMHKG PSEGAYDVIL PRATANSQVM
410 420 430 440
GSANSTLRAE DMYMVQSHQV ATPTKDGKIS QDQSPKNKTR W
Length:441
Mass (Da):48,449
Last modified:October 3, 2006 - v2
Checksum:iC5185C88E1E4E687
GO

Sequence cautioni

The sequence AAI05782 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105781 mRNA Translation: AAI05782.1 Different initiation.
UniGeneiRn.3658

Similar proteinsi

Entry informationi

Entry nameiGPC5C_RAT
AccessioniPrimary (citable) accession number: Q3KRC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: May 23, 2018
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health