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Protein

G-protein coupled receptor family C group 5 member C

Gene

Gprc5c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor family C group 5 member C
Gene namesi
Name:Gprc5c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1311408. Gprc5c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 4927ExtracellularSequence analysisAdd
BLAST
Transmembranei50 – 7021HelicalSequence analysisAdd
BLAST
Topological domaini71 – 8414CytoplasmicSequence analysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence analysisAdd
BLAST
Topological domaini106 – 11914ExtracellularSequence analysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence analysisAdd
BLAST
Topological domaini141 – 15414CytoplasmicSequence analysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence analysisAdd
BLAST
Topological domaini176 – 20732ExtracellularSequence analysisAdd
BLAST
Transmembranei208 – 22821HelicalSequence analysisAdd
BLAST
Topological domaini229 – 24012CytoplasmicSequence analysisAdd
BLAST
Transmembranei241 – 26121HelicalSequence analysisAdd
BLAST
Topological domaini262 – 27817ExtracellularSequence analysisAdd
BLAST
Transmembranei279 – 29921HelicalSequence analysisAdd
BLAST
Topological domaini300 – 441142CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 441419G-protein coupled receptor family C group 5 member CPRO_0000251136Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence analysis
Modified residuei343 – 3431PhosphoserineBy similarity
Modified residuei382 – 3821PhosphoserineBy similarity
Modified residuei402 – 4021PhosphoserineBy similarity
Modified residuei405 – 4051PhosphoserineBy similarity
Modified residuei413 – 4131PhosphotyrosineBy similarity
Modified residuei422 – 4221PhosphothreonineBy similarity
Modified residuei434 – 4341PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ3KRC4.

PTM databases

iPTMnetiQ3KRC4.
PhosphoSiteiQ3KRC4.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004256.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEI6. Eukaryota.
ENOG4110E9P. LUCA.
HOGENOMiHOG000116197.
HOVERGENiHBG051794.
InParanoidiQ3KRC4.
PhylomeDBiQ3KRC4.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3KRC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATHKTLLMC LGLPLFFPGA LAQNHAPPGC SPDLDPLYYN LCDRSGAWGI
60 70 80 90 100
VLEAVAGAGI ITTFVLTIIL VASLPFVQDT KKRSLLGTQV FFLLGTLGLF
110 120 130 140 150
CLVFACVVKP DFSTCASRRF LFGVLFAICF SCLIAHTLSL NFLARKNHGP
160 170 180 190 200
RGWVIFTVAL LLTLVEVIIN TEWLIITLVR GGGQVSTPGN GSADWTVTSP
210 220 230 240 250
CAIANMDFVM ALIYVMLLLL AAFLGAWPTL CGRFKRWRKH GVFVLLTTAT
260 270 280 290 300
SIAIWVVWIV MYTYGNKQHH SPTWDDPTLA IALAANAWTF VFFYVIPEVS
310 320 330 340 350
QVTKPSPEQS YQGDMYPTRG VGYETILKEQ TGQSMFVENK AFSMDEPASA
360 370 380 390 400
KRPVSPYSGY NGQLLTSVYQ PTEMALMHKG PSEGAYDVIL PRATANSQVM
410 420 430 440
GSANSTLRAE DMYMVQSHQV ATPTKDGKIS QDQSPKNKTR W
Length:441
Mass (Da):48,449
Last modified:October 3, 2006 - v2
Checksum:iC5185C88E1E4E687
GO

Sequence cautioni

The sequence AAI05782.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105781 mRNA. Translation: AAI05782.1. Different initiation.
UniGeneiRn.3658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105781 mRNA. Translation: AAI05782.1. Different initiation.
UniGeneiRn.3658.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004256.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ3KRC4.
PhosphoSiteiQ3KRC4.

Proteomic databases

PaxDbiQ3KRC4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi1311408. Gprc5c.

Phylogenomic databases

eggNOGiENOG410IEI6. Eukaryota.
ENOG4110E9P. LUCA.
HOGENOMiHOG000116197.
HOVERGENiHBG051794.
InParanoidiQ3KRC4.
PhylomeDBiQ3KRC4.

Miscellaneous databases

PROiQ3KRC4.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-434, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGPC5C_RAT
AccessioniPrimary (citable) accession number: Q3KRC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: July 6, 2016
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.