Reviewed, UniProtKB/Swiss-Prot Q3KRB8 (RHGBB_HUMAN)

Names and origin

Protein names

Recommended name:
    Rho GTPase-activating protein 11B
Alternative name(s):
    Rho-type GTPase-activating protein 11B

Gene names

Name:

ARHGAP11B

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 1 Rho-GAP domain.

Ontologies

Keywords
Molecular function	GTPase activation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Rho GTPase-activating protein 11B		PRO_0000317291
Regions
	Domain	49 – 250	202	Rho-GAP

Sequences

	Sequence		Length	Mass (Da)
	Q3KRB8-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 6817B9B13951F4BA	FASTA	267	30,251
	10 20 30 40 50 60 MWDQRLVKLA LLQHLRAFYG IKVKGVRGQC DRRRHETAAT EIGGKIFGVP FNALPHSAVP 70 80 90 100 110 120 EYGHIPSFLV DACTSLEEHI HTEGLFRKSG SVIRLKALKN KVDHGEGCLS SAPPCDIAGL 130 140 150 160 170 180 LKQFFRELPE PILPADLHEA LLKAQQLGTE EKNKAILLLS CLLADHTVHV LRYFFNFLRN 190 200 210 220 230 240 VSLRSSENKM DSSNLAVIFA PNLLQTSEGH EKMSSNAEKK GVYQTLSWKR YQPCWVLMVS 250 260 VLLHHWKALK KVNMKLLVNI REREDNV

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC105788 mRNA. Translation: AAI05789.1.
IPI	IPI00654746.
RefSeq	NP_001034930.1.
UniGene	Hs.659621
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3KRB8.
Proteomic databases
PeptideAtlas	Q3KRB8.
PRIDE	Q3KRB8.
Genome annotation databases
Ensembl	ENST00000341721; ENSP00000342291; ENSG00000187951; Homo sapiens. [Genome view] ENST00000428041; ENSP00000392760; ENSG00000187951; Homo sapiens. [Genome view]
GeneID	89839.
KEGG	hsa:89839.
UCSC	uc001zet.1. human.
Organism-specific databases
CTD	89839.
GeneCards	GC15P028707.
HGNC	HGNC:15782. ARHGAP11B.
PharmGKB	PA27981.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q3KRB8.
HOVERGEN	Q3KRB8.
OMA	VNIRERE
OrthoDB	EOG980MGF
Enzyme and pathway databases
Reactome	REACT_11044. Signaling by Rho GTPases.
Gene expression databases
Bgee	Q3KRB8.
CleanEx	HS_ARHGAP11B.
Genevestigator	Q3KRB8.
Family and domain databases
InterPro	IPR008936. Rho_GTPase_activation_prot. IPR000198. RhoGAP. [Graphical view]
Gene3D	G3DSA:1.10.555.10. RhoGAP. 1 hit.
Pfam	PF00620. RhoGAP. 1 hit. [Graphical view]
SMART	SM00324. RhoGAP. 1 hit. [Graphical view]
PROSITE	PS50238. RHOGAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	76323.

Entry information

Entry name

RHGBB_HUMAN

Accession

Primary (citable) accession number: Q3KRB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 8, 2005
Last modified:	November 24, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.