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Protein

Rho GTPase-activating protein 11B

Gene

ARHGAP11B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis (PubMed:25721503). Does not posses GTPase activator activity (PubMed:25721503).1 Publication

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 11BCurated
Alternative name(s):
Protein FAM7B1Curated
Rho-type GTPase-activating protein 11BCurated
Gene namesi
Name:ARHGAP11BImported
Synonyms:FAM7B1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:15782. ARHGAP11B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134987257.

Polymorphism and mutation databases

BioMutaiARHGAP11B.
DMDMi121942629.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Rho GTPase-activating protein 11BPRO_0000317291Add
BLAST

Proteomic databases

PaxDbiQ3KRB8.
PeptideAtlasiQ3KRB8.
PRIDEiQ3KRB8.

Expressioni

Developmental stagei

Specifically expressed in radial glia cells of cortical neural stem and progenitor cells (NPCs) during neocortex development. Preferentially expressed in apical and basal radial glia. Not detected in cortical neurons and cortical plate.1 Publication

Gene expression databases

BgeeiQ3KRB8.
CleanExiHS_ARHGAP11B.

Organism-specific databases

HPAiHPA064479.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000392760.

Structurei

3D structure databases

ProteinModelPortaliQ3KRB8.
SMRiQ3KRB8. Positions 3-226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 250202Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2710. Eukaryota.
ENOG410YVI5. LUCA.
GeneTreeiENSGT00760000119123.
HOGENOMiHOG000203174.
HOVERGENiHBG094432.
InParanoidiQ3KRB8.
OMAiHHWKALK.
OrthoDBiEOG7W41CJ.
PhylomeDBiQ3KRB8.
TreeFamiTF342052.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3KRB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWDQRLVKLA LLQHLRAFYG IKVKGVRGQC DRRRHETAAT EIGGKIFGVP
60 70 80 90 100
FNALPHSAVP EYGHIPSFLV DACTSLEEHI HTEGLFRKSG SVIRLKALKN
110 120 130 140 150
KVDHGEGCLS SAPPCDIAGL LKQFFRELPE PILPADLHEA LLKAQQLGTE
160 170 180 190 200
EKNKAILLLS CLLADHTVHV LRYFFNFLRN VSLRSSENKM DSSNLAVIFA
210 220 230 240 250
PNLLQTSEGH EKMSSNAEKK GVYQTLSWKR YQPCWVLMVS VLLHHWKALK
260
KVNMKLLVNI REREDNV
Length:267
Mass (Da):30,251
Last modified:November 8, 2005 - v1
Checksum:i6817B9B13951F4BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC243687 Genomic DNA. No translation available.
BC105788 mRNA. Translation: AAI05789.1.
CCDSiCCDS32185.1.
RefSeqiNP_001034930.1. NM_001039841.1.
UniGeneiHs.659621.
Hs.739267.

Genome annotation databases

EnsembliENST00000428041; ENSP00000392760; ENSG00000187951.
ENST00000563110; ENSP00000457054; ENSG00000187951.
ENST00000622744; ENSP00000481934; ENSG00000187951.
GeneIDi89839.
KEGGihsa:89839.
UCSCiuc001zet.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC243687 Genomic DNA. No translation available.
BC105788 mRNA. Translation: AAI05789.1.
CCDSiCCDS32185.1.
RefSeqiNP_001034930.1. NM_001039841.1.
UniGeneiHs.659621.
Hs.739267.

3D structure databases

ProteinModelPortaliQ3KRB8.
SMRiQ3KRB8. Positions 3-226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000392760.

Polymorphism and mutation databases

BioMutaiARHGAP11B.
DMDMi121942629.

Proteomic databases

PaxDbiQ3KRB8.
PeptideAtlasiQ3KRB8.
PRIDEiQ3KRB8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000428041; ENSP00000392760; ENSG00000187951.
ENST00000563110; ENSP00000457054; ENSG00000187951.
ENST00000622744; ENSP00000481934; ENSG00000187951.
GeneIDi89839.
KEGGihsa:89839.
UCSCiuc001zet.2. human.

Organism-specific databases

CTDi89839.
GeneCardsiARHGAP11B.
HGNCiHGNC:15782. ARHGAP11B.
HPAiHPA064479.
MIMi616310. gene.
neXtProtiNX_Q3KRB8.
PharmGKBiPA134987257.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2710. Eukaryota.
ENOG410YVI5. LUCA.
GeneTreeiENSGT00760000119123.
HOGENOMiHOG000203174.
HOVERGENiHBG094432.
InParanoidiQ3KRB8.
OMAiHHWKALK.
OrthoDBiEOG7W41CJ.
PhylomeDBiQ3KRB8.
TreeFamiTF342052.

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Miscellaneous databases

GenomeRNAii89839.
NextBioi76323.
PROiQ3KRB8.
SOURCEiSearch...

Gene expression databases

BgeeiQ3KRB8.
CleanExiHS_ARHGAP11B.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: FUNCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiRHGBB_HUMAN
AccessioniPrimary (citable) accession number: Q3KRB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 8, 2005
Last modified: March 16, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

When expressed in embryonic mouse neocortex, promotes basal progenitor generation and self-renewal, and can increase cortical plate area and induce gyrification.1 Publication
ARHGAP11B arose from partial duplication of ARHGAP11A on the human lineage after separation from the chimpanzee lineage, but before the divergence from Neandertals.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.