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Q3KRA9

- ALKB6_HUMAN

UniProt

Q3KRA9 - ALKB6_HUMAN

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Protein
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6
Gene
ALKBH6, ABH6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron By similarity.

Cofactori

Binds 1 Fe2+ ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi114 – 1141Iron; catalytic By similarity
Metal bindingi116 – 1161Iron; catalytic By similarity
Metal bindingi182 – 1821Iron; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors Source: InterPro
  3. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 (EC:1.14.11.-)
    Alternative name(s):
    Alkylated DNA repair protein alkB homolog 6
    Gene namesi
    Name:ALKBH6
    Synonyms:ABH6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:28243. ALKBH6.

    Subcellular locationi

    Cytoplasm. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485295.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 238238Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6
    PRO_0000323716Add
    BLAST

    Proteomic databases

    MaxQBiQ3KRA9.
    PaxDbiQ3KRA9.
    PRIDEiQ3KRA9.

    PTM databases

    PhosphoSiteiQ3KRA9.

    Expressioni

    Tissue specificityi

    Widely expressed, with highest expression in testis and pancreas.1 Publication

    Gene expression databases

    ArrayExpressiQ3KRA9.
    BgeeiQ3KRA9.
    CleanExiHS_ALKBH6.
    GenevestigatoriQ3KRA9.

    Interactioni

    Subunit structurei

    Interacts with VCPKMT.1 Publication

    Protein-protein interaction databases

    STRINGi9606.ENSP00000368152.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3KRA9.
    SMRiQ3KRA9. Positions 56-226.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini96 – 227132Fe2OG dioxygenase
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni103 – 1053Alpha-ketoglutarate binding By similarity
    Regioni218 – 2247Alpha-ketoglutarate binding By similarity

    Sequence similaritiesi

    Belongs to the alkB family.

    Phylogenomic databases

    eggNOGiNOG254390.
    HOGENOMiHOG000210721.
    HOVERGENiHBG056765.
    InParanoidiQ3KRA9.
    KOiK10768.
    OMAiGKTANHV.
    PhylomeDBiQ3KRA9.
    TreeFamiTF314467.

    Family and domain databases

    Gene3Di2.60.120.590. 1 hit.
    InterProiIPR027450. AlkB-like.
    IPR005123. Oxoglu/Fe-dep_dioxygenase.
    [Graphical view]
    PfamiPF13532. 2OG-FeII_Oxy_2. 1 hit.
    [Graphical view]
    PROSITEiPS51471. FE2OG_OXY. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3KRA9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEEQDARVPA LEPFRVEQAP PVIYYVPDFI SKEEEEYLLR QVFNAPKPKW    50
    TQLSGRKLQN WGGLPHPRGM VPERLPPWLQ RYVDKVSNLS LFGGLPANHV 100
    LVNQYLPGEG IMPHEDGPLY YPTVSTISLG SHTVLDFYEP RRPEDDDPTE 150
    QPRPPPRPTT SLLLEPRSLL VLRGPAYTRL LHGIAAARVD ALDAASSPPN 200
    AAACPSARPG ACLVRGTRVS LTIRRVPRVL RAGLLLGK 238
    Length:238
    Mass (Da):26,483
    Last modified:March 18, 2008 - v2
    Checksum:i2CA6EEDA8DB61388
    GO
    Isoform 2 (identifier: Q3KRA9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MAGRGMGMLNLEIGGDAGGRIGCKELVLM

    Show »
    Length:266
    Mass (Da):29,285
    Checksum:i65D9DAF9D01E59BC
    GO
    Isoform 3 (identifier: Q3KRA9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MAGRGMGMLNLEIGGDAGGRIGCKELVLM
         64-238: LPHPRGMVPE...VLRAGLLLGK → PSGPHCLPQV...LEASQLTMSS

    Show »
    Length:140
    Mass (Da):15,325
    Checksum:i6468CF74757A398B
    GO

    Sequence cautioni

    The sequence AAI05802.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MAGRGMGMLNLEIGGDAGGR IGCKELVLM in isoform 2 and isoform 3.
    VSP_032056
    Alternative sequencei64 – 238175LPHPR…LLLGK → PSGPHCLPQVGFLIPEGWFL SGCPHGSSATWTKCQTSASL EASQLTMSS in isoform 3.
    VSP_032057Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB273714 mRNA. Translation: BAF63844.1.
    AF038458 Genomic DNA. No translation available.
    AK310704 mRNA. No translation available.
    BC105801 mRNA. Translation: AAI05802.1. Different initiation.
    CCDSiCCDS12485.2. [Q3KRA9-2]
    RefSeqiNP_116267.3. NM_032878.3. [Q3KRA9-2]
    XP_005259414.1. XM_005259357.2. [Q3KRA9-1]
    XP_005259415.1. XM_005259358.2. [Q3KRA9-1]
    UniGeneiHs.71941.

    Genome annotation databases

    EnsembliENST00000252984; ENSP00000252984; ENSG00000239382. [Q3KRA9-1]
    ENST00000378875; ENSP00000368152; ENSG00000239382. [Q3KRA9-2]
    GeneIDi84964.
    KEGGihsa:84964.
    UCSCiuc002ocv.1. human. [Q3KRA9-2]
    uc002ocx.1. human. [Q3KRA9-1]

    Polymorphism databases

    DMDMi172046713.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB273714 mRNA. Translation: BAF63844.1 .
    AF038458 Genomic DNA. No translation available.
    AK310704 mRNA. No translation available.
    BC105801 mRNA. Translation: AAI05802.1 . Different initiation.
    CCDSi CCDS12485.2. [Q3KRA9-2 ]
    RefSeqi NP_116267.3. NM_032878.3. [Q3KRA9-2 ]
    XP_005259414.1. XM_005259357.2. [Q3KRA9-1 ]
    XP_005259415.1. XM_005259358.2. [Q3KRA9-1 ]
    UniGenei Hs.71941.

    3D structure databases

    ProteinModelPortali Q3KRA9.
    SMRi Q3KRA9. Positions 56-226.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000368152.

    PTM databases

    PhosphoSitei Q3KRA9.

    Polymorphism databases

    DMDMi 172046713.

    Proteomic databases

    MaxQBi Q3KRA9.
    PaxDbi Q3KRA9.
    PRIDEi Q3KRA9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252984 ; ENSP00000252984 ; ENSG00000239382 . [Q3KRA9-1 ]
    ENST00000378875 ; ENSP00000368152 ; ENSG00000239382 . [Q3KRA9-2 ]
    GeneIDi 84964.
    KEGGi hsa:84964.
    UCSCi uc002ocv.1. human. [Q3KRA9-2 ]
    uc002ocx.1. human. [Q3KRA9-1 ]

    Organism-specific databases

    CTDi 84964.
    GeneCardsi GC19M036500.
    HGNCi HGNC:28243. ALKBH6.
    MIMi 613304. gene.
    neXtProti NX_Q3KRA9.
    PharmGKBi PA143485295.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG254390.
    HOGENOMi HOG000210721.
    HOVERGENi HBG056765.
    InParanoidi Q3KRA9.
    KOi K10768.
    OMAi GKTANHV.
    PhylomeDBi Q3KRA9.
    TreeFami TF314467.

    Miscellaneous databases

    GenomeRNAii 84964.
    NextBioi 75486.
    PROi Q3KRA9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3KRA9.
    Bgeei Q3KRA9.
    CleanExi HS_ALKBH6.
    Genevestigatori Q3KRA9.

    Family and domain databases

    Gene3Di 2.60.120.590. 1 hit.
    InterProi IPR027450. AlkB-like.
    IPR005123. Oxoglu/Fe-dep_dioxygenase.
    [Graphical view ]
    Pfami PF13532. 2OG-FeII_Oxy_2. 1 hit.
    [Graphical view ]
    PROSITEi PS51471. FE2OG_OXY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Testis.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Testis.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-238 (ISOFORM 2).
      Tissue: Urinary bladder.
    5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Lysine methylation of VCP by a member of a novel human protein methyltransferase family."
      Kernstock S., Davydova E., Jakobsson M., Moen A., Pettersen S., Maelandsmo G.M., Egge-Jacobsen W., Falnes P.O.
      Nat. Commun. 3:1038-1038(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH VCPKMT.

    Entry informationi

    Entry nameiALKB6_HUMAN
    AccessioniPrimary (citable) accession number: Q3KRA9
    Secondary accession number(s): A5LGM8, A6NLP1, A8MU96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: March 18, 2008
    Last modified: July 9, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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