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Q3KRA9

- ALKB6_HUMAN

UniProt

Q3KRA9 - ALKB6_HUMAN

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Protein

Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6

Gene

ALKBH6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron.By similarity

Cofactori

Binds 1 Fe2+ ion per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi114 – 1141Iron; catalyticPROSITE-ProRule annotation
Metal bindingi116 – 1161Iron; catalyticPROSITE-ProRule annotation
Metal bindingi182 – 1821Iron; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 (EC:1.14.11.-)
Alternative name(s):
Alkylated DNA repair protein alkB homolog 6
Gene namesi
Name:ALKBH6
Synonyms:ABH6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:28243. ALKBH6.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485295.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6PRO_0000323716Add
BLAST

Proteomic databases

MaxQBiQ3KRA9.
PaxDbiQ3KRA9.
PRIDEiQ3KRA9.

PTM databases

PhosphoSiteiQ3KRA9.

Expressioni

Tissue specificityi

Widely expressed, with highest expression in testis and pancreas.1 Publication

Gene expression databases

BgeeiQ3KRA9.
CleanExiHS_ALKBH6.
ExpressionAtlasiQ3KRA9. baseline and differential.
GenevestigatoriQ3KRA9.

Interactioni

Subunit structurei

Interacts with VCPKMT.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000368152.

Structurei

3D structure databases

ProteinModelPortaliQ3KRA9.
SMRiQ3KRA9. Positions 56-226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini96 – 227132Fe2OG dioxygenasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni103 – 1053Alpha-ketoglutarate bindingBy similarity
Regioni218 – 2247Alpha-ketoglutarate bindingBy similarity

Sequence similaritiesi

Belongs to the alkB family.Curated
Contains 1 Fe2OG dioxygenase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG254390.
GeneTreeiENSGT00510000048626.
HOGENOMiHOG000210721.
HOVERGENiHBG056765.
InParanoidiQ3KRA9.
KOiK10768.
OMAiGKTANHV.
PhylomeDBiQ3KRA9.
TreeFamiTF314467.

Family and domain databases

Gene3Di2.60.120.590. 1 hit.
InterProiIPR027450. AlkB-like.
IPR005123. Oxoglu/Fe-dep_dioxygenase.
[Graphical view]
PfamiPF13532. 2OG-FeII_Oxy_2. 1 hit.
[Graphical view]
PROSITEiPS51471. FE2OG_OXY. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3KRA9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEQDARVPA LEPFRVEQAP PVIYYVPDFI SKEEEEYLLR QVFNAPKPKW
60 70 80 90 100
TQLSGRKLQN WGGLPHPRGM VPERLPPWLQ RYVDKVSNLS LFGGLPANHV
110 120 130 140 150
LVNQYLPGEG IMPHEDGPLY YPTVSTISLG SHTVLDFYEP RRPEDDDPTE
160 170 180 190 200
QPRPPPRPTT SLLLEPRSLL VLRGPAYTRL LHGIAAARVD ALDAASSPPN
210 220 230
AAACPSARPG ACLVRGTRVS LTIRRVPRVL RAGLLLGK
Length:238
Mass (Da):26,483
Last modified:March 18, 2008 - v2
Checksum:i2CA6EEDA8DB61388
GO
Isoform 2 (identifier: Q3KRA9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGRGMGMLNLEIGGDAGGRIGCKELVLM

Show »
Length:266
Mass (Da):29,285
Checksum:i65D9DAF9D01E59BC
GO
Isoform 3 (identifier: Q3KRA9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGRGMGMLNLEIGGDAGGRIGCKELVLM
     64-238: LPHPRGMVPE...VLRAGLLLGK → PSGPHCLPQV...LEASQLTMSS

Show »
Length:140
Mass (Da):15,325
Checksum:i6468CF74757A398B
GO

Sequence cautioni

The sequence AAI05802.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MAGRGMGMLNLEIGGDAGGR IGCKELVLM in isoform 2 and isoform 3. 2 PublicationsVSP_032056
Alternative sequencei64 – 238175LPHPR…LLLGK → PSGPHCLPQVGFLIPEGWFL SGCPHGSSATWTKCQTSASL EASQLTMSS in isoform 3. 1 PublicationVSP_032057Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB273714 mRNA. Translation: BAF63844.1.
AF038458 Genomic DNA. No translation available.
AK310704 mRNA. No translation available.
BC105801 mRNA. Translation: AAI05802.1. Different initiation.
CCDSiCCDS12485.2. [Q3KRA9-2]
CCDS74342.1. [Q3KRA9-1]
RefSeqiNP_116267.3. NM_032878.3. [Q3KRA9-2]
XP_005259414.1. XM_005259357.2. [Q3KRA9-1]
UniGeneiHs.71941.

Genome annotation databases

EnsembliENST00000252984; ENSP00000252984; ENSG00000239382. [Q3KRA9-1]
ENST00000378875; ENSP00000368152; ENSG00000239382. [Q3KRA9-2]
GeneIDi84964.
KEGGihsa:84964.
UCSCiuc002ocv.1. human. [Q3KRA9-2]
uc002ocx.1. human. [Q3KRA9-1]

Polymorphism databases

DMDMi172046713.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB273714 mRNA. Translation: BAF63844.1 .
AF038458 Genomic DNA. No translation available.
AK310704 mRNA. No translation available.
BC105801 mRNA. Translation: AAI05802.1 . Different initiation.
CCDSi CCDS12485.2. [Q3KRA9-2 ]
CCDS74342.1. [Q3KRA9-1 ]
RefSeqi NP_116267.3. NM_032878.3. [Q3KRA9-2 ]
XP_005259414.1. XM_005259357.2. [Q3KRA9-1 ]
UniGenei Hs.71941.

3D structure databases

ProteinModelPortali Q3KRA9.
SMRi Q3KRA9. Positions 56-226.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000368152.

PTM databases

PhosphoSitei Q3KRA9.

Polymorphism databases

DMDMi 172046713.

Proteomic databases

MaxQBi Q3KRA9.
PaxDbi Q3KRA9.
PRIDEi Q3KRA9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000252984 ; ENSP00000252984 ; ENSG00000239382 . [Q3KRA9-1 ]
ENST00000378875 ; ENSP00000368152 ; ENSG00000239382 . [Q3KRA9-2 ]
GeneIDi 84964.
KEGGi hsa:84964.
UCSCi uc002ocv.1. human. [Q3KRA9-2 ]
uc002ocx.1. human. [Q3KRA9-1 ]

Organism-specific databases

CTDi 84964.
GeneCardsi GC19M036500.
HGNCi HGNC:28243. ALKBH6.
MIMi 613304. gene.
neXtProti NX_Q3KRA9.
PharmGKBi PA143485295.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG254390.
GeneTreei ENSGT00510000048626.
HOGENOMi HOG000210721.
HOVERGENi HBG056765.
InParanoidi Q3KRA9.
KOi K10768.
OMAi GKTANHV.
PhylomeDBi Q3KRA9.
TreeFami TF314467.

Miscellaneous databases

GenomeRNAii 84964.
NextBioi 75486.
PROi Q3KRA9.
SOURCEi Search...

Gene expression databases

Bgeei Q3KRA9.
CleanExi HS_ALKBH6.
ExpressionAtlasi Q3KRA9. baseline and differential.
Genevestigatori Q3KRA9.

Family and domain databases

Gene3Di 2.60.120.590. 1 hit.
InterProi IPR027450. AlkB-like.
IPR005123. Oxoglu/Fe-dep_dioxygenase.
[Graphical view ]
Pfami PF13532. 2OG-FeII_Oxy_2. 1 hit.
[Graphical view ]
PROSITEi PS51471. FE2OG_OXY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-238 (ISOFORM 2).
    Tissue: Urinary bladder.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Lysine methylation of VCP by a member of a novel human protein methyltransferase family."
    Kernstock S., Davydova E., Jakobsson M., Moen A., Pettersen S., Maelandsmo G.M., Egge-Jacobsen W., Falnes P.O.
    Nat. Commun. 3:1038-1038(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH VCPKMT.

Entry informationi

Entry nameiALKB6_HUMAN
AccessioniPrimary (citable) accession number: Q3KRA9
Secondary accession number(s): A5LGM8, A6NLP1, A8MU96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: October 29, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3