Reviewed, UniProtKB/Swiss-Prot Q3KRA9 (ALKB6_HUMAN)

Names and origin

Protein names

Recommended name:
    Alkylated DNA repair protein alkB homolog 6

Gene names

Name:

ALKBH6

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the alkB family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q3KRA9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q3KRA9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGRGMGMLNLEIGGDAGGRIGCKELVLM

Isoform 3 (identifier: Q3KRA9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGRGMGMLNLEIGGDAGGRIGCKELVLM
     64-238: LPHPRGMVPE...VLRAGLLLGK → PSGPHCLPQV...LEASQLTMSS

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 238	238	Alkylated DNA repair protein alkB homolog 6		PRO_0000323716
Amino acid modifications
	Modified residue	222	1	Phosphothreonine Ref.5
Natural variations
	Alternative sequence	1	1	M → MAGRGMGMLNLEIGGDAGGR IGCKELVLM in isoform 2 and isoform 3.		VSP_032056
	Alternative sequence	64 – 238	175	LPHPR…LLLGK → PSGPHCLPQVGFLIPEGWFL SGCPHGSSATWTKCQTSASL EASQLTMSS in isoform 3.		VSP_032057

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 18, 2008. Version 2. Checksum: 2CA6EEDA8DB61388	FASTA	238	26,483
	10 20 30 40 50 60 MEEQDARVPA LEPFRVEQAP PVIYYVPDFI SKEEEEYLLR QVFNAPKPKW TQLSGRKLQN 70 80 90 100 110 120 WGGLPHPRGM VPERLPPWLQ RYVDKVSNLS LFGGLPANHV LVNQYLPGEG IMPHEDGPLY 130 140 150 160 170 180 YPTVSTISLG SHTVLDFYEP RRPEDDDPTE QPRPPPRPTT SLLLEPRSLL VLRGPAYTRL 190 200 210 220 230 LHGIAAARVD ALDAASSPPN AAACPSARPG ACLVRGTRVS LTIRRVPRVL RAGLLLGK
	Isoform 2. Checksum: 65D9DAF9D01E59BC	FASTA	266	29,285
	10 20 30 40 50 60 MAGRGMGMLN LEIGGDAGGR IGCKELVLME EQDARVPALE PFRVEQAPPV IYYVPDFISK 70 80 90 100 110 120 EEEEYLLRQV FNAPKPKWTQ LSGRKLQNWG GLPHPRGMVP ERLPPWLQRY VDKVSNLSLF 130 140 150 160 170 180 GGLPANHVLV NQYLPGEGIM PHEDGPLYYP TVSTISLGSH TVLDFYEPRR PEDDDPTEQP 190 200 210 220 230 240 RPPPRPTTSL LLEPRSLLVL RGPAYTRLLH GIAAARVDAL DAASSPPNAA ACPSARPGAC 250 260 LVRGTRVSLT IRRVPRVLRA GLLLGK
	Isoform 3. Checksum: 6468CF74757A398B	FASTA	140	15,325
	10 20 30 40 50 60 MAGRGMGMLN LEIGGDAGGR IGCKELVLME EQDARVPALE PFRVEQAPPV IYYVPDFISK 70 80 90 100 110 120 EEEEYLLRQV FNAPKPKWTQ LSGRKLQNWG GPSGPHCLPQ VGFLIPEGWF LSGCPHGSSA 130 140 TWTKCQTSAS LEASQLTMSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression and subcellular localization of human ABH family molecules." Tsujikawa K., Koike K., Shinkawa A., Arima H., Suzuki T., Kitae K., Tsuchiya M., Makino Y., Furukawa T., Konishi N., Yamamoto H. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Testis.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-238 (ISOFORM 2). Tissue: Urinary bladder.
[5]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-222, MASS SPECTROMETRY. Tissue: Epithelium.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB273714 mRNA. Translation: BAF63844.1. AF038458 Genomic DNA. No translation available. AK310704 mRNA. No translation available. BC105801 mRNA. Translation: AAI05802.1. Different initiation.
IPI	IPI00394729. IPI00792409. IPI00797675.
RefSeq	NP_116267.3.
UniGene	Hs.71941
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3KRA9.
Genome annotation databases
Ensembl	ENST00000252984; ENSP00000252984; ENSG00000239382; Homo sapiens. [Genome view] ENST00000378875; ENSP00000368152; ENSG00000239382; Homo sapiens. [Genome view]
GeneID	84964.
KEGG	hsa:84964.
UCSC	uc002oct.2. human.
Organism-specific databases
CTD	84964.
GeneCards	GC19M041192.
HGNC	HGNC:28243. ALKBH6.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q3KRA9.
OMA	GTAYTRL
Gene expression databases
ArrayExpress	Q3KRA9.
Bgee	Q3KRA9.
CleanEx	HS_ALKBH6.
Genevestigator	Q3KRA9.
Family and domain databases
InterPro	IPR005123. Oxoglutarate/Fe-dep_oxygenase. [Graphical view]
Pfam	PF03171. 2OG-FeII_Oxy. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	75486.

Entry information

Entry name

ALKB6_HUMAN

Accession

Primary (citable) accession number: Q3KRA9
Secondary accession number(s): A5LGM8, A6NLP1, A8MU96

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 18, 2008
Last modified:	November 24, 2009
This is version 39 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.