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Q3KR97

- BI2L1_RAT

UniProt

Q3KR97 - BI2L1_RAT

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Protein

Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Gene

Baiap2l1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection (By similarity).By similarity

GO - Molecular functioni

  1. proline-rich region binding Source: UniProtKB

GO - Biological processi

  1. filopodium assembly Source: InterPro
  2. positive regulation of actin cytoskeleton reorganization Source: UniProtKB
  3. positive regulation of actin filament polymerization Source: UniProtKB
  4. response to bacterium Source: UniProtKB
  5. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
Short name:
BAI1-associated protein 2-like protein 1
Gene namesi
Name:Baiap2l1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 12

Organism-specific databases

RGDi1308452. Baiap2l1.

Subcellular locationi

Cytoplasmcytoskeleton By similarity
Note: Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.By similarity

GO - Cellular componenti

  1. actin cytoskeleton Source: Ensembl
  2. cytosol Source: UniProtKB
  3. extracellular vesicular exosome Source: Ensembl
  4. nucleus Source: Ensembl
  5. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1PRO_0000247856Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei248 – 2481PhosphothreonineBy similarity
Modified residuei257 – 2571PhosphothreonineBy similarity
Modified residuei261 – 2611PhosphoserineBy similarity
Modified residuei281 – 2811PhosphoserineBy similarity
Modified residuei332 – 3321PhosphoserineBy similarity
Modified residuei413 – 4131PhosphothreonineBy similarity
Modified residuei423 – 4231PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated on tyrosine in response to insulin.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3KR97.
PRIDEiQ3KR97.

PTM databases

PhosphoSiteiQ3KR97.

Expressioni

Gene expression databases

GenevestigatoriQ3KR97.

Interactioni

Subunit structurei

Interacts with RAC1. Binds to F-actin. Interacts with FASLG (By similarity).By similarity

Protein-protein interaction databases

IntActiQ3KR97. 1 interaction.
STRINGi10116.ENSRNOP00000057568.

Structurei

3D structure databases

ProteinModelPortaliQ3KR97.
SMRiQ3KR97. Positions 343-401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 249249IMDPROSITE-ProRule annotationAdd
BLAST
Domaini340 – 40364SH3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni488 – 51629Binds F-actinBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili115 – 14834Sequence AnalysisAdd
BLAST

Domaini

The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation (By similarity).By similarity

Sequence similaritiesi

Contains 1 IMD (IRSp53/MIM homology) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiNOG71665.
GeneTreeiENSGT00390000005995.
HOGENOMiHOG000038005.
HOVERGENiHBG054462.
InParanoidiQ3KR97.
OMAiYRNVMEQ.
OrthoDBiEOG7N0C3W.
PhylomeDBiQ3KR97.
TreeFamiTF325648.

Family and domain databases

InterProiIPR027681. BAIAP2.
IPR013606. IRSp53/MIM_homology_IMD.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR14206. PTHR14206. 1 hit.
PfamiPF08397. IMD. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3KR97-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRGPEEVNR LTENTYRNVV EQFNPGLRNL INLGKNYEKA VNAMILAGKA
60 70 80 90 100
YYDGVAKIGE IATGSPVSTE LGHVLIEISS THKKLNETLD ENFKKFHKEI
110 120 130 140 150
IHELEKKTEL DVKYMNATLK RYQAEHRNKL DSLEKSQAEL KKIRRKSQGG
160 170 180 190 200
RNALKYEHKE IEYVETVTSR QSEIQKFIAD GCKEALLEEK RRFCFLVDKH
210 220 230 240 250
CSFASHIHRY HLQSAELLNS KLPRWQETCC DATKVPEKIM NMIEEIKTPI
260 270 280 290 300
STPVSGTPQP SPMTERSKMI GKDYDTLSKY SPKMPPAPSV KAYTSPLIDM
310 320 330 340 350
FNNPATAGQS AEKTNNSTAN TGDDPSLQRS VSVATGLNMM KKQKVKTIFP
360 370 380 390 400
HTAGNNKTLL SFAQGDVLTL LIPEEKDGWL YGEHDTTKVR GWFPSSYTKL
410 420 430 440 450
LEENMKEAMS VPTPSSAPVR SISTVDLTEK SSVVIPPPDY LECLSMGATS
460 470 480 490 500
DKRADAAKIP STSTFKAPVP RPDATSTSPS DSNGTAKPPF LSGENPFATV
510
KLRPTVTNDR SAPIIR
Length:516
Mass (Da):57,468
Last modified:November 8, 2005 - v1
Checksum:i97ED6E2199E853EB
GO
Isoform 2 (identifier: Q3KR97-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Show »
Length:473
Mass (Da):52,537
Checksum:iD87F9CC806A8BBBB
GO

Sequence cautioni

The sequence AAH89216.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4343Missing in isoform 2. 1 PublicationVSP_020077Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC089216 mRNA. Translation: AAH89216.1. Different initiation.
BC105815 mRNA. Translation: AAI05816.1.
RefSeqiNP_001029312.1. NM_001034140.1. [Q3KR97-1]
UniGeneiRn.21473.

Genome annotation databases

EnsembliENSRNOT00000060843; ENSRNOP00000057568; ENSRNOG00000001007. [Q3KR97-2]
GeneIDi304282.
KEGGirno:304282.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC089216 mRNA. Translation: AAH89216.1 . Different initiation.
BC105815 mRNA. Translation: AAI05816.1 .
RefSeqi NP_001029312.1. NM_001034140.1. [Q3KR97-1 ]
UniGenei Rn.21473.

3D structure databases

ProteinModelPortali Q3KR97.
SMRi Q3KR97. Positions 343-401.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q3KR97. 1 interaction.
STRINGi 10116.ENSRNOP00000057568.

PTM databases

PhosphoSitei Q3KR97.

Proteomic databases

PaxDbi Q3KR97.
PRIDEi Q3KR97.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000060843 ; ENSRNOP00000057568 ; ENSRNOG00000001007 . [Q3KR97-2 ]
GeneIDi 304282.
KEGGi rno:304282.

Organism-specific databases

CTDi 55971.
RGDi 1308452. Baiap2l1.

Phylogenomic databases

eggNOGi NOG71665.
GeneTreei ENSGT00390000005995.
HOGENOMi HOG000038005.
HOVERGENi HBG054462.
InParanoidi Q3KR97.
OMAi YRNVMEQ.
OrthoDBi EOG7N0C3W.
PhylomeDBi Q3KR97.
TreeFami TF325648.

Miscellaneous databases

NextBioi 652774.

Gene expression databases

Genevestigatori Q3KR97.

Family and domain databases

InterProi IPR027681. BAIAP2.
IPR013606. IRSp53/MIM_homology_IMD.
IPR001452. SH3_domain.
[Graphical view ]
PANTHERi PTHR14206. PTHR14206. 1 hit.
Pfami PF08397. IMD. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Ovary and Spleen.

Entry informationi

Entry nameiBI2L1_RAT
AccessioniPrimary (citable) accession number: Q3KR97
Secondary accession number(s): Q5FWT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 8, 2005
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3