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Q3KR97 (BI2L1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Short name=BAI1-associated protein 2-like protein 1
Gene names
Name:Baiap2l1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length516 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection By similarity.

Subunit structure

Interacts with RAC1. Binds to F-actin. Interacts with FASLG By similarity.

Subcellular location

Cytoplasmcytoskeleton By similarity. Note: Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites By similarity.

Domain

The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation By similarity.

Post-translational modification

Phosphorylated on tyrosine in response to insulin By similarity.

Sequence similarities

Contains 1 IMD (IRSp53/MIM homology) domain.

Contains 1 SH3 domain.

Sequence caution

The sequence AAH89216.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q3KR97-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q3KR97-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 516516Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
PRO_0000247856

Regions

Domain1 – 249249IMD
Domain340 – 40364SH3
Region488 – 51629Binds F-actin By similarity
Coiled coil115 – 14834 Potential

Amino acid modifications

Modified residue2481Phosphothreonine By similarity
Modified residue2571Phosphothreonine By similarity
Modified residue2611Phosphoserine By similarity
Modified residue2811Phosphoserine By similarity
Modified residue3321Phosphoserine By similarity
Modified residue4131Phosphothreonine By similarity
Modified residue4231Phosphoserine By similarity

Natural variations

Alternative sequence1 – 4343Missing in isoform 2.
VSP_020077

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 97ED6E2199E853EB

FASTA51657,468
        10         20         30         40         50         60 
MSRGPEEVNR LTENTYRNVV EQFNPGLRNL INLGKNYEKA VNAMILAGKA YYDGVAKIGE 

        70         80         90        100        110        120 
IATGSPVSTE LGHVLIEISS THKKLNETLD ENFKKFHKEI IHELEKKTEL DVKYMNATLK 

       130        140        150        160        170        180 
RYQAEHRNKL DSLEKSQAEL KKIRRKSQGG RNALKYEHKE IEYVETVTSR QSEIQKFIAD 

       190        200        210        220        230        240 
GCKEALLEEK RRFCFLVDKH CSFASHIHRY HLQSAELLNS KLPRWQETCC DATKVPEKIM 

       250        260        270        280        290        300 
NMIEEIKTPI STPVSGTPQP SPMTERSKMI GKDYDTLSKY SPKMPPAPSV KAYTSPLIDM 

       310        320        330        340        350        360 
FNNPATAGQS AEKTNNSTAN TGDDPSLQRS VSVATGLNMM KKQKVKTIFP HTAGNNKTLL 

       370        380        390        400        410        420 
SFAQGDVLTL LIPEEKDGWL YGEHDTTKVR GWFPSSYTKL LEENMKEAMS VPTPSSAPVR 

       430        440        450        460        470        480 
SISTVDLTEK SSVVIPPPDY LECLSMGATS DKRADAAKIP STSTFKAPVP RPDATSTSPS 

       490        500        510 
DSNGTAKPPF LSGENPFATV KLRPTVTNDR SAPIIR 

« Hide

Isoform 2 [UniParc].

Checksum: D87F9CC806A8BBBB
Show »

FASTA47352,537

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Ovary and Spleen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC089216 mRNA. Translation: AAH89216.1. Different initiation.
BC105815 mRNA. Translation: AAI05816.1.
RefSeqNP_001029312.1. NM_001034140.1.
UniGeneRn.21473.

3D structure databases

ProteinModelPortalQ3KR97.
SMRQ3KR97. Positions 343-401.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ3KR97. 1 interaction.
STRING10116.ENSRNOP00000057568.

PTM databases

PhosphoSiteQ3KR97.

Proteomic databases

PaxDbQ3KR97.
PRIDEQ3KR97.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000060843; ENSRNOP00000057568; ENSRNOG00000001007. [Q3KR97-2]
GeneID304282.
KEGGrno:304282.

Organism-specific databases

CTD55971.
RGD1308452. Baiap2l1.

Phylogenomic databases

eggNOGNOG71665.
GeneTreeENSGT00390000005995.
HOGENOMHOG000038005.
HOVERGENHBG054462.
OMAYRNVMEQ.
OrthoDBEOG7N0C3W.
PhylomeDBQ3KR97.
TreeFamTF325648.

Gene expression databases

GenevestigatorQ3KR97.

Family and domain databases

InterProIPR027681. BAIAP2.
IPR013606. IRSp53/MIM_homology_IMD.
IPR001452. SH3_domain.
[Graphical view]
PANTHERPTHR14206. PTHR14206. 1 hit.
PfamPF08397. IMD. 1 hit.
[Graphical view]
SMARTSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
PROSITEPS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio652774.

Entry information

Entry nameBI2L1_RAT
AccessionPrimary (citable) accession number: Q3KR97
Secondary accession number(s): Q5FWT2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 8, 2005
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families