Q3KR97 (BI2L1_RAT) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 65.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 Short name=BAI1-associated protein 2-like protein 1 | ||
| Gene names |
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| Organism | Rattus norvegicus (Rat) [Reference proteome] | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 516 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection By similarity. |
| Subunit structure | Interacts with RAC1. Binds to F-actin. Interacts with FASLG By similarity. |
| Subcellular location | Cytoplasm › cytoskeleton By similarity. Note: Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites By similarity. |
| Domain | The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation By similarity. |
| Post-translational modification | Phosphorylated on tyrosine in response to insulin By similarity. |
| Sequence similarities | Contains 1 IMD (IRSp53/MIM homology) domain. Contains 1 SH3 domain. |
| Sequence caution | The sequence AAH89216.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q3KR97-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q3KR97-2) The sequence of this isoform differs from the canonical sequence as follows: 1-43: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 516 | 516 | Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 | PRO_0000247856 | |||||
Regions | |||||||||
| Domain | 1 – 249 | 249 | IMD | ||||||
| Domain | 340 – 403 | 64 | SH3 | ||||||
| Region | 488 – 516 | 29 | Binds F-actin By similarity | ||||||
| Coiled coil | 115 – 148 | 34 | Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 248 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 257 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 261 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 281 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 330 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 332 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 413 | 1 | Phosphothreonine By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 43 | 43 | Missing in isoform 2. | VSP_020077 | |||||
Sequences
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References
| [1] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Ovary and Spleen. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BC089216 mRNA. Translation: AAH89216.1. Different initiation. BC105815 mRNA. Translation: AAI05816.1. |
| IPI | IPI00655255. IPI00776806. |
| RefSeq | NP_001029312.1. NM_001034140.1. |
| UniGene | Rn.21473. |
3D structure databases | |
| ProteinModelPortal | Q3KR97. |
| SMR | Q3KR97. Positions 343-401. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q3KR97. 1 interaction. |
| STRING | 10116.ENSRNOP00000057568. |
PTM databases | |
| PhosphoSite | Q3KR97. |
Proteomic databases | |
| PaxDb | Q3KR97. |
| PRIDE | Q3KR97. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSRNOT00000060843; ENSRNOP00000057568; ENSRNOG00000001007. |
| GeneID | 304282. |
| KEGG | rno:304282. |
Organism-specific databases | |
| CTD | 55971. |
| RGD | 1308452. Baiap2l1. |
Phylogenomic databases | |
| eggNOG | NOG71665. |
| GeneTree | ENSGT00390000005995. |
| HOGENOM | HOG000038005. |
| HOVERGEN | HBG054462. |
| OrthoDB | EOG4GXFMT. |
Gene expression databases | |
| Genevestigator | Q3KR97. |
| GermOnline | ENSRNOG00000001007. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR013606. IRSp53/MIM_homology_IMD. IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view] |
| Pfam | PF08397. IMD. 1 hit. PF07653. SH3_2. 1 hit. [Graphical view] |
| SMART | SM00326. SH3. 1 hit. [Graphical view] |
| SUPFAM | SSF50044. SH3. 1 hit. |
| PROSITE | PS51338. IMD. 1 hit. PS50002. SH3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 652774. |
Entry information
| Entry name | BI2L1_RAT | ||||||||
| Accession | Primary (citable) accession number: Q3KR97 Secondary accession number(s): Q5FWT2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |