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Q3KR97

- BI2L1_RAT

UniProt

Q3KR97 - BI2L1_RAT

Protein

Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Gene

Baiap2l1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection By similarity.By similarity

    GO - Molecular functioni

    1. proline-rich region binding Source: UniProtKB

    GO - Biological processi

    1. filopodium assembly Source: InterPro
    2. positive regulation of actin cytoskeleton reorganization Source: UniProtKB
    3. positive regulation of actin filament polymerization Source: UniProtKB
    4. response to bacterium Source: UniProtKB
    5. signal transduction Source: InterPro

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
    Short name:
    BAI1-associated protein 2-like protein 1
    Gene namesi
    Name:Baiap2l1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 12

    Organism-specific databases

    RGDi1308452. Baiap2l1.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity
    Note: Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.By similarity

    GO - Cellular componenti

    1. actin cytoskeleton Source: Ensembl
    2. cell junction Source: Ensembl
    3. cytosol Source: UniProtKB
    4. nucleus Source: Ensembl
    5. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 516516Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1PRO_0000247856Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei248 – 2481PhosphothreonineBy similarity
    Modified residuei257 – 2571PhosphothreonineBy similarity
    Modified residuei261 – 2611PhosphoserineBy similarity
    Modified residuei281 – 2811PhosphoserineBy similarity
    Modified residuei332 – 3321PhosphoserineBy similarity
    Modified residuei413 – 4131PhosphothreonineBy similarity
    Modified residuei423 – 4231PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated on tyrosine in response to insulin.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ3KR97.
    PRIDEiQ3KR97.

    PTM databases

    PhosphoSiteiQ3KR97.

    Expressioni

    Gene expression databases

    GenevestigatoriQ3KR97.

    Interactioni

    Subunit structurei

    Interacts with RAC1. Binds to F-actin. Interacts with FASLG By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ3KR97. 1 interaction.
    STRINGi10116.ENSRNOP00000057568.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3KR97.
    SMRiQ3KR97. Positions 343-401.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 249249IMDPROSITE-ProRule annotationAdd
    BLAST
    Domaini340 – 40364SH3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni488 – 51629Binds F-actinBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili115 – 14834Sequence AnalysisAdd
    BLAST

    Domaini

    The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation By similarity.By similarity

    Sequence similaritiesi

    Contains 1 IMD (IRSp53/MIM homology) domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, SH3 domain

    Phylogenomic databases

    eggNOGiNOG71665.
    GeneTreeiENSGT00390000005995.
    HOGENOMiHOG000038005.
    HOVERGENiHBG054462.
    OMAiYRNVMEQ.
    OrthoDBiEOG7N0C3W.
    PhylomeDBiQ3KR97.
    TreeFamiTF325648.

    Family and domain databases

    InterProiIPR027681. BAIAP2.
    IPR013606. IRSp53/MIM_homology_IMD.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR14206. PTHR14206. 1 hit.
    PfamiPF08397. IMD. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS51338. IMD. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3KR97-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRGPEEVNR LTENTYRNVV EQFNPGLRNL INLGKNYEKA VNAMILAGKA    50
    YYDGVAKIGE IATGSPVSTE LGHVLIEISS THKKLNETLD ENFKKFHKEI 100
    IHELEKKTEL DVKYMNATLK RYQAEHRNKL DSLEKSQAEL KKIRRKSQGG 150
    RNALKYEHKE IEYVETVTSR QSEIQKFIAD GCKEALLEEK RRFCFLVDKH 200
    CSFASHIHRY HLQSAELLNS KLPRWQETCC DATKVPEKIM NMIEEIKTPI 250
    STPVSGTPQP SPMTERSKMI GKDYDTLSKY SPKMPPAPSV KAYTSPLIDM 300
    FNNPATAGQS AEKTNNSTAN TGDDPSLQRS VSVATGLNMM KKQKVKTIFP 350
    HTAGNNKTLL SFAQGDVLTL LIPEEKDGWL YGEHDTTKVR GWFPSSYTKL 400
    LEENMKEAMS VPTPSSAPVR SISTVDLTEK SSVVIPPPDY LECLSMGATS 450
    DKRADAAKIP STSTFKAPVP RPDATSTSPS DSNGTAKPPF LSGENPFATV 500
    KLRPTVTNDR SAPIIR 516
    Length:516
    Mass (Da):57,468
    Last modified:November 8, 2005 - v1
    Checksum:i97ED6E2199E853EB
    GO
    Isoform 2 (identifier: Q3KR97-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-43: Missing.

    Show »
    Length:473
    Mass (Da):52,537
    Checksum:iD87F9CC806A8BBBB
    GO

    Sequence cautioni

    The sequence AAH89216.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4343Missing in isoform 2. 1 PublicationVSP_020077Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC089216 mRNA. Translation: AAH89216.1. Different initiation.
    BC105815 mRNA. Translation: AAI05816.1.
    RefSeqiNP_001029312.1. NM_001034140.1. [Q3KR97-1]
    UniGeneiRn.21473.

    Genome annotation databases

    EnsembliENSRNOT00000060843; ENSRNOP00000057568; ENSRNOG00000001007. [Q3KR97-2]
    GeneIDi304282.
    KEGGirno:304282.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC089216 mRNA. Translation: AAH89216.1 . Different initiation.
    BC105815 mRNA. Translation: AAI05816.1 .
    RefSeqi NP_001029312.1. NM_001034140.1. [Q3KR97-1 ]
    UniGenei Rn.21473.

    3D structure databases

    ProteinModelPortali Q3KR97.
    SMRi Q3KR97. Positions 343-401.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q3KR97. 1 interaction.
    STRINGi 10116.ENSRNOP00000057568.

    PTM databases

    PhosphoSitei Q3KR97.

    Proteomic databases

    PaxDbi Q3KR97.
    PRIDEi Q3KR97.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000060843 ; ENSRNOP00000057568 ; ENSRNOG00000001007 . [Q3KR97-2 ]
    GeneIDi 304282.
    KEGGi rno:304282.

    Organism-specific databases

    CTDi 55971.
    RGDi 1308452. Baiap2l1.

    Phylogenomic databases

    eggNOGi NOG71665.
    GeneTreei ENSGT00390000005995.
    HOGENOMi HOG000038005.
    HOVERGENi HBG054462.
    OMAi YRNVMEQ.
    OrthoDBi EOG7N0C3W.
    PhylomeDBi Q3KR97.
    TreeFami TF325648.

    Miscellaneous databases

    NextBioi 652774.

    Gene expression databases

    Genevestigatori Q3KR97.

    Family and domain databases

    InterProi IPR027681. BAIAP2.
    IPR013606. IRSp53/MIM_homology_IMD.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR14206. PTHR14206. 1 hit.
    Pfami PF08397. IMD. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS51338. IMD. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Ovary and Spleen.

    Entry informationi

    Entry nameiBI2L1_RAT
    AccessioniPrimary (citable) accession number: Q3KR97
    Secondary accession number(s): Q5FWT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3