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Protein

Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Gene

Baiap2l1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
Short name:
BAI1-associated protein 2-like protein 1
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1308452. Baiap2l1.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity

  • Note: Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002478561 – 516Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1Add BLAST516

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei248PhosphothreonineBy similarity1
Modified residuei257PhosphothreonineBy similarity1
Modified residuei261PhosphoserineCombined sources1
Modified residuei281PhosphoserineCombined sources1
Modified residuei332PhosphoserineCombined sources1
Modified residuei413PhosphothreonineBy similarity1
Modified residuei415PhosphoserineBy similarity1
Modified residuei421PhosphoserineBy similarity1
Modified residuei423PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine in response to insulin.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3KR97.
PRIDEiQ3KR97.

PTM databases

iPTMnetiQ3KR97.
PhosphoSitePlusiQ3KR97.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001007.
GenevisibleiQ3KR97. RN.

Interactioni

Subunit structurei

Interacts with RAC1. Binds to F-actin. Interacts with FASLG (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ3KR97. 1 interactor.
STRINGi10116.ENSRNOP00000057568.

Structurei

3D structure databases

ProteinModelPortaliQ3KR97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 249IMDPROSITE-ProRule annotationAdd BLAST249
Domaini340 – 403SH3PROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni488 – 516Binds F-actinBy similarityAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili115 – 148Sequence analysisAdd BLAST34

Domaini

The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation (By similarity).By similarity

Sequence similaritiesi

Contains 1 IMD (IRSp53/MIM homology) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiENOG410IGQC. Eukaryota.
ENOG410Y6FF. LUCA.
GeneTreeiENSGT00390000005995.
HOGENOMiHOG000038005.
HOVERGENiHBG054462.
InParanoidiQ3KR97.
KOiK20127.
OMAiYRNVMEQ.
OrthoDBiEOG091G05ZV.
PhylomeDBiQ3KR97.
TreeFamiTF325648.

Family and domain databases

InterProiIPR013606. I-BAR_dom.
IPR027681. IRSp53/IRTKS/Pinkbar.
IPR030060. IRTKS.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR14206. PTHR14206. 1 hit.
PTHR14206:SF4. PTHR14206:SF4. 1 hit.
PfamiPF08397. IMD. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3KR97-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRGPEEVNR LTENTYRNVV EQFNPGLRNL INLGKNYEKA VNAMILAGKA
60 70 80 90 100
YYDGVAKIGE IATGSPVSTE LGHVLIEISS THKKLNETLD ENFKKFHKEI
110 120 130 140 150
IHELEKKTEL DVKYMNATLK RYQAEHRNKL DSLEKSQAEL KKIRRKSQGG
160 170 180 190 200
RNALKYEHKE IEYVETVTSR QSEIQKFIAD GCKEALLEEK RRFCFLVDKH
210 220 230 240 250
CSFASHIHRY HLQSAELLNS KLPRWQETCC DATKVPEKIM NMIEEIKTPI
260 270 280 290 300
STPVSGTPQP SPMTERSKMI GKDYDTLSKY SPKMPPAPSV KAYTSPLIDM
310 320 330 340 350
FNNPATAGQS AEKTNNSTAN TGDDPSLQRS VSVATGLNMM KKQKVKTIFP
360 370 380 390 400
HTAGNNKTLL SFAQGDVLTL LIPEEKDGWL YGEHDTTKVR GWFPSSYTKL
410 420 430 440 450
LEENMKEAMS VPTPSSAPVR SISTVDLTEK SSVVIPPPDY LECLSMGATS
460 470 480 490 500
DKRADAAKIP STSTFKAPVP RPDATSTSPS DSNGTAKPPF LSGENPFATV
510
KLRPTVTNDR SAPIIR
Length:516
Mass (Da):57,468
Last modified:November 8, 2005 - v1
Checksum:i97ED6E2199E853EB
GO
Isoform 2 (identifier: Q3KR97-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Show »
Length:473
Mass (Da):52,537
Checksum:iD87F9CC806A8BBBB
GO

Sequence cautioni

The sequence AAH89216 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0200771 – 43Missing in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089216 mRNA. Translation: AAH89216.1. Different initiation.
BC105815 mRNA. Translation: AAI05816.1.
RefSeqiNP_001029312.1. NM_001034140.1. [Q3KR97-1]
UniGeneiRn.21473.

Genome annotation databases

EnsembliENSRNOT00000060843; ENSRNOP00000057568; ENSRNOG00000001007. [Q3KR97-1]
ENSRNOT00000092610; ENSRNOP00000075796; ENSRNOG00000001007. [Q3KR97-2]
GeneIDi304282.
KEGGirno:304282.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089216 mRNA. Translation: AAH89216.1. Different initiation.
BC105815 mRNA. Translation: AAI05816.1.
RefSeqiNP_001029312.1. NM_001034140.1. [Q3KR97-1]
UniGeneiRn.21473.

3D structure databases

ProteinModelPortaliQ3KR97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3KR97. 1 interactor.
STRINGi10116.ENSRNOP00000057568.

PTM databases

iPTMnetiQ3KR97.
PhosphoSitePlusiQ3KR97.

Proteomic databases

PaxDbiQ3KR97.
PRIDEiQ3KR97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000060843; ENSRNOP00000057568; ENSRNOG00000001007. [Q3KR97-1]
ENSRNOT00000092610; ENSRNOP00000075796; ENSRNOG00000001007. [Q3KR97-2]
GeneIDi304282.
KEGGirno:304282.

Organism-specific databases

CTDi55971.
RGDi1308452. Baiap2l1.

Phylogenomic databases

eggNOGiENOG410IGQC. Eukaryota.
ENOG410Y6FF. LUCA.
GeneTreeiENSGT00390000005995.
HOGENOMiHOG000038005.
HOVERGENiHBG054462.
InParanoidiQ3KR97.
KOiK20127.
OMAiYRNVMEQ.
OrthoDBiEOG091G05ZV.
PhylomeDBiQ3KR97.
TreeFamiTF325648.

Miscellaneous databases

PROiQ3KR97.

Gene expression databases

BgeeiENSRNOG00000001007.
GenevisibleiQ3KR97. RN.

Family and domain databases

InterProiIPR013606. I-BAR_dom.
IPR027681. IRSp53/IRTKS/Pinkbar.
IPR030060. IRTKS.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR14206. PTHR14206. 1 hit.
PTHR14206:SF4. PTHR14206:SF4. 1 hit.
PfamiPF08397. IMD. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBI2L1_RAT
AccessioniPrimary (citable) accession number: Q3KR97
Secondary accession number(s): Q5FWT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 8, 2005
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.