Q3KR92 (TPST1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein-tyrosine sulfotransferase 1
EC=2.8.2.20

Alternative name(s):
Tyrosylprotein sulfotransferase 1
Short name=TPST-1

Gene names

Name:

Tpst1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	370 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides By similarity.
Catalytic activity	3'-phosphoadenylyl sulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate.
Subcellular location	Golgi apparatus membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Belongs to the protein sulfotransferase family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein-tyrosine sulfotransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 370	370	Protein-tyrosine sulfotransferase 1		PRO_0000253722
Regions
	Topological domain	1 – 8	8	Cytoplasmic Potential
	Transmembrane	9 – 25	17	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	26 – 370	345	Lumenal Potential
Amino acid modifications
	Glycosylation	60	1	N-linked (GlcNAc...) Potential
	Glycosylation	262	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3KR92 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: A14A57DD5E62ED2E	FASTA	370	42,135
	10 20 30 40 50 60 MVGKLKQNLL LACLVISSVT VFYLGQHAME CHHRIEERSQ PARLENPKAT VRTGLDIKAN 70 80 90 100 110 120 KTFTYHKNMP LIFIGGVPRS GTTLMRAMLD AHPDIRCGEE TRVIPRILAL KQMWSRSSKE 130 140 150 160 170 180 KIRLDEAGVT DEVLDSAMQA FLLEVIVKHG EPAPYLCNKD PFALKSLTYL ARLFPNAKFL 190 200 210 220 230 240 LMVRDGRASV HSMISRKVTI AGFDLNSYRD CLTKWNRAIE TMYNQCMEVG YKKCMLVHYE 250 260 270 280 290 300 QLVLHPERWM RTLLKFLHIP WNHSVLHHEE MIGKAGGVSL SKVERSTDQV IKPVNVGALS 310 320 330 340 350 360 KWVGKIPPDV LQDMAVIAPM LAKLGYDPYA NPPNYGKPDP KILENTRRVH KGEFQLPDFL 370 KEKPQTEQVE

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC105826 mRNA. Translation: AAI05827.1.
IPI	IPI00559675.
RefSeq	NP_001011903.2. NM_001011903.2.
UniGene	Rn.144004.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3KR92.
Proteomic databases
PRIDE	Q3KR92.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000065868; ENSRNOP00000060104; ENSRNOG00000000900.
GeneID	288617.
KEGG	rno:288617.
UCSC	BC105826. rat.
Organism-specific databases
CTD	8460.
RGD	1308473. Tpst1.
Phylogenomic databases
GeneTree	ENSGT00390000006030.
HOVERGEN	HBG001270.
InParanoid	Q3KR92.
Gene expression databases
ArrayExpress	Q3KR92.
Genevestigator	Q3KR92.
GermOnline	ENSRNOG00000000900. Rattus norvegicus.
Family and domain databases
InterPro	IPR000863. Sulfotransferase_dom. [Graphical view]
KO	K01021.
Pfam	PF00685. Sulfotransfer_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	628431.

Entry information

Entry name

TPST1_RAT

Accession

Primary (citable) accession number: Q3KR92

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	November 8, 2005
Last modified:	November 16, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program