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Protein

Adenosine deaminase domain-containing protein 1

Gene

Adad1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in spermatogenesis. Binds to RNA but not to DNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, RNA-binding
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine deaminase domain-containing protein 1
Alternative name(s):
Testis nuclear RNA-binding protein
Gene namesi
Name:Adad1
Synonyms:Tenr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1359309. Adad1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003095221 – 619Adenosine deaminase domain-containing protein 1Add BLAST619

Proteomic databases

PaxDbiQ3KR54.
PRIDEiQ3KR54.

Expressioni

Gene expression databases

BgeeiENSRNOG00000017246.
ExpressionAtlasiQ3KR54. baseline.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023282.

Structurei

3D structure databases

ProteinModelPortaliQ3KR54.
SMRiQ3KR54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini138 – 206DRBMPROSITE-ProRule annotationAdd BLAST69
Domaini291 – 617A to I editasePROSITE-ProRule annotationAdd BLAST327

Sequence similaritiesi

Belongs to the ADAD family.Curated

Phylogenomic databases

eggNOGiKOG2777. Eukaryota.
ENOG410XT0Z. LUCA.
GeneTreeiENSGT00550000074412.
HOGENOMiHOG000033798.
HOVERGENiHBG058021.
InParanoidiQ3KR54.
OMAiWIVKSPC.
OrthoDBiEOG091G04IU.
PhylomeDBiQ3KR54.
TreeFamiTF315806.

Family and domain databases

InterProiView protein in InterPro
IPR002466. A_deamin.
IPR014720. dsRBD_dom.
PfamiView protein in Pfam
PF02137. A_deamin. 1 hit.
PF00035. dsrm. 1 hit.
SMARTiView protein in SMART
SM00552. ADEAMc. 1 hit.
SM00358. DSRM. 1 hit.
PROSITEiView protein in PROSITE
PS50141. A_DEAMIN_EDITASE. 1 hit.
PS50137. DS_RBD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3KR54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAGGSRRA PVPGPRLGLP LAAHLPASLG GEGAKDSLGG EKTSGNNDWF
60 70 80 90 100
QSSRVPSFAQ MLKKNLPVQS SAQTVTLPTG YSSESCSLSN MASKVTQVTG
110 120 130 140 150
NFPEPLLSKG LSSISNPVLP PKKIPKEFIM KYRRGEINPV SALHQFAQMQ
160 170 180 190 200
RVQLDLKETV TTGNVMGPYF AFCAVVDGIQ YKTGLGQNKK ESRSNAAKLA
210 220 230 240 250
LDELLQLDEP EPRALEPAGP PPIPAEPIVT PEAAYISKVQ YEGRQVQYAK
260 270 280 290 300
ISQLVKETFS QLISSHSQYL KCSSSLAAFI IERGGHHEVV AIGTGEYNYS
310 320 330 340 350
QCIKPNGRVL HDTHAVVTAR RSLLRYFYRQ LLLFYSKNPA MMEKSIFCTE
360 370 380 390 400
PASNLLTLKQ NINLYLYMNQ LPKGSAQIKS QLRLNPHSIS AFEANEELSL
410 420 430 440 450
HVAVEGKIYL TVYCSADGVN RVNSMSSSDK LTRWEVLGVQ GALLSHFIQP
460 470 480 490 500
VYISSILVGD GNCNDTRGLE IAINQRVDDA LTSKLPMFYL VNRPHISLVP
510 520 530 540 550
TAYPLQINLD HKSLSLNWAQ GDNSLEIVDG LSGKITESSP FKSGLSMASR
560 570 580 590 600
LCKAAMLSRF NLLAKEAKTD DLLEARTYHA AKCLSGPYQE AKALLKAYLQ
610
QHGYGSWIVK SPCIEQFSM
Length:619
Mass (Da):67,816
Last modified:November 8, 2005 - v1
Checksum:i0580AB1A80F88707
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105906 mRNA. Translation: AAI05907.1.
RefSeqiNP_001006978.2. NM_001006977.2.
UniGeneiRn.162573.

Genome annotation databases

EnsembliENSRNOT00000023282; ENSRNOP00000023282; ENSRNOG00000017246.
GeneIDi294979.
KEGGirno:294979.
UCSCiRGD:1359309. rat.

Similar proteinsi

Entry informationi

Entry nameiADAD1_RAT
AccessioniPrimary (citable) accession number: Q3KR54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 8, 2005
Last modified: August 30, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families