Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adenosine deaminase domain-containing protein 1

Gene

Adad1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in spermatogenesis. Binds to RNA but not to DNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine deaminase domain-containing protein 1
Alternative name(s):
Testis nuclear RNA-binding protein
Gene namesi
Name:Adad1
Synonyms:Tenr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1359309. Adad1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619Adenosine deaminase domain-containing protein 1PRO_0000309522Add
BLAST

Proteomic databases

PaxDbiQ3KR54.

Expressioni

Gene expression databases

ExpressionAtlasiQ3KR54. baseline.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023282.

Structurei

3D structure databases

ProteinModelPortaliQ3KR54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini138 – 20669DRBMPROSITE-ProRule annotationAdd
BLAST
Domaini291 – 617327A to I editasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ADAD family.Curated
Contains 1 A to I editase domain.PROSITE-ProRule annotation
Contains 1 DRBM (double-stranded RNA-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2777. Eukaryota.
ENOG410XT0Z. LUCA.
GeneTreeiENSGT00550000074412.
HOGENOMiHOG000033798.
HOVERGENiHBG058021.
InParanoidiQ3KR54.
OMAiLHDSHAV.
OrthoDBiEOG7K0ZC7.
PhylomeDBiQ3KR54.
TreeFamiTF315806.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR002466. A_deamin.
IPR014720. dsRBD_dom.
[Graphical view]
PfamiPF02137. A_deamin. 1 hit.
PF00035. dsrm. 1 hit.
[Graphical view]
SMARTiSM00552. ADEAMc. 1 hit.
SM00358. DSRM. 1 hit.
[Graphical view]
PROSITEiPS50141. A_DEAMIN_EDITASE. 1 hit.
PS50137. DS_RBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3KR54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAGGSRRA PVPGPRLGLP LAAHLPASLG GEGAKDSLGG EKTSGNNDWF
60 70 80 90 100
QSSRVPSFAQ MLKKNLPVQS SAQTVTLPTG YSSESCSLSN MASKVTQVTG
110 120 130 140 150
NFPEPLLSKG LSSISNPVLP PKKIPKEFIM KYRRGEINPV SALHQFAQMQ
160 170 180 190 200
RVQLDLKETV TTGNVMGPYF AFCAVVDGIQ YKTGLGQNKK ESRSNAAKLA
210 220 230 240 250
LDELLQLDEP EPRALEPAGP PPIPAEPIVT PEAAYISKVQ YEGRQVQYAK
260 270 280 290 300
ISQLVKETFS QLISSHSQYL KCSSSLAAFI IERGGHHEVV AIGTGEYNYS
310 320 330 340 350
QCIKPNGRVL HDTHAVVTAR RSLLRYFYRQ LLLFYSKNPA MMEKSIFCTE
360 370 380 390 400
PASNLLTLKQ NINLYLYMNQ LPKGSAQIKS QLRLNPHSIS AFEANEELSL
410 420 430 440 450
HVAVEGKIYL TVYCSADGVN RVNSMSSSDK LTRWEVLGVQ GALLSHFIQP
460 470 480 490 500
VYISSILVGD GNCNDTRGLE IAINQRVDDA LTSKLPMFYL VNRPHISLVP
510 520 530 540 550
TAYPLQINLD HKSLSLNWAQ GDNSLEIVDG LSGKITESSP FKSGLSMASR
560 570 580 590 600
LCKAAMLSRF NLLAKEAKTD DLLEARTYHA AKCLSGPYQE AKALLKAYLQ
610
QHGYGSWIVK SPCIEQFSM
Length:619
Mass (Da):67,816
Last modified:November 8, 2005 - v1
Checksum:i0580AB1A80F88707
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105906 mRNA. Translation: AAI05907.1.
RefSeqiNP_001006978.2. NM_001006977.2.
UniGeneiRn.162573.

Genome annotation databases

EnsembliENSRNOT00000023282; ENSRNOP00000023282; ENSRNOG00000017246.
GeneIDi294979.
KEGGirno:294979.
UCSCiRGD:1359309. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105906 mRNA. Translation: AAI05907.1.
RefSeqiNP_001006978.2. NM_001006977.2.
UniGeneiRn.162573.

3D structure databases

ProteinModelPortaliQ3KR54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023282.

Proteomic databases

PaxDbiQ3KR54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023282; ENSRNOP00000023282; ENSRNOG00000017246.
GeneIDi294979.
KEGGirno:294979.
UCSCiRGD:1359309. rat.

Organism-specific databases

CTDi132612.
RGDi1359309. Adad1.

Phylogenomic databases

eggNOGiKOG2777. Eukaryota.
ENOG410XT0Z. LUCA.
GeneTreeiENSGT00550000074412.
HOGENOMiHOG000033798.
HOVERGENiHBG058021.
InParanoidiQ3KR54.
OMAiLHDSHAV.
OrthoDBiEOG7K0ZC7.
PhylomeDBiQ3KR54.
TreeFamiTF315806.

Miscellaneous databases

NextBioi638819.
PROiQ3KR54.

Gene expression databases

ExpressionAtlasiQ3KR54. baseline.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR002466. A_deamin.
IPR014720. dsRBD_dom.
[Graphical view]
PfamiPF02137. A_deamin. 1 hit.
PF00035. dsrm. 1 hit.
[Graphical view]
SMARTiSM00552. ADEAMc. 1 hit.
SM00358. DSRM. 1 hit.
[Graphical view]
PROSITEiPS50141. A_DEAMIN_EDITASE. 1 hit.
PS50137. DS_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiADAD1_RAT
AccessioniPrimary (citable) accession number: Q3KR54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 8, 2005
Last modified: May 11, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.