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Protein

GRAM domain-containing protein 1B

Gene

GRAMD1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Protein family/group databases

TCDBi9.B.198.2.5. the membrane-anchored lipid-binding protein (lam) family.

Names & Taxonomyi

Protein namesi
Recommended name:
GRAM domain-containing protein 1B
Gene namesi
Name:GRAMD1B
Synonyms:KIAA1201
ORF Names:UNQ3032/PRO9834
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000023171.14.
HGNCiHGNC:29214. GRAMD1B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei623 – 643HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57476.
OpenTargetsiENSG00000023171.
PharmGKBiPA142671708.

Polymorphism and mutation databases

DMDMi121942617.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002874491 – 738GRAM domain-containing protein 1BAdd BLAST738

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28PhosphoserineBy similarity1
Modified residuei30PhosphoserineCombined sources1
Modified residuei274PhosphoserineCombined sources1
Modified residuei389PhosphotyrosineCombined sources1
Modified residuei550PhosphoserineCombined sources1
Modified residuei581PhosphoserineCombined sources1
Modified residuei584PhosphothreonineBy similarity1
Modified residuei585PhosphothreonineCombined sources1
Modified residuei587PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3KR37.
PaxDbiQ3KR37.
PeptideAtlasiQ3KR37.
PRIDEiQ3KR37.

PTM databases

iPTMnetiQ3KR37.
PhosphoSitePlusiQ3KR37.

Expressioni

Gene expression databases

BgeeiENSG00000023171.
CleanExiHS_GRAMD1B.
ExpressionAtlasiQ3KR37. baseline and differential.
GenevisibleiQ3KR37. HS.

Organism-specific databases

HPAiHPA008557.

Interactioni

Protein-protein interaction databases

BioGridi121546. 24 interactors.
STRINGi9606.ENSP00000436500.

Structurei

3D structure databases

ProteinModelPortaliQ3KR37.
SMRiQ3KR37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 163GRAMAdd BLAST68
Domaini372 – 543VAStPROSITE-ProRule annotationAdd BLAST172

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1032. Eukaryota.
ENOG410XRQQ. LUCA.
GeneTreeiENSGT00580000081380.
HOGENOMiHOG000294164.
HOVERGENiHBG062004.
InParanoidiQ3KR37.
OrthoDBiEOG091G051I.
PhylomeDBiQ3KR37.
TreeFamiTF327695.

Family and domain databases

InterProiView protein in InterPro
IPR004182. GRAM.
IPR031968. VASt.
PfamiView protein in Pfam
PF16016. DUF4782. 1 hit.
PF02893. GRAM. 1 hit.
SMARTiView protein in SMART
SM00568. GRAM. 1 hit.
PROSITEiView protein in PROSITE
PS51778. VAST. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3KR37-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKGFKLSCTA SNSNRSTPAC SPILRKRSRS PTPQNQDGDT MVEKGSDHSS
60 70 80 90 100
DKSPSTPEQG VQRSCSSQSG RSGGKNSKKS QSWYNVLSPT YKQRNEDFRK
110 120 130 140 150
LFKQLPDTER LIVDYSCALQ RDILLQGRLY LSENWICFYS NIFRWETLLT
160 170 180 190 200
VRLKDICSMT KEKTARLIPN AIQVCTDSEK HFFTSFGARD RTYMMMFRLW
210 220 230 240 250
QNALLEKPLC PKELWHFVHQ CYGNELGLTS DDEDYVPPDD DFNTMGYCEE
260 270 280 290 300
IPVEENEVND SSSKSSIETK PDASPQLPKK SITNSTLTST GSSEAPVSFD
310 320 330 340 350
GLPLEEEALE GDGSLEKELA IDNIMGEKIE MIAPVNSPSL DFNDNEDIPT
360 370 380 390 400
ELSDSSDTHD EGEVQAFYED LSGRQYVNEV FNFSVDKLYD LLFTNSPFQR
410 420 430 440 450
DFMEQRRFSD IIFHPWKKEE NGNQSRVILY TITLTNPLAP KTATVRETQT
460 470 480 490 500
MYKASQESEC YVIDAEVLTH DVPYHDYFYT INRYTLTRVA RNKSRLRVST
510 520 530 540 550
ELRYRKQPWG LVKTFIEKNF WSGLEDYFRH LESELAKTES TYLAEMHRQS
560 570 580 590 600
PKEKASKTTT VRRRKRPHAH LRVPHLEEVM SPVTTPTDED VGHRIKHVAG
610 620 630 640 650
STQTRHIPED TPNGFHLQSV SKLLLVISCV ICFSLVLLVI LNMMLFYKLW
660 670 680 690 700
MLEYTTQTLT AWQGLRLQER LPQSQTEWAQ LLESQQKYHD TELQKWREII
710 720 730
KSSVMLLDQM KDSLINLQNG IRSRDYTSES EEKRNRYH
Length:738
Mass (Da):85,400
Last modified:November 8, 2005 - v1
Checksum:i96784D4504307393
GO
Isoform 2 (identifier: Q3KR37-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: Missing.

Note: No experimental confirmation available.
Show »
Length:698
Mass (Da):81,079
Checksum:i29D47C008D52509A
GO
Isoform 3 (identifier: Q3KR37-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-309: Missing.
     310-361: EGDGSLEKEL...LSDSSDTHDE → MPTSSAVLLR...CLLPDPLFCA
     631-634: Missing.

Note: No experimental confirmation available.
Show »
Length:425
Mass (Da):49,786
Checksum:iBDE9CC95661A6D4B
GO
Isoform 4 (identifier: Q3KR37-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-78: K → KSHKRLSK

Show »
Length:745
Mass (Da):86,237
Checksum:i8A3676F1CC5F873D
GO

Sequence cautioni

The sequence BAA86515 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti336N → H in BAG54507 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0254691 – 309Missing in isoform 3. 1 PublicationAdd BLAST309
Alternative sequenceiVSP_0254701 – 40Missing in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_05757378K → KSHKRLSK in isoform 4. 1
Alternative sequenceiVSP_025471310 – 361EGDGS…DTHDE → MPTSSAVLLRVLSIPLLTVL ILARDLSALGGCPWGPLPLR CHCLLPDPLFCA in isoform 3. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_025472631 – 634Missing in isoform 3. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033027 mRNA. Translation: BAA86515.1. Different initiation.
AY358924 mRNA. Translation: AAQ89283.1.
AK127457 mRNA. Translation: BAG54507.1.
AP000841 Genomic DNA. No translation available.
AP002765 Genomic DNA. No translation available.
BC105741 mRNA. Translation: AAI05742.1.
BC105932 mRNA. Translation: AAI05933.1.
BC105931 mRNA. Translation: AAI05932.1.
BC107480 mRNA. Translation: AAI07481.1.
CCDSiCCDS53720.1. [Q3KR37-1]
CCDS66253.1. [Q3KR37-4]
CCDS66254.1. [Q3KR37-2]
RefSeqiNP_001273492.1. NM_001286563.1. [Q3KR37-4]
NP_001273493.1. NM_001286564.1. [Q3KR37-2]
NP_065767.1. NM_020716.2. [Q3KR37-1]
XP_016873536.1. XM_017018047.1. [Q3KR37-2]
XP_016873537.1. XM_017018048.1. [Q3KR37-2]
UniGeneiHs.144725.
Hs.732509.
Hs.738493.

Genome annotation databases

EnsembliENST00000450171; ENSP00000388458; ENSG00000023171. [Q3KR37-3]
ENST00000456860; ENSP00000402457; ENSG00000023171. [Q3KR37-4]
ENST00000529432; ENSP00000432987; ENSG00000023171. [Q3KR37-2]
ENST00000529750; ENSP00000436500; ENSG00000023171. [Q3KR37-1]
GeneIDi57476.
KEGGihsa:57476.
UCSCiuc001pyw.4. human.
uc001pyx.4. human. [Q3KR37-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGRM1B_HUMAN
AccessioniPrimary (citable) accession number: Q3KR37
Secondary accession number(s): B3KXJ5
, E7EPH8, Q6UW85, Q9ULL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: November 8, 2005
Last modified: September 27, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM