Q3KR16 (PKHG6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pleckstrin homology domain-containing family G member 6
Short name=PH domain-containing family G member 6

Alternative name(s):
Myosin-interacting guanine nucleotide exchange factor
Short name=MyoGEF

Gene names

Name:

PLEKHG6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	790 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. Ref.6 Ref.7
Subunit structure	Interacts with MYH10. Interacts with ELMO1 and EZR (in an open conformation). Interacts with CSPP1. Ref.6 Ref.7 Ref.8
Subcellular location	Cytoplasm. Cytoplasm › cytoskeleton › spindle. Cytoplasm › cytoskeleton › spindle pole. Cleavage furrow. Note: During mitosis, localizes to the spindle pole, central spindle and cleavage furrow. In epithelial cells, recruited to the apical membrane by EZR. Ref.6 Ref.7
Tissue specificity	Highest expression in the placenta. Low levels in small intestine, lung, liver, kidney, thymus and heart.
Sequence similarities	Contains 1 DH (DBL-homology) domain. Contains 1 PH domain.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	GTPase activation
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of GTPase activity Inferred from electronic annotation. Source: GOC regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	cleavage furrow Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell spindle pole Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q3KR16-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q3KR16-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: MKAFGPPHEGPLQGLVASRIETYGGRHRASAQSTAGRLYPRGYPVL → MGCRLHAPGEKAAH

Note: No experimental confirmation available.

Isoform 3 (identifier: Q3KR16-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-470: Missing.
     471-508: SFLLIHLTEF...QWLEKTQQAQ → MCPREGGRAS...GEPKIQHPLK

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 790	790	Pleckstrin homology domain-containing family G member 6		PRO_0000307912
Regions
	Domain	161 – 353	193	DH
	Domain	409 – 509	101	PH
	Compositional bias	364 – 367	4	Poly-Ala
	Compositional bias	714 – 718	5	Poly-Glu
Amino acid modifications
	Modified residue	33	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 470	470	Missing in isoform 3.		VSP_028856
	Alternative sequence	1 – 46	46	MKAFG…GYPVL → MGCRLHAPGEKAAH in isoform 2.		VSP_028857
	Alternative sequence	471 – 508	38	SFLLI…TQQAQ → MCPREGGRASTIHQKTEKAF GQLLCQPLGEPKIQHPLK in isoform 3.		VSP_028858
	Natural variant	35	1	A → T. Ref.1 Ref.5 Corresponds to variant rs740842 [ dbSNP | Ensembl ].		VAR_036710
Experimental info
	Mutagenesis	351	1	N → A: Loss of exchange activity. Ref.7
	Sequence conflict	384	1	E → G in AAI04752. Ref.5
	Sequence conflict	459	1	E → D in BAA91741. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 3, 2011. Version 3. Checksum: 34A2555DEF431EF4	FASTA	790	88,960
	10 20 30 40 50 60 MKAFGPPHEG PLQGLVASRI ETYGGRHRAS AQSTAGRLYP RGYPVLDPSR RRLQQYVPFA 70 80 90 100 110 120 RGSGQARGLS PMRLRDPEPE KRHGGHVGAG LLHSPKLKEL TKAHELEVRL HTFSMFGMPR 130 140 150 160 170 180 LPPEDRRHWE IGEGGDSGLT IEKSWRELVP GHKEMSQELC HQQEALWELL TTELIYVRKL 190 200 210 220 230 240 KIMTDLLAAG LLNLQRVGLL MEVSAETLFG NVPSLIRTHR SFWDEVLGPT LEETRASGQP 250 260 270 280 290 300 LDPIGLQSGF LTFGQRFHPY VQYCLRVKQT MAYAREQQET NPLFHAFVQW CEKHKRSGRQ 310 320 330 340 350 360 MLCDLLIKPH QRITKYPLLL HAVLKRSPEA RAQEALNAMI EAVESFLRHI NGQVRQGEEQ 370 380 390 400 410 420 ESLAAAAQRI GPYEVLEPPS DEVEKNLRPF STLDLTSPML GVASEHTRQL LLEGPVRVKE 430 440 450 460 470 480 GREGKLDVYL FLFSDVLLVT KPQRKADKAK VIRPPLMLEK LVCQPLRDPN SFLLIHLTEF 490 500 510 520 530 540 QCVSSALLVH CPSPTDRAQW LEKTQQAQAA LQKLKAEEYV QQKRELLTLY RDQDRESPST 550 560 570 580 590 600 RPSTPSLEGS QSSAEGRTPE FSTIIPHLVV TEDTDEDAPL VPDDTSDSGY GTLIPGTPTG 610 620 630 640 650 660 SRSPLSRLRQ RALRRDPRLT FSTLELRDIP LRPHPPDPQA PQRRSAPELP EGILKGGSLP 670 680 690 700 710 720 QEDPPTWSEE EDGASERGNV VVETLHRARL RGQLPSSPTH ADSAGESPWE SSGEEEEEGP 730 740 750 760 770 780 LFLKAGHTSL RPMRAEDMLR EIREELASQR IEGAEEPRDS RPRKLTRAQL QRMRGPHIIQ 790 LDTPLSASEV
	Isoform 2 [UniParc]. Checksum: 403CED373E96DA23	FASTA	758	85,486
	10 20 30 40 50 60 MGCRLHAPGE KAAHDPSRRR LQQYVPFARG SGQARGLSPM RLRDPEPEKR HGGHVGAGLL 70 80 90 100 110 120 HSPKLKELTK AHELEVRLHT FSMFGMPRLP PEDRRHWEIG EGGDSGLTIE KSWRELVPGH 130 140 150 160 170 180 KEMSQELCHQ QEALWELLTT ELIYVRKLKI MTDLLAAGLL NLQRVGLLME VSAETLFGNV 190 200 210 220 230 240 PSLIRTHRSF WDEVLGPTLE ETRASGQPLD PIGLQSGFLT FGQRFHPYVQ YCLRVKQTMA 250 260 270 280 290 300 YAREQQETNP LFHAFVQWCE KHKRSGRQML CDLLIKPHQR ITKYPLLLHA VLKRSPEARA 310 320 330 340 350 360 QEALNAMIEA VESFLRHING QVRQGEEQES LAAAAQRIGP YEVLEPPSDE VEKNLRPFST 370 380 390 400 410 420 LDLTSPMLGV ASEHTRQLLL EGPVRVKEGR EGKLDVYLFL FSDVLLVTKP QRKADKAKVI 430 440 450 460 470 480 RPPLMLEKLV CQPLRDPNSF LLIHLTEFQC VSSALLVHCP SPTDRAQWLE KTQQAQAALQ 490 500 510 520 530 540 KLKAEEYVQQ KRELLTLYRD QDRESPSTRP STPSLEGSQS SAEGRTPEFS TIIPHLVVTE 550 560 570 580 590 600 DTDEDAPLVP DDTSDSGYGT LIPGTPTGSR SPLSRLRQRA LRRDPRLTFS TLELRDIPLR 610 620 630 640 650 660 PHPPDPQAPQ RRSAPELPEG ILKGGSLPQE DPPTWSEEED GASERGNVVV ETLHRARLRG 670 680 690 700 710 720 QLPSSPTHAD SAGESPWESS GEEEEEGPLF LKAGHTSLRP MRAEDMLREI REELASQRIE 730 740 750 GAEEPRDSRP RKLTRAQLQR MRGPHIIQLD TPLSASEV
	Isoform 3 [UniParc]. Checksum: 4A0D7A82830B807F	FASTA	320	35,568
	10 20 30 40 50 60 MCPREGGRAS TIHQKTEKAF GQLLCQPLGE PKIQHPLKAA LQKLKAEEYV QQKRELLTLY 70 80 90 100 110 120 RDQDRESPST RPSTPSLEGS QSSAEGRTPE FSTIIPHLVV TEDTDEDAPL VPDDTSDSGY 130 140 150 160 170 180 GTLIPGTPTG SRSPLSRLRQ RALRRDPRLT FSTLELRDIP LRPHPPDPQA PQRRSAPELP 190 200 210 220 230 240 EGILKGGSLP QEDPPTWSEE EDGASERGNV VVETLHRARL RGQLPSSPTH ADSAGESPWE 250 260 270 280 290 300 SSGEEEEEGP LFLKAGHTSL RPMRAEDMLR EIREELASQR IEGAEEPRDS RPRKLTRAQL 310 320 QRMRGPHIIQ LDTPLSASEV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-35. Tissue: Tongue.
[2]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[3]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-35.
[6]	"A novel guanine nucleotide exchange factor MyoGEF is required for cytokinesis." Wu D., Asiedu M., Adelstein R.S., Wei Q. Cell Cycle 5:1234-1239(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH MYH10, SUBCELLULAR LOCATION.
[7]	"Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells." D'Angelo R., Aresta S., Blangy A., Del Maestro L., Louvard D., Arpin M. Mol. Biol. Cell 18:4780-4793(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH ELMO1 AND EZR, SUBCELLULAR LOCATION, MUTAGENESIS OF ASN-351.
[8]	"Centrosome/spindle pole-associated protein regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle." Asiedu M., Wu D., Matsumura F., Wei Q. Mol. Biol. Cell 20:1428-1440(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CSPP1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK001527 mRNA. Translation: BAA91741.1. AK095373 mRNA. Translation: BAC04539.1. AF289613 mRNA. Translation: AAL55797.1. BC104751 mRNA. Translation: AAI04752.1. BC105961 mRNA. Translation: AAI05962.1. BC109095 mRNA. Translation: AAI09096.1. AC006057 Genomic DNA. No translation available. CH471116 Genomic DNA. Translation: EAW88809.1.
IPI	IPI00018837. IPI00103883. IPI00793050.
RefSeq	NP_001138328.1. NM_001144856.1. NP_001138329.1. NM_001144857.1. NP_060643.2. NM_018173.3.
UniGene	Hs.631660.
3D structure databases
ProteinModelPortal	Q3KR16.
SMR	Q3KR16. Positions 145-507.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000011684.
PTM databases
PhosphoSite	Q3KR16.
Polymorphism databases
DMDM	221222471.
Proteomic databases
PaxDb	Q3KR16.
PRIDE	Q3KR16.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000011684; ENSP00000011684; ENSG00000008323. ENST00000304581; ENSP00000304640; ENSG00000008323. ENST00000396988; ENSP00000380185; ENSG00000008323. ENST00000449001; ENSP00000393194; ENSG00000008323.
GeneID	55200.
KEGG	hsa:55200.
UCSC	uc001qnr.3. human. uc010sex.2. human.
Organism-specific databases
CTD	55200.
GeneCards	GC12P006419.
HGNC	HGNC:25562. PLEKHG6.
HPA	HPA041459.
MIM	611743. gene.
neXtProt	NX_Q3KR16.
PharmGKB	PA142671165.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5422.
HOGENOM	HOG000169625.
HOVERGEN	HBG108257.
InParanoid	Q3KR16.
OMA	AQRIGPY.
OrthoDB	EOG4RFKS4.
PhylomeDB	Q3KR16.
Gene expression databases
ArrayExpress	Q3KR16.
Bgee	Q3KR16.
CleanEx	HS_PLEKHG6.
Genevestigator	Q3KR16.
Family and domain databases
Gene3D	1.20.900.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR000219. DH-domain. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR015721. RhoGEF-like. [Graphical view]
PANTHER	PTHR22825. PTHR22825. 1 hit.
Pfam	PF00621. RhoGEF. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. [Graphical view]
SUPFAM	SSF48065. DH-domain. 1 hit.
PROSITE	PS00741. DH_1. False negative. PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PLEKHG6. human.
GenomeRNAi	55200.
NextBio	59086.
SOURCE	Search...

Entry information

Entry name

PKHG6_HUMAN

Accession

Primary (citable) accession number: Q3KR16
Secondary accession number(s): Q3SWR1 , Q8N1P1, Q8WYY1, Q9H8F4, Q9NVK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	May 3, 2011
Last modified:	May 1, 2013
This is version 76 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.