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Protein

Zinc finger protein 792

Gene

ZNF792

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri132 – 15423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri254 – 27623C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri534 – 55623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri562 – 58423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 792
Gene namesi
Name:ZNF792
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:24751. ZNF792.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410535.

Polymorphism and mutation databases

BioMutaiZNF792.
DMDMi215273919.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 632632Zinc finger protein 792PRO_0000293698Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei196 – 1961PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3KQV3.
PaxDbiQ3KQV3.
PeptideAtlasiQ3KQV3.
PRIDEiQ3KQV3.

PTM databases

iPTMnetiQ3KQV3.
PhosphoSiteiQ3KQV3.

Expressioni

Gene expression databases

BgeeiQ3KQV3.
CleanExiHS_ZNF792.
ExpressionAtlasiQ3KQV3. baseline and differential.
GenevisibleiQ3KQV3. HS.

Organism-specific databases

HPAiHPA035158.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HNRNPKP619783EBI-10240849,EBI-304185
KRT40Q6A1623EBI-10240849,EBI-10171697
KRTAP10-5P603703EBI-10240849,EBI-10172150
KRTAP10-7P604093EBI-10240849,EBI-10172290
KRTAP10-9P604113EBI-10240849,EBI-10172052
MID2Q9UJV3-23EBI-10240849,EBI-10172526
SSX2IPQ9Y2D83EBI-10240849,EBI-2212028
ZNF408Q9H9D43EBI-10240849,EBI-347633
ZNF473Q8WTR73EBI-10240849,EBI-751409

Protein-protein interaction databases

BioGridi125986. 13 interactions.
IntActiQ3KQV3. 9 interactions.
STRINGi9606.ENSP00000385099.

Structurei

3D structure databases

ProteinModelPortaliQ3KQV3.
SMRiQ3KQV3. Positions 129-590.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8572KRABPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 54Poly-Ala

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri132 – 15423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri254 – 27623C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri534 – 55623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri562 – 58423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ3KQV3.
KOiK09228.
OMAiPDSVDMT.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ3KQV3.
TreeFamiTF342033.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3KQV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAALRDPA QGCVTFEDVT IYFSQEEWVL LDEAQRLLYC DVMLENFALI
60 70 80 90 100
ASLGLISFRS HIVSQLEMGK EPWVPDSVDM TSAMARGAYG RPGSDFCHGT
110 120 130 140 150
EGKDLPSEHN VSVEGVAQDR SPEATLCPQK TCPCDICGLR LKDILHLAEH
160 170 180 190 200
QTTHPRQKPF VCEAYVKGSE FSANLPRKQV QQNVHNPIRT EEGQASPVKT
210 220 230 240 250
CRDHTSDQLS TCREGGKDFV ATAGFLQCEV TPSDGEPHEA TEGVVDFHIA
260 270 280 290 300
LRHNKCCESG DAFNNKSTLV QHQRIHSRER PYECSKCGIF FTYAADLTQH
310 320 330 340 350
QKVHNRGKPY ECCECGKFFS QHSSLVKHRR VHTGESPHVC GDCGKFFSRS
360 370 380 390 400
SNLIQHKRVH TGEKPYECSD CGKFFSQRSN LIHHKRVHTG RSAHECSECG
410 420 430 440 450
KSFNCNSSLI KHWRVHTGER PYKCNECGKF FSHIASLIQH QIVHTGERPH
460 470 480 490 500
GCGECGKAFS RSSDLMKHQR VHTGERPYEC NECGKLFSQS SSLNSHRRLH
510 520 530 540 550
TGERPYQCSE CGKFFNQSSS LNNHRRLHTG ERPYECSECG KTFRQRSNLR
560 570 580 590 600
QHLKVHKPDR PYECSECGKA FNQRPTLIRH QKIHIRERSM ENVLLPCSQH
610 620 630
TPEISSENRP YQGAVNYKLK LVHPSTHPGE VP
Length:632
Mass (Da):71,577
Last modified:November 25, 2008 - v2
Checksum:i332B2A8E3E0ED873
GO

Sequence cautioni

The sequence AAI01119.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI01120.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI01121.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti590 – 5901M → T in BAG65345 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti177 – 1771R → Q.1 Publication
Corresponds to variant rs2651079 [ dbSNP | Ensembl ].
VAR_033106
Natural varianti525 – 5251R → W.
Corresponds to variant rs3746244 [ dbSNP | Ensembl ].
VAR_047354

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304550 mRNA. Translation: BAG65345.1.
AC008555 Genomic DNA. No translation available.
BC101118 mRNA. Translation: AAI01119.1. Different initiation.
BC101119 mRNA. Translation: AAI01120.1. Different initiation.
BC101120 mRNA. Translation: AAI01121.1. Different initiation.
CCDSiCCDS12440.2.
RefSeqiNP_787068.3. NM_175872.4.
UniGeneiHs.50405.

Genome annotation databases

EnsembliENST00000404801; ENSP00000385099; ENSG00000180884.
GeneIDi126375.
KEGGihsa:126375.
UCSCiuc002nxh.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304550 mRNA. Translation: BAG65345.1.
AC008555 Genomic DNA. No translation available.
BC101118 mRNA. Translation: AAI01119.1. Different initiation.
BC101119 mRNA. Translation: AAI01120.1. Different initiation.
BC101120 mRNA. Translation: AAI01121.1. Different initiation.
CCDSiCCDS12440.2.
RefSeqiNP_787068.3. NM_175872.4.
UniGeneiHs.50405.

3D structure databases

ProteinModelPortaliQ3KQV3.
SMRiQ3KQV3. Positions 129-590.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125986. 13 interactions.
IntActiQ3KQV3. 9 interactions.
STRINGi9606.ENSP00000385099.

PTM databases

iPTMnetiQ3KQV3.
PhosphoSiteiQ3KQV3.

Polymorphism and mutation databases

BioMutaiZNF792.
DMDMi215273919.

Proteomic databases

EPDiQ3KQV3.
PaxDbiQ3KQV3.
PeptideAtlasiQ3KQV3.
PRIDEiQ3KQV3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000404801; ENSP00000385099; ENSG00000180884.
GeneIDi126375.
KEGGihsa:126375.
UCSCiuc002nxh.1. human.

Organism-specific databases

CTDi126375.
GeneCardsiZNF792.
HGNCiHGNC:24751. ZNF792.
HPAiHPA035158.
neXtProtiNX_Q3KQV3.
PharmGKBiPA162410535.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ3KQV3.
KOiK09228.
OMAiPDSVDMT.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ3KQV3.
TreeFamiTF342033.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii126375.
PROiQ3KQV3.

Gene expression databases

BgeeiQ3KQV3.
CleanExiHS_ZNF792.
ExpressionAtlasiQ3KQV3. baseline and differential.
GenevisibleiQ3KQV3. HS.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 74-632, VARIANT GLN-177.
  4. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.

Entry informationi

Entry nameiZN792_HUMAN
AccessioniPrimary (citable) accession number: Q3KQV3
Secondary accession number(s): B4E333
, Q495L1, Q495L3, Q8N932
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 25, 2008
Last modified: July 6, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.