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Protein

Zinc finger protein 792

Gene

ZNF792

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri132 – 154C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 792
Gene namesi
Name:ZNF792
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000180884.9
HGNCiHGNC:24751 ZNF792
neXtProtiNX_Q3KQV3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi126375
OpenTargetsiENSG00000180884
PharmGKBiPA162410535

Polymorphism and mutation databases

BioMutaiZNF792
DMDMi215273919

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002936981 – 632Zinc finger protein 792Add BLAST632

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei196PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3KQV3
MaxQBiQ3KQV3
PaxDbiQ3KQV3
PeptideAtlasiQ3KQV3
PRIDEiQ3KQV3

PTM databases

iPTMnetiQ3KQV3
PhosphoSitePlusiQ3KQV3

Expressioni

Gene expression databases

BgeeiENSG00000180884
CleanExiHS_ZNF792
ExpressionAtlasiQ3KQV3 baseline and differential
GenevisibleiQ3KQV3 HS

Organism-specific databases

HPAiHPA035157
HPA035158

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi125986, 13 interactors
IntActiQ3KQV3, 35 interactors
STRINGi9606.ENSP00000385099

Structurei

3D structure databases

ProteinModelPortaliQ3KQV3
SMRiQ3KQV3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 5Poly-Ala4

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri132 – 154C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ3KQV3
KOiK09228
OMAiPDSVDMT
OrthoDBiEOG091G02KC
PhylomeDBiQ3KQV3
TreeFamiTF342033

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequencei

Sequence statusi: Complete.

Q3KQV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAALRDPA QGCVTFEDVT IYFSQEEWVL LDEAQRLLYC DVMLENFALI
60 70 80 90 100
ASLGLISFRS HIVSQLEMGK EPWVPDSVDM TSAMARGAYG RPGSDFCHGT
110 120 130 140 150
EGKDLPSEHN VSVEGVAQDR SPEATLCPQK TCPCDICGLR LKDILHLAEH
160 170 180 190 200
QTTHPRQKPF VCEAYVKGSE FSANLPRKQV QQNVHNPIRT EEGQASPVKT
210 220 230 240 250
CRDHTSDQLS TCREGGKDFV ATAGFLQCEV TPSDGEPHEA TEGVVDFHIA
260 270 280 290 300
LRHNKCCESG DAFNNKSTLV QHQRIHSRER PYECSKCGIF FTYAADLTQH
310 320 330 340 350
QKVHNRGKPY ECCECGKFFS QHSSLVKHRR VHTGESPHVC GDCGKFFSRS
360 370 380 390 400
SNLIQHKRVH TGEKPYECSD CGKFFSQRSN LIHHKRVHTG RSAHECSECG
410 420 430 440 450
KSFNCNSSLI KHWRVHTGER PYKCNECGKF FSHIASLIQH QIVHTGERPH
460 470 480 490 500
GCGECGKAFS RSSDLMKHQR VHTGERPYEC NECGKLFSQS SSLNSHRRLH
510 520 530 540 550
TGERPYQCSE CGKFFNQSSS LNNHRRLHTG ERPYECSECG KTFRQRSNLR
560 570 580 590 600
QHLKVHKPDR PYECSECGKA FNQRPTLIRH QKIHIRERSM ENVLLPCSQH
610 620 630
TPEISSENRP YQGAVNYKLK LVHPSTHPGE VP
Length:632
Mass (Da):71,577
Last modified:November 25, 2008 - v2
Checksum:i332B2A8E3E0ED873
GO

Sequence cautioni

The sequence AAI01119 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI01120 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI01121 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti590M → T in BAG65345 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033106177R → Q1 PublicationCorresponds to variant dbSNP:rs2651079Ensembl.1
Natural variantiVAR_047354525R → W. Corresponds to variant dbSNP:rs3746244Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304550 mRNA Translation: BAG65345.1
AC008555 Genomic DNA No translation available.
BC101118 mRNA Translation: AAI01119.1 Different initiation.
BC101119 mRNA Translation: AAI01120.1 Different initiation.
BC101120 mRNA Translation: AAI01121.1 Different initiation.
CCDSiCCDS12440.2
RefSeqiNP_787068.3, NM_175872.4
UniGeneiHs.50405

Genome annotation databases

EnsembliENST00000404801; ENSP00000385099; ENSG00000180884
GeneIDi126375
KEGGihsa:126375
UCSCiuc002nxh.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN792_HUMAN
AccessioniPrimary (citable) accession number: Q3KQV3
Secondary accession number(s): B4E333
, Q495L1, Q495L3, Q8N932
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 25, 2008
Last modified: May 23, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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