Q3KQU3 (MA7D1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
MAP7 domain-containing protein 1

Alternative name(s):
Arginine/proline-rich coiled-coil domain-containing protein 1
Proline/arginine-rich coiled-coil domain-containing protein 1

Gene names

Name:	MAP7D1
Synonyms:	KIAA1187, PARCC1, RPRC1
ORF Names:	PP2464

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	841 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cytoplasm › cytoskeleton › spindle Ref.9.
Sequence similarities	Belongs to the MAP7 family.
Sequence caution	The sequence AAG17244.1 differs from that shown. Reason: Frameshift at positions 80, 207 and 736. The sequence BAA86501.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW spindle Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q3KQU3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q3KQU3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     247-283: Missing.
     729-729: Missing.

Isoform 3 (identifier: Q3KQU3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-454: Missing.
     455-459: TASEL → MNGPV
     570-578: Missing.
     729-729: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q3KQU3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     325-356: Missing.
     729-729: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 841	841	MAP7 domain-containing protein 1		PRO_0000306807
Regions
	Coiled coil	128 – 222	95	Potential
	Coiled coil	412 – 441	30	Potential
	Coiled coil	593 – 721	129	Potential
	Compositional bias	14 – 127	114	Pro-rich
	Compositional bias	467 – 589	123	Pro-rich
Amino acid modifications
	Modified residue	41	1	Phosphoserine Ref.17
	Modified residue	47	1	Phosphothreonine Ref.17
	Modified residue	51	1	Phosphothreonine Ref.17
	Modified residue	70	1	Phosphoserine Ref.14
	Modified residue	72	1	Phosphoserine Ref.18
	Modified residue	86	1	Phosphoserine Ref.14 Ref.17 Ref.18
	Modified residue	88	1	Phosphoserine Ref.14
	Modified residue	97	1	Phosphothreonine Ref.14
	Modified residue	113	1	Phosphoserine Ref.17
	Modified residue	116	1	Phosphoserine Ref.17
	Modified residue	118	1	Phosphothreonine Ref.18
	Modified residue	123	1	Phosphoserine Ref.14
	Modified residue	125	1	Phosphoserine Ref.14 Ref.17 Ref.19
	Modified residue	252	1	Phosphoserine Ref.14
	Modified residue	274	1	Phosphoserine By similarity
	Modified residue	302	1	Phosphothreonine Ref.15
	Modified residue	313	1	Phosphoserine Ref.15
	Modified residue	399	1	Phosphoserine Ref.10
	Modified residue	442	1	Phosphoserine Ref.17
	Modified residue	446	1	Phosphoserine Ref.17
	Modified residue	460	1	Phosphoserine Ref.11 Ref.12 Ref.14 Ref.16 Ref.17 Ref.18 Ref.19
	Modified residue	544	1	Phosphoserine Ref.10 Ref.12 Ref.17 Ref.18 Ref.19
	Modified residue	548	1	Phosphoserine Ref.10 Ref.12 Ref.17 Ref.18 Ref.19
	Modified residue	552	1	Phosphoserine Ref.12 Ref.17 Ref.18
	Modified residue	554	1	Phosphothreonine Ref.18
	Modified residue	576	1	Phosphoserine Ref.15
	Modified residue	585	1	Phosphothreonine Ref.15
	Modified residue	741	1	Phosphoserine Ref.10
	Modified residue	753	1	Phosphoserine Ref.14
	Modified residue	834	1	Phosphoserine Ref.10 Ref.11 Ref.12 Ref.14 Ref.16 Ref.17 Ref.18
	Cross-link	439		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.13
Natural variations
	Alternative sequence	1 – 454	454	Missing in isoform 3.		VSP_028483
	Alternative sequence	247 – 283	37	Missing in isoform 2.		VSP_028484
	Alternative sequence	325 – 356	32	Missing in isoform 4.		VSP_028485
	Alternative sequence	455 – 459	5	TASEL → MNGPV in isoform 3.		VSP_028486
	Alternative sequence	570 – 578	9	Missing in isoform 3.		VSP_028487
	Alternative sequence	729	1	Missing in isoform 2, isoform 3 and isoform 4.		VSP_028488
	Natural variant	104	1	R → W. Corresponds to variant rs2296266 [ dbSNP | Ensembl ].		VAR_035312
	Natural variant	531	1	R → S. Corresponds to variant rs12563354 [ dbSNP | Ensembl ].		VAR_053970
Experimental info
	Sequence conflict	207	1	N → S in AAG17244. Ref.6
	Sequence conflict	794	1	H → R in BAC04654. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 47F5931376A931EF	FASTA	841	92,820
	10 20 30 40 50 60 MESGPRAELG AGAPPAVVAR TPPEPRPSPE GDPSPPPPPM SALVPDTPPD TPPAMKNATS 70 80 90 100 110 120 SKQLPLEPES PSGQVGPRPA PPQEESPSSE AKSRGPTPPA MGPRDARPPR RSSQPSPTAV 130 140 150 160 170 180 PASDSPPTKQ EVKKAGERHK LAKERREERA KYLAAKKAVW LEKEEKAKAL REKQLQERRR 190 200 210 220 230 240 RLEEQRLKAE QRRAALEERQ RQKLEKNKER YEAAIQRSVK KTWAEIRQQR WSWAGALHHS 250 260 270 280 290 300 SPGHKTSGSR CSVSAVNLPK HVDSIINKRL SKSSATLWNS PSRNRSLQLS AWESSIVDRL 310 320 330 340 350 360 MTPTLSFLAR SRSAVTLPRN GRDQGRGCDP GRGPTWGRAG ASLARGPQPD RTHPSAAVPV 370 380 390 400 410 420 CPRSASASPL TPCSVTRSVH RCAPAGERGE RRKPNAGGSP APVRRRPEAS PVQKKEKKDK 430 440 450 460 470 480 ERENEKEKSA LARERSLKKR QSLPASPRAR LSASTASELS PKSKARPSSP STSWHRPASP 490 500 510 520 530 540 CPSPGPGHTL PPKPPSPRGT TASPKGRVRR KEEAKESPSA AGPEDKSQSK RRASNEKESA 550 560 570 580 590 600 APASPAPSPA PSPTPAPPQK EQPPAETPTD AAVLTSPPAP APPVTPSKPM AGTTDREEAT 610 620 630 640 650 660 RLLAEKRRQA REQREREEQE RRLQAERDKR MREEQLAREA EARAEREAEA RRREEQEARE 670 680 690 700 710 720 KAQAEQEEQE RLQKQKEEAE ARSREEAERQ RLEREKHFQQ QEQERQERRK RLEEIMKRTR 730 740 750 760 770 780 KSEVSETKQK QDSKEANANG SSPEPVKAVE ARSPGLQKEA VQKEEPIPQE PQWSLPSKEL 790 800 810 820 830 840 PASLVNGLQP LPAHQENGFS TNGPSGDKSL SRTPETLLPF AEAEAFLKKA VVQSPQVTEV L
	Isoform 2 [UniParc]. Checksum: 5B8E46883590DF6A	FASTA	803	88,726
	10 20 30 40 50 60 MESGPRAELG AGAPPAVVAR TPPEPRPSPE GDPSPPPPPM SALVPDTPPD TPPAMKNATS 70 80 90 100 110 120 SKQLPLEPES PSGQVGPRPA PPQEESPSSE AKSRGPTPPA MGPRDARPPR RSSQPSPTAV 130 140 150 160 170 180 PASDSPPTKQ EVKKAGERHK LAKERREERA KYLAAKKAVW LEKEEKAKAL REKQLQERRR 190 200 210 220 230 240 RLEEQRLKAE QRRAALEERQ RQKLEKNKER YEAAIQRSVK KTWAEIRQQR WSWAGALHHS 250 260 270 280 290 300 SPGHKTNRSL QLSAWESSIV DRLMTPTLSF LARSRSAVTL PRNGRDQGRG CDPGRGPTWG 310 320 330 340 350 360 RAGASLARGP QPDRTHPSAA VPVCPRSASA SPLTPCSVTR SVHRCAPAGE RGERRKPNAG 370 380 390 400 410 420 GSPAPVRRRP EASPVQKKEK KDKERENEKE KSALARERSL KKRQSLPASP RARLSASTAS 430 440 450 460 470 480 ELSPKSKARP SSPSTSWHRP ASPCPSPGPG HTLPPKPPSP RGTTASPKGR VRRKEEAKES 490 500 510 520 530 540 PSAAGPEDKS QSKRRASNEK ESAAPASPAP SPAPSPTPAP PQKEQPPAET PTDAAVLTSP 550 560 570 580 590 600 PAPAPPVTPS KPMAGTTDRE EATRLLAEKR RQAREQRERE EQERRLQAER DKRMREEQLA 610 620 630 640 650 660 REAEARAERE AEARRREEQE AREKAQAEQE EQERLQKQKE EAEARSREEA ERQRLEREKH 670 680 690 700 710 720 FQQQEQERQE RRKRLEEIMK RTRKSEVSET KKQDSKEANA NGSSPEPVKA VEARSPGLQK 730 740 750 760 770 780 EAVQKEEPIP QEPQWSLPSK ELPASLVNGL QPLPAHQENG FSTNGPSGDK SLSRTPETLL 790 800 PFAEAEAFLK KAVVQSPQVT EVL
	Isoform 3 [UniParc]. Checksum: E220BB255F897F21	FASTA	377	42,105
	10 20 30 40 50 60 MNGPVSPKSK ARPSSPSTSW HRPASPCPSP GPGHTLPPKP PSPRGTTASP KGRVRRKEEA 70 80 90 100 110 120 KESPSAAGPE DKSQSKRRAS NEKESAAPAS PAPSPAPSPT PAPPQKEQPP AETPTAPAPP 130 140 150 160 170 180 VTPSKPMAGT TDREEATRLL AEKRRQAREQ REREEQERRL QAERDKRMRE EQLAREAEAR 190 200 210 220 230 240 AEREAEARRR EEQEAREKAQ AEQEEQERLQ KQKEEAEARS REEAERQRLE REKHFQQQEQ 250 260 270 280 290 300 ERQERRKRLE EIMKRTRKSE VSETKKQDSK EANANGSSPE PVKAVEARSP GLQKEAVQKE 310 320 330 340 350 360 EPIPQEPQWS LPSKELPASL VNGLQPLPAH QENGFSTNGP SGDKSLSRTP ETLLPFAEAE 370 AFLKKAVVQS PQVTEVL
	Isoform 4 [UniParc]. Checksum: BB3AFDF24FBB8273	FASTA	808	89,467
	10 20 30 40 50 60 MESGPRAELG AGAPPAVVAR TPPEPRPSPE GDPSPPPPPM SALVPDTPPD TPPAMKNATS 70 80 90 100 110 120 SKQLPLEPES PSGQVGPRPA PPQEESPSSE AKSRGPTPPA MGPRDARPPR RSSQPSPTAV 130 140 150 160 170 180 PASDSPPTKQ EVKKAGERHK LAKERREERA KYLAAKKAVW LEKEEKAKAL REKQLQERRR 190 200 210 220 230 240 RLEEQRLKAE QRRAALEERQ RQKLEKNKER YEAAIQRSVK KTWAEIRQQR WSWAGALHHS 250 260 270 280 290 300 SPGHKTSGSR CSVSAVNLPK HVDSIINKRL SKSSATLWNS PSRNRSLQLS AWESSIVDRL 310 320 330 340 350 360 MTPTLSFLAR SRSAVTLPRN GRDQAVPVCP RSASASPLTP CSVTRSVHRC APAGERGERR 370 380 390 400 410 420 KPNAGGSPAP VRRRPEASPV QKKEKKDKER ENEKEKSALA RERSLKKRQS LPASPRARLS 430 440 450 460 470 480 ASTASELSPK SKARPSSPST SWHRPASPCP SPGPGHTLPP KPPSPRGTTA SPKGRVRRKE 490 500 510 520 530 540 EAKESPSAAG PEDKSQSKRR ASNEKESAAP ASPAPSPAPS PTPAPPQKEQ PPAETPTDAA 550 560 570 580 590 600 VLTSPPAPAP PVTPSKPMAG TTDREEATRL LAEKRRQARE QREREEQERR LQAERDKRMR 610 620 630 640 650 660 EEQLAREAEA RAEREAEARR REEQEAREKA QAEQEEQERL QKQKEEAEAR SREEAERQRL 670 680 690 700 710 720 EREKHFQQQE QERQERRKRL EEIMKRTRKS EVSETKKQDS KEANANGSSP EPVKAVEARS 730 740 750 760 770 780 PGLQKEAVQK EEPIPQEPQW SLPSKELPAS LVNGLQPLPA HQENGFSTNG PSGDKSLSRT 790 800 PETLLPFAEA EAFLKKAVVQ SPQVTEVL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain." Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O. DNA Res. 6:329-336(1999) [PubMed: 10574461] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Heart and Teratocarcinoma.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 625-841 (ISOFORMS 2/3/4). Tissue: Bone and Uterus.
[6]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed: 15498874] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 77-841 (ISOFORM 4).
[7]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 546-841 (ISOFORM 2). Tissue: Amygdala.
[8]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 590-841 (ISOFORMS 2/3/4).
[9]	"Proteome analysis of the human mitotic spindle." Sauer G., Koerner R., Hanisch A., Ries A., Nigg E.A., Sillje H.H.W. Mol. Cell. Proteomics 4:35-43(2005) [PubMed: 15561729] [Abstract] Cited for: SUBCELLULAR LOCATION, MASS SPECTROMETRY.
[10]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-399; SER-544; SER-548; SER-741 AND SER-834, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460 AND SER-834, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Phosphoproteome analysis of the human mitotic spindle." Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R. Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006) [PubMed: 16565220] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460; SER-544; SER-548; SER-552 AND SER-834, MASS SPECTROMETRY. Tissue: Cervix adenocarcinoma.
[13]	"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry." Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D. Proteomics 7:868-874(2007) [PubMed: 17370265] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-439, MASS SPECTROMETRY. Tissue: Mammary cancer.
[14]	"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; SER-86; SER-88; THR-97; SER-123; SER-125; SER-252; SER-460; SER-753 AND SER-834, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-302; SER-313; SER-576 AND THR-585, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460 AND SER-834, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[17]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41; THR-47; THR-51; SER-86; SER-113; SER-116; SER-125; SER-442; SER-446; SER-460; SER-544; SER-548; SER-552 AND SER-834, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[18]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72; SER-86; THR-118; SER-460; SER-544; SER-548; SER-552; THR-554 AND SER-834, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[19]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125; SER-460; SER-544 AND SER-548, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB033013 mRNA. Translation: BAA86501.2. Different initiation. AK001212 mRNA. Translation: BAA91557.1. AK095939 mRNA. Translation: BAC04654.1. CH471059 Genomic DNA. Translation: EAX07381.1. CH471059 Genomic DNA. Translation: EAX07382.1. BC027334 mRNA. Translation: AAH27334.1. BC106053 mRNA. Translation: AAI06054.1. AF218002 mRNA. Translation: AAG17244.1. Frameshift. AL136547 mRNA. Translation: CAB66482.2. CR457254 mRNA. Translation: CAG33535.1.
IPI	IPI00167009. IPI00645814. IPI00654605. IPI00867630.
RefSeq	NP_060537.3. NM_018067.3.
UniGene	Hs.356096.
3D structure databases
ProteinModelPortal	Q3KQU3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q3KQU3. 9 interactions.
MINT	MINT-2874531.
STRING	Q3KQU3.
PTM databases
PhosphoSite	Q3KQU3.
Polymorphism databases
DMDM	121942584.
Proteomic databases
PRIDE	Q3KQU3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373151; ENSP00000362244; ENSG00000116871.
GeneID	55700.
KEGG	hsa:55700.
UCSC	uc001bzz.1. human. uc001caa.1. human. uc001cab.1. human. uc001cad.1. human.
Organism-specific databases
CTD	55700.
GeneCards	GC01P036621.
H-InvDB	HIX0000427.
HGNC	HGNC:25514. MAP7D1.
HPA	HPA028075.
neXtProt	NX_Q3KQU3.
PharmGKB	PA162394970.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG071099.
InParanoid	Q3KQU3.
OMA	AMKNATS.
Gene expression databases
ArrayExpress	Q3KQU3.
Bgee	Q3KQU3.
CleanEx	HS_MAP7D1.
Genevestigator	Q3KQU3.
Family and domain databases
InterPro	IPR008604. E-MAP-115. [Graphical view]
PANTHER	PTHR15073. E-MAP-115. 1 hit.
Pfam	PF05672. MAP7. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	60538.

Entry information

Entry name

MA7D1_HUMAN

Accession

Primary (citable) accession number: Q3KQU3
Secondary accession number(s): D3DPS4 , Q7L8J5, Q8N905, Q8TAK0, Q9HBQ2, Q9NW29, Q9ULN3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	November 8, 2005
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.