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Protein

MAP7 domain-containing protein 1

Gene

MAP7D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
MAP7 domain-containing protein 1
Alternative name(s):
Arginine/proline-rich coiled-coil domain-containing protein 1
Proline/arginine-rich coiled-coil domain-containing protein 1
Gene namesi
Name:MAP7D1
Synonyms:KIAA1187, PARCC1, RPRC1
ORF Names:PP2464
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25514. MAP7D1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000116871.
PharmGKBiPA162394970.

Polymorphism and mutation databases

BioMutaiMAP7D1.
DMDMi121942584.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003068071 – 841MAP7 domain-containing protein 1Add BLAST841

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47PhosphothreonineCombined sources1
Modified residuei51PhosphothreonineCombined sources1
Modified residuei70PhosphoserineCombined sources1
Modified residuei86PhosphoserineCombined sources1
Modified residuei93PhosphoserineCombined sources1
Modified residuei97PhosphothreonineCombined sources1
Modified residuei113PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei118PhosphothreonineCombined sources1
Modified residuei123PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Modified residuei254PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1
Modified residuei313PhosphoserineCombined sources1
Modified residuei366PhosphoserineCombined sources1
Modified residuei399PhosphoserineCombined sources1
Modified residuei442PhosphoserineCombined sources1
Modified residuei446PhosphoserineCombined sources1
Modified residuei452PhosphoserineCombined sources1
Modified residuei454PhosphoserineCombined sources1
Modified residuei460PhosphoserineCombined sources1
Modified residuei479PhosphoserineBy similarity1
Modified residuei496PhosphoserineBy similarity1
Modified residuei544PhosphoserineCombined sources1
Modified residuei548PhosphoserineCombined sources1
Modified residuei552PhosphoserineCombined sources1
Modified residuei554PhosphothreonineCombined sources1
Modified residuei742PhosphoserineCombined sources1
Modified residuei753PhosphoserineCombined sources1
Modified residuei813PhosphothreonineCombined sources1
Modified residuei816PhosphothreonineCombined sources1
Modified residuei834PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3KQU3.
MaxQBiQ3KQU3.
PaxDbiQ3KQU3.
PeptideAtlasiQ3KQU3.
PRIDEiQ3KQU3.

PTM databases

iPTMnetiQ3KQU3.
PhosphoSitePlusiQ3KQU3.

Expressioni

Gene expression databases

BgeeiENSG00000116871.
CleanExiHS_MAP7D1.
ExpressionAtlasiQ3KQU3. baseline and differential.
GenevisibleiQ3KQU3. HS.

Organism-specific databases

HPAiHPA028075.

Interactioni

Protein-protein interaction databases

BioGridi120825. 35 interactors.
IntActiQ3KQU3. 33 interactors.
MINTiMINT-2874531.
STRINGi9606.ENSP00000362244.

Structurei

3D structure databases

ProteinModelPortaliQ3KQU3.
SMRiQ3KQU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili128 – 222Sequence analysisAdd BLAST95
Coiled coili412 – 441Sequence analysisAdd BLAST30
Coiled coili593 – 721Sequence analysisAdd BLAST129

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 127Pro-richAdd BLAST114
Compositional biasi467 – 589Pro-richAdd BLAST123

Sequence similaritiesi

Belongs to the MAP7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH56. Eukaryota.
ENOG410XTH2. LUCA.
GeneTreeiENSGT00660000095160.
HOVERGENiHBG071099.
InParanoidiQ3KQU3.
KOiK16806.
OMAiAPQEPQW.
OrthoDBiEOG091G07NV.
PhylomeDBiQ3KQU3.
TreeFamiTF332273.

Family and domain databases

InterProiIPR008604. MAP7_fam.
[Graphical view]
PANTHERiPTHR15073. PTHR15073. 2 hits.
PfamiPF05672. MAP7. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3KQU3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESGPRAELG AGAPPAVVAR TPPEPRPSPE GDPSPPPPPM SALVPDTPPD
60 70 80 90 100
TPPAMKNATS SKQLPLEPES PSGQVGPRPA PPQEESPSSE AKSRGPTPPA
110 120 130 140 150
MGPRDARPPR RSSQPSPTAV PASDSPPTKQ EVKKAGERHK LAKERREERA
160 170 180 190 200
KYLAAKKAVW LEKEEKAKAL REKQLQERRR RLEEQRLKAE QRRAALEERQ
210 220 230 240 250
RQKLEKNKER YEAAIQRSVK KTWAEIRQQR WSWAGALHHS SPGHKTSGSR
260 270 280 290 300
CSVSAVNLPK HVDSIINKRL SKSSATLWNS PSRNRSLQLS AWESSIVDRL
310 320 330 340 350
MTPTLSFLAR SRSAVTLPRN GRDQGRGCDP GRGPTWGRAG ASLARGPQPD
360 370 380 390 400
RTHPSAAVPV CPRSASASPL TPCSVTRSVH RCAPAGERGE RRKPNAGGSP
410 420 430 440 450
APVRRRPEAS PVQKKEKKDK ERENEKEKSA LARERSLKKR QSLPASPRAR
460 470 480 490 500
LSASTASELS PKSKARPSSP STSWHRPASP CPSPGPGHTL PPKPPSPRGT
510 520 530 540 550
TASPKGRVRR KEEAKESPSA AGPEDKSQSK RRASNEKESA APASPAPSPA
560 570 580 590 600
PSPTPAPPQK EQPPAETPTD AAVLTSPPAP APPVTPSKPM AGTTDREEAT
610 620 630 640 650
RLLAEKRRQA REQREREEQE RRLQAERDKR MREEQLAREA EARAEREAEA
660 670 680 690 700
RRREEQEARE KAQAEQEEQE RLQKQKEEAE ARSREEAERQ RLEREKHFQQ
710 720 730 740 750
QEQERQERRK RLEEIMKRTR KSEVSETKQK QDSKEANANG SSPEPVKAVE
760 770 780 790 800
ARSPGLQKEA VQKEEPIPQE PQWSLPSKEL PASLVNGLQP LPAHQENGFS
810 820 830 840
TNGPSGDKSL SRTPETLLPF AEAEAFLKKA VVQSPQVTEV L
Length:841
Mass (Da):92,820
Last modified:November 8, 2005 - v1
Checksum:i47F5931376A931EF
GO
Isoform 2 (identifier: Q3KQU3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     247-283: Missing.
     729-729: Missing.

Show »
Length:803
Mass (Da):88,726
Checksum:i5B8E46883590DF6A
GO
Isoform 3 (identifier: Q3KQU3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-454: Missing.
     455-459: TASEL → MNGPV
     570-578: Missing.
     729-729: Missing.

Note: No experimental confirmation available.
Show »
Length:377
Mass (Da):42,105
Checksum:iE220BB255F897F21
GO
Isoform 4 (identifier: Q3KQU3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-356: Missing.
     729-729: Missing.

Show »
Length:808
Mass (Da):89,467
Checksum:iBB3AFDF24FBB8273
GO

Sequence cautioni

The sequence AAG17244 differs from that shown. Reason: Frameshift at positions 80, 207 and 736.Curated
The sequence BAA86501 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti207N → S in AAG17244 (PubMed:15498874).Curated1
Sequence conflicti794H → R in BAC04654 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035312104R → W.Corresponds to variant rs2296266dbSNPEnsembl.1
Natural variantiVAR_053970531R → S.Corresponds to variant rs12563354dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0284831 – 454Missing in isoform 3. 1 PublicationAdd BLAST454
Alternative sequenceiVSP_028484247 – 283Missing in isoform 2. 2 PublicationsAdd BLAST37
Alternative sequenceiVSP_028485325 – 356Missing in isoform 4. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_028486455 – 459TASEL → MNGPV in isoform 3. 1 Publication5
Alternative sequenceiVSP_028487570 – 578Missing in isoform 3. 1 Publication9
Alternative sequenceiVSP_028488729Missing in isoform 2, isoform 3 and isoform 4. 4 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033013 mRNA. Translation: BAA86501.2. Different initiation.
AK001212 mRNA. Translation: BAA91557.1.
AK095939 mRNA. Translation: BAC04654.1.
CH471059 Genomic DNA. Translation: EAX07381.1.
CH471059 Genomic DNA. Translation: EAX07382.1.
BC027334 mRNA. Translation: AAH27334.1.
BC106053 mRNA. Translation: AAI06054.1.
AF218002 mRNA. Translation: AAG17244.1. Frameshift.
AL136547 mRNA. Translation: CAB66482.2.
CR457254 mRNA. Translation: CAG33535.1.
CCDSiCCDS30673.1. [Q3KQU3-1]
CCDS65492.1. [Q3KQU3-4]
CCDS65493.1. [Q3KQU3-2]
RefSeqiNP_001273294.1. NM_001286365.1. [Q3KQU3-2]
NP_001273295.1. NM_001286366.1. [Q3KQU3-4]
NP_060537.3. NM_018067.4. [Q3KQU3-1]
UniGeneiHs.356096.

Genome annotation databases

EnsembliENST00000316156; ENSP00000320228; ENSG00000116871. [Q3KQU3-2]
ENST00000373150; ENSP00000362243; ENSG00000116871. [Q3KQU3-4]
ENST00000373151; ENSP00000362244; ENSG00000116871. [Q3KQU3-1]
GeneIDi55700.
KEGGihsa:55700.
UCSCiuc001bzz.5. human. [Q3KQU3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033013 mRNA. Translation: BAA86501.2. Different initiation.
AK001212 mRNA. Translation: BAA91557.1.
AK095939 mRNA. Translation: BAC04654.1.
CH471059 Genomic DNA. Translation: EAX07381.1.
CH471059 Genomic DNA. Translation: EAX07382.1.
BC027334 mRNA. Translation: AAH27334.1.
BC106053 mRNA. Translation: AAI06054.1.
AF218002 mRNA. Translation: AAG17244.1. Frameshift.
AL136547 mRNA. Translation: CAB66482.2.
CR457254 mRNA. Translation: CAG33535.1.
CCDSiCCDS30673.1. [Q3KQU3-1]
CCDS65492.1. [Q3KQU3-4]
CCDS65493.1. [Q3KQU3-2]
RefSeqiNP_001273294.1. NM_001286365.1. [Q3KQU3-2]
NP_001273295.1. NM_001286366.1. [Q3KQU3-4]
NP_060537.3. NM_018067.4. [Q3KQU3-1]
UniGeneiHs.356096.

3D structure databases

ProteinModelPortaliQ3KQU3.
SMRiQ3KQU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120825. 35 interactors.
IntActiQ3KQU3. 33 interactors.
MINTiMINT-2874531.
STRINGi9606.ENSP00000362244.

PTM databases

iPTMnetiQ3KQU3.
PhosphoSitePlusiQ3KQU3.

Polymorphism and mutation databases

BioMutaiMAP7D1.
DMDMi121942584.

Proteomic databases

EPDiQ3KQU3.
MaxQBiQ3KQU3.
PaxDbiQ3KQU3.
PeptideAtlasiQ3KQU3.
PRIDEiQ3KQU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316156; ENSP00000320228; ENSG00000116871. [Q3KQU3-2]
ENST00000373150; ENSP00000362243; ENSG00000116871. [Q3KQU3-4]
ENST00000373151; ENSP00000362244; ENSG00000116871. [Q3KQU3-1]
GeneIDi55700.
KEGGihsa:55700.
UCSCiuc001bzz.5. human. [Q3KQU3-1]

Organism-specific databases

CTDi55700.
GeneCardsiMAP7D1.
H-InvDBHIX0000427.
HGNCiHGNC:25514. MAP7D1.
HPAiHPA028075.
neXtProtiNX_Q3KQU3.
OpenTargetsiENSG00000116871.
PharmGKBiPA162394970.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH56. Eukaryota.
ENOG410XTH2. LUCA.
GeneTreeiENSGT00660000095160.
HOVERGENiHBG071099.
InParanoidiQ3KQU3.
KOiK16806.
OMAiAPQEPQW.
OrthoDBiEOG091G07NV.
PhylomeDBiQ3KQU3.
TreeFamiTF332273.

Miscellaneous databases

ChiTaRSiMAP7D1. human.
GenomeRNAii55700.
PROiQ3KQU3.

Gene expression databases

BgeeiENSG00000116871.
CleanExiHS_MAP7D1.
ExpressionAtlasiQ3KQU3. baseline and differential.
GenevisibleiQ3KQU3. HS.

Family and domain databases

InterProiIPR008604. MAP7_fam.
[Graphical view]
PANTHERiPTHR15073. PTHR15073. 2 hits.
PfamiPF05672. MAP7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMA7D1_HUMAN
AccessioniPrimary (citable) accession number: Q3KQU3
Secondary accession number(s): D3DPS4
, Q7L8J5, Q8N905, Q8TAK0, Q9HBQ2, Q9NW29, Q9ULN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 8, 2005
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.