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Protein

Testicular acid phosphatase homolog

Gene

acp4

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei39NucleophileBy similarity1
Active sitei286Proton donorBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Testicular acid phosphatase homolog (EC:3.1.3.2)
Alternative name(s):
Acid phosphatase 4By similarity
Gene namesi
Name:acp4By similarity
Synonyms:acptBy similarity
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-960834. acpp.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 385ExtracellularSequence analysisAdd BLAST361
Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
Topological domaini407 – 420CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000025964425 – 420Testicular acid phosphatase homologAdd BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi156 ↔ 369By similarity
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi211 ↔ 309By similarity
Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi272N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi344 ↔ 348By similarity
Glycosylationi352N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi383N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ3KQG9.
SMRiQ3KQG9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG002203.
KOiK19284.

Family and domain databases

CDDicd07061. HP_HAP_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
InterProiView protein in InterPro
IPR033379. Acid_Pase_AS.
IPR000560. His_Pase_clade-2.
IPR029033. His_PPase_superfam.
PfamiView protein in Pfam
PF00328. His_Phos_2. 1 hit.
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiView protein in PROSITE
PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3KQG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRAVVILWL PLAFTNLYIL TTFCQRTDNL TFVVAVFRHG DRAPIDTYPN
60 70 80 90 100
DPHKEKLWPN GLQQLTQEGM RQQYELGRFL RRRYDHFLSS TYNRQEIYVR
110 120 130 140 150
STDYDRTLMS AQASLAGLYP PNGSQLWHRD IHWQPIPVHT VPASQDRLLK
160 170 180 190 200
FPSKDCPRYY ELMRETIQQP EYQDKVNSWK DFMERIANYT GYRAETTISR
210 220 230 240 250
WVWKVYDTLF CQKSHNISLP SWATADVVKT LKEISAFDVK THVEMHKTNE
260 270 280 290 300
KARLTGGILV DALLRNFSDV VNKSLPLKML MYSAHDSTLI ALQGALKVYN
310 320 330 340 350
GLHPPYSSCH IIEFYKEADG THSVRMFYRN ETVREPYELA LPGCDSPCPL
360 370 380 390 400
LNFTQLMAPV ISMDWKKDCA SDGSLQYRIG SENNTVLALS ICVGILGLTL
410 420
TVMLFCLWRT YKLPVRRYQR
Length:420
Mass (Da):48,860
Last modified:November 8, 2005 - v1
Checksum:iF9EA0D73B4470B0F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171E → D in AAH94140 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094140 mRNA. Translation: AAH94140.1.
BC106212 mRNA. Translation: AAI06213.1.
RefSeqiNP_001087080.1. NM_001093611.1.
UniGeneiXl.48988.

Genome annotation databases

GeneIDi446918.
KEGGixla:446918.

Similar proteinsi

Entry informationi

Entry nameiPPAT_XENLA
AccessioniPrimary (citable) accession number: Q3KQG9
Secondary accession number(s): Q52KY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 8, 2005
Last modified: December 20, 2017
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families