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Q3KQG9

- PPAT_XENLA

UniProt

Q3KQG9 - PPAT_XENLA

Protein

Testicular acid phosphatase homolog

Gene

acpt

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei39 – 391NucleophileBy similarity
    Active sitei286 – 2861Proton donorBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Testicular acid phosphatase homolog (EC:3.1.3.2)
    Gene namesi
    Name:acpt
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-960834. acpp.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 420396Testicular acid phosphatase homologPRO_0000259644Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi156 ↔ 369By similarity
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi211 ↔ 309By similarity
    Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi344 ↔ 348By similarity
    Glycosylationi352 – 3521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ3KQG9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 385361ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini407 – 42014CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei386 – 40621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidine acid phosphatase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG002203.
    KOiK14410.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    InterProiIPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00328. His_Phos_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.
    PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3KQG9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRAVVILWL PLAFTNLYIL TTFCQRTDNL TFVVAVFRHG DRAPIDTYPN    50
    DPHKEKLWPN GLQQLTQEGM RQQYELGRFL RRRYDHFLSS TYNRQEIYVR 100
    STDYDRTLMS AQASLAGLYP PNGSQLWHRD IHWQPIPVHT VPASQDRLLK 150
    FPSKDCPRYY ELMRETIQQP EYQDKVNSWK DFMERIANYT GYRAETTISR 200
    WVWKVYDTLF CQKSHNISLP SWATADVVKT LKEISAFDVK THVEMHKTNE 250
    KARLTGGILV DALLRNFSDV VNKSLPLKML MYSAHDSTLI ALQGALKVYN 300
    GLHPPYSSCH IIEFYKEADG THSVRMFYRN ETVREPYELA LPGCDSPCPL 350
    LNFTQLMAPV ISMDWKKDCA SDGSLQYRIG SENNTVLALS ICVGILGLTL 400
    TVMLFCLWRT YKLPVRRYQR 420
    Length:420
    Mass (Da):48,860
    Last modified:November 8, 2005 - v1
    Checksum:iF9EA0D73B4470B0F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti171 – 1711E → D in AAH94140. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC094140 mRNA. Translation: AAH94140.1.
    BC106212 mRNA. Translation: AAI06213.1.
    RefSeqiNP_001087080.1. NM_001093611.1.
    UniGeneiXl.48988.

    Genome annotation databases

    GeneIDi446918.
    KEGGixla:446918.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC094140 mRNA. Translation: AAH94140.1 .
    BC106212 mRNA. Translation: AAI06213.1 .
    RefSeqi NP_001087080.1. NM_001093611.1.
    UniGenei Xl.48988.

    3D structure databases

    ProteinModelPortali Q3KQG9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 446918.
    KEGGi xla:446918.

    Organism-specific databases

    CTDi 55.
    Xenbasei XB-GENE-960834. acpp.

    Phylogenomic databases

    HOVERGENi HBG002203.
    KOi K14410.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    InterProi IPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00328. His_Phos_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo and Kidney.

    Entry informationi

    Entry nameiPPAT_XENLA
    AccessioniPrimary (citable) accession number: Q3KQG9
    Secondary accession number(s): Q52KY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3