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Q3KQG9 (PPAT_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Testicular acid phosphatase homolog

EC=3.1.3.2
Gene names
Name:acpt
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Subunit structure

Homodimer By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the histidine acid phosphatase family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionHydrolase
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionacid phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 420396Testicular acid phosphatase homolog
PRO_0000259644

Regions

Topological domain25 – 385361Extracellular Potential
Transmembrane386 – 40621Helical; Potential
Topological domain407 – 42014Cytoplasmic Potential

Sites

Active site391Nucleophile By similarity
Active site2861Proton donor By similarity

Amino acid modifications

Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation1221N-linked (GlcNAc...) Potential
Glycosylation1881N-linked (GlcNAc...) Potential
Glycosylation2161N-linked (GlcNAc...) Potential
Glycosylation2661N-linked (GlcNAc...) Potential
Glycosylation2721N-linked (GlcNAc...) Potential
Glycosylation3301N-linked (GlcNAc...) Potential
Glycosylation3521N-linked (GlcNAc...) Potential
Glycosylation3831N-linked (GlcNAc...) Potential
Disulfide bond156 ↔ 369 By similarity
Disulfide bond211 ↔ 309 By similarity
Disulfide bond344 ↔ 348 By similarity

Experimental info

Sequence conflict1711E → D in AAH94140. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q3KQG9 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: F9EA0D73B4470B0F

FASTA42048,860
        10         20         30         40         50         60 
MKRAVVILWL PLAFTNLYIL TTFCQRTDNL TFVVAVFRHG DRAPIDTYPN DPHKEKLWPN 

        70         80         90        100        110        120 
GLQQLTQEGM RQQYELGRFL RRRYDHFLSS TYNRQEIYVR STDYDRTLMS AQASLAGLYP 

       130        140        150        160        170        180 
PNGSQLWHRD IHWQPIPVHT VPASQDRLLK FPSKDCPRYY ELMRETIQQP EYQDKVNSWK 

       190        200        210        220        230        240 
DFMERIANYT GYRAETTISR WVWKVYDTLF CQKSHNISLP SWATADVVKT LKEISAFDVK 

       250        260        270        280        290        300 
THVEMHKTNE KARLTGGILV DALLRNFSDV VNKSLPLKML MYSAHDSTLI ALQGALKVYN 

       310        320        330        340        350        360 
GLHPPYSSCH IIEFYKEADG THSVRMFYRN ETVREPYELA LPGCDSPCPL LNFTQLMAPV 

       370        380        390        400        410        420 
ISMDWKKDCA SDGSLQYRIG SENNTVLALS ICVGILGLTL TVMLFCLWRT YKLPVRRYQR 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo and Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC094140 mRNA. Translation: AAH94140.1.
BC106212 mRNA. Translation: AAI06213.1.
RefSeqNP_001087080.1. NM_001093611.1.
UniGeneXl.48988.

3D structure databases

ProteinModelPortalQ3KQG9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID446918.
KEGGxla:446918.

Organism-specific databases

CTD55.
XenbaseXB-GENE-960834. acpp.

Phylogenomic databases

HOVERGENHBG002203.
KOK14410.

Family and domain databases

InterProIPR000560. His_Pase_superF_clade-2.
[Graphical view]
PfamPF00328. His_Phos_2. 1 hit.
[Graphical view]
PROSITEPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePPAT_XENLA
AccessionPrimary (citable) accession number: Q3KQG9
Secondary accession number(s): Q52KY6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 8, 2005
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families