Q3KQ62 (WDR83_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat domain-containing protein 83

Alternative name(s):
Mitogen-activated protein kinase organizer 1
Short name=MAPK organizer 1

Gene names

Name:	wdr83
Synonyms:	morg1

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the WD repeat MORG1 family. Contains 7 WD repeats.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Repeat WD repeat
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	WD repeat domain-containing protein 83		PRO_0000235267
Regions
	Repeat	23 – 62	40	WD 1
	Repeat	65 – 104	40	WD 2
	Repeat	107 – 146	40	WD 3
	Repeat	151 – 188	38	WD 4
	Repeat	189 – 228	40	WD 5
	Repeat	231 – 272	42	WD 6
	Repeat	275 – 313	39	WD 7

Sequences

	Sequence		Length	Mass (Da)
	Q3KQ62 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 8ADC1660BD0B181B	FASTA	314	34,176
	10 20 30 40 50 60 MSFPAPKPKA PELPQKLQHK LECNQGAVRA VRFNVDGNYC MTCGSDKSLK LWNPHKGSLL 70 80 90 100 110 120 KTYSGHGYEV LDTAGSCDNS QLCSCSSDKT VILWDVAQGQ VVRKFRGHAG KVNCVQFNEE 130 140 150 160 170 180 ATVIISGSID SSIRCWDCRS RRPDAIQIMD EAKDGISSVK VSAHEILAGS VDGNLRRYDL 190 200 210 220 230 240 RKGEMCADYL GSPITCVSFS QDSQCLLASS LDSTLRLLDK DTGELLGEYT GHQNLSYKLD 250 260 270 280 290 300 SCLSEKDTHV LSCSEDGTVC FWDLVEGSLV LKLPVGKAVV QSLSFHPTEC CLLTASEGGV 310 QVWRGASYEE EGGS

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC106371 mRNA. Translation: AAI06372.1.
RefSeq	NP_001089704.1. NM_001096235.1.
UniGene	Xl.48573.
3D structure databases
ProteinModelPortal	Q3KQ62.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	734767.
KEGG	xla:734767.
Organism-specific databases
CTD	84292.
Xenbase	XB-GENE-969402. wdr83.
Phylogenomic databases
HOVERGEN	HBG105288.
KO	K13124.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
InterPro	IPR020472. G-protein_beta_WD-40_rep. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF00400. WD40. 6 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
SMART	SM00320. WD40. 7 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 2 hits. PS50082. WD_REPEATS_2. 3 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

WDR83_XENLA

Accession

Primary (citable) accession number: Q3KQ62

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	November 8, 2005
Last modified:	March 6, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program