Reviewed, UniProtKB/Swiss-Prot Q3KPP4 (MOGT1_XENLA)

Names and origin

Protein names

Recommended name:
    2-acylglycerol O-acyltransferase 1
    EC=2.3.1.22
Alternative name(s):
    Monoacylglycerol O-acyltransferase 1
    Acyl CoA:monoacylglycerol acyltransferase 1
      Short name=MGAT1

Gene names

Name:

mogat1

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA By similarity.
Catalytic activity	Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.
Pathway	Glycerolipid metabolism; triacylglycerol biosynthesis.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the diacylglycerol acyltransferase family.

Ontologies

Keywords
Biological process	Glycerol metabolism Lipid metabolism Lipid synthesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Molecular function	Acyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	glycerol metabolic process Inferred from electronic annotation. Source: UniProtKB-KW lipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	2-acylglycerol O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	2-acylglycerol O-acyltransferase 1		PRO_0000249060
Regions
	Transmembrane	24 – 44	21	Potential
	Transmembrane	47 – 67	21	Potential
Amino acid modifications
	Glycosylation	125	1	N-linked (GlcNAc...) Potential
	Glycosylation	180	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	220	1	Y → H in AAH45058. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q3KPP4-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 84AE02E094F36D42	FASTA	335	38,625
	10 20 30 40 50 60 MKVEFAPLNI PLARRLQTTA VFQWVFSFLL LAQCCIGIFI CLVLARVWLL LALYVLWLYL 70 80 90 100 110 120 DWETPQAGGR RWEWVRNWPV WKYFKDYFPI RLVKTCDLDP QHNYIMGFHP HGVLVAGAFG 130 140 150 160 170 180 NFCTNYTGFK ELFPGLTPYL HILPFWFRCP FFREYIMSVG LVSASKKSVN HVLSKEDGGN 190 200 210 220 230 240 VSIIVTGGAE ESLDAHPGSL TLNILKRKGF IKVALKRGAY LVPVFSFGEN ELFQQVSNPK 250 260 270 280 290 300 GSLLRCVQER LQRIMGLAMP LFHARGIFQY SFGLMPYRMP IHTVVGRPIP VKETSHPTQE 310 320 330 EIESLHQQYL GALQELFEEH KKRYGIPEHE SLIFI

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC045058 mRNA. Translation: AAH45058.1. BC106627 mRNA. Translation: AAI06628.1.
RefSeq	NP_001080699.1.
UniGene	Xl.7867
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	380391.
KEGG	xla:380391.
Organism-specific databases
CTD	380391.
Xenbase	XB-FEAT-1004225.
Phylogenomic databases
HOVERGEN	Q3KPP4.
Enzyme and pathway databases
BRENDA	2.3.1.22. 648.
Family and domain databases
InterPro	IPR007130. DAGAT. [Graphical view]
PANTHER	PTHR12317. DAGAT. 1 hit.
Pfam	PF03982. DAGAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MOGT1_XENLA

Accession

Primary (citable) accession number: Q3KPP4
Secondary accession number(s): Q7ZXC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	November 8, 2005
Last modified:	October 13, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project