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Protein
Submitted name:

PTPRD protein

Gene

PTPRD

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
PTPRD proteinImported
Submitted name:
Receptor-type tyrosine-protein phosphatase deltaImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:PTPRDImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:9668. PTPRD.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei851 – 87424HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34013.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 14961476Sequence analysisPRO_5007702111Add
BLAST

Proteomic databases

PeptideAtlasiQ3KPI9.

Expressioni

Gene expression databases

BgeeiENSG00000153707.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000348812.

Structurei

3D structure databases

SMRiQ3KPI9. Positions 21-599, 915-1490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 11491Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini126 – 21893Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini230 – 31283Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini319 – 40991Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini414 – 51097Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini512 – 60190Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini604 – 69087Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini941 – 1196256Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini1116 – 118772TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST
Domaini1228 – 1487260Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini1405 – 147874TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOVERGENiHBG053758.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF49265. SSF49265. 4 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3KPI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHVARLLLL LLTFFLRTDA ETPPRFTRTP VDQTGVSGGV ASFICQATGD
60 70 80 90 100
PRPKIVWNKK GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA
110 120 130 140 150
SNNVGEISVS TRLTVLREDQ IPRGFPTIDM GPQLKVVERT RTATMLCAAS
160 170 180 190 200
GNPDPEITWF KDFLPVDTSN NNGRIKQLRS ESIGALQIEQ SEESDQGKYE
210 220 230 240 250
CVATNSAGTR YSAPANLYVR ELREVRRVPP RFSIPPTNHE IMPGGSVNIT
260 270 280 290 300
CVAVGSPMPY VKWMLGAEDL TPEDDMPIGR NVLELNDVRQ SANYTCVAMS
310 320 330 340 350
TLGVIEAIAQ ITVKALPKPP GTPVVTESTA TSITLTWDSG NPEPVSYYII
360 370 380 390 400
QHKPKNSEEL YKEIDGVATT RYSVAGLSPY SDYEFRVVAV NNIGRGPPSE
410 420 430 440 450
PVLTQTSEQA PSSAPRDVQA RMLSSTTILV QWKEPEEPNG QIQGYRVYYT
460 470 480 490 500
MDPTQHVNNW MKHNVADSQI TTIGNLVPQK TYSVKVLAFT SIGDGPLSSD
510 520 530 540 550
IQVITQTGVP GQPLNFKAEP ESETSILLSW TPPRSDTIAN YELVYKDGEH
560 570 580 590 600
GEEQRITIEP GTSYRLQGLK PNSLYYFRLA ARSPQGLGAS TAEISARTMQ
610 620 630 640 650
STVFAKNFHV KAVMKTSVLL SWEIPENYNS AMPFKILYDD GKMVEEVDGR
660 670 680 690 700
ATQKLIVNLK PEKSYSFVLT NRGNSAGGLQ HRVTAKTAPD VLRTKPAFIG
710 720 730 740 750
KTNLDGMITV QLPEVPANEN IKGYYIIIVP LKKSRGKFIK PWESPDEMEL
760 770 780 790 800
DELLKEISRK RRSIRYGREV ELKPYIAAHF DVLPTEFTLG DDKHYGGFTN
810 820 830 840 850
KQLQSGQEYV FFVLAVMEHA ESKMYATSPY SDPVVSMDLD PQPITDEEEG
860 870 880 890 900
LIWVVGPVLA VVFIICIVIA ILLYKRKRAE SDSRKSSIPN NKEIPSHHPT
910 920 930 940 950
DPVELRRLNF QTPGMASHPP IPILELADHI ERLKANDNLK FSQEYESIDP
960 970 980 990 1000
GQQFTWEHSN LEVNKPKNRY ANVIAYDHSR VLLSAIEGIP GSDYVNANYI
1010 1020 1030 1040 1050
DGYRKQNAYI ATQGSLPETF GDFWRMIWEQ RSATVVMMTK LEERSRVKCD
1060 1070 1080 1090 1100
QYWPSRGTET HGLVQVTLLD TVELATYCVR TFALYKNGSS EKREVRQFQF
1110 1120 1130 1140 1150
TAWPDHGVPE HPTPFLAFLR RVKTCNPPDA GPMVVHCSAG VGRTGCFIVI
1160 1170 1180 1190 1200
DAMLERIKHE KTVDIYGHVT LMRAQRNYMV QTEDQYIFIH DALLEAVTCG
1210 1220 1230 1240 1250
NTEVPARNLY AYIQKLTQIE TGENVTGMEL EFKRLASSKA HTSRFISANL
1260 1270 1280 1290 1300
PCNKFKNRLV NIMPYESTRV CLQPIRGVEG SDYINASFID GYRQQKAYIA
1310 1320 1330 1340 1350
TQGPLAETTE DFWRMLWEHN STIVVMLTKL REMGREKCHQ YWPAERSARY
1360 1370 1380 1390 1400
QYFVVDPMAE YNMPQYILRE FKVTDARDGQ SRTVRQFQFT DWPEQGVPKS
1410 1420 1430 1440 1450
GEGFIDFIGQ VHKTKEQFGQ DGPISVHCSA GVGRTGVFIT LSIVLERMRY
1460 1470 1480 1490
EGVVDIFQTV KMLRTQRPAM VQTEDQYQFS YRAALEYLGS FDHYAT
Length:1,496
Mass (Da):168,666
Last modified:November 8, 2005 - v1
Checksum:iBB9C92B895E91FE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245202 Genomic DNA. No translation available.
AL137125 Genomic DNA. No translation available.
AL353638 Genomic DNA. No translation available.
AL356584 Genomic DNA. No translation available.
AL445926 Genomic DNA. No translation available.
AL451130 Genomic DNA. No translation available.
AL583805 Genomic DNA. No translation available.
AL590397 Genomic DNA. No translation available.
AL591133 Genomic DNA. No translation available.
AL596451 Genomic DNA. No translation available.
AL669908 Genomic DNA. No translation available.
BC106716 mRNA. Translation: AAI06717.1.
RefSeqiNP_569077.2. NM_130393.3.
XP_006716900.1. XM_006716837.3.
UniGeneiHs.446083.

Genome annotation databases

EnsembliENST00000537002; ENSP00000440515; ENSG00000153707.
ENST00000634498; ENSP00000489264; ENSG00000282932.
GeneIDi5789.
UCSCiuc003zkr.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245202 Genomic DNA. No translation available.
AL137125 Genomic DNA. No translation available.
AL353638 Genomic DNA. No translation available.
AL356584 Genomic DNA. No translation available.
AL445926 Genomic DNA. No translation available.
AL451130 Genomic DNA. No translation available.
AL583805 Genomic DNA. No translation available.
AL590397 Genomic DNA. No translation available.
AL591133 Genomic DNA. No translation available.
AL596451 Genomic DNA. No translation available.
AL669908 Genomic DNA. No translation available.
BC106716 mRNA. Translation: AAI06717.1.
RefSeqiNP_569077.2. NM_130393.3.
XP_006716900.1. XM_006716837.3.
UniGeneiHs.446083.

3D structure databases

SMRiQ3KPI9. Positions 21-599, 915-1490.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000348812.

Proteomic databases

PeptideAtlasiQ3KPI9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000537002; ENSP00000440515; ENSG00000153707.
ENST00000634498; ENSP00000489264; ENSG00000282932.
GeneIDi5789.
UCSCiuc003zkr.4. human.

Organism-specific databases

CTDi5789.
HGNCiHGNC:9668. PTPRD.
PharmGKBiPA34013.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOVERGENiHBG053758.

Miscellaneous databases

ChiTaRSiPTPRD. human.
GenomeRNAii5789.

Gene expression databases

BgeeiENSG00000153707.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF49265. SSF49265. 4 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3KPI9_HUMAN
AccessioniPrimary (citable) accession number: Q3KPI9
Secondary accession number(s): F5GWY7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.