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Protein
Submitted name:

PTPRD protein

Gene

PTPRD

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1137Phosphocysteine intermediatePROSITE-ProRule annotation1
Active sitei1428Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
PTPRD proteinImported
Submitted name:
Receptor-type tyrosine-protein phosphatase deltaImported
Gene namesi
Name:PTPRDImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000153707.15
HGNCiHGNC:9668 PTPRD

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei851 – 874HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000153707
PharmGKBiPA34013

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501458631821 – 1496Sequence analysisAdd BLAST1476

Expressioni

Gene expression databases

BgeeiENSG00000153707

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 114Ig-likeInterPro annotationAdd BLAST91
Domaini126 – 218Ig-likeInterPro annotationAdd BLAST93
Domaini230 – 312Ig-likeInterPro annotationAdd BLAST83
Domaini319 – 409Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini414 – 510Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini512 – 601Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini604 – 690Fibronectin type-IIIInterPro annotationAdd BLAST87
Domaini941 – 1196Tyrosine-protein phosphataseInterPro annotationAdd BLAST256
Domaini1116 – 1187TYR_PHOSPHATASE_2InterPro annotationAdd BLAST72
Domaini1228 – 1487Tyrosine-protein phosphataseInterPro annotationAdd BLAST260
Domaini1405 – 1478TYR_PHOSPHATASE_2InterPro annotationAdd BLAST74

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118900
HOVERGENiHBG053758

Family and domain databases

CDDicd00063 FN3, 4 hits
Gene3Di2.60.40.10, 7 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF07679 I-set, 2 hits
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
SSF49265 SSF49265, 4 hits
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS50835 IG_LIKE, 3 hits
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

Sequencei

Sequence statusi: Complete.

Q3KPI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHVARLLLL LLTFFLRTDA ETPPRFTRTP VDQTGVSGGV ASFICQATGD
60 70 80 90 100
PRPKIVWNKK GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA
110 120 130 140 150
SNNVGEISVS TRLTVLREDQ IPRGFPTIDM GPQLKVVERT RTATMLCAAS
160 170 180 190 200
GNPDPEITWF KDFLPVDTSN NNGRIKQLRS ESIGALQIEQ SEESDQGKYE
210 220 230 240 250
CVATNSAGTR YSAPANLYVR ELREVRRVPP RFSIPPTNHE IMPGGSVNIT
260 270 280 290 300
CVAVGSPMPY VKWMLGAEDL TPEDDMPIGR NVLELNDVRQ SANYTCVAMS
310 320 330 340 350
TLGVIEAIAQ ITVKALPKPP GTPVVTESTA TSITLTWDSG NPEPVSYYII
360 370 380 390 400
QHKPKNSEEL YKEIDGVATT RYSVAGLSPY SDYEFRVVAV NNIGRGPPSE
410 420 430 440 450
PVLTQTSEQA PSSAPRDVQA RMLSSTTILV QWKEPEEPNG QIQGYRVYYT
460 470 480 490 500
MDPTQHVNNW MKHNVADSQI TTIGNLVPQK TYSVKVLAFT SIGDGPLSSD
510 520 530 540 550
IQVITQTGVP GQPLNFKAEP ESETSILLSW TPPRSDTIAN YELVYKDGEH
560 570 580 590 600
GEEQRITIEP GTSYRLQGLK PNSLYYFRLA ARSPQGLGAS TAEISARTMQ
610 620 630 640 650
STVFAKNFHV KAVMKTSVLL SWEIPENYNS AMPFKILYDD GKMVEEVDGR
660 670 680 690 700
ATQKLIVNLK PEKSYSFVLT NRGNSAGGLQ HRVTAKTAPD VLRTKPAFIG
710 720 730 740 750
KTNLDGMITV QLPEVPANEN IKGYYIIIVP LKKSRGKFIK PWESPDEMEL
760 770 780 790 800
DELLKEISRK RRSIRYGREV ELKPYIAAHF DVLPTEFTLG DDKHYGGFTN
810 820 830 840 850
KQLQSGQEYV FFVLAVMEHA ESKMYATSPY SDPVVSMDLD PQPITDEEEG
860 870 880 890 900
LIWVVGPVLA VVFIICIVIA ILLYKRKRAE SDSRKSSIPN NKEIPSHHPT
910 920 930 940 950
DPVELRRLNF QTPGMASHPP IPILELADHI ERLKANDNLK FSQEYESIDP
960 970 980 990 1000
GQQFTWEHSN LEVNKPKNRY ANVIAYDHSR VLLSAIEGIP GSDYVNANYI
1010 1020 1030 1040 1050
DGYRKQNAYI ATQGSLPETF GDFWRMIWEQ RSATVVMMTK LEERSRVKCD
1060 1070 1080 1090 1100
QYWPSRGTET HGLVQVTLLD TVELATYCVR TFALYKNGSS EKREVRQFQF
1110 1120 1130 1140 1150
TAWPDHGVPE HPTPFLAFLR RVKTCNPPDA GPMVVHCSAG VGRTGCFIVI
1160 1170 1180 1190 1200
DAMLERIKHE KTVDIYGHVT LMRAQRNYMV QTEDQYIFIH DALLEAVTCG
1210 1220 1230 1240 1250
NTEVPARNLY AYIQKLTQIE TGENVTGMEL EFKRLASSKA HTSRFISANL
1260 1270 1280 1290 1300
PCNKFKNRLV NIMPYESTRV CLQPIRGVEG SDYINASFID GYRQQKAYIA
1310 1320 1330 1340 1350
TQGPLAETTE DFWRMLWEHN STIVVMLTKL REMGREKCHQ YWPAERSARY
1360 1370 1380 1390 1400
QYFVVDPMAE YNMPQYILRE FKVTDARDGQ SRTVRQFQFT DWPEQGVPKS
1410 1420 1430 1440 1450
GEGFIDFIGQ VHKTKEQFGQ DGPISVHCSA GVGRTGVFIT LSIVLERMRY
1460 1470 1480 1490
EGVVDIFQTV KMLRTQRPAM VQTEDQYQFS YRAALEYLGS FDHYAT
Length:1,496
Mass (Da):168,666
Last modified:November 8, 2005 - v1
Checksum:iBB9C92B895E91FE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245202 Genomic DNA No translation available.
AL137125 Genomic DNA No translation available.
AL353638 Genomic DNA No translation available.
AL356584 Genomic DNA No translation available.
AL445926 Genomic DNA No translation available.
AL451130 Genomic DNA No translation available.
AL583805 Genomic DNA No translation available.
AL590397 Genomic DNA No translation available.
AL591133 Genomic DNA No translation available.
AL596451 Genomic DNA No translation available.
AL669908 Genomic DNA No translation available.
BC106716 mRNA Translation: AAI06717.1
RefSeqiNP_569077.2, NM_130393.3
XP_006716900.1, XM_006716837.3
UniGeneiHs.446083

Genome annotation databases

EnsembliENST00000537002; ENSP00000440515; ENSG00000153707
ENST00000634498; ENSP00000489264; ENSG00000282932
GeneIDi5789
UCSCiuc003zkr.4 human

Similar proteinsi

Entry informationi

Entry nameiQ3KPI9_HUMAN
AccessioniPrimary (citable) accession number: Q3KPI9
Secondary accession number(s): F5GWY7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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