Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Carcinoembryonic antigen-related cell adhesion molecule 21

Gene

CEACAM21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 21
Gene namesi
ORF Names:UNQ3098/PRO10075
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000007129.17.
HGNCiHGNC:28834. CEACAM21.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini35 – 240ExtracellularSequence analysisAdd BLAST206
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 293CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi90273.
PharmGKBiPA142672135.

Polymorphism and mutation databases

BioMutaiCEACAM21.
DMDMi156630480.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000029761535 – 293Carcinoembryonic antigen-related cell adhesion molecule 21Add BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi166 ↔ 214PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3KPI0.
PRIDEiQ3KPI0.
TopDownProteomicsiQ3KPI0-2. [Q3KPI0-2]

PTM databases

iPTMnetiQ3KPI0.
PhosphoSitePlusiQ3KPI0.

Expressioni

Gene expression databases

BgeeiENSG00000007129.
CleanExiHS_CEACAM21.
ExpressionAtlasiQ3KPI0. baseline and differential.
GenevisibleiQ3KPI0. HS.

Organism-specific databases

HPAiHPA043411.

Interactioni

Protein-protein interaction databases

BioGridi124686. 48 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ3KPI0.
SMRiQ3KPI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini147 – 231Ig-like C2-typeAdd BLAST85

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9PH. Eukaryota.
ENOG4111D5D. LUCA.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ3KPI0.
KOiK06499.
OrthoDBiEOG091G0AMM.
PhylomeDBiQ3KPI0.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
PfamiView protein in Pfam
PF00047. ig. 1 hit.
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3KPI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPPSACPHR ECIPWQGLLL TASLLTFWNA PTTAWLFIAS APFEVAEGEN
60 70 80 90 100
VHLSVVYLPE NLYSYGWYKG KTVEPNQLIA AYVIDTHVRT PGPAYSGRET
110 120 130 140 150
ISPSGDLHFQ NVTLEDTGYY TLQVTYRNSQ IEQASHHLRV YESVAQPSIQ
160 170 180 190 200
ASSTTVTEKG SVVLTCHTNN TGTSFQWIFN NQRLQVTKRM KLSWFNHMLT
210 220 230 240 250
IDPIRQEDAG EYQCEVSNPV SSNRSDPLKL TVKSDDNTLG ILIGVLVGSL
260 270 280 290
LVAALVCFLL LRKTGRASDQ SDFREQQPPA STPGHGPSDS SIS
Length:293
Mass (Da):32,373
Last modified:August 21, 2007 - v2
Checksum:iE1B159DFB2A35448
GO
Isoform 2 (identifier: Q3KPI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-235: SD → Y

Show »
Length:292
Mass (Da):32,334
Checksum:i942860178935946F
GO
Isoform 3 (identifier: Q3KPI0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-293: ESVAQPSIQA...GHGPSDSSIS → GECSKFDSEI...PQSQRRAPWS

Show »
Length:191
Mass (Da):21,511
Checksum:i169BD02A7BEC9D52
GO

Sequence cautioni

Q3KPI0: The sequence AAC34569 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034651121T → N2 PublicationsCorresponds to variant dbSNP:rs714106Ensembl.1
Natural variantiVAR_034652198M → V2 PublicationsCorresponds to variant dbSNP:rs2302188Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027303142 – 293ESVAQ…DSSIS → GECSKFDSEISEDAAWPQDT FCWSLYPQSQWLSPPSKPAA PQSQRRAPWS in isoform 3. 1 PublicationAdd BLAST152
Alternative sequenceiVSP_027304234 – 235SD → Y in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358084 mRNA. Translation: AAQ88451.1.
AC006129 Genomic DNA. No translation available.
AC005626 Genomic DNA. Translation: AAC34569.1. Sequence problems.
BC012001 mRNA. Translation: AAH12001.1.
BC106727 mRNA. Translation: AAI06728.1.
CCDSiCCDS46086.1. [Q3KPI0-1]
CCDS46087.1. [Q3KPI0-2]
RefSeqiNP_001091976.3. NM_001098506.3.
NP_001275702.2. NM_001288773.2.
NP_001277042.1. NM_001290113.1.
NP_291021.4. NM_033543.5.
XP_005278453.1. XM_005278396.4.
XP_005278454.1. XM_005278397.3.
UniGeneiHs.655885.

Genome annotation databases

EnsembliENST00000187608; ENSP00000187608; ENSG00000007129.
ENST00000401445; ENSP00000385739; ENSG00000007129.
ENST00000457737; ENSP00000390697; ENSG00000007129.
ENST00000611554; ENSP00000483598; ENSG00000278565.
GeneIDi90273.
KEGGihsa:90273.
UCSCiuc002ore.5. human. [Q3KPI0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCEA21_HUMAN
AccessioniPrimary (citable) accession number: Q3KPI0
Secondary accession number(s): B7WNQ6
, O75296, Q6UY47, Q96ER7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: October 25, 2017
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families