Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Carcinoembryonic antigen-related cell adhesion molecule 21

Gene

CEACAM21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 21
Gene namesi
ORF Names:UNQ3098/PRO10075
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28834. CEACAM21.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 240206ExtracellularSequence analysisAdd
BLAST
Transmembranei241 – 26121HelicalSequence analysisAdd
BLAST
Topological domaini262 – 29332CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672135.

Polymorphism and mutation databases

BioMutaiCEACAM21.
DMDMi156630480.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence analysisAdd
BLAST
Chaini35 – 293259Carcinoembryonic antigen-related cell adhesion molecule 21PRO_0000297615Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence analysis
Disulfide bondi166 ↔ 214PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3KPI0.
PRIDEiQ3KPI0.
TopDownProteomicsiQ3KPI0-2. [Q3KPI0-2]

PTM databases

iPTMnetiQ3KPI0.
PhosphoSiteiQ3KPI0.

Expressioni

Gene expression databases

BgeeiENSG00000007129.
CleanExiHS_CEACAM21.
ExpressionAtlasiQ3KPI0. baseline and differential.
GenevisibleiQ3KPI0. HS.

Organism-specific databases

HPAiHPA043411.

Interactioni

Protein-protein interaction databases

BioGridi124686. 46 interactions.
STRINGi9606.ENSP00000385739.

Structurei

3D structure databases

ProteinModelPortaliQ3KPI0.
SMRiQ3KPI0. Positions 34-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini147 – 23185Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9PH. Eukaryota.
ENOG4111D5D. LUCA.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ3KPI0.
KOiK06499.
OrthoDBiEOG091G0AMM.
PhylomeDBiQ3KPI0.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3KPI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPPSACPHR ECIPWQGLLL TASLLTFWNA PTTAWLFIAS APFEVAEGEN
60 70 80 90 100
VHLSVVYLPE NLYSYGWYKG KTVEPNQLIA AYVIDTHVRT PGPAYSGRET
110 120 130 140 150
ISPSGDLHFQ NVTLEDTGYY TLQVTYRNSQ IEQASHHLRV YESVAQPSIQ
160 170 180 190 200
ASSTTVTEKG SVVLTCHTNN TGTSFQWIFN NQRLQVTKRM KLSWFNHMLT
210 220 230 240 250
IDPIRQEDAG EYQCEVSNPV SSNRSDPLKL TVKSDDNTLG ILIGVLVGSL
260 270 280 290
LVAALVCFLL LRKTGRASDQ SDFREQQPPA STPGHGPSDS SIS
Length:293
Mass (Da):32,373
Last modified:August 21, 2007 - v2
Checksum:iE1B159DFB2A35448
GO
Isoform 2 (identifier: Q3KPI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-235: SD → Y

Show »
Length:292
Mass (Da):32,334
Checksum:i942860178935946F
GO
Isoform 3 (identifier: Q3KPI0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-293: ESVAQPSIQA...GHGPSDSSIS → GECSKFDSEI...PQSQRRAPWS

Show »
Length:191
Mass (Da):21,511
Checksum:i169BD02A7BEC9D52
GO

Sequence cautioni

The sequence AAC34569 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti121 – 1211T → N.2 Publications
Corresponds to variant rs714106 [ dbSNP | Ensembl ].
VAR_034651
Natural varianti198 – 1981M → V.2 Publications
Corresponds to variant rs2302188 [ dbSNP | Ensembl ].
VAR_034652

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei142 – 293152ESVAQ…DSSIS → GECSKFDSEISEDAAWPQDT FCWSLYPQSQWLSPPSKPAA PQSQRRAPWS in isoform 3. 1 PublicationVSP_027303Add
BLAST
Alternative sequencei234 – 2352SD → Y in isoform 2. 1 PublicationVSP_027304

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358084 mRNA. Translation: AAQ88451.1.
AC006129 Genomic DNA. No translation available.
AC005626 Genomic DNA. Translation: AAC34569.1. Sequence problems.
BC012001 mRNA. Translation: AAH12001.1.
BC106727 mRNA. Translation: AAI06728.1.
CCDSiCCDS46086.1. [Q3KPI0-1]
CCDS46087.1. [Q3KPI0-2]
RefSeqiNP_001091976.3. NM_001098506.3.
NP_001275702.2. NM_001288773.2.
NP_001277042.1. NM_001290113.1.
NP_291021.4. NM_033543.5.
XP_005278453.1. XM_005278396.4.
XP_005278454.1. XM_005278397.3.
UniGeneiHs.655885.

Genome annotation databases

EnsembliENST00000187608; ENSP00000187608; ENSG00000007129.
ENST00000401445; ENSP00000385739; ENSG00000007129.
ENST00000457737; ENSP00000390697; ENSG00000007129.
ENST00000611554; ENSP00000483598; ENSG00000278565.
GeneIDi90273.
KEGGihsa:90273.
UCSCiuc002ore.5. human. [Q3KPI0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358084 mRNA. Translation: AAQ88451.1.
AC006129 Genomic DNA. No translation available.
AC005626 Genomic DNA. Translation: AAC34569.1. Sequence problems.
BC012001 mRNA. Translation: AAH12001.1.
BC106727 mRNA. Translation: AAI06728.1.
CCDSiCCDS46086.1. [Q3KPI0-1]
CCDS46087.1. [Q3KPI0-2]
RefSeqiNP_001091976.3. NM_001098506.3.
NP_001275702.2. NM_001288773.2.
NP_001277042.1. NM_001290113.1.
NP_291021.4. NM_033543.5.
XP_005278453.1. XM_005278396.4.
XP_005278454.1. XM_005278397.3.
UniGeneiHs.655885.

3D structure databases

ProteinModelPortaliQ3KPI0.
SMRiQ3KPI0. Positions 34-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124686. 46 interactions.
STRINGi9606.ENSP00000385739.

PTM databases

iPTMnetiQ3KPI0.
PhosphoSiteiQ3KPI0.

Polymorphism and mutation databases

BioMutaiCEACAM21.
DMDMi156630480.

Proteomic databases

PaxDbiQ3KPI0.
PRIDEiQ3KPI0.
TopDownProteomicsiQ3KPI0-2. [Q3KPI0-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000187608; ENSP00000187608; ENSG00000007129.
ENST00000401445; ENSP00000385739; ENSG00000007129.
ENST00000457737; ENSP00000390697; ENSG00000007129.
ENST00000611554; ENSP00000483598; ENSG00000278565.
GeneIDi90273.
KEGGihsa:90273.
UCSCiuc002ore.5. human. [Q3KPI0-1]

Organism-specific databases

CTDi90273.
GeneCardsiCEACAM21.
HGNCiHGNC:28834. CEACAM21.
HPAiHPA043411.
neXtProtiNX_Q3KPI0.
PharmGKBiPA142672135.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9PH. Eukaryota.
ENOG4111D5D. LUCA.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ3KPI0.
KOiK06499.
OrthoDBiEOG091G0AMM.
PhylomeDBiQ3KPI0.
TreeFamiTF336859.

Miscellaneous databases

ChiTaRSiCEACAM21. human.
GenomeRNAii90273.
PROiQ3KPI0.

Gene expression databases

BgeeiENSG00000007129.
CleanExiHS_CEACAM21.
ExpressionAtlasiQ3KPI0. baseline and differential.
GenevisibleiQ3KPI0. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCEA21_HUMAN
AccessioniPrimary (citable) accession number: Q3KPI0
Secondary accession number(s): B7WNQ6
, O75296, Q6UY47, Q96ER7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.