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Protein

Carcinoembryonic antigen-related cell adhesion molecule 21

Gene

CEACAM21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 21
Gene namesi
ORF Names:UNQ3098/PRO10075
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000007129.17
HGNCiHGNC:28834 CEACAM21
neXtProtiNX_Q3KPI0

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini35 – 240ExtracellularSequence analysisAdd BLAST206
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 293CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi90273
PharmGKBiPA142672135

Polymorphism and mutation databases

BioMutaiCEACAM21
DMDMi156630480

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000029761535 – 293Carcinoembryonic antigen-related cell adhesion molecule 21Add BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi166 ↔ 214PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3KPI0
PRIDEiQ3KPI0
TopDownProteomicsiQ3KPI0-2 [Q3KPI0-2]

PTM databases

iPTMnetiQ3KPI0
PhosphoSitePlusiQ3KPI0

Expressioni

Gene expression databases

BgeeiENSG00000007129
CleanExiHS_CEACAM21
ExpressionAtlasiQ3KPI0 baseline and differential
GenevisibleiQ3KPI0 HS

Organism-specific databases

HPAiHPA043411

Interactioni

Protein-protein interaction databases

BioGridi124686, 48 interactors

Structurei

3D structure databases

ProteinModelPortaliQ3KPI0
SMRiQ3KPI0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini147 – 231Ig-like C2-typeAdd BLAST85

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9PH Eukaryota
ENOG4111D5D LUCA
HOGENOMiHOG000233417
HOVERGENiHBG007922
InParanoidiQ3KPI0
KOiK06499
OrthoDBiEOG091G0AMM
PhylomeDBiQ3KPI0
TreeFamiTF336859

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3KPI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPPSACPHR ECIPWQGLLL TASLLTFWNA PTTAWLFIAS APFEVAEGEN
60 70 80 90 100
VHLSVVYLPE NLYSYGWYKG KTVEPNQLIA AYVIDTHVRT PGPAYSGRET
110 120 130 140 150
ISPSGDLHFQ NVTLEDTGYY TLQVTYRNSQ IEQASHHLRV YESVAQPSIQ
160 170 180 190 200
ASSTTVTEKG SVVLTCHTNN TGTSFQWIFN NQRLQVTKRM KLSWFNHMLT
210 220 230 240 250
IDPIRQEDAG EYQCEVSNPV SSNRSDPLKL TVKSDDNTLG ILIGVLVGSL
260 270 280 290
LVAALVCFLL LRKTGRASDQ SDFREQQPPA STPGHGPSDS SIS
Length:293
Mass (Da):32,373
Last modified:August 21, 2007 - v2
Checksum:iE1B159DFB2A35448
GO
Isoform 2 (identifier: Q3KPI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-235: SD → Y

Show »
Length:292
Mass (Da):32,334
Checksum:i942860178935946F
GO
Isoform 3 (identifier: Q3KPI0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-293: ESVAQPSIQA...GHGPSDSSIS → GECSKFDSEI...PQSQRRAPWS

Show »
Length:191
Mass (Da):21,511
Checksum:i169BD02A7BEC9D52
GO

Sequence cautioni

The sequence AAC34569 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034651121T → N2 PublicationsCorresponds to variant dbSNP:rs714106Ensembl.1
Natural variantiVAR_034652198M → V2 PublicationsCorresponds to variant dbSNP:rs2302188Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027303142 – 293ESVAQ…DSSIS → GECSKFDSEISEDAAWPQDT FCWSLYPQSQWLSPPSKPAA PQSQRRAPWS in isoform 3. 1 PublicationAdd BLAST152
Alternative sequenceiVSP_027304234 – 235SD → Y in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358084 mRNA Translation: AAQ88451.1
AC006129 Genomic DNA No translation available.
AC005626 Genomic DNA Translation: AAC34569.1 Sequence problems.
BC012001 mRNA Translation: AAH12001.1
BC106727 mRNA Translation: AAI06728.1
CCDSiCCDS46086.1 [Q3KPI0-1]
CCDS46087.1 [Q3KPI0-2]
RefSeqiNP_001091976.3, NM_001098506.3
NP_001275702.2, NM_001288773.2
NP_001277042.1, NM_001290113.1
NP_291021.4, NM_033543.5
XP_005278453.1, XM_005278396.4
XP_005278454.1, XM_005278397.3
UniGeneiHs.655885

Genome annotation databases

EnsembliENST00000187608; ENSP00000187608; ENSG00000007129
ENST00000401445; ENSP00000385739; ENSG00000007129
ENST00000457737; ENSP00000390697; ENSG00000007129
ENST00000611554; ENSP00000483598; ENSG00000278565
GeneIDi90273
KEGGihsa:90273
UCSCiuc002ore.5 human [Q3KPI0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCEA21_HUMAN
AccessioniPrimary (citable) accession number: Q3KPI0
Secondary accession number(s): B7WNQ6
, O75296, Q6UY47, Q96ER7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: April 25, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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